Prkg2 (protein kinase cGMP-dependent 2) - Rat Genome Database

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Gene: Prkg2 (protein kinase cGMP-dependent 2) Rattus norvegicus
Analyze
Symbol: Prkg2
Name: protein kinase cGMP-dependent 2
RGD ID: 3401
Description: Enables cGMP-dependent protein kinase activity and identical protein binding activity. Involved in several processes, including negative regulation of chloride transport; peptidyl-serine autophosphorylation; and positive regulation of chondrocyte differentiation. Located in nuclear membrane. Biomarker of withdrawal disorder. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2); PARTICIPATES IN long term depression; INTERACTS WITH 17beta-estradiol 3-benzoate; 3,4-methylenedioxymethamphetamine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGK 2; cGK2; cGKII; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; GDPKII; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; protein kinase, cGMP-dependent, type II; type II cGMP-dependent protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   KMI/Tky  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81410,864,020 - 10,972,617 (+)NCBIGRCr8
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1410,540,037 - 10,640,477 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01411,839,852 - 11,940,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01410,529,813 - 10,630,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aldehydo-D-glucose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
FR900359  (ISO)
glucose  (ISO)
glyphosate  (EXP)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methylphenidate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
palytoxin  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
tadalafil  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
venlafaxine hydrochloride  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24.
3. ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. Fürst J, etal., J Biol Chem. 2005 Sep 2;280(35):31276-82. Epub 2005 May 19.
4. Inhibition of cGMP-dependent protein kinase II by its own splice isoform. Gambaryan S, etal., Biochem Biophys Res Commun 2002 May 24;293(5):1438-44.
5. cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. Gambaryan S, etal., J Biol Chem 2003 Aug 8;278(32):29640-8. Epub 2003 May 29.
6. Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Golin-Bisello F, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C708-16. Epub 2005 May 4.
10. Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Jarchau T, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9426-30.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.
21. Autophosphorylation of cGMP-dependent protein kinase type II. Vaandrager AB, etal., J Biol Chem 2003 Aug 1;278(31):28651-8. Epub 2003 May 22.
22. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23.
Additional References at PubMed
PMID:12725729   PMID:14960318   PMID:15312652   PMID:15582712   PMID:15763176   PMID:15958724   PMID:17341596   PMID:17626895   PMID:18656450   PMID:22203739   PMID:23545413   PMID:24966379  
PMID:28057484  


Genomics

Comparative Map Data
Prkg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81410,864,020 - 10,972,617 (+)NCBIGRCr8
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1410,540,037 - 10,640,477 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01411,839,852 - 11,940,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01410,529,813 - 10,630,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
PRKG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38481,087,370 - 81,217,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl481,087,370 - 81,215,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37482,008,524 - 82,136,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,228,861 - 82,345,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 34482,367,015 - 82,483,394NCBI
Celera479,302,549 - 79,418,932 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef477,753,401 - 77,870,008 (-)NCBIHuRef
CHM1_1481,986,323 - 82,102,706 (-)NCBICHM1_1
T2T-CHM13v2.0484,417,063 - 84,547,534 (-)NCBIT2T-CHM13v2.0
Prkg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,077,632 - 99,185,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl599,077,632 - 99,185,210 (-)EnsemblGRCm39 Ensembl
GRCm38598,929,773 - 99,037,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37599,358,792 - 99,466,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36599,171,570 - 99,277,381 (-)NCBIMGSCv36mm8
Celera596,252,278 - 96,360,518 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.35NCBI
Prkg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554335,286,153 - 5,491,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554335,286,594 - 5,387,571 (-)NCBIChiLan1.0ChiLan1.0
PRKG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2348,855,500 - 48,982,421 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1449,044,222 - 49,172,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0442,987,217 - 43,114,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1448,836,953 - 48,960,383 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl448,836,953 - 48,960,383 (+)Ensemblpanpan1.1panPan2
PRKG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,266,435 - 5,365,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,266,442 - 5,365,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,517,409 - 36,617,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,294,681 - 5,395,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,294,693 - 5,395,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,324,348 - 5,424,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,231,256 - 5,331,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03234,635,113 - 34,735,693 (+)NCBIUU_Cfam_GSD_1.0
Prkg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052856,966,547 - 7,070,004 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936749900,208 - 991,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,755,469 - 136,852,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,754,698 - 136,854,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28146,048,858 - 146,148,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1729,511,796 - 29,629,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl729,511,380 - 29,618,330 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660378,011,684 - 8,129,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247579,798,808 - 9,906,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247579,799,777 - 9,904,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkg2
1708 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:44
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000003237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat

Markers in Region
D14Got16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,654,327 - 10,654,483 (+)MAPPERmRatBN7.2
Rnor_6.01412,301,002 - 12,301,157NCBIRnor6.0
Rnor_5.01412,243,454 - 12,243,609UniSTSRnor5.0
RGSC_v3.41411,992,408 - 11,992,564RGDRGSC3.4
RGSC_v3.41411,992,409 - 11,992,564UniSTSRGSC3.4
RGSC_v3.11411,992,408 - 11,992,564RGD
Celera1410,743,200 - 10,743,355UniSTS
RH 2.0 Map14178.6RGD
Cytogenetic Map14p22UniSTS
BE120376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,571,897 - 10,572,086 (+)MAPPERmRatBN7.2
Rnor_6.01412,218,561 - 12,218,749NCBIRnor6.0
Rnor_5.01412,160,818 - 12,161,006UniSTSRnor5.0
RGSC_v3.41411,889,541 - 11,889,729UniSTSRGSC3.4
Celera1410,668,115 - 10,668,303UniSTS
Cytogenetic Map14p22UniSTS
RH137660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,666,550 - 10,666,727 (+)MAPPERmRatBN7.2
Rnor_6.01412,313,279 - 12,313,455NCBIRnor6.0
Rnor_5.01412,255,657 - 12,255,833UniSTSRnor5.0
RGSC_v3.41412,005,210 - 12,005,386UniSTSRGSC3.4
Celera1410,755,499 - 10,755,675UniSTS
Cytogenetic Map14p22UniSTS


Related Rat Strains
The following Strains have been annotated to Prkg2
KMI/Tky    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 46 112 52 50 21 21 21 6 173 90 92 45 56 29

Sequence


Ensembl Acc Id: ENSRNOT00000003237   ⟹   ENSRNOP00000003237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)Ensembl
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)Ensembl
RefSeq Acc Id: NM_013012   ⟹   NP_037144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81410,864,020 - 10,971,056 (+)NCBI
mRatBN7.21410,559,882 - 10,666,918 (+)NCBI
Rnor_6.01412,217,121 - 12,313,616 (+)NCBI
Rnor_5.01412,159,378 - 12,255,994 (+)NCBI
RGSC_v3.41411,888,101 - 12,005,547 (+)RGD
Celera1410,666,687 - 10,755,836 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091638   ⟹   XP_038947566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81410,864,132 - 10,972,617 (+)NCBI
mRatBN7.21410,560,003 - 10,668,479 (+)NCBI
RefSeq Acc Id: XM_063272876   ⟹   XP_063128946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81410,864,132 - 10,932,871 (+)NCBI
RefSeq Acc Id: XM_063272877   ⟹   XP_063128947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81410,930,835 - 10,972,617 (+)NCBI
RefSeq Acc Id: NP_037144   ⟸   NM_013012
- UniProtKB: Q64595 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003237   ⟸   ENSRNOT00000003237
RefSeq Acc Id: XP_038947566   ⟸   XM_039091638
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128946   ⟸   XM_063272876
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128947   ⟸   XM_063272877
- Peptide Label: isoform X3
Protein Domains
AGC-kinase C-terminal   Cyclic nucleotide-binding   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64595-F1-model_v2 AlphaFold Q64595 1-762 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3401 AgrOrtholog
BioCyc Gene G2FUF-16367 BioCyc
Ensembl Genes ENSRNOG00000002361 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055006240 UniProtKB/Swiss-Prot
  ENSRNOG00060023270 UniProtKB/Swiss-Prot
  ENSRNOG00065018715 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003237.5 UniProtKB/Swiss-Prot
  ENSRNOT00055010131 UniProtKB/Swiss-Prot
  ENSRNOT00060040299 UniProtKB/Swiss-Prot
  ENSRNOT00065031441 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  cGMP_dep_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_cGK UniProtKB/Swiss-Prot
KEGG Report rno:25523 UniProtKB/Swiss-Prot
NCBI Gene 25523 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24353:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Prkg2 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/Swiss-Prot
PRINTS CGMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002361 RatGTEx
  ENSRNOG00055006240 RatGTEx
  ENSRNOG00060023270 RatGTEx
  ENSRNOG00065018715 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP cAMP-binding domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC234258
UniProt A6K641_RAT UniProtKB/TrEMBL
  KGP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-27 Prkg2  protein kinase cGMP-dependent 2  Prkg2  protein kinase, cGMP-dependent, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Prkg2  protein kinase, cGMP-dependent, type II    protein kinase, cGMP- dependent, type II  Name updated 1299863 APPROVED
2002-06-10 Prkg2  protein kinase, cGMP- dependent, type 2      Symbol and Name status set to approved 70586 APPROVED
2001-10-24 Prkg2  protein kinase, cGMP- dependent, type II      Name updated 68913 APPROVED
2001-10-24 Prkg2  protein kinase, cAMP- dependent, type II      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in intestinal mucosa and in kidney juxtaglomerular cells, ascending thin limb of Henles loop, and brush border of proximal tubules 61502
gene_process involved in the osmotic changes regulating granule swelling and exocytosis in intestinal brush border 61502
gene_process may have a role in regulating renin release 61502