Padi1 (peptidyl arginine deiminase 1)

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Gene: Padi1 (peptidyl arginine deiminase 1) Rattus norvegicus

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Symbol:

Padi1

Name:

peptidyl arginine deiminase 1

RGD ID:

3287

Description:

Enables protein-arginine deiminase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI1 (peptidyl arginine deiminase 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

PAD-R11; Pdi1; peptidyl arginine deiminase type I; peptidyl arginine deiminase, type 1; peptidyl arginine deiminase, type I; peptidylarginine deiminase I; protein-arginine deiminase type I; protein-arginine deiminase type-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PADI1 (peptidyl arginine deiminase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Padi1 (peptidyl arginine deiminase, type I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Padi1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PADI1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PADI1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Padi1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PADI1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PADI1 (peptidyl arginine deiminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Padi1 (peptidyl arginine deiminase, type I)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PADI1 (peptidyl arginine deiminase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	padi2 (peptidyl arginine deiminase, type II)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	padi2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	creb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	158,402,614 - 158,435,077 (-)	NCBI		GRCr8
mRatBN7.2	5	153,119,566 - 153,152,034 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	153,119,566 - 153,152,034 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	155,808,770 - 155,842,124 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	157,583,072 - 157,615,507 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	157,571,691 - 157,604,213 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	159,338,850 - 159,371,313 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	159,338,850 - 159,371,313 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	163,045,278 - 163,077,738 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	159,671,725 - 159,704,188 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	159,681,912 - 159,714,376 (-)	NCBI
Celera	5	151,477,068 - 151,509,531 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

carbon nanotube (EXP)

cisplatin (ISO)

corosolic acid (ISO)

diazinon (ISO)

diethylstilbestrol (ISO)

folic acid (ISO)

genistein (ISO)

perfluorooctanoic acid (EXP)

propanal (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA)

Molecular Function

calcium ion binding (IEA,ISO,ISS)

histone H1R54 arginine deiminase activity (IEA)

histone H2AR3 arginine deiminase activity (IEA)

histone H3R17 arginine deiminase activity (IEA)

histone H3R2 arginine deiminase activity (IEA)

histone H3R26 arginine deiminase activity (IEA)

histone H3R8 arginine deiminase activity (IEA)

histone H4R3 arginine deiminase activity (IEA)

protein binding (ISO)

protein-arginine deiminase activity (IBA,IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin.	Ishigami A, etal., Arch Biochem Biophys. 2002 Nov 1;407(1):25-31.
3.	Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid-treated culture of a newborn rat keratinocyte cell line.	Ishigami A, etal., FEBS Lett 1998 Aug 14;433(1-2):113-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12416996	PMID:23376485	PMID:27393304

Genomics

Comparative Map Data

Padi1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	158,402,614 - 158,435,077 (-)	NCBI		GRCr8
mRatBN7.2	5	153,119,566 - 153,152,034 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	153,119,566 - 153,152,034 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	155,808,770 - 155,842,124 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	157,583,072 - 157,615,507 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	157,571,691 - 157,604,213 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	159,338,850 - 159,371,313 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	159,338,850 - 159,371,313 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	163,045,278 - 163,077,738 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	159,671,725 - 159,704,188 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	159,681,912 - 159,714,376 (-)	NCBI
Celera	5	151,477,068 - 151,509,531 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

PADI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	17,205,128 - 17,246,007 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	17,205,128 - 17,246,007 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	17,531,623 - 17,572,502 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	17,404,208 - 17,445,088 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	17,276,935 - 17,316,654	NCBI
Celera	1	15,854,608 - 15,895,194 (+)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	15,775,640 - 15,816,163 (+)	NCBI		HuRef
CHM1_1	1	17,640,028 - 17,680,932 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	17,016,414 - 17,057,242 (+)	NCBI		T2T-CHM13v2.0

Padi1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	140,540,292 - 140,573,089 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	140,540,294 - 140,573,089 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	140,812,981 - 140,845,778 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	140,812,983 - 140,845,778 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	140,368,896 - 140,401,693 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	140,085,057 - 140,117,854 (-)	NCBI		MGSCv36	mm8
Celera	4	142,625,585 - 142,659,167 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	72.62	NCBI

Padi1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	1,610,064 - 1,642,379 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	1,610,643 - 1,641,953 (-)	NCBI	ChiLan1.0	ChiLan1.0

PADI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	209,883,230 - 209,923,725 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	209,002,081 - 209,042,579 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	16,150,407 - 16,190,901 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	17,205,538 - 17,245,972 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	17,205,452 - 17,245,972 (+)	Ensembl	panpan1.1		panPan2

PADI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	80,997,563 - 81,036,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	80,996,021 - 81,036,942 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	77,533,555 - 77,574,493 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	81,643,691 - 81,684,606 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	81,643,693 - 81,689,788 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	78,396,618 - 78,437,587 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	79,412,393 - 79,453,539 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	80,482,086 - 80,523,026 (-)	NCBI		UU_Cfam_GSD_1.0

Padi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	38,282,998 - 38,338,780 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	4,134,737 - 4,161,958 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	4,121,948 - 4,163,562 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PADI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	75,830,046 - 75,871,911 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	75,830,053 - 75,871,929 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	70,173,382 - 70,214,300 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PADI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	115,341,430 - 115,388,234 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	115,343,203 - 115,381,634 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	731,523 - 778,340 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Padi1
145 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	156
Interacting mature miRNAs:	186
Transcripts:	ENSRNOT00000009921
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat

Markers in Region

RH134209

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	153,119,584 - 153,119,789 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	159,338,869 - 159,339,073	NCBI	Rnor6.0
Rnor_5.0	5	163,045,297 - 163,045,501	UniSTS	Rnor5.0
RGSC_v3.4	5	159,671,744 - 159,671,948	UniSTS	RGSC3.4
Celera	5	151,477,087 - 151,477,291	UniSTS
RH 3.4 Map	5	1053.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	2	7	18	20	33	9	5	9	5	64	15	12	29	47	24

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB010998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009921 ⟹ ENSRNOP00000009921

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	153,119,566 - 153,152,034 (-)	Ensembl
Rnor_6.0 Ensembl	5	159,338,850 - 159,371,313 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118533 ⟹ ENSRNOP00000092569

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	153,119,566 - 153,152,034 (-)	Ensembl

RefSeq Acc Id:

NM_019332 ⟹ NP_062205

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	158,402,614 - 158,435,077 (-)	NCBI
mRatBN7.2	5	153,119,566 - 153,152,034 (-)	NCBI
Rnor_6.0	5	159,338,850 - 159,371,313 (-)	NCBI
Rnor_5.0	5	163,045,278 - 163,077,738 (-)	NCBI
RGSC_v3.4	5	159,671,725 - 159,704,188 (-)	RGD
Celera	5	151,477,068 - 151,509,531 (-)	RGD

Sequence:

show sequence

ATCAGAACGCACGCTCCTACCCGGCAGCCGGGTGTCCCCAAGAAGAGCTGGGGATCCGGGGCAC
AGCTGAGGCTTGTGGCTGCTGGGTACCCAAGCTGACCCGATCAGGAGACTGGAAGCTGGGCCCA
GGATGGCCTCCCAGCGAGCTGTGCAGCTGTCTCTGAGAAAGCCTGCTCATGCCGTGTGTGTGAT
AGGTGTGGGGACACTGGTGGATGTGTACAGTGATGTGCCCAAAGGCGCCAAGACCTTTGAGGTG
TCCGGGAGCTCTGAGGTGAAGATCTACATGGTCTACGATCCCTCAAGAGTGGCAGAGCCCGCAG
GCCCGGCCCACTGGCCCCTGGATGCCAATGTGGATGTGGTGGTGGTGGCGGACACAGTCAGTAA
GAACTTACACGACCTCAAGGTAAAGGTATCATACTTCAAGTCCCAGGACACTGCCGCCCTGGCC
CACAGCCTTCTCTACCTAACCGCTGTTGATGTGTCCCTTGATGTCGACACAGGCCGCACAGGCA
AGGTGAAGAAAGGCTCTGGTGACAAGAAAAACTGGCGCTGGGGCTCCGGGGGCTCCGGGGCTAT
CCTGTTGGTGAACTGTGACAGAGATGTGCATGGGTCCAGAGAGGACCTGCATGATAGCCATTTG
AGGTCACTGGAGGACCTGCAGGACATGTCCCCAATGGTGTTGAGCTGTGACGGCCCTGATGATC
TTTTTAAGAGCCACAAGCCGGTCTTGAAGGCATCTTTGCCGGATTCCAGAAGACTGGGGGTCTT
TTGTGCCCGGGGTGGGACCTCCCTCTCCAACTACAAACAGGTGCTGGGGCCCCGTCATAACTCC
TATGAGGTGGAAAGGCATCCTGGGGAGAGGGACATTCAGTTCTACGTGGAAGGACTCGCCTTCC
CTGATGCCAGTTTCTCAGGGCTGCTGTCTCTCAGTGTCAGCCTGGTAGACACACGGCCCCTCTC
CGAGGTGTTGGTCTTCACGGACAGCGTGACCTTCCGAGTGGCCCCCTGGATCATGACCCCCAAC
ACCCAGCCGCCCCTGGAACTGTACGTGTGCAGCGTGACAGATATGCATGGCAGCAACGACAAGT
TCTTGGAGGACATGTCCCACCTGGCCACGAAGGCCAACTGCAAACTAGTGGTCTGTCCCCGGCT
AGAGAATCGCAATGATCGATGGATCCAGGATGAGATGGAGTTTGGCTACATTGATGCCCCTCAC
AAATCGTTCCCTGTGGTCTTTGATTCCCCCCGAAACAGAGGCTTGAGGGACTTCGCCCTTAAGA
AGATCCTGGGTCCTGACTTTGGATATGTGACCCGGGAGATCCAGTTCGCAGGTGCCTCTGGCCT
GGATTCCTTCGGCAACCTGGATGTGAGCCCGCCAGTGAGGGTGGGCAACACAGAGTACCCCCTC
GGCAGAATCCTCATCGGTGGCAACTTCCCTAAGTCCAGCGGGCGGCGGATGGCCAGGGTGGTGC
GTGACTTCCTGCATGCCCAGCAGGTGCAGGCTCCGGTGGAACTCTACTCTGACTGGCTCTCCGT
GGGCCACGTGGATGAGTTTCTGAGCTTCGTGCCCACCTCTGACCAAAAGGGCTTCCGGTTACTC
CTGGCCAGCCCCAGCGCCTGCCTCCAGCTGTTCCAGGAGAAGAAGGAGGAGGGCTACGGGGAGG
CCAAGCAGTTTGATGGCCTCAAGCATAAGACAAAGAGAAGCATCAATGACATCTTAGCTGACAG
GCACCTCAGGAGGGACAGTGCACATGTGCAGAAATGCATCGACTGGAACCGTGAGGTGCTAAAA
CAGGAGCTGGGCCTCTCCGAGAGCGACATCGTGGATATTCCACAGCTCTTCTTCCTGAAGGGAG
CCTACGCTGAAGCCTTCTTTCCTGACATGGTCAATATGGTGGTCCTCGGCAAGTACCTGGGCAT
CCCCAAGCCCTTCGGGCCCATCATCAATGGCCGCTGCTGCCTGGAAGAGAAGGTGCGCTCCCTG
CTGGAGCCGCTGGGTCTACGCTGCGTCTTTATCGACGACTTTCTCTTTTACCACCAACTGCTTG
GAGAGATCCATTGTGGCACTAATGTGCGGAGGAAACCTTTTGCCTTTAGGTGGTGGAACTCCGT
GCCCTGAGCCTGCCCGACCACCACCCTCGCTGCCCTGCTGATGAGAACCCCAGAGCAAGGGCAA
GGGCCACGAACCAGCTTCCACCCTCCTGGAGCCTGAAAGCGGACTGACTACTGTGGTCAGCTGG
GCTCCCGGAGGACAACACACTTCTTCGTTTCTGGAGTCGCCTGTCCTGCCCAGGAGACTATTGA
CACTTTTCCTTCACCCTTTCCCAGCCAGAGCCCCCAGAGGGTCAAGGTCGGAAGCTAAGCCTGT
AGGCCACGCCCTACTTTGAGCTGTTTCCCCCCTCCCTTCTGGACACCTCTCTGATGCTGTTTCA
GAAATGCCCACCATGCCAGGACCCTGGGGCACGAACACCATAGTTTCGTATGACTCCTGGATTG
CGCAAGATGAAAAGGAAGATTTGGGGCGTCTTTTTTTCCCAGAGGACCTCAGGCCATGGCCCCC
TGGCACCCTTCAGCTCAACGTAGGCAAACAAAGGCAGGAAATCCCAGTCCTTGAAAGCGGGCAG
GCACAAAAGCCCCTCTAATGCCAAACTCCATCCAGTCCCACCTCTGCAGAATGCTTGTTACCTG
TTGGGGCAGCCTTTAATTACGAGCCCTGGTGCTTCCTGTTGGAAGATGCTTCGGGGCATAGGGA
GGCCCTCGGAAGTCTGCAAGCGTGGGTGGGGGTGGGGAAGGGTGGGCAGGAAGGTCGCACCAGG
AAGGCAGAGAGGTTGCCCATCTCGGGGTGGGGGAACCTCGAAGCCTGGAACTCTTGGCTGGGTG
TTTGGGGCCCCTGAACCTGACGGCTGTTGGTCCAGATGTGAAGGGGATGGGGCCCAAGGTATTA
GAAGATGGTGGGGTAGGCCATTAAGTTACATCTGGAGGTGAGGCTTAATTTCCTCTAATAGTCT
CTAATTACTCCCTAACCTGCTGCAGGCAGTGGGAGGGGAGGGCCCACACTCCCCCAGCAGCCTG
GGACCCTACACAACACTTGTACAGCCCCAGTAAACCCCATGGCAGGCCTGTGTCCCCCCTCCCA
CAGTAGGACAGACAGCTGGCCTGGAGGCTAATAGCATTGGGTGAGGTCACAGAGACATGTGTCG
GCAAGCAGGCAGGCCAACCGGCTGCAGGGCACGGCTGGCAGAGGCTTCCTCTGGTCAAGGAGCC
ACAACAGGCTGCTGGATTCTGTCTTTGTATTTTGGTAGCTTCTGGTGCCACCCCTGACTTGAGG
CAGCTGCTGTCACTTGGTAACCACTGGACACTTAGTTAGCAAAGGCTTCCTTGGAGCTGTTAGG
ATAGGCATGGCCAGGTAGACATTGGCTCTTCCCCCTTCCAGAAGGTTCTGTGGAACTGGAACCC
CCATTTGTAGGCTCCCCACACCAACACCCTCCTCTATGATCATGGCCTGGCTGAGGTTAAGCCA
TGGAGAAGGAGAAGAAGAAGAAGATAAAGGGGGATGAGAAGGTTGGGGGCGGGGCCTGGCCTCT
GAAGACTCAGGAGACTGACTACAGAGCCTCGGCAAGCATGGGAGCAAGTCTTCTGCGCCACATG
AGGTGGGCTCTGGAGTCGCTACTCAGACCGTCTGGGGGCCTGGCTGACTGGCCACCCTCTCCCT
CATCAATTAAAAACATCGTTGTGCATTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_062205	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA32099	(Get FASTA)	NCBI Sequence Viewer
	EDL80947	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009921.1
	ENSRNOP00000092569.1
GenBank Protein	O88806	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062205 ⟸ NM_019332

- UniProtKB:

O88806 (UniProtKB/Swiss-Prot), A6ITP6 (UniProtKB/TrEMBL), G3V6Y0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASQRAVQLSLRKPAHAVCVIGVGTLVDVYSDVPKGAKTFEVSGSSEVKIYMVYDPSRVAEPAG
PAHWPLDANVDVVVVADTVSKNLHDLKVKVSYFKSQDTAALAHSLLYLTAVDVSLDVDTGRTGK
VKKGSGDKKNWRWGSGGSGAILLVNCDRDVHGSREDLHDSHLRSLEDLQDMSPMVLSCDGPDDL
FKSHKPVLKASLPDSRRLGVFCARGGTSLSNYKQVLGPRHNSYEVERHPGERDIQFYVEGLAFP
DASFSGLLSLSVSLVDTRPLSEVLVFTDSVTFRVAPWIMTPNTQPPLELYVCSVTDMHGSNDKF
LEDMSHLATKANCKLVVCPRLENRNDRWIQDEMEFGYIDAPHKSFPVVFDSPRNRGLRDFALKK
ILGPDFGYVTREIQFAGASGLDSFGNLDVSPPVRVGNTEYPLGRILIGGNFPKSSGRRMARVVR
DFLHAQQVQAPVELYSDWLSVGHVDEFLSFVPTSDQKGFRLLLASPSACLQLFQEKKEEGYGEA
KQFDGLKHKTKRSINDILADRHLRRDSAHVQKCIDWNREVLKQELGLSESDIVDIPQLFFLKGA
YAEAFFPDMVNMVVLGKYLGIPKPFGPIINGRCCLEEKVRSLLEPLGLRCVFIDDFLFYHQLLG
EIHCGTNVRRKPFAFRWWNSVP

hide sequence

Ensembl Acc Id:

ENSRNOP00000009921 ⟸ ENSRNOT00000009921

Ensembl Acc Id:

ENSRNOP00000092569 ⟸ ENSRNOT00000118533

Protein Domains

Protein-arginine deiminase (PAD) central Protein-arginine deiminase (PAD) N-terminal Protein-arginine deiminase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88806-F1-model_v2	AlphaFold	O88806	1-662	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3287	AgrOrtholog
BioCyc Gene	G2FUF-39384	BioCyc
BioCyc Pathway	PWY-4921 [protein citrullination]	BioCyc
BioCyc Pathway Image	PWY-4921	BioCyc
Ensembl Genes	ENSRNOG00000007067	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009921.3	UniProtKB/TrEMBL
	ENSRNOT00000118533.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.1700	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.1860	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cupredoxin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_central_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_Arg_deaminase_cen_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:54282	UniProtKB/Swiss-Prot
NCBI Gene	54282	ENTREZGENE
PANTHER	PROTEIN-ARGININE DEIMINASE TYPE-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10837	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_M	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Padi1	PhenoGen
PIRSF	Protein-arginine_deiminase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007067	RatGTEx
Superfamily-SCOP	Pentein	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF110083	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49503	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC221075
UniProt	A0A8I6GK86_RAT	UniProtKB/TrEMBL
	A6ITP6	ENTREZGENE, UniProtKB/TrEMBL
	G3V6Y0	ENTREZGENE, UniProtKB/TrEMBL
	O88806	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-14	Padi1	peptidyl arginine deiminase 1	Padi1	peptidyl arginine deiminase, type I	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Padi1	peptidyl arginine deiminase, type I	Pdi1	peptidyl arginine deiminase, type 1	Symbol and Name updated	1299863	APPROVED
2002-06-10	Pdi1	peptidyl arginine deiminase, type 1			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	member of a family of peptidylarginine deiminases	69924

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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