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Gene: Nxph1 (neurexophilin 1) Rattus norvegicus

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Symbol:

Nxph1

Name:

neurexophilin 1

RGD ID:

3218

Description:

Predicted to enable signaling receptor binding activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be located in extracellular region. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and synaptic cleft. Orthologous to human NXPH1 (neurexophilin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC124635; neurexophilin-1; neurophilin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NXPH1 (neurexophilin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Nxph1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nxph1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NXPH1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NXPH1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nxph1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NXPH1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NXPH1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nxph1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nxph1 (neurexophilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ANAPC10 (anaphase promoting complex subunit 10)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Nxph1 (neurexophilin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nxph1 (neurexophilin 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NXPH1 (neurexophilin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NXPH1 (neurexophilin 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nxph1 (neurexophilin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nxph1 (neurexophilin 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nxph1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nxph1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	37,964,325 - 38,277,364 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	38,223,093 - 38,277,172 (+)	Ensembl				GRCr8
mRatBN7.2	4	36,998,068 - 37,311,135 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	36,997,669 - 37,311,132 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	41,960,430 - 42,273,235 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	37,886,650 - 38,199,435 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	36,290,119 - 36,602,927 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	34,959,721 - 35,281,017 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	35,279,063 - 35,281,013 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	34,816,883 - 35,142,708 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	34,024,058 - 34,339,465 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	32,482,516 - 32,794,851 (+)	NCBI		Celera
RGSC_v3.1	4	34,143,518 - 34,457,332 (+)	NCBI
Cytogenetic Map	4	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

choline (ISO)

crocidolite asbestos (ISO)

dimethylarsinic acid (EXP)

epoxiconazole (ISO)

fenamidone (ISO)

folic acid (ISO)

genistein (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

niclosamide (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

Soman (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

modulation of chemical synaptic transmission (ISO)

Cellular Component

extracellular region (IEA)

GABA-ergic synapse (ISO)

glutamatergic synapse (ISO)

synaptic cleft (ISO)

Molecular Function

signaling receptor binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.	Clarris HJ, etal., Int J Dev Biol 2002;46(4):649-52.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Structure and evolution of neurexophilin.	Petrenko AG, etal., J Neurosci 1996 Jul 15;16(14):4360-9.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:9856994	PMID:12477932	PMID:25157101	PMID:25420124

Genomics

Comparative Map Data

Nxph1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	37,964,325 - 38,277,364 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	38,223,093 - 38,277,172 (+)	Ensembl				GRCr8
mRatBN7.2	4	36,998,068 - 37,311,135 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	36,997,669 - 37,311,132 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	41,960,430 - 42,273,235 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	37,886,650 - 38,199,435 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	36,290,119 - 36,602,927 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	34,959,721 - 35,281,017 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	35,279,063 - 35,281,013 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	34,816,883 - 35,142,708 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	34,024,058 - 34,339,465 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	32,482,516 - 32,794,851 (+)	NCBI		Celera
RGSC_v3.1	4	34,143,518 - 34,457,332 (+)	NCBI
Cytogenetic Map	4	q21	NCBI

NXPH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	8,433,609 - 8,752,961 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	8,433,609 - 8,752,961 (+)	Ensembl			hg38	GRCh38
GRCh37	7	8,473,239 - 8,792,591 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	8,440,110 - 8,759,118 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	8,246,824 - 8,565,830	NCBI
Celera	7	8,443,733 - 8,762,700 (+)	NCBI		Celera
Cytogenetic Map	7	p21.3	NCBI
HuRef	7	8,326,049 - 8,644,820 (+)	NCBI		HuRef
CHM1_1	7	8,473,354 - 8,791,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	8,554,700 - 8,873,809 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	8,522,178 - 8,840,927 (+)	NCBI

Nxph1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	8,948,154 - 9,259,863 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	8,948,431 - 9,249,032 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	8,948,614 - 9,249,619 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	8,948,431 - 9,249,032 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	8,900,019 - 9,198,578 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	8,899,815 - 9,199,267 (+)	NCBI		MGSCv36	mm8
Celera	6	9,088,736 - 9,380,304 (+)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	4.38	NCBI

Nxph1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	15,439,144 - 15,736,905 (+)	Ensembl
ChiLan1.0	NW_004955432	15,437,646 - 15,738,233 (+)	NCBI	ChiLan1.0	ChiLan1.0

NXPH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	13,334,588 - 13,647,638 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	61,659,305 - 61,972,355 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	9,159,585 - 9,472,699 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	8,509,930 - 8,823,581 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	8,511,688 - 8,822,387 (+)	Ensembl			panPan2	panpan1.1

NXPH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	23,953,318 - 24,250,419 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	24,129,959 - 24,249,222 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	23,390,551 - 23,489,374 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
Dog10K_Boxer_Tasha	14	23,528,435 - 23,822,156 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	23,630,005 - 24,065,454 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	23,770,882 - 24,065,445 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	23,782,084 - 24,216,199 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	23,520,098 - 23,953,454 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	23,771,960 - 24,205,470 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nxph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	37,313,942 - 37,603,533 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936585	1,260,952 - 1,547,742 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936585	1,259,759 - 1,549,320 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NXPH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	78,653,987 - 78,961,848 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	78,652,691 - 78,974,101 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	86,301,758 - 86,610,524 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NXPH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	49,453,998 - 49,769,058 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666042	54,631,579 - 54,949,405 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nxph1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624813	6,050,525 - 6,341,120 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624813	6,049,483 - 6,342,308 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nxph1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	129,202,906 - 129,205,213 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nxph1
2305 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	311
Count of miRNA genes:	180
Interacting mature miRNAs:	230
Transcripts:	ENSRNOT00000011833
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	13080146	58080146	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	15644309	60644309	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
8655949	Rf62	Renal function QTL 62	22		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	4	35396600	45429897	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	22288453	40471598	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	18900697	63900697	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	22288453	63245191	Rat
2290374	Gluco32	Glucose level QTL 32	6.27		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	38144194	45429897	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	18900697	63900697	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	18913151	63913151	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	27862204	62997402	Rat
4889511	Gluco61	Glucose level QTL 61	4.7	0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	38144194	41835141	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
11530004	Niddm71	Non-insulin dependent diabetes mellitus QTL 71		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	33538816	53719714	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	22288453	45429897	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10758701	40490708	Rat

Markers in Region

D4Rat115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	38,144,194 - 38,144,424 (+)	Marker Load Pipeline
mRatBN7.2	4	37,177,950 - 37,178,180 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	35,138,860 - 35,139,089	NCBI	Rnor6.0
Rnor_5.0	4	34,996,009 - 34,996,238	UniSTS	Rnor5.0
RGSC_v3.4	4	34,206,019 - 34,206,249	RGD	RGSC3.4
RGSC_v3.4	4	34,206,020 - 34,206,249	UniSTS	RGSC3.4
Celera	4	32,661,853 - 32,662,082	UniSTS
RGSC_v3.1	4	34,324,560 - 34,324,789	RGD
RH 3.4 Map	4	191.8	RGD
RH 3.4 Map	4	191.8	UniSTS
RH 2.0 Map	4	255.1	RGD
SHRSP x BN Map	4	19.87	RGD
FHH x ACI Map	4	23.1799	RGD
Cytogenetic Map	4	q21	UniSTS

D4Got21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	37,233,142 - 37,233,308 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	35,203,031 - 35,203,196	NCBI	Rnor6.0
Rnor_5.0	4	35,060,582 - 35,060,747	UniSTS	Rnor5.0
RGSC_v3.4	4	34,261,469 - 34,261,634	UniSTS	RGSC3.4
RGSC_v3.4	4	34,261,468 - 34,261,634	RGD	RGSC3.4
Celera	4	32,716,910 - 32,717,075	UniSTS
RGSC_v3.1	4	34,380,009 - 34,380,174	RGD
RH 3.4 Map	4	196.8	UniSTS
RH 3.4 Map	4	196.8	RGD
RH 2.0 Map	4	272.5	RGD
Cytogenetic Map	4	q21	UniSTS

BF417863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	36,996,768 - 36,996,867 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	34,958,426 - 34,958,524	NCBI	Rnor6.0
Rnor_5.0	4	34,815,588 - 34,815,686	UniSTS	Rnor5.0
RGSC_v3.4	4	34,022,762 - 34,022,860	UniSTS	RGSC3.4
Celera	4	32,481,366 - 32,481,464	UniSTS
RH 3.4 Map	4	199.4	UniSTS
Cytogenetic Map	4	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
5	7	51	146	35	33	13	24	13	4	172	89	6	138	59	88	20	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC105770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L27867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011833 ⟹ ENSRNOP00000011833

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	38,223,093 - 38,277,172 (+)	Ensembl
mRatBN7.2 Ensembl	4	36,997,669 - 37,311,132 (+)	Ensembl
Rnor_6.0 Ensembl	4	35,279,063 - 35,281,013 (+)	Ensembl

RefSeq Acc Id:

NM_012994 ⟹ NP_037126

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	37,964,325 - 38,277,364 (+)	NCBI
mRatBN7.2	4	36,998,068 - 37,311,135 (+)	NCBI
Rnor_6.0	4	34,959,721 - 35,281,017 (+)	NCBI
Rnor_5.0	4	34,816,883 - 35,142,708 (+)	NCBI
RGSC_v3.4	4	34,024,058 - 34,339,465 (+)	RGD
Celera	4	32,482,516 - 32,794,851 (+)	RGD

Sequence:

show sequence

CAGCAACCCGGCGCATTCGTCTCTCTCCCTTTCTTCCTTTCTCCGTCGTCTTCTCTACCTGCCC
CTCCTTCTCTTGCCTCTTAAGTTTCCTGCACCGGGAATCCAACTGTGCCAAGCCTAGGCTCCCG
CGGATCAATCCTGATCGCGACCGGGGCACTGGGACAACGACTCTGCCAAGGCTGGACGAGGCAG
CTGGACCGGTCCTCGCCCGAGCATGGAGACGGAGCTCCAGGGAGGGCACGTCCCGGGCGCTGGA
GACTCCAGGCCATAGTCGCTCCTCCATGGAGCCTGTTCAGAGCGGTCTCTGCTCGCTGCATTTG
CCTCCAGTCCTGTGCGGCTGCTGAGAGCGCTCCCTGCTCTGTAAAGTGGATGTCAGGTGGATCT
ATGTTTTTGAAGGAACAAAGACTCAGCCAAGGCACCGCCAAGGAAGTTTGAGAGGAGGGAGGAT
GCAGGCTGCGTGCTGGTACGTTCTTCTTCTCCTGCAGCCCACCGTCTACTTGGTCACGTGTGCC
AATCTAACAAATGGTGGAAAGTCGGAACTTCTGAAGTCAGGAAACAGCAAGTCTACACTAAAAC
ACATATGGACAGAAAGCAGCAAAGACTTGTCTATCAGTCGGCTCCTCTCACAGACTTTCCGTGG
TAAAGAAAATGGCACAGATTTGGACCTGCGCTATGACACCCCAGAACCTTATTCCGAGCAAGAC
CTCTGGGACTGGTTGAGGAACTCCACAGATCTTCAGGAGCCTCGGCCCAGGGCCAAAAGACGGC
CCATTGTTAAAACCGGCAAGTTTAAGAAAATGTTCGGATGGGGTGATTTTCATTCCAACATCAA
AACAGTGAAGCTAAACCTGTTGATAACTGGGAAAATTGTAGATCATGGCAATGGAACGTTTAGT
GTGTATTTCAGGCATAATTCCACTGGTCAAGGGAATGTATCTGTCAGCCTGGTGCCCCCAACAA
AAATTGTGGAATTCGATTTGGCACAACAAACCGTGATTGATGCCAAAGATTCCAAGTCCTTCAA
CTGTCGTATTGAATATGAGAAGGTTGACAAGGCCACCAAGAACACACTCTGCAACTACGACCCT
TCAAAAACCTGTTACCAGGAGCAGACCCAAAGTCACGTGTCCTGGCTCTGCTCTAAGCCCTTCA
AGGTGATCTGTATTTACATTTCCTTTTATAGTACAGACTATAAACTAGTACAGAAAGTATGCCC
TGACTACAACTACCACAGTGACACACCTTACTTCCCCTCCGGATGAAGACGAACAGGGCATGAG
ACTGAAGCCTGAGGAATTACAGGTCATAGGACAGGGCTGTTACCTTAAGGAAGAAGGTCACATC
TGTTGCCTGGAATGTGTCTACACTGCTGCTCTTGTTGACTGGTGCGAACATGCTAGTGGAAAAC
AATTGATGTAATTTCTGCACAGTCAGCTTCATCTCTCAGCATAGTTGTAAATCACCATAGCTCT
CAGAGTCTCATCTGAAGACATGCTGTCACTGTAGAGACACATGAGCACCCACTCCTGCACATTT
CAGCTCACATCTATCATGGTACCCTTTGAGAGGGCTTTCATTGTCTTGACTCATGATGGTTCAG
GATAAACTATGATCAAACACAAAGAATTAACTAGACAGAGGATGTATCTAACATGCCGTTATGG
AAATCTCTTTTAAGGTCTTGAGTCCATGCTAATCAATAGTCCCCACTCATGCATTCCTACTGCT
TGGAGTAGCTGTGCTGGTGAATACTACTGTAGGAGTTATATGCTTGTTAAATGGAAAAAAATGT
GTCTTTAGAGCTCAGTATTCTTTATTTTATGAACACAACACAGTGTAGTAGCTTTTTCCCAGCA
TACAGTAGGCACATTCAAGGTGATACAGGATGGCTTTTCTTTCTGTGGAGGGAGGAGCTTGTTC
TGAGTAAAGATGAGCAAACATTTGGAATTTACATGTGGGCAGACACTGGGAATTACAGCTTTTC
TTGCCTATCACCGGACCTTTGCAATGTTGAGACCAACTAAGGCTGCTTAACACAAGTTCTGATC
ATTATATAAGAAGGAAAATGCCGGGCAGACACCATGTAAGTTATAAGTGTCTGTCTTATCTTTA
CTACACATATTGTAACAAACTCAATATCCTAGTCTTCATTTGTATGAATGGTTTGTACTGTATA
TAGTTTAACCAAGTGTTATTTGAGCTGCTTATTAATATTAAATTGTACTTGTCTCTCTGCTTGT
TATTGGTTAAAAAGAAAAAAGGATCTAAGGAATCAATTTTATCAATGTAGCTGTGAACTCCATT
AAAAAAAGACAAATTTAATATACAAAGCATCTATTCAGCTCAAGTATTGTTGAAAGCTATACAT
ATACAACATTACACTGTCTGTATTTAGATATTTTATTTCTGGAAAAAATGTACATAAAAATAAA
ACCGTTAAAGTTGAGTTTCAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_037126	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB18420	(Get FASTA)	NCBI Sequence Viewer
	AAI05771	(Get FASTA)	NCBI Sequence Viewer
	EDM15070	(Get FASTA)	NCBI Sequence Viewer
	EDM15071	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011833.3
GenBank Protein	Q63366	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037126 ⟸ NM_012994
- Peptide Label:	precursor
- UniProtKB:	Q3KRD4 (UniProtKB/Swiss-Prot), Q63366 (UniProtKB/Swiss-Prot), A6IDY4 (UniProtKB/TrEMBL), F1LRY8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQAACWYVLLLLQPTVYLVTCANLTNGGKSELLKSGNSKSTLKHIWTESSKDLSISRLLSQTFR GKENGTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNI KTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSF NCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVC PDYNYHSDTPYFPSG hide sequence

Ensembl Acc Id:

ENSRNOP00000011833 ⟸ ENSRNOT00000011833

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63366-F1-model_v2	AlphaFold	Q63366	1-271	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3218	AgrOrtholog
BioCyc Gene	G2FUF-45655	BioCyc
Ensembl Genes	ENSRNOG00000008939	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011833.5	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7930348	IMAGE-MGC_LOAD
InterPro	Nxph	UniProtKB/Swiss-Prot
	NXPH/NXPE	UniProtKB/Swiss-Prot
KEGG Report	rno:25501	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124635	IMAGE-MGC_LOAD
NCBI Gene	25501	ENTREZGENE
PANTHER	NEUREXOPHILIN-1	UniProtKB/Swiss-Prot
	PTHR17103	UniProtKB/Swiss-Prot
Pfam	Neurexophilin	UniProtKB/Swiss-Prot
PhenoGen	Nxph1	PhenoGen
PIRSF	Neurexophilin	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008939	RatGTEx
TIGR	TC236593
UniProt	A6IDY4	ENTREZGENE, UniProtKB/TrEMBL
	F1LRY8	ENTREZGENE, UniProtKB/TrEMBL
	NXPH1_RAT	UniProtKB/Swiss-Prot
	Q3KRD4	ENTREZGENE
	Q63366	ENTREZGENE
UniProt Secondary	Q3KRD4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Nxph1	Neurexophilin 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	may be involved in development of synaptic connections in the primary olfactory pathway	727397
gene_protein	29 kDa protein	729057

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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