Mgp (matrix Gla protein) - Rat Genome Database

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Gene: Mgp (matrix Gla protein) Rattus norvegicus
Analyze
Symbol: Mgp
Name: matrix Gla protein
RGD ID: 3088
Description: Enables calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; response to calcium ion; and response to glucocorticoid. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein); INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Mglap
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,497,472 - 171,500,888 (-)NCBIGRCr8
mRatBN7.24169,766,290 - 169,769,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,766,279 - 169,769,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,061,104 - 176,064,425 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,842,750 - 171,846,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,466,773 - 170,470,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,856,783 - 170,860,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,856,751 - 170,860,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,113,783 - 235,117,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,910,595 - 173,913,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,155,718 - 174,159,041 (-)NCBI
Celera4158,349,108 - 158,352,430 (-)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acetohydrazide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
bacitracin  (EXP)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethylene glycol  (EXP)
ethylenediaminetetraacetic acid  (ISO)
etidronic acid  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (ISO)
graphite  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
losartan  (EXP)
manganese(II) chloride  (EXP)
methidathion  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phylloquinone  (EXP,ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP,ISO)
undecane  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (EXP)
warfarin  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis. Barone LM, etal., J Cell Biochem. 1991 Aug;46(4):351-65.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer. de Wilde J, etal., Int J Cancer. 2008 Feb 15;122(4):877-88.
4. Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. Farzaneh-Far A, etal., Biochem Biophys Res Commun. 2000 Nov 2;277(3):736-40.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung. Gilbert KA and Rannels SR, Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L569-77. Epub 2003 May 16.
7. Matrix GLA protein modulates branching morphogenesis in fetal rat lung. Gilbert KA and Rannels SR, Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1179-87.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction. Herrmann SM, etal., Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2386-93.
10. Coordinately up-regulated genes in ovarian cancer. Hough CD, etal., Cancer Res. 2001 May 15;61(10):3869-76.
11. Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Jono S, etal., Thromb Haemost. 2004 Apr;91(4):790-4.
12. Expression of the matrix Gla protein in urogenital malignancies. Levedakou EN, etal., Int J Cancer. 1992 Oct 21;52(4):534-7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Munroe PB, etal., Nat Genet. 1999 Jan;21(1):142-4.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Matrix Gla Protein Is Associated With Risk Factors for Atherosclerosis but not With Coronary Artery Calcification. O'donnell CJ, etal., Arterioscler Thromb Vasc Biol. 2006 Sep 14;.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Biochemical characterization of the serum fetuin-mineral complex. Price PA, etal., J Biol Chem. 2003 Jun 13;278(24):22153-60. Epub 2003 Apr 3.
19. Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase. Price PA, etal., Proc Natl Acad Sci U S A 1987 Dec;84(23):8335-9.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Expression of bone matrix proteins mRNA during distraction osteogenesis. Sato M, etal., J Bone Miner Res. 1998 Aug;13(8):1221-31.
24. Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification. Sato Y, etal., Circ Res. 2005 Sep 16;97(6):550-7. Epub 2005 Aug 11.
25. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Schurgers LJ, etal., Blood. 2007 Apr 1;109(7):2823-31.
26. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. Shanahan CM, etal., J Clin Invest. 1994 Jun;93(6):2393-402.
27. Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Spronk HM, etal., Biochem Biophys Res Commun. 2001 Nov 30;289(2):485-90.
28. Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. Sweatt A, etal., J Thromb Haemost. 2003 Jan;1(1):178-85.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Matrix Gla protein synthesis and gamma-carboxylation in the aortic vessel wall and proliferating vascular smooth muscle cells--a cell system which resembles the system in bone cells. Wallin R, etal., Thromb Haemost. 1999 Dec;82(6):1764-7.
31. Expression of bone matrix proteins in urolithiasis model rats. Yasui T, etal., Urol Res. 1999 Aug;27(4):255-61.
Additional References at PubMed
PMID:8061611   PMID:12477932   PMID:15561265   PMID:15982861   PMID:19199708   PMID:19910445   PMID:19919401   PMID:20551380   PMID:20689249   PMID:21161195   PMID:21705322   PMID:23118128  
PMID:23223575   PMID:23445897   PMID:23979707   PMID:27068509   PMID:27559042   PMID:28707070   PMID:35352799  


Genomics

Comparative Map Data
Mgp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,497,472 - 171,500,888 (-)NCBIGRCr8
mRatBN7.24169,766,290 - 169,769,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,766,279 - 169,769,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,061,104 - 176,064,425 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,842,750 - 171,846,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,466,773 - 170,470,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,856,783 - 170,860,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,856,751 - 170,860,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,113,783 - 235,117,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,910,595 - 173,913,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,155,718 - 174,159,041 (-)NCBI
Celera4158,349,108 - 158,352,430 (-)NCBICelera
Cytogenetic Map4q43NCBI
MGP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,880,864 - 14,885,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,880,864 - 14,885,857 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,033,798 - 15,038,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,926,094 - 14,930,095 (-)NCBINCBI36Build 36hg18NCBI36
Build 341214,926,093 - 14,930,095NCBI
Celera1220,179,103 - 20,183,841 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,803,571 - 14,808,309 (-)NCBIHuRef
CHM1_11215,000,196 - 15,004,934 (-)NCBICHM1_1
T2T-CHM13v2.01214,758,207 - 14,763,197 (-)NCBIT2T-CHM13v2.0
Mgp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,849,433 - 136,852,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,849,433 - 136,852,821 (-)EnsemblGRCm39 Ensembl
GRCm386136,872,435 - 136,875,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,872,435 - 136,875,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv376136,820,956 - 136,824,326 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,836,632 - 136,840,001 (-)NCBIMGSCv36mm8
Celera6139,906,448 - 139,909,847 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.72NCBI
Mgp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,615,078 - 11,618,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541311,614,851 - 11,618,090 (-)NCBIChiLan1.0ChiLan1.0
MGP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,333,390 - 20,337,473 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,330,153 - 20,334,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,887,806 - 14,891,796 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,284,635 - 15,288,794 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,284,883 - 15,288,523 (-)Ensemblpanpan1.1panPan2
MGP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,735,301 - 31,738,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,734,660 - 31,738,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,710,348 - 14,713,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,041,879 - 32,045,251 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,041,914 - 32,045,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,931,196 - 31,934,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,889,700 - 31,893,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,442,533 - 14,445,905 (-)NCBIUU_Cfam_GSD_1.0
Mgp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,873,783 - 92,878,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,601,312 - 2,605,870 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,601,419 - 2,605,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,665,248 - 57,669,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,665,272 - 57,669,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,054,230 - 61,058,317 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,776,668 - 14,780,796 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,776,209 - 14,780,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,529,753 - 20,533,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475223,146,166 - 23,149,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475223,146,025 - 23,149,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgp
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:34
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000007577
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH127843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,766,438 - 169,766,632 (+)MAPPERmRatBN7.2
Rnor_6.04170,856,932 - 170,857,125NCBIRnor6.0
Rnor_5.04235,113,932 - 235,114,125UniSTSRnor5.0
RGSC_v3.44173,910,744 - 173,910,937UniSTSRGSC3.4
Celera4158,349,257 - 158,349,450UniSTS
RH 3.4 Map41023.7UniSTS
Cytogenetic Map4q43UniSTS
RH94560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,766,325 - 169,766,423 (+)MAPPERmRatBN7.2
Rnor_6.04170,856,819 - 170,856,916NCBIRnor6.0
Rnor_5.04235,113,819 - 235,113,916UniSTSRnor5.0
RGSC_v3.44173,910,631 - 173,910,728UniSTSRGSC3.4
Celera4158,349,144 - 158,349,241UniSTS
Cytogenetic Map4q43UniSTS
Mgp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,766,505 - 169,767,081 (+)MAPPERmRatBN7.2
Rnor_6.04170,856,999 - 170,857,574NCBIRnor6.0
Rnor_5.04235,113,999 - 235,114,574UniSTSRnor5.0
RGSC_v3.44173,910,811 - 173,911,386UniSTSRGSC3.4
Celera4158,349,324 - 158,349,899UniSTS
Cytogenetic Map4q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007577   ⟹   ENSRNOP00000007577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,766,279 - 169,769,667 (-)Ensembl
Rnor_6.0 Ensembl4170,856,751 - 170,860,225 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106211   ⟹   ENSRNOP00000089872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,766,283 - 169,769,667 (-)Ensembl
RefSeq Acc Id: NM_012862   ⟹   NP_036994
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,497,482 - 171,500,804 (-)NCBI
mRatBN7.24169,766,290 - 169,769,612 (-)NCBI
Rnor_6.04170,856,783 - 170,860,105 (-)NCBI
Rnor_5.04235,113,783 - 235,117,184 (-)NCBI
RGSC_v3.44173,910,595 - 173,913,917 (-)RGD
Celera4158,349,108 - 158,352,430 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285599   ⟹   XP_063141669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,497,472 - 171,500,888 (-)NCBI
RefSeq Acc Id: NP_036994   ⟸   NM_012862
- Peptide Label: precursor
- UniProtKB: P08494 (UniProtKB/Swiss-Prot),   Q5RK05 (UniProtKB/TrEMBL),   F7FN71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007577   ⟸   ENSRNOT00000007577
Ensembl Acc Id: ENSRNOP00000089872   ⟸   ENSRNOT00000106211
RefSeq Acc Id: XP_063141669   ⟸   XM_063285599
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A910 (UniProtKB/TrEMBL)
Protein Domains
Gla

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08494-F1-model_v2 AlphaFold P08494 1-103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693467
Promoter ID:EPDNEW_R3992
Type:multiple initiation site
Name:Mgp_1
Description:matrix Gla protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04170,860,158 - 170,860,218EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3088 AgrOrtholog
BioCyc Gene G2FUF-42591 BioCyc
Ensembl Genes ENSRNOG00000005695 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007577.6 UniProtKB/TrEMBL
  ENSRNOT00000106211.1 UniProtKB/TrEMBL
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303359 IMAGE-MGC_LOAD
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_trans_35 UniProtKB/TrEMBL
  MGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteocalcin/MGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25333 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105492 IMAGE-MGC_LOAD
NCBI Gene 25333 ENTREZGENE
PANTHER GLYCOGEN PHOSPHORYLASE, MUSCLE FORM UniProtKB/TrEMBL
  MATRIX GLA PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11468 UniProtKB/TrEMBL
PharmGKB MGP RGD
PhenoGen Mgp PhenoGen
PRINTS GLABONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005695 RatGTEx
SMART GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/TrEMBL
TIGR TC228582
UniProt A0A8I6A910 ENTREZGENE, UniProtKB/TrEMBL
  A6IMJ0_RAT UniProtKB/TrEMBL
  A6IMJ2_RAT UniProtKB/TrEMBL
  A6IMJ3_RAT UniProtKB/TrEMBL
  F7FN71 ENTREZGENE, UniProtKB/TrEMBL
  MGP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5RK05 ENTREZGENE, UniProtKB/TrEMBL
  Q64607_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Mgp  matrix Gla protein    Matrix Gla protein  Name updated 625702 APPROVED
2002-06-10 Mgp  Matrix Gla protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in bone, dentin, and cartilage 728971