Mgp (matrix Gla protein) - Rat Genome Database

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Gene: Mgp (matrix Gla protein) Ictidomys tridecemlineatus
Analyze
Symbol: Mgp
Name: matrix Gla protein
RGD ID: 12729738
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); lung development (ortholog); ossification (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); arteriosclerosis (ortholog); autosomal dominant intellectual developmental disorder 6 (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101976563
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,873,783 - 92,878,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,601,312 - 2,605,870 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,601,419 - 2,605,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MgpSquirrelarteriosclerosis  ISOMGP (Homo sapiens)9068941 RGDPMID:8200973 and REF_RGD_ID:1582504
MgpSquirrelbrain infarction  ISOMgp (Rattus norvegicus)9068941mRNA:increased expression:brain (rat)RGDPMID:23251410 and REF_RGD_ID:329845556
MgpSquirrelcalcinosis  ISOMGP (Homo sapiens)9068941 RGDPMID:15045141 and REF_RGD_ID:1582501
MgpSquirrelcervix uteri carcinoma in situ  ISOMGP (Homo sapiens)9068941 RGDPMID:17960611 and REF_RGD_ID:2293584
MgpSquirrelCoronary Disease susceptibilityISOMGP (Homo sapiens)9068941 RGDPMID:16973975 and REF_RGD_ID:1582502
MgpSquirrelgerminoma  ISOMGP (Homo sapiens)9068941mRNA:increased expression:tumorRGDPMID:1399132 and REF_RGD_ID:2293578
MgpSquirrelKidney Calculi  ISOMgp (Rattus norvegicus)9068941 RGDPMID:10460895 and REF_RGD_ID:1582511
MgpSquirrelmyocardial infarction susceptibilityISOMGP (Homo sapiens)9068941 RGDPMID:11073842 and REF_RGD_ID:1582503
MgpSquirrelOvarian Neoplasms  ISOMGP (Homo sapiens)9068941mRNA:increased expression:tumor:39/39 (100%) of tumors showed >10x increase over normal tissue and 87% showed >100x increaseRGDPMID:11358798 and REF_RGD_ID:2293586
MgpSquirrelprostate carcinoma  ISOMGP (Homo sapiens)9068941mRNA:increased expression:primary tumor and mRNA:decreased expression:metastatic tissue:decreased or absent expression in metastases and cell lines from metastatic tumorsRGDPMID:1399132 and REF_RGD_ID:2293578
MgpSquirrelrenal cell carcinoma disease_progressionISOMGP (Homo sapiens)9068941mRNA:increased expression:tumor:inversely related to tumor size (0.025RGDPMID:1399132 and REF_RGD_ID:2293578
MgpSquirrelUterine Cervical Neoplasms  ISOMGP (Homo sapiens)9068941protein:increased expression:tumor and adjacent dysplastic cervical epithelium:7/8 (88%) cervical squamous cell carcinomasRGDPMID:17960611 and REF_RGD_ID:2293584
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MgpSquirrelautosomal dominant intellectual developmental disorder 6  ISOMGP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and autosomal dominant 6ClinVarPMID:28492532
MgpSquirrelDwarfism  ISOMGP (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVarPMID:25741868 more ...
MgpSquirrelgenetic disease  ISOMGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
MgpSquirrelKeutel Syndrome  ISOMGP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15810001 more ...
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MgpSquirrelAnimal Mammary Neoplasms  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
MgpSquirrelbicuspid aortic valve disease  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19350115
MgpSquirrelcarcinoma  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
MgpSquirrelExperimental Liver Cirrhosis  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
MgpSquirrelExperimental Mammary Neoplasms  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
MgpSquirrelSpontaneous Abortions  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18539642
MgpSquirreluremia  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19092814
MgpSquirrelvaricose veins  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17643059
MgpSquirrelVascular Calcification  ISOMGP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21705322
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MgpSquirrelKeutel Syndrome  ISOMGP (Homo sapiens)7240710 OMIM 


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MgpSquirrelbranching morphogenesis of an epithelial tube  ISOMgp (Rattus norvegicus)9068941fetal lungRGDPMID:15136295 and REF_RGD_ID:1582506
MgpSquirrelcartilage development involved_inIEAUniProtKB-KW:KW-0891150520179 UniProtGO_REF:0000043
MgpSquirrelcell differentiation involved_inIEAUniProtKB-KW:KW-0221150520179 UniProtGO_REF:0000043
MgpSquirrellung development  ISOMgp (Rattus norvegicus)9068941 RGDPMID:15136295 and REF_RGD_ID:1582506
MgpSquirrelossification  ISOMgp (Rattus norvegicus)9068941 RGDPMID:9718189 and REF_RGD_ID:1582512
MgpSquirrelossification involved_inIEAUniProtKB-KW:KW-0892150520179 UniProtGO_REF:0000043
MgpSquirrelprotein-containing complex assembly  ISOAhsg (Rattus norvegicus) more ...9068941fetuin-mineral complexRGDPMID:12676928 and REF_RGD_ID:1582508
MgpSquirrelregulation of bone mineralization involved_inIEAInterPro:IPR002384150520179 InterProGO_REF:0000002
MgpSquirrelresponse to calcium ion  ISOMgp (Rattus norvegicus)9068941 RGDPMID:11062022 and REF_RGD_ID:1582509
MgpSquirrelresponse to glucocorticoid  ISOMgp (Rattus norvegicus)9068941 RGDPMID:12754193 and REF_RGD_ID:1582507
MgpSquirrelresponse to hormone  ISOMgp (Rattus norvegicus)9068941 RGDPMID:16100044 and REF_RGD_ID:1582505
MgpSquirrelresponse to mechanical stimulus  ISOMgp (Rattus norvegicus)9068941 RGDPMID:9718189 and REF_RGD_ID:1582512
MgpSquirrelresponse to nutrient  ISOMgp (Rattus norvegicus)9068941 RGDPMID:1757478 and REF_RGD_ID:1582514
MgpSquirrelsystem development involved_inIEAARBA:ARBA00027702150520179 UniProtGO_REF:0000117
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Cellular Component
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1 to 9 of 9 rows

Molecular Function

  

PMID:22301074   PMID:30032202  



Mgp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,873,783 - 92,878,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,601,312 - 2,605,870 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,601,419 - 2,605,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,880,864 - 14,885,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,880,864 - 14,885,857 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,033,798 - 15,038,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,926,094 - 14,930,095 (-)NCBINCBI36Build 36hg18NCBI36
Build 341214,926,093 - 14,930,095NCBI
Celera1220,179,103 - 20,183,841 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,803,571 - 14,808,309 (-)NCBIHuRef
CHM1_11215,000,196 - 15,004,934 (-)NCBICHM1_1
T2T-CHM13v2.01214,758,207 - 14,763,197 (-)NCBIT2T-CHM13v2.0
Mgp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,849,433 - 136,852,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,849,433 - 136,852,821 (-)EnsemblGRCm39 Ensembl
GRCm386136,872,435 - 136,875,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,872,435 - 136,875,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv376136,820,956 - 136,824,326 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,836,632 - 136,840,001 (-)NCBIMGSCv36mm8
Celera6139,906,448 - 139,909,847 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.72NCBI
Mgp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,497,472 - 171,500,888 (-)NCBIGRCr8
mRatBN7.24169,766,290 - 169,769,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,766,279 - 169,769,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,061,104 - 176,064,425 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,842,750 - 171,846,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,466,773 - 170,470,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,856,783 - 170,860,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,856,751 - 170,860,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,113,783 - 235,117,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,910,595 - 173,913,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,155,718 - 174,159,041 (-)NCBI
Celera4158,349,108 - 158,352,430 (-)NCBICelera
Cytogenetic Map4q43NCBI
Mgp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,615,078 - 11,618,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541311,614,851 - 11,618,090 (-)NCBIChiLan1.0ChiLan1.0
MGP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,333,390 - 20,337,473 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,330,153 - 20,334,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,887,806 - 14,891,796 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,284,635 - 15,288,794 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,284,883 - 15,288,523 (-)Ensemblpanpan1.1panPan2
MGP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,735,301 - 31,738,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,734,660 - 31,738,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,710,348 - 14,713,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,041,879 - 32,045,251 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,041,914 - 32,045,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,931,196 - 31,934,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,889,700 - 31,893,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,442,533 - 14,445,905 (-)NCBIUU_Cfam_GSD_1.0
MGP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,665,248 - 57,669,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,665,272 - 57,669,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,054,230 - 61,058,317 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,776,668 - 14,780,796 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,776,209 - 14,780,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,529,753 - 20,533,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475223,146,166 - 23,149,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475223,146,025 - 23,149,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_005331884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000011245   ⟹   ENSSTOP00000010086
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365872,601,312 - 2,605,870 (+)Ensembl
RefSeq Acc Id: XM_005331884   ⟹   XP_005331941
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494592,873,783 - 92,878,213 (+)NCBI
SpeTri2.0NW_0049365872,601,419 - 2,605,848 (+)NCBI
Sequence:
Protein RefSeqs XP_005331941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000010086.2
GenBank Protein KAG3292333 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005331941   ⟸   XM_005331884
- UniProtKB: I3MGY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000010086   ⟸   ENSSTOT00000011245
Gla



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000011249 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011245.3 UniProtKB/TrEMBL
InterPro GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  MGP UniProtKB/TrEMBL
  Osteocalcin/MGP UniProtKB/TrEMBL
NCBI Gene Mgp ENTREZGENE
PANTHER MATRIX GLA PROTEIN UniProtKB/TrEMBL
  PTHR10109 UniProtKB/TrEMBL
PRINTS GLABONE UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
SMART GLA UniProtKB/TrEMBL
Superfamily-SCOP SSF57630 UniProtKB/TrEMBL
UniProt I3MGY5 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 Mgp  matrix Gla protein  LOC101976563  matrix Gla protein  Symbol and/or name change 5135510 APPROVED
2021-03-26 LOC101976563  matrix Gla protein  Mgp  matrix Gla protein  Symbol and/or name change 5135510 APPROVED