Cckbr (cholecystokinin B receptor) - Rat Genome Database

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Gene: Cckbr (cholecystokinin B receptor) Rattus norvegicus
Analyze
Symbol: Cckbr
Name: cholecystokinin B receptor
RGD ID: 2290
Description: Enables gastrin receptor activity. Involved in several processes, including ERK1 and ERK2 cascade; estrous cycle; and positive regulation of cell communication. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in plasma membrane. Used to study colitis and pancreatic cancer. Biomarker of pancreatic cancer and toxic shock syndrome. Human ortholog(s) of this gene implicated in pancreatic cancer and panic disorder. Orthologous to human CCKBR (cholecystokinin B receptor); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH (+)-catechin; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CCK(B) receptor; CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; Cck2r; cholecystokinin-2 receptor; CHOLREC; gastrin/cholecystokinin type B receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,183,578 - 169,193,583 (+)NCBIGRCr8
mRatBN7.21159,771,733 - 159,781,738 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,771,733 - 159,814,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,792,933 - 167,803,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,978,922 - 174,989,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,874,190 - 167,885,118 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,262,218 - 170,272,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,262,156 - 170,272,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,269,044 - 177,279,480 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,156,914 - 163,166,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,252,390 - 163,262,446 (+)NCBI
Celera1157,706,263 - 157,716,114 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
apomorphine  (ISO)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
DPDPE  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fentanyl  (EXP)
gastrin-17  (ISO)
genistein  (EXP)
glyphosate  (EXP)
lead(0)  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
omeprazole  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
Soman  (EXP)
sulpiride  (ISO)
testosterone  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cholecystokinin-2 receptors modulate freezing and escape behaviors evoked by the electrical stimulation of the rat dorsolateral periaqueductal gray. Bertoglio LJ, etal., Brain Res. 2007 Jul 2;1156:133-8. Epub 2007 Apr 21.
2. Neuronal excitability in the periaqueductal grey matter during the estrous cycle in female Wistar rats. Brack KE and Lovick TA, Neuroscience. 2007 Jan 5;144(1):325-35. Epub 2006 Oct 11.
3. Cholecystokinin excites interneurons in rat basolateral amygdala. Chung L and Moore SD, J Neurophysiol. 2009 Jul;102(1):272-84. Epub 2009 Apr 22.
4. Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala. Chung L and Moore SD, Neuropeptides. 2007 Dec;41(6):453-63. Epub 2007 Sep 27.
5. Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. El-Kouhen K and Morisset J, Pancreas. 2010 Mar;39(2):127-34.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors. Gulpinar MA, etal., Life Sci. 2004 May 21;75(1):77-91.
9. Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. Hernandez-Gomez AM, etal., Amino Acids 2002;23(1-3):283-90.
10. Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. Hosing VG, etal., J Neural Transm Suppl 2004;(68):147-56.
11. Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and partial determination of the cholecystokinin B receptor gene structure. Jagerschmidt A, etal., J Neurochem 1994 Oct;63(4):1199-206.
12. Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response. Juarez-Rojop IE, etal., Pain. 2006 May;122(1-2):118-25. Epub 2006 Mar 9.
13. Regulation of rat pancreatic CCKB receptor and somatostatin expression by insulin. Julien S, etal., Diabetes 2004 Jun;53(6):1526-34.
14. A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Kidd M, etal., Regul Pept. 2007 Oct 4;143(1-3):109-17. Epub 2007 Apr 29.
15. CCK1 and 2 receptors are expressed in immortalized rat brain neuroblasts: intracellular signals after cholecystokinin stimulation. Langmesser S, etal., J Cell Biochem. 2007 Mar 1;100(4):851-64.
16. Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation. Mathieu A, etal., Int J Cancer. 2005 May 20;115(1):46-54.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and GABA release. Perez de la Mora M, etal., Eur J Neurosci. 2007 Dec;26(12):3614-30.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Temporal expression of the gastrin (CCK-B) receptor during azaserine-induced pancreatic carcinogenesis. Povoski SP, etal., Pancreas. 1993 Sep;8(5):615-21.
23. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Reubi JC, etal., Gastroenterology. 2003 Jul;125(1):98-106.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines. Savage K, etal., Int J Oncol. 2006 Dec;29(6):1429-35.
27. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Wank SA, etal., Proc Natl Acad Sci U S A 1992 Sep 15;89(18):8691-5.
28. The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation. Xanthos DN, etal., Neuropharmacology. 2009 Mar;56(3):684-91. Epub 2008 Dec 11.
29. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. Xie JY, etal., J Neurosci. 2005 Jan 12;25(2):409-16.
30. Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats. Zhao XY, etal., World J Gastroenterol. 2005 Jun 14;11(22):3405-10.
31. Novel expression of gastrin (cholecystokinin-B) receptors in azaserine-induced rat pancreatic carcinoma: receptor determination and characterization. Zhou W, etal., Cancer Res. 1992 Dec 15;52(24):6905-11.
32. Overexpression of messenger RNA for cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine-induced rat pancreatic carcinoma. Zhou W, etal., Carcinogenesis. 1993 Oct;14(10):2189-92.
33. CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cells. Zhukova E, etal., J Cell Physiol 2001 Dec;189(3):291-305.
Additional References at PubMed
PMID:1280419   PMID:7681836   PMID:8185642   PMID:8876222   PMID:10913157   PMID:12457239   PMID:12708535   PMID:12800239   PMID:12891702   PMID:14698681   PMID:15476751   PMID:15817487  
PMID:16168394   PMID:16556659   PMID:17505309   PMID:17581850   PMID:19448635   PMID:19497313   PMID:20843811   PMID:22981453   PMID:25601282   PMID:35674015  


Genomics

Comparative Map Data
Cckbr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,183,578 - 169,193,583 (+)NCBIGRCr8
mRatBN7.21159,771,733 - 159,781,738 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,771,733 - 159,814,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,792,933 - 167,803,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,978,922 - 174,989,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,874,190 - 167,885,118 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,262,218 - 170,272,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,262,156 - 170,272,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,269,044 - 177,279,480 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,156,914 - 163,166,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,252,390 - 163,262,446 (+)NCBI
Celera1157,706,263 - 157,716,114 (+)NCBICelera
Cytogenetic Map1q32NCBI
CCKBR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,259,838 - 6,272,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,259,806 - 6,272,127 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,281,068 - 6,293,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,237,542 - 6,249,932 (+)NCBINCBI36Build 36hg18NCBI36
Build 34116,237,541 - 6,249,932NCBI
Celera116,400,020 - 6,412,407 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef115,940,913 - 5,953,262 (+)NCBIHuRef
CHM1_1116,280,135 - 6,292,585 (+)NCBICHM1_1
T2T-CHM13v2.0116,318,278 - 6,330,559 (+)NCBIT2T-CHM13v2.0
Cckbr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,075,201 - 105,085,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,074,938 - 105,120,105 (+)EnsemblGRCm39 Ensembl
GRCm387105,425,676 - 105,436,339 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,425,731 - 105,470,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,574,334 - 112,584,852 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,299,641 - 105,310,159 (+)NCBIMGSCv36mm8
Celera7105,697,876 - 105,708,369 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.86NCBI
Cckbr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,000,436 - 22,011,433 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,001,351 - 22,011,275 (+)NCBIChiLan1.0ChiLan1.0
CCKBR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v298,698,647 - 8,710,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,662,495 - 8,674,829 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,393,435 - 6,405,821 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,075,816 - 6,088,145 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,075,816 - 6,088,145 (+)Ensemblpanpan1.1panPan2
CCKBR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,602,066 - 29,606,343 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,604,150 - 29,605,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,297,763 - 29,308,469 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,421,897 - 30,432,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,421,820 - 30,432,621 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12129,743,138 - 29,753,834 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02129,908,906 - 29,919,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,103,537 - 30,114,256 (+)NCBIUU_Cfam_GSD_1.0
Cckbr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,333,683 - 56,346,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842329,376 - 341,808 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842329,551 - 341,491 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCKBR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.193,409,222 - 3,419,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,150,565 - 4,158,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCKBR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,555,463 - 58,569,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,555,321 - 58,568,031 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,392,791 - 156,405,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cckbr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248177,743,865 - 7,755,453 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248177,744,422 - 7,754,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cckbr
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:76
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000024077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1150452391168228760Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Bda31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,781,186 - 159,781,455 (+)MAPPERmRatBN7.2
Rnor_6.01170,271,747 - 170,272,015NCBIRnor6.0
Rnor_5.01177,278,929 - 177,279,197UniSTSRnor5.0
RGSC_v3.41163,166,418 - 163,166,686UniSTSRGSC3.4
Celera1157,715,563 - 157,715,831UniSTS
Cytogenetic Map1q33UniSTS
RH142004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,781,613 - 159,781,829 (+)MAPPERmRatBN7.2
Rnor_6.01170,272,174 - 170,272,389NCBIRnor6.0
Rnor_5.01177,279,356 - 177,279,571UniSTSRnor5.0
RGSC_v3.41163,166,845 - 163,167,060UniSTSRGSC3.4
Celera1157,715,990 - 157,716,205UniSTS
RH 3.4 Map11302.8UniSTS
Cytogenetic Map1q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 2 28 108 28 18 4 16 4 3 91 56 93 24 40 14

Sequence


Ensembl Acc Id: ENSRNOT00000024077   ⟹   ENSRNOP00000024077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,771,733 - 159,781,738 (+)Ensembl
Rnor_6.0 Ensembl1170,262,156 - 170,272,298 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085395   ⟹   ENSRNOP00000072790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,771,733 - 159,780,987 (+)Ensembl
Rnor_6.0 Ensembl1170,262,253 - 170,271,547 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113071   ⟹   ENSRNOP00000081099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,771,733 - 159,814,881 (+)Ensembl
RefSeq Acc Id: NM_013165   ⟹   NP_037297
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,183,578 - 169,193,583 (+)NCBI
mRatBN7.21159,771,733 - 159,781,738 (+)NCBI
Rnor_6.01170,262,218 - 170,272,298 (+)NCBI
Rnor_5.01177,269,044 - 177,279,480 (+)NCBI
RGSC_v3.41163,156,914 - 163,166,969 (+)RGD
Celera1157,706,263 - 157,716,114 (+)RGD
Sequence:
RefSeq Acc Id: NP_037297   ⟸   NM_013165
- UniProtKB: P30553 (UniProtKB/Swiss-Prot),   G3V8A8 (UniProtKB/TrEMBL),   A6I7I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024077   ⟸   ENSRNOT00000024077
Ensembl Acc Id: ENSRNOP00000072790   ⟸   ENSRNOT00000085395
Ensembl Acc Id: ENSRNOP00000081099   ⟸   ENSRNOT00000113071
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30553-F1-model_v2 AlphaFold P30553 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690298
Promoter ID:EPDNEW_R808
Type:single initiation site
Name:Cckbr_1
Description:cholecystokinin B receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,262,270 - 170,262,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2290 AgrOrtholog
BioCyc Gene G2FUF-58019 BioCyc
Ensembl Genes ENSRNOG00000017679 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055024046 UniProtKB/Swiss-Prot
  ENSRNOG00060017559 UniProtKB/Swiss-Prot
  ENSRNOG00065031807 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024077.4 UniProtKB/TrEMBL
  ENSRNOT00000085395.2 UniProtKB/TrEMBL
  ENSRNOT00000113071.1 UniProtKB/TrEMBL
  ENSRNOT00055041320 UniProtKB/Swiss-Prot
  ENSRNOT00060030034 UniProtKB/Swiss-Prot
  ENSRNOT00065054794 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cholcskin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25706 UniProtKB/Swiss-Prot
NCBI Gene 25706 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cckbr PhenoGen
PRINTS CCYSTOKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GASTRINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017679 RatGTEx
  ENSRNOG00055024046 RatGTEx
  ENSRNOG00060017559 RatGTEx
  ENSRNOG00065031807 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3V3_RAT UniProtKB/TrEMBL
  A0A8I5ZR98_RAT UniProtKB/TrEMBL
  A6I7I2 ENTREZGENE, UniProtKB/TrEMBL
  A6I7I3_RAT UniProtKB/TrEMBL
  G3V8A8 ENTREZGENE, UniProtKB/TrEMBL
  GASR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Cckbr  cholecystokinin B receptor    Cholecystokinin B receptor  Name updated 629478 APPROVED
2002-06-10 Cckbr  Cholecystokinin B receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed predominantly in CNS 634707
gene_function binds sulfated and non-sulfated cholecystokinin peptides 634707
gene_process mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression 634708