Bcar1 (BCAR1 scaffold protein, Cas family member) - Rat Genome Database

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Gene: Bcar1 (BCAR1 scaffold protein, Cas family member) Heterocephalus glaber
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Symbol: Bcar1
Name: BCAR1 scaffold protein, Cas family member
RGD ID: 18921421
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); antigen receptor-mediated signaling pathway (ortholog); PARTICIPATES IN endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; ASSOCIATED WITH breast cancer (ortholog); breast ductal carcinoma (ortholog); Ductal Carcinoma (ortholog); FOUND IN actin cytoskeleton (ortholog); lamellipodium (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474611,660,426 - 11,695,988 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474611,660,859 - 11,695,991 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bcar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474611,660,426 - 11,695,988 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474611,660,859 - 11,695,991 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
BCAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,228,181 - 75,268,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1675,228,181 - 75,268,053 (-)Ensemblhg38GRCh38
GRCh371675,262,079 - 75,301,905 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,820,429 - 73,843,004 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341673,820,429 - 73,843,004NCBI
Celera1659,556,476 - 59,596,268 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1661,013,718 - 61,052,474 (-)NCBIHuRef
CHM1_11676,675,047 - 76,714,069 (-)NCBICHM1_1
T2T-CHM13v2.01681,274,930 - 81,314,755 (-)NCBIT2T-CHM13v2.0
Bcar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,437,106 - 112,470,481 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,437,106 - 112,470,441 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,710,474 - 111,743,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,710,474 - 111,743,809 (-)Ensemblmm10GRCm38
MGSCv378114,234,374 - 114,267,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368114,597,147 - 114,630,482 (-)NCBIMGSCv36mm8
Celera8115,938,849 - 115,972,131 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
Bcar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,588,500 - 56,623,190 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,588,500 - 56,623,190 (-)EnsemblGRCr8
mRatBN7.21939,679,215 - 39,713,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,679,204 - 39,713,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,538,528 - 46,573,365 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,191,851 - 47,226,683 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,436,088 - 49,470,662 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1950,419,939 - 50,454,777 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1948,543,405 - 48,578,243 (-)NCBILyon_Normotensive
Lyon_Hypertensive1950,418,166 - 50,453,005 (-)NCBILyon_Hypertensive
F344_StmMcwi1948,119,303 - 48,153,891 (-)NCBIF344_StmMcwi
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1939,039,406 - 39,062,496 (-)NCBICelera
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Cytogenetic Map19q12NCBI
Bcar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,227,337 - 2,260,565 (+)Ensembl
ChiLan1.0NW_0049554842,223,306 - 2,258,444 (+)NCBIChiLan1.0ChiLan1.0
BCAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,947,203 - 84,987,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11690,869,485 - 90,909,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01655,798,578 - 55,838,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11675,149,280 - 75,186,883 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,150,122 - 75,188,775 (-)EnsemblpanPan2panpan1.1
BCAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,463,906 - 75,499,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,463,926 - 75,512,476 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha575,439,949 - 75,476,374 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0575,819,916 - 75,856,356 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl575,820,630 - 75,856,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1575,712,186 - 75,748,588 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0575,547,221 - 75,583,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,038,420 - 76,074,849 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bcar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,556,294 - 35,594,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,992,193 - 24,033,031 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,994,130 - 24,032,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,367,758 - 12,404,818 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1612,369,332 - 12,404,822 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,225,439 - 12,247,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,709,409 - 60,749,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,707,006 - 60,732,882 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604715,305,423 - 15,350,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcar1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11731,404,835 - 31,440,000 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024153   ⟹   ENSHGLP00000023935
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474611,660,426 - 11,695,988 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000024154   ⟹   ENSHGLP00000023936
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474611,673,247 - 11,695,988 (+)Ensembl
RefSeq Acc Id: XM_004842838   ⟹   XP_004842895
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474611,673,898 - 11,695,991 (+)NCBI
RefSeq Acc Id: XM_004842839   ⟹   XP_004842896
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474611,673,898 - 11,695,991 (+)NCBI
RefSeq Acc Id: XM_013071485   ⟹   XP_012926939
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474611,660,859 - 11,695,991 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004842895 (Get FASTA)   NCBI Sequence Viewer  
  XP_004842896 (Get FASTA)   NCBI Sequence Viewer  
  XP_012926939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023935
  ENSHGLP00000023936
GenBank Protein JAO00431 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012926939   ⟸   XM_013071485
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QWG3 (UniProtKB/TrEMBL),   G5B5X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842895   ⟸   XM_004842838
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JHG4 (UniProtKB/TrEMBL),   G5B5X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842896   ⟸   XM_004842839
- Peptide Label: isoform X3
- UniProtKB: A0AAX6P3R1 (UniProtKB/TrEMBL),   G5B5X8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023936   ⟸   ENSHGLT00000024154
Ensembl Acc Id: ENSHGLP00000023935   ⟸   ENSHGLT00000024153


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017063 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024153 ENTREZGENE
  ENSHGLT00000024154 ENTREZGENE
Gene3D-CATH 1.20.120.830 UniProtKB/TrEMBL
  Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro BCAR1_C UniProtKB/TrEMBL
  BCAR1_SH3 UniProtKB/TrEMBL
  CAS_C UniProtKB/TrEMBL
  CAS_fam UniProtKB/TrEMBL
  Serine_rich_dom UniProtKB/TrEMBL
  Serine_rich_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report hgl:101709701 UniProtKB/TrEMBL
NCBI Gene Bcar1 ENTREZGENE
PANTHER PTHR10654 UniProtKB/TrEMBL
  PTHR10654:SF15 UniProtKB/TrEMBL
Pfam CAS_C UniProtKB/TrEMBL
  Serine_rich UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
UniProt A0A0P6JHG4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P3R1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QWG3 ENTREZGENE, UniProtKB/TrEMBL
  G5B5X8 ENTREZGENE, UniProtKB/TrEMBL