TOP3B (DNA topoisomerase III beta) - Rat Genome Database

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Pathways
Gene: TOP3B (DNA topoisomerase III beta) Chlorocebus sabaeus
Analyze
Symbol: TOP3B
Name: DNA topoisomerase III beta
RGD ID: 18780009
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN chromosome segregation (ortholog); FOUND IN condensed chromosome (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 3-beta-1; topoisomerase (DNA) III beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,137,823 - 4,163,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOP3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,137,823 - 4,163,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TOP3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,957,025 - 21,982,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,957,025 - 21,982,813 (-)Ensemblhg38GRCh38
GRCh372222,311,397 - 22,337,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,641,403 - 20,667,147 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342220,635,957 - 20,661,701NCBI
Celera226,128,944 - 6,154,663 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,268,479 - 5,294,196 (-)NCBIHuRef
CHM1_12222,311,501 - 22,337,220 (-)NCBICHM1_1
T2T-CHM13v2.02222,370,556 - 22,396,320 (-)NCBIT2T-CHM13v2.0
Top3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,688,587 - 16,710,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,688,600 - 16,710,854 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381616,870,722 - 16,892,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,870,736 - 16,892,990 (+)Ensemblmm10GRCm38
MGSCv371616,870,984 - 16,893,079 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361616,784,454 - 16,806,549 (+)NCBIMGSCv36mm8
Celera1617,442,801 - 17,464,977 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.46NCBI
Top3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,601,223 - 97,629,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,601,231 - 97,629,597 (-)EnsemblGRCr8
mRatBN7.21184,097,018 - 84,125,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,821,137 - 92,849,383 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,482,270 - 85,510,510 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,535,862 - 84,564,108 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1199,461,132 - 99,489,396 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1197,661,616 - 97,689,988 (-)NCBILyon_Normotensive
Lyon_Hypertensive1198,581,792 - 98,610,036 (-)NCBILyon_Hypertensive
F344_StmMcwi1197,391,505 - 97,419,877 (-)NCBIF344_StmMcwi
Rnor_6.01188,346,305 - 88,374,896 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)Ensemblrn6Rnor6.0
Rnor_5.01191,401,389 - 91,429,964 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,116,936 - 86,145,314 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,851,647 - 82,880,025 (-)NCBICelera
RGSC_v3.11186,157,538 - 86,185,850 (-)NCBI
Cytogenetic Map11q23NCBI
Top3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,200,453 - 17,225,335 (+)Ensembl
ChiLan1.0NW_00495544217,201,079 - 17,223,824 (+)NCBIChiLan1.0ChiLan1.0
TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,498,751 - 31,524,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,047,630 - 34,073,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,076,295 - 4,102,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,557,248 - 20,583,307 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,557,248 - 20,583,464 (-)EnsemblpanPan2panpan1.1
TOP3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,198,371 - 31,223,133 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,198,382 - 31,215,134 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2631,154,388 - 31,178,817 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02632,604,302 - 32,628,806 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,604,310 - 32,628,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,652,585 - 30,677,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,276,606 - 30,301,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,367,160 - 31,391,836 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,971,807 - 140,997,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,756,791 - 1,785,953 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,756,829 - 1,782,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,020,509 - 50,037,856 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11450,020,412 - 50,037,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,462,935 - 53,480,381 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Top3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Top3b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v142,155,300 - 2,185,805 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in TOP3B
591 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000011826   ⟹   ENSCSAP00000009886
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)Ensembl
RefSeq Acc Id: XM_007974906   ⟹   XP_007973097
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1194,137,823 - 4,163,860 (+)NCBI
Vero_WHO_p1.0NW_0236660852,839,441 - 2,865,520 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007974907   ⟹   XP_007973098
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1194,137,854 - 4,163,860 (+)NCBI
Vero_WHO_p1.0NW_0236660852,839,447 - 2,865,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994793   ⟹   XP_037850721
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660852,839,447 - 2,865,467 (-)NCBI
RefSeq Acc Id: XM_037994794   ⟹   XP_037850722
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBI
RefSeq Acc Id: XR_493635
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1194,137,826 - 4,163,372 (+)NCBI
Vero_WHO_p1.0NW_0236660852,839,903 - 2,865,520 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973097 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973098 (Get FASTA)   NCBI Sequence Viewer  
  XP_072863069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009886.1
RefSeq Acc Id: XP_007973097   ⟸   XM_007974906
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RMP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973098   ⟸   XM_007974907
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RMP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009886   ⟸   ENSCSAT00000011826
RefSeq Acc Id: XP_037850722   ⟸   XM_037994794
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037850721   ⟸   XM_037994793
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013729 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011826.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.290.10 UniProtKB/TrEMBL
  1.10.460.10 UniProtKB/TrEMBL
  2.70.20.10 UniProtKB/TrEMBL
  3.40.50.140 UniProtKB/TrEMBL
InterPro Topo_IA UniProtKB/TrEMBL
  Topo_IA_2 UniProtKB/TrEMBL
  Topo_IA_AS UniProtKB/TrEMBL
  Topo_IA_cen UniProtKB/TrEMBL
  Topo_IA_cen_sub1 UniProtKB/TrEMBL
  Topo_IA_cen_sub2 UniProtKB/TrEMBL
  Topo_IA_cen_sub3 UniProtKB/TrEMBL
  Topo_IA_core_domain UniProtKB/TrEMBL
  Topo_IA_DNA-bd_dom UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoIII UniProtKB/TrEMBL
  Zn_ribbon_TOP3B UniProtKB/TrEMBL
KEGG Report csab:103222938 UniProtKB/TrEMBL
NCBI Gene TOP3B ENTREZGENE
PANTHER DNA TOPOISOMERASE 3-BETA-1 UniProtKB/TrEMBL
  PTHR11390 UniProtKB/TrEMBL
Pfam Topoisom_bac UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  Zn_ribbon_TOP3B UniProtKB/TrEMBL
PRINTS PRTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPO_IA_2 UniProtKB/TrEMBL
  TOPOISOMERASE_I_PROK UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
SMART TOP1Ac UniProtKB/TrEMBL
  TOP1Bc UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
Superfamily-SCOP SSF56712 UniProtKB/TrEMBL
UniProt A0A0D9RMP7 ENTREZGENE, UniProtKB/TrEMBL