TOP3B (DNA topoisomerase III beta)

Gene: TOP3B (DNA topoisomerase III beta) Canis lupus familiaris

Analyze

Symbol:

TOP3B

Name:

DNA topoisomerase III beta

RGD ID:

12189258

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN chromosome segregation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); FOUND IN condensed chromosome (ortholog); DNA topoisomerase III-beta-TDRD3 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 3-beta-1; topoisomerase (DNA) III beta

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOP3B (DNA topoisomerase III beta)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Top3b (topoisomerase (DNA) III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Top3b (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Top3b (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOP3B (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Top3b (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOP3B (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOP3B (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Top3b (DNA topoisomerase III beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,198,371 - 31,223,133 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,604,302 - 32,628,806 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,604,310 - 32,628,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,652,585 - 30,677,122 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,276,606 - 30,301,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,836 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

DiGeorge syndrome (ISO)

genetic disease (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome segregation (ISO)

DNA topological change (IEA)

Cellular Component

condensed chromosome (ISO)

DNA topoisomerase III-beta-TDRD3 complex (ISO)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,198,371 - 31,223,133 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,604,302 - 32,628,806 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,604,310 - 32,628,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,652,585 - 30,677,122 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,276,606 - 30,301,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,836 (-)	NCBI		UU_Cfam_GSD_1.0

TOP3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,957,025 - 21,982,787 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,957,025 - 21,982,813 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,311,397 - 22,337,184 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,641,403 - 20,667,147 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,635,957 - 20,661,701	NCBI
Celera	22	6,128,944 - 6,154,663 (-)	NCBI		Celera
Cytogenetic Map	22	q11.22	NCBI
HuRef	22	5,268,479 - 5,294,196 (-)	NCBI		HuRef
CHM1_1	22	22,311,501 - 22,337,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,370,556 - 22,396,320 (-)	NCBI		T2T-CHM13v2.0

Top3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,688,587 - 16,710,850 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,688,600 - 16,710,854 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	16,870,722 - 16,892,986 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	16,870,736 - 16,892,990 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	16,870,984 - 16,893,079 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	16,784,454 - 16,806,549 (+)	NCBI		MGSCv36	mm8
Celera	16	17,442,801 - 17,464,977 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.46	NCBI

Top3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,601,223 - 97,629,678 (-)	NCBI		GRCr8
mRatBN7.2	11	84,097,018 - 84,125,474 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	84,097,026 - 84,125,392 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,821,137 - 92,849,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,482,270 - 85,510,510 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,535,862 - 84,564,108 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,346,305 - 88,374,896 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,346,313 - 88,374,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,401,389 - 91,429,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	86,116,936 - 86,145,314 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,157,538 - 86,185,850 (-)	NCBI
Celera	11	82,851,647 - 82,880,025 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Top3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,200,453 - 17,225,335 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,201,079 - 17,223,824 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,557 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	34,047,630 - 34,073,423 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl	panpan1.1		panPan2

Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,971,807 - 140,997,296 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,756,791 - 1,785,953 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,756,829 - 1,782,063 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,020,509 - 50,037,856 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,020,412 - 50,037,854 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,462,935 - 53,480,381 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,137,823 - 4,163,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,137,862 - 4,166,436 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,836,805 - 2,865,520 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,446,412 - 1,473,600 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,450,236 - 1,473,467 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TOP3B
488 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	3	5	18	2	2	2	6	6	12	8	10	6
Low	2		4	4	4	4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005636633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005636634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014108221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038437643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038437644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038437645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038437646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038437647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038459151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_534771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000024557 ⟹ ENSCAFP00000022795

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000071362 ⟹ ENSCAFP00000063550

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046997 ⟹ ENSCAFP00845036878

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	26	32,604,310 - 32,628,701 (-)	Ensembl

RefSeq Acc Id:

XM_005636633 ⟹ XP_005636690

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,198,371 - 31,222,885 (-)	NCBI
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,555 (-)	NCBI

Sequence:

show sequence

ATCGACCCTCCCGCGGGGCTCTGAGGTGCGGGCTGCGGCCACAGGTGGGGAGACGGAGGTGCGG
GGGGCCGCCTGCCGCCCCGGGCCCGGCCCGGCCTTGAGGGCTCCCGGGTGTGTTTCTCCGAGTT
GTTGGTGGACAGACTCGCCGGATTCAGTTCTCGCAGGTGAAAGGGAGGACTGGCCTTATCCTGC
CTCTTTGCCACTCAGCCTTCGGGAGAGGACGTGGGAAGGTCCGCCCAGAGTGGGCTTGATGGCC
ACGGAGCCCCGAGGTGCCCCTAGAGCCGCGGCAAAGGTCGCCTGGGCCTCGGCCGCATTGTTCT
GAGCCTCGGTCCGCTCGCAGTCAGAAAACTGCCCAGGCCAGCCTCGAGGCGTGACGGGCCAGGC
TGGAGAGAGCGGCGGCGTGCGGAGCGGGGCTTGCGTGCAGAGGAGGGGCTTGCTCTCCGGACCC
CGCGGCACCGGGTTAAGTGGCCAAGGTGGAGATCCTGCTCTCGGTGCTGTCTGCGCCACCGCTG
GGCCTCCACCCCCAAGCCGAGTTCCGTTGTTCGTAAGACTGACAGGGGAGGACTTGGTGTACCG
CGACCCCCGAGGGCACCCACCGTTGCTGATCCTGCTGCCCAGAGGAGAGTCCGCCGACCGGCAG
AGTCAGCTTTGATGGTAGTGTTGAGCTGCAGAAGAACAGTTTCTGAACTTCATCTCCATCCCTC
TGAAACTGGAGTGTGAAGGGCCAAAACCCCGGGCAGCTTTCAGACAAGATGAAGACCGTGCTCA
TGGTTGCAGAAAAGCCATCCTTGGCCCAGTCCATTGCTAAAATCCTCTCTCGGGGAAACATGTC
CTCCCACAAAGGGCTGAACGGAACATGCTCCGTGCATGAGTACAGCGGGACCTTTGCTGGCCAG
CCCGTCCGCTTCAAGATGACATCCGTCTGTGGTCATGTGATGACCTTGGATTTCCTGGGAAAGT
ACAACAAATGGGACAAGGTGGACCCCGCAGAGCTGTTCAGCCAAGCCCCGACAGAGAAGAAGGA
GGCTAACCCCAAGCTGAACATGGTGAAGTTCCTGCAGGTGGAGGGCAAAGGCTGCGACTATATT
GTGCTATGGCTGGACTGCGACAAGGAGGGAGAGAACATCTGTTTTGAGGTCCTGGACGCTGTGC
TGCCCGTCATGAATCCAACCCATAGTGGCGAAAAGACCGTGTTCCGGGCCAGGTTCAGCTCCAT
CACAGACACGGACATCTGTGCTGCCATGGCCCGCCTGGGCGAGCCAGACCACAACGAGGCGCTG
TCGGTGGACGCCAGGCAAGAGCTGGACCTGCGCATCGGCTGTGCGTTCACCAGATTTCAAACTA
AGTACTTCCAGGGAAAATATGGCAATCTAGACAGCTCCCTCATCTCCTTTGGGCCATGTCAAAC
CCCTACCCTGGGCTTCTGCGTGGAGAGACATGATAAAATCCAGTCCTTCAAACCGGAGACGTAC
TGGGTGCTGCAGGCCAAGGTCAATGCCGATAAAGACAGATCTCTTCTTTTGGACTGGGACCGAG
TACGAGTGTTCGACCGGGAGATCGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAAGC
CCAGGTGGAGGCCACAAGCAGGAAAGAGAAGGCCAAGCAGAGGCCCCTCGCCCTTAACACTGTG
GAGATGCTGCGTGTCGCTAGCTCTTCTCTGGGCATGGGGCCACAGCATGCCATGCAGACCGCTG
AGCGCCTCTACACGCAAGGCTACATCAGCTACCCGAGGACTGAGACTACCCACTACCCCGAGAA
CTTTGACCTGAAGGGCCCTCTGCGGCAGCAGGCCAACCACCCCTACTGGGCCGACACGGTAAAG
CGCTTGTTAGCCGAAGGTATCAACCGGCCACGGAAAGGCCATGATGCCGGCGACCATCCTCCCA
TCACCCCCATGAGATCTGCCACAGAGGCTGAATTAGGGAGTGAGGCGTGGCGGCTCTATGAGTA
CATCACCAGACACTTCATCGCCACTGTTAGCTATGACTGCAAGTACCTCCAGAGCACCATTTCC
TTCAGAATCGGGCCTGAGCACTTCACGTGCACGGGGAAAACCGTCATCTCTCCAGGCTTCACGG
AGATCATGCCTTGGCAGAGTGTGCCTCTGGAGGAGAGCCTGCCCACCTGCCAGAGGGGCGACTG
CTTTCCTGTGAGCGAGATGAAGATGCTAGAGAAGCAGACCAGCCCGCCCGACTACCTGACGGAG
GCTGAGCTCATCACACTCATGGAGAAGCACGGCATTGGGACAGACGCCAGCATCCCCGTGCACA
TCAACAACATCTGCCAGCGCAACTACGTCACTGTGGAGAGCGGGCGCCGCCTCAAACCCACCAA
CCTGGGCATCGTCCTGGTGCACGGCTACTACAAGATTGATGCAGAGCTCGTGCTCCCCACTATC
CGCAGCGCAGTGGAGAAGCAGCTGAACCTGATCGCCCAGGGCAAGGCTGACTACCGCCAGGTCC
TGGGCCACACGCTGGACGTCTTCAAGAGGAAGTTCCACTACTTTGTGGACTCCATCGCCGGGAT
GGACGAGCTGATGGAGGTGTCTTTTTCACCCCTGGCAGCCACGGGCAAGCCCCTCTCCCGCTGT
GGAAAGTGCCACCGGTTCATGAAGTACATTCAGGCCAAGCCAAGCCGCCTACACTGCTCACACT
GTGACGAGACCTACACCCTCCCCCAGAATGGCACCATCAAGCTCTACAAGGAGCTCCGGTGTCC
ACTGGATGACTTCGAGCTGGTCCTGTGGTCATCGGGCTCTCGGGGCAAGAGCTACCCACTGTGC
CCCTATTGCTCCAACCACCCACCCTTCCGAGACATGAAGAAAGGCATGGGCTGCAATGAGTGCA
CACACCCCACCTGCCAGCACTCACTGAGCATGCTGGGCATCGGCCAGTGCGTGGAATGTGAGAG
CGGCGTGCTGGTGCTGGACCCCACCTCAGGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCAAC
GTGGTGGCACACTGCTTTGAGAATGCCTACCGTGTGCGGGTGTCTGCCGACACCTGCCCCACCT
GTGAGGCTGCCCTGCTTGCCGTGGACTTCAACAAGGCCAAATCCCCGCTCCCAGGTGACGAGAC
ACAGCACACAGGCTGCGTCTTCTGCGACCCTGTCTTCCAGGAGCTGGTGGAGCTGAAGCACGCA
GCCTCCTGCCACCCCATGCACCGGGGAGGGCCAGGGAGGAGGCAGGGCCGAGGGCGGGCTCGGG
GCCGGCGGCCCACAGGGAAGCCCAGTGCCAGGCGGCCGAAGGACAAGATGTCAGCCCTGGCTGC
CTACTTTGTATGACGGCCCCGCCAACCCTCACCAGGCTCCACATAGTTTCCCGTGGGCCTCGGA
AATCATTAAAATGCAATTTGTCGTCTTCAGAGCAAGCAA

hide sequence

RefSeq Acc Id:

XM_005636634 ⟹ XP_005636691

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,198,371 - 31,222,887 (-)	NCBI
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,556 (-)	NCBI

Sequence:

show sequence

CCATCGACCCTCCCGCGGGGCTCTGAGGTGCGGGCTGCGGCCACAGGTGGGGAGACGGAGGTGC
GGGGGGCCGCCTGCCGCCCCGGGCCCGGCCCGGCCTTGAGGGCTCCCGGGTGTGTTTCTCCGAG
TTGTTGGTGGACAGACTCGCCGGATTCAGTTCTCGCAGGTGAAAGGGAGGACTGGCCTTATCCT
GCCTCTTTGCCACTCAGCCTTCGGGAGAGGACGTGGGAAGGTCCGCCCAGAGTGGGCTTGATGG
CCACGGAGCCCCGAGGTGCCCCTAGAGCCGCGGCAAAGGTCGCCTGGGCCTCGGCCGCATTGTT
CTGAGCCTCGGTCCGCTCGCAGTCAGAAAACTGCCCAGGCCAGCCTCGAGGCGTGACGGGCCAG
GCTGGAGAGAGCGGCGGCGTGCGGAGCGGGGCTTGCGTGCAGAGGAGGGGCTTGCTCTCCGGAC
CCCGCGGCACCGGGTTAAGTGGCCAAGGTGGAGATCCTGCTCTCGGTGCTGTCTGCGCCACCGC
TGGGCCTCCACCCCCAAGCCGAGTTCCGTTGTTCGTAAGACTGACAGGGGAGGACTTGGTGTAC
CGCGACCCCCGAGGGCACCCACCGTTGCTGATCCTGCTGCCCAGAGGAGAGTCCGCCGACCGGC
AGAGTCAGCTTTGATGGTAGTGTTGAGCTGCAGAAGAACAGTTTCTGAACTTCATCTCCATCCC
TCTGAAACTGGAGTGTGAAGGGCCAAAACCCCGGGCAGCTTTCAGACAAGATGAAGACCGTGCT
CATGGTTGCAGAAAAGCCATCCTTGGCCCAGTCCATTGCTAAAATCCTCTCTCGGGGAAACATG
TCCTCCCACAAAGGGCTGAACGGAACATGCTCCGTGCATGAGTACAGCGGGACCTTTGCTGGCC
AGCCCGTCCGCTTCAAGATGACATCCGTCTGTGGTCATGTGATGACCTTGGATTTCCTGGGAAA
GTACAACAAATGGGACAAGGTGGACCCCGCAGAGCTGTTCAGCCAAGCCCCGACAGAGAAGAAG
GAGGCTAACCCCAAGCTGAACATGGTGAAGTTCCTGCAGGTGGAGGGCAAAGGCTGCGACTATA
TTGTGCTATGGCTGGACTGCGACAAGGAGGGAGAGAACATCTGTTTTGAGGTCCTGGACGCTGT
GCTGCCCGTCATGAATCCAACCCATAGTGGCGAAAAGACCGTGTTCCGGGCCAGGTTCAGCTCC
ATCACAGACACGGACATCTGTGCTGCCATGGCCCGCCTGGGCGAGCCAGACCACAACGAGGCGC
TGTCGGTGGACGCCAGGCAAGAGCTGGACCTGCGCATCGGCTGTGCGTTCACCAGATTTCAAAC
TAAGTACTTCCAGGGAAAATATGGCAATCTAGACAGCTCCCTCATCTCCTTTGGGCCATGTCAA
ACCCCTACCCTGGGCTTCTGCGTGGAGAGACATGATAAAATCCAGTCCTTCAAACCGGAGACGT
ACTGGGTGCTGCAGGCCAAGGTCAATGCCGATAAAGACAGATCTCTTCTTTTGGACTGGGACCG
AGTACGAGTGTTCGACCGGGAGATCGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAA
GCCCAGGTGGAGGCCACAAGCAGGAAAGAGAAGGCCAAGCAGAGGCCCCTCGCCCTTAACACTG
TGGAGATGCTGCGTGTCGCTAGCTCTTCTCTGGGCATGGGGCCACAGCATGCCATGCAGACCGC
TGAGCGCCTCTACACGCAAGGCTACATCAGCTACCCGAGGACTGAGACTACCCACTACCCCGAG
AACTTTGACCTGAAGGGCCCTCTGCGGCAGCAGGCCAACCACCCCTACTGGGCCGACACGGTAA
AGCGCTTGTTAGCCGAAGGTATCAACCGGCCACGGAAAGGCCATGATGCCGGCGACCATCCTCC
CATCACCCCCATGAGATCTGCCACAGAGGCTGAATTAGGGAGTGAGGCGTGGCGGCTCTATGAG
TACATCACCAGACACTTCATCGCCACTGTTAGCTATGACTGCAAGTACCTCCAGAGCACCATTT
CCTTCAGAATCGGGCCTGAGCACTTCACGTGCACGGGGAAAACCGTCATCTCTCCAGGCTTCAC
GGAGATCATGCCTTGGCAGAGTGTGCCTCTGGAGGAGAGCCTGCCCACCTGCCAGAGGGGCGAC
TGCTTTCCTGTGAGCGAGATGAAGATGCTAGAGAAGCAGACCAGCCCGCCCGACTACCTGACGG
AGGCTGAGCTCATCACACTCATGGAGAAGCACGGCATTGGGACAGACGCCAGCATCCCCGTGCA
CATCAACAACATCTGCCAGCGCAACTACGTCACTGTGGAGAGCGGGCGCCGCCTCAAACCCACC
AACCTGGGCATCGTCCTGGTGCACGGCTACTACAAGATTGATGCAGAGCTCGTGCTCCCCACTA
TCCGCAGCGCAGTGGAGAAGCAGCTGAACCTGATCGCCCAGGGCAAGGCTGACTACCGCCAGGT
CCTGGGCCACACGCTGGACGTCTTCAAGAGGAAGTTCCACTACTTTGTGGACTCCATCGCCGCC
ACGGGCAAGCCCCTCTCCCGCTGTGGAAAGTGCCACCGGTTCATGAAGTACATTCAGGCCAAGC
CAAGCCGCCTACACTGCTCACACTGTGACGAGACCTACACCCTCCCCCAGAATGGCACCATCAA
GCTCTACAAGGAGCTCCGGTGTCCACTGGATGACTTCGAGCTGGTCCTGTGGTCATCGGGCTCT
CGGGGCAAGAGCTACCCACTGTGCCCCTATTGCTCCAACCACCCACCCTTCCGAGACATGAAGA
AAGGCATGGGCTGCAATGAGTGCACACACCCCACCTGCCAGCACTCACTGAGCATGCTGGGCAT
CGGCCAGTGCGTGGAATGTGAGAGCGGCGTGCTGGTGCTGGACCCCACCTCAGGCCCCAAGTGG
AAGGTGGCCTGCAACAAGTGCAACGTGGTGGCACACTGCTTTGAGAATGCCTACCGTGTGCGGG
TGTCTGCCGACACCTGCCCCACCTGTGAGGCTGCCCTGCTTGCCGTGGACTTCAACAAGGCCAA
ATCCCCGCTCCCAGGTGACGAGACACAGCACACAGGCTGCGTCTTCTGCGACCCTGTCTTCCAG
GAGCTGGTGGAGCTGAAGCACGCAGCCTCCTGCCACCCCATGCACCGGGGAGGGCCAGGGAGGA
GGCAGGGCCGAGGGCGGGCTCGGGGCCGGCGGCCCACAGGGAAGCCCAGTGCCAGGCGGCCGAA
GGACAAGATGTCAGCCCTGGCTGCCTACTTTGTATGACGGCCCCGCCAACCCTCACCAGGCTCC
ACATAGTTTCCCGTGGGCCTCGGAAATCATTAAAATGCAATTTGTCGTCTTCAGAGCAAGCAA

hide sequence

RefSeq Acc Id:

XM_014108221 ⟹ XP_013963696

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,198,461 - 31,213,836 (-)	NCBI
Dog10K_Boxer_Tasha	26	31,154,478 - 31,169,498 (-)	NCBI

Sequence:

show sequence

GGAAACATGTCCTCCCACAAAGGGCTGAACGGAACATGCTCCGTGCATGAGTACAGCGGGACCT
TTGCTGGCCAGCCCGTCCGCTTCAAGATGACATCCGTCTGTGGTCATGTGATGACCTTGGATTT
CCTGGGATTGAGGACTCAGTGTGACGGTGAAGGAAGAGAGCTTAGTGCACAGCAAAGTCTCAAT
ACTTCTTGTTGCCCAGTGACAACAAGGACATTGATTCAGTCGTGTGGCCAAGCATTTGGACTCT
TGAGTTTTATCACCAGCCAGCAGGAAAGTACAACAAATGGGACAAGGTGGACCCCGCAGAGCTG
TTCAGCCAAGCCCCGACAGAGAAGAAGGAGGCTAACCCCAAGCTGAACATGGTGAAGTTCCTGC
AGGTGGAGGGCAAAGGCTGCGACTATATTGTGCTATGGCTGGACTGCGACAAGGAGGGAGAGAA
CATCTGTTTTGAGGTCCTGGACGCTGTGCTGCCCGTCATGAATCCAACCCATAGTGGCGAAAAG
ACCGTGTTCCGGGCCAGGTTCAGCTCCATCACAGACACGGACATCTGTGCTGCCATGGCCCGCC
TGGGCGAGCCAGACCACAACGAGGCGCTGTCGGTGGACGCCAGGCAAGAGCTGGACCTGCGCAT
CGGCTGTGCGTTCACCAGATTTCAAACTAAGTACTTCCAGGGAAAATATGGCAATCTAGACAGC
TCCCTCATCTCCTTTGGGCCATGTCAAACCCCTACCCTGGGCTTCTGCGTGGAGAGACATGATA
AAATCCAGTCCTTCAAACCGGAGACGTACTGGGTGCTGCAGGCCAAGGTCAATGCCGATAAAGA
CAGATCTCTTCTTTTGGACTGGGACCGAGTACGAGTGTTCGACCGGGAGATCGCACAGATGTTT
TTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAGAAGGCCA
AGCAGAGGCCCCTCGCCCTTAACACTGTGGAGATGCTGCGTGTCGCTAGCTCTTCTCTGGGCAT
GGGGCCACAGCATGCCATGCAGACCGCTGAGCGCCTCTACACGCAAGGCTACATCAGCTACCCG
AGGACTGAGACTACCCACTACCCCGAGAACTTTGACCTGAAGGGCCCTCTGCGGCAGCAGGCCA
ACCACCCCTACTGGGCCGACACGGTAAAGCGCTTGTTAGCCGAAGGTATCAACCGGCCACGGAA
AGGCCATGATGCCGGCGACCATCCTCCCATCACCCCCATGAGATCTGCCACAGAGGCTGAATTA
GGGAGTGAGGCGTGGCGGCTCTATGAGTACATCACCAGACACTTCATCGCCACTGTTAGCTATG
ACTGCAAGTACCTCCAGAGCACCATTTCCTTCAGAATCGGGCCTGAGCACTTCACGTGCACGGG
GAAAACCGTCATCTCTCCAGGCTTCACGGAGATCATGCCTTGGCAGAGTGTGCCTCTGGAGGAG
AGCCTGCCCACCTGCCAGAGGGGCGACTGCTTTCCTGTGAGCGAGATGAAGATGCTAGAGAAGC
AGACCAGCCCGCCCGACTACCTGACGGAGGCTGAGCTCATCACACTCATGGAGAAGCACGGCAT
TGGGACAGACGCCAGCATCCCCGTGCACATCAACAACATCTGCCAGCGCAACTACGTCACTGTG
GAGAGCGGGCGCCGCCTCAAACCCACCAACCTGGGCATCGTCCTGGTGCACGGCTACTACAAGA
TTGATGCAGAGCTCGTGCTCCCCACTATCCGCAGCGCAGTGGAGAAGCAGCTGAACCTGATCGC
CCAGGGCAAGGCTGACTACCGCCAGGTCCTGGGCCACACGCTGGACGTCTTCAAGAGGAAGTTC
CACTACTTTGTGGACTCCATCGCCGGGATGGACGAGCTGATGGAGGTGTCTTTTTCACCCCTGG
CAGCCACGGGCAAGCCCCTCTCCCGCTGTGGAAAGTGCCACCGGTTCATGAAGTACATTCAGGC
CAAGCCAAGCCGCCTACACTGCTCACACTGTGACGAGACCTACACCCTCCCCCAGAATGGCACC
ATCAAGCTCTACAAGGAGCTCCGGTGTCCACTGGATGACTTCGAGCTGGTCCTGTGGTCATCGG
GCTCTCGGGGCAAGAGCTACCCACTGTGCCCCTATTGCTCCAACCACCCACCCTTCCGAGACAT
GAAGAAAGGCATGGGCTGCAATGAGTGCACACACCCCACCTGCCAGCACTCACTGAGCATGCTG
GGCATCGGCCAGTGCGTGGAATGTGAGAGCGGCGTGCTGGTGCTGGACCCCACCTCAGGCCCCA
AGTGGAAGGTGGCCTGCAACAAGTGCAACGTGGTGGCACACTGCTTTGAGAATGCCTACCGTGT
GCGGGTGTCTGCCGACACCTGCCCCACCTGTGAGGCTGCCCTGCTTGCCGTGGACTTCAACAAG
GCCAAATCCCCGCTCCCAGGTGACGAGACACAGCACACAGGCTGCGTCTTCTGCGACCCTGTCT
TCCAGGAGCTGGTGGAGCTGAAGCACGCAGCCTCCTGCCACCCCATGCACCGGGGAGGGCCAGG
GAGGAGGCAGGGCCGAGGGCGGGCTCGGGGCCGGCGGCCCACAGGGAAGCCCAGTGCCAGGCGG
CCGAAGGACAAGATGTCAGCCCTGGCTGCCTACTTTGTATGA

hide sequence

RefSeq Acc Id:

XM_038437643 ⟹ XP_038293571

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	26	32,604,392 - 32,628,760 (-)	NCBI

RefSeq Acc Id:

XM_038437644 ⟹ XP_038293572

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	26	32,604,392 - 32,628,806 (-)	NCBI

RefSeq Acc Id:

XM_038437645 ⟹ XP_038293573

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	26	32,604,302 - 32,628,544 (-)	NCBI

RefSeq Acc Id:

XM_038437646 ⟹ XP_038293574

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	26	32,604,302 - 32,628,546 (-)	NCBI

RefSeq Acc Id:

XM_038437647 ⟹ XP_038293575

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	26	32,604,392 - 32,619,509 (-)	NCBI

RefSeq Acc Id:

XM_038459151 ⟹ XP_038315079

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	26	31,154,478 - 31,178,771 (-)	NCBI

RefSeq Acc Id:

XM_038512510 ⟹ XP_038368438

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	26	30,652,675 - 30,677,076 (-)	NCBI

RefSeq Acc Id:

XM_038512511 ⟹ XP_038368439

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	26	30,652,675 - 30,677,122 (-)	NCBI

RefSeq Acc Id:

XM_038512512 ⟹ XP_038368440

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	26	30,652,585 - 30,676,860 (-)	NCBI

RefSeq Acc Id:

XM_038512513 ⟹ XP_038368441

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	26	30,652,585 - 30,676,861 (-)	NCBI

RefSeq Acc Id:

XM_038512514 ⟹ XP_038368442

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	26	30,652,675 - 30,667,803 (-)	NCBI

RefSeq Acc Id:

XM_038576004 ⟹ XP_038431932

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	26	31,367,250 - 31,391,790 (-)	NCBI

RefSeq Acc Id:

XM_038576005 ⟹ XP_038431933

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	26	31,367,250 - 31,391,836 (-)	NCBI

RefSeq Acc Id:

XM_038576006 ⟹ XP_038431934

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,573 (-)	NCBI

RefSeq Acc Id:

XM_038576007 ⟹ XP_038431935

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,575 (-)	NCBI

RefSeq Acc Id:

XM_038576008 ⟹ XP_038431936

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	26	31,367,250 - 31,382,316 (-)	NCBI

RefSeq Acc Id:

XM_038640214 ⟹ XP_038496142

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	26	30,276,696 - 30,301,165 (-)	NCBI

RefSeq Acc Id:

XM_038640215 ⟹ XP_038496143

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	26	30,276,696 - 30,301,211 (-)	NCBI

RefSeq Acc Id:

XM_038640216 ⟹ XP_038496144

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	26	30,276,606 - 30,300,948 (-)	NCBI

RefSeq Acc Id:

XM_038640217 ⟹ XP_038496145

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	26	30,276,606 - 30,300,950 (-)	NCBI

RefSeq Acc Id:

XM_038640218 ⟹ XP_038496146

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	26	30,276,696 - 30,291,713 (-)	NCBI

RefSeq Acc Id:

XM_534771 ⟹ XP_534771

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,198,461 - 31,223,133 (-)	NCBI
Dog10K_Boxer_Tasha	26	31,154,478 - 31,178,817 (-)	NCBI

Sequence:

show sequence

CCGGACCGGAAGTGGAGGCTGCCGAGTCCGCCCCCCGAGCGGAAGCTGCGGCGGGAGCCCCGGC
GGGGGCCGCGGCGGGGCTGCGGGAGTCAGCTTTGATGGTAGTGTTGAGCTGCAGAAGAACAGTT
TCTGAACTTCATCTCCATCCCTCTGAAACTGGAGTGTGAAGGGCCAAAACCCCGGGCAGCTTTC
AGACAAGATGAAGACCGTGCTCATGGTTGCAGAAAAGCCATCCTTGGCCCAGTCCATTGCTAAA
ATCCTCTCTCGGGGAAACATGTCCTCCCACAAAGGGCTGAACGGAACATGCTCCGTGCATGAGT
ACAGCGGGACCTTTGCTGGCCAGCCCGTCCGCTTCAAGATGACATCCGTCTGTGGTCATGTGAT
GACCTTGGATTTCCTGGGAAAGTACAACAAATGGGACAAGGTGGACCCCGCAGAGCTGTTCAGC
CAAGCCCCGACAGAGAAGAAGGAGGCTAACCCCAAGCTGAACATGGTGAAGTTCCTGCAGGTGG
AGGGCAAAGGCTGCGACTATATTGTGCTATGGCTGGACTGCGACAAGGAGGGAGAGAACATCTG
TTTTGAGGTCCTGGACGCTGTGCTGCCCGTCATGAATCCAACCCATAGTGGCGAAAAGACCGTG
TTCCGGGCCAGGTTCAGCTCCATCACAGACACGGACATCTGTGCTGCCATGGCCCGCCTGGGCG
AGCCAGACCACAACGAGGCGCTGTCGGTGGACGCCAGGCAAGAGCTGGACCTGCGCATCGGCTG
TGCGTTCACCAGATTTCAAACTAAGTACTTCCAGGGAAAATATGGCAATCTAGACAGCTCCCTC
ATCTCCTTTGGGCCATGTCAAACCCCTACCCTGGGCTTCTGCGTGGAGAGACATGATAAAATCC
AGTCCTTCAAACCGGAGACGTACTGGGTGCTGCAGGCCAAGGTCAATGCCGATAAAGACAGATC
TCTTCTTTTGGACTGGGACCGAGTACGAGTGTTCGACCGGGAGATCGCACAGATGTTTTTAAAC
ATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAGAAGGCCAAGCAGA
GGCCCCTCGCCCTTAACACTGTGGAGATGCTGCGTGTCGCTAGCTCTTCTCTGGGCATGGGGCC
ACAGCATGCCATGCAGACCGCTGAGCGCCTCTACACGCAAGGCTACATCAGCTACCCGAGGACT
GAGACTACCCACTACCCCGAGAACTTTGACCTGAAGGGCCCTCTGCGGCAGCAGGCCAACCACC
CCTACTGGGCCGACACGGTAAAGCGCTTGTTAGCCGAAGGTATCAACCGGCCACGGAAAGGCCA
TGATGCCGGCGACCATCCTCCCATCACCCCCATGAGATCTGCCACAGAGGCTGAATTAGGGAGT
GAGGCGTGGCGGCTCTATGAGTACATCACCAGACACTTCATCGCCACTGTTAGCTATGACTGCA
AGTACCTCCAGAGCACCATTTCCTTCAGAATCGGGCCTGAGCACTTCACGTGCACGGGGAAAAC
CGTCATCTCTCCAGGCTTCACGGAGATCATGCCTTGGCAGAGTGTGCCTCTGGAGGAGAGCCTG
CCCACCTGCCAGAGGGGCGACTGCTTTCCTGTGAGCGAGATGAAGATGCTAGAGAAGCAGACCA
GCCCGCCCGACTACCTGACGGAGGCTGAGCTCATCACACTCATGGAGAAGCACGGCATTGGGAC
AGACGCCAGCATCCCCGTGCACATCAACAACATCTGCCAGCGCAACTACGTCACTGTGGAGAGC
GGGCGCCGCCTCAAACCCACCAACCTGGGCATCGTCCTGGTGCACGGCTACTACAAGATTGATG
CAGAGCTCGTGCTCCCCACTATCCGCAGCGCAGTGGAGAAGCAGCTGAACCTGATCGCCCAGGG
CAAGGCTGACTACCGCCAGGTCCTGGGCCACACGCTGGACGTCTTCAAGAGGAAGTTCCACTAC
TTTGTGGACTCCATCGCCGGGATGGACGAGCTGATGGAGGTGTCTTTTTCACCCCTGGCAGCCA
CGGGCAAGCCCCTCTCCCGCTGTGGAAAGTGCCACCGGTTCATGAAGTACATTCAGGCCAAGCC
AAGCCGCCTACACTGCTCACACTGTGACGAGACCTACACCCTCCCCCAGAATGGCACCATCAAG
CTCTACAAGGAGCTCCGGTGTCCACTGGATGACTTCGAGCTGGTCCTGTGGTCATCGGGCTCTC
GGGGCAAGAGCTACCCACTGTGCCCCTATTGCTCCAACCACCCACCCTTCCGAGACATGAAGAA
AGGCATGGGCTGCAATGAGTGCACACACCCCACCTGCCAGCACTCACTGAGCATGCTGGGCATC
GGCCAGTGCGTGGAATGTGAGAGCGGCGTGCTGGTGCTGGACCCCACCTCAGGCCCCAAGTGGA
AGGTGGCCTGCAACAAGTGCAACGTGGTGGCACACTGCTTTGAGAATGCCTACCGTGTGCGGGT
GTCTGCCGACACCTGCCCCACCTGTGAGGCTGCCCTGCTTGCCGTGGACTTCAACAAGGCCAAA
TCCCCGCTCCCAGGTGACGAGACACAGCACACAGGCTGCGTCTTCTGCGACCCTGTCTTCCAGG
AGCTGGTGGAGCTGAAGCACGCAGCCTCCTGCCACCCCATGCACCGGGGAGGGCCAGGGAGGAG
GCAGGGCCGAGGGCGGGCTCGGGGCCGGCGGCCCACAGGGAAGCCCAGTGCCAGGCGGCCGAAG
GACAAGATGTCAGCCCTGGCTGCCTACTTTGTATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005636690	(Get FASTA)	NCBI Sequence Viewer
	XP_005636691	(Get FASTA)	NCBI Sequence Viewer
	XP_013963696	(Get FASTA)	NCBI Sequence Viewer
	XP_038293571	(Get FASTA)	NCBI Sequence Viewer
	XP_038293572	(Get FASTA)	NCBI Sequence Viewer
	XP_038293573	(Get FASTA)	NCBI Sequence Viewer
	XP_038293574	(Get FASTA)	NCBI Sequence Viewer
	XP_038293575	(Get FASTA)	NCBI Sequence Viewer
	XP_038315079	(Get FASTA)	NCBI Sequence Viewer
	XP_038368438	(Get FASTA)	NCBI Sequence Viewer
	XP_038368439	(Get FASTA)	NCBI Sequence Viewer
	XP_038368440	(Get FASTA)	NCBI Sequence Viewer
	XP_038368441	(Get FASTA)	NCBI Sequence Viewer
	XP_038368442	(Get FASTA)	NCBI Sequence Viewer
	XP_038431932	(Get FASTA)	NCBI Sequence Viewer
	XP_038431933	(Get FASTA)	NCBI Sequence Viewer
	XP_038431934	(Get FASTA)	NCBI Sequence Viewer
	XP_038431935	(Get FASTA)	NCBI Sequence Viewer
	XP_038431936	(Get FASTA)	NCBI Sequence Viewer
	XP_038496142	(Get FASTA)	NCBI Sequence Viewer
	XP_038496143	(Get FASTA)	NCBI Sequence Viewer
	XP_038496144	(Get FASTA)	NCBI Sequence Viewer
	XP_038496145	(Get FASTA)	NCBI Sequence Viewer
	XP_038496146	(Get FASTA)	NCBI Sequence Viewer
	XP_534771	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000022795.3
	ENSCAFP00030041239.1
	ENSCAFP00040036425.1
	ENSCAFP00040036472.1
	ENSCAFP00845036878
	ENSCAFP00845036878.1

RefSeq Acc Id:	XP_534771 ⟸ XM_534771
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGTCSVHEYSGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGKGCDYIVLWLDCDKEGENICFE VLDAVLPVMNPTHSGEKTVFRARFSSITDTDICAAMARLGEPDHNEALSVDARQELDLRIGCAF TRFQTKYFQGKYGNLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLL LDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH AMQTAERLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDA GDHPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKTVI SPGFTEIMPWQSVPLEESLPTCQRGDCFPVSEMKMLEKQTSPPDYLTEAELITLMEKHGIGTDA SIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKA DYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR LHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCSNHPPFRDMKKGM GCNECTHPTCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSA DTCPTCEAALLAVDFNKAKSPLPGDETQHTGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQG RGRARGRRPTGKPSARRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_005636691 ⟸ XM_005636634
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGTCSVHEYSGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGKGCDYIVLWLDCDKEGENICFE VLDAVLPVMNPTHSGEKTVFRARFSSITDTDICAAMARLGEPDHNEALSVDARQELDLRIGCAF TRFQTKYFQGKYGNLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLL LDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH AMQTAERLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDA GDHPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKTVI SPGFTEIMPWQSVPLEESLPTCQRGDCFPVSEMKMLEKQTSPPDYLTEAELITLMEKHGIGTDA SIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKA DYRQVLGHTLDVFKRKFHYFVDSIAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQ NGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCSNHPPFRDMKKGMGCNECTHPTCQHSL SMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCPTCEAALLAVD FNKAKSPLPGDETQHTGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPTGKPS ARRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_005636690 ⟸ XM_005636633
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGTCSVHEYSGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGKGCDYIVLWLDCDKEGENICFE VLDAVLPVMNPTHSGEKTVFRARFSSITDTDICAAMARLGEPDHNEALSVDARQELDLRIGCAF TRFQTKYFQGKYGNLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLL LDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH AMQTAERLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDA GDHPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKTVI SPGFTEIMPWQSVPLEESLPTCQRGDCFPVSEMKMLEKQTSPPDYLTEAELITLMEKHGIGTDA SIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKA DYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR LHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCSNHPPFRDMKKGM GCNECTHPTCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSA DTCPTCEAALLAVDFNKAKSPLPGDETQHTGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQG RGRARGRRPTGKPSARRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_013963696 ⟸ XM_014108221
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVKFLQVEGKGCDYIVLWLDCDKEGENICFEVLDAVLPVMNPTHSGEKTVFRARFSSITDTDIC AAMARLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGNLDSSLISFGPCQTPTLGFC VERHDKIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATS RKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGP LRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMRSATEAELGSEAWRLYEYITRHFI ATVSYDCKYLQSTISFRIGPEHFTCTGKTVISPGFTEIMPWQSVPLEESLPTCQRGDCFPVSEM KMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLV HGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEV SFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFEL VLWSSGSRGKSYPLCPYCSNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECESGVLVLD PTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCPTCEAALLAVDFNKAKSPLPGDETQHTGCV FCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPTGKPSARRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:

ENSCAFP00000022795 ⟸ ENSCAFT00000024557

RefSeq Acc Id:

ENSCAFP00000063550 ⟸ ENSCAFT00000071362

RefSeq Acc Id:	XP_038368441 ⟸ XM_038512513
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038368440 ⟸ XM_038512512
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038368439 ⟸ XM_038512511
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038368438 ⟸ XM_038512510
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038368442 ⟸ XM_038512514
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038496145 ⟸ XM_038640217
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038496144 ⟸ XM_038640216
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038496143 ⟸ XM_038640215
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038496142 ⟸ XM_038640214
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038496146 ⟸ XM_038640218
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038293574 ⟸ XM_038437646
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038293573 ⟸ XM_038437645
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038293572 ⟸ XM_038437644
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038293571 ⟸ XM_038437643
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038293575 ⟸ XM_038437647
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038315079 ⟸ XM_038459151
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038431935 ⟸ XM_038576007
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038431934 ⟸ XM_038576006
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038431933 ⟸ XM_038576005
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038431932 ⟸ XM_038576004
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KQJ5 (UniProtKB/TrEMBL), A0A8C0TFI5 (UniProtKB/TrEMBL), A0A8C0TLE8 (UniProtKB/TrEMBL), A0A8I3PSZ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038431936 ⟸ XM_038576008
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0TFI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845036878 ⟸ ENSCAFT00845046997

Protein Domains

Toprim

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000015482	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030025517	UniProtKB/TrEMBL
	ENSCAFG00040022493	UniProtKB/TrEMBL
	ENSCAFG00845026653	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000024557.5	UniProtKB/TrEMBL
	ENSCAFT00030047169.1	UniProtKB/TrEMBL
	ENSCAFT00040041755.1	UniProtKB/TrEMBL
	ENSCAFT00040041806.1	UniProtKB/TrEMBL
	ENSCAFT00845046997	ENTREZGENE
	ENSCAFT00845046997.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.290.10	UniProtKB/TrEMBL
	1.10.460.10	UniProtKB/TrEMBL
	2.70.20.10	UniProtKB/TrEMBL
	3.40.50.140	UniProtKB/TrEMBL
InterPro	Topo_IA	UniProtKB/TrEMBL
	Topo_IA_2	UniProtKB/TrEMBL
	Topo_IA_AS	UniProtKB/TrEMBL
	Topo_IA_cen	UniProtKB/TrEMBL
	Topo_IA_cen_sub1	UniProtKB/TrEMBL
	Topo_IA_cen_sub2	UniProtKB/TrEMBL
	Topo_IA_cen_sub3	UniProtKB/TrEMBL
	Topo_IA_core_domain	UniProtKB/TrEMBL
	Topo_IA_DNA-bd_dom	UniProtKB/TrEMBL
	TOPRIM_domain	UniProtKB/TrEMBL
	TOPRIM_TopoIII	UniProtKB/TrEMBL
KEGG Report	cfa:477576	UniProtKB/TrEMBL
NCBI Gene	TOP3B	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 3-BETA-1	UniProtKB/TrEMBL
	PTHR11390	UniProtKB/TrEMBL
Pfam	Topoisom_bac	UniProtKB/TrEMBL
	Toprim	UniProtKB/TrEMBL
PRINTS	PRTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_PROK	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
SMART	TOP1Ac	UniProtKB/TrEMBL
	TOP1Bc	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56712	UniProtKB/TrEMBL
UniProt	A0A8C0KQJ5	ENTREZGENE
	A0A8C0TFI5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TLE8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PSZ4	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:49634	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-08	TOP3B	DNA topoisomerase III beta		topoisomerase (DNA) III beta	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar