Top3b (topoisomerase (DNA) III beta) - Rat Genome Database

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Gene: Top3b (topoisomerase (DNA) III beta) Mus musculus
Analyze
Symbol: Top3b
Name: topoisomerase (DNA) III beta
RGD ID: 1319826
MGI Page MGI
Description: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within chromosome segregation. Located in condensed chromosome. Is expressed in liver. Orthologous to human TOP3B (DNA topoisomerase III beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1; Topo III beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,688,587 - 16,710,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,688,600 - 16,710,854 (+)EnsemblGRCm39 Ensembl
GRCm381616,870,722 - 16,892,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,870,736 - 16,892,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,870,984 - 16,893,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,784,454 - 16,806,549 (+)NCBIMGSCv36mm8
Celera1617,442,801 - 17,464,977 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9786843   PMID:10349636   PMID:10636841   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11331780   PMID:12477932   PMID:12520002   PMID:12591952  
PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17517607   PMID:17967808   PMID:18367668   PMID:18799693   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:23912945   PMID:23912948   PMID:28671696   PMID:30973865   PMID:31040226   PMID:31138677   PMID:32325033   PMID:32561719   PMID:34884616   PMID:35449600   PMID:36966960  
PMID:38355793  


Genomics

Comparative Map Data
Top3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,688,587 - 16,710,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,688,600 - 16,710,854 (+)EnsemblGRCm39 Ensembl
GRCm381616,870,722 - 16,892,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,870,736 - 16,892,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,870,984 - 16,893,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,784,454 - 16,806,549 (+)NCBIMGSCv36mm8
Celera1617,442,801 - 17,464,977 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.46NCBI
TOP3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,957,025 - 21,982,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,957,025 - 21,982,813 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,311,397 - 22,337,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,641,403 - 20,667,147 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,635,957 - 20,661,701NCBI
Celera226,128,944 - 6,154,663 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,268,479 - 5,294,196 (-)NCBIHuRef
CHM1_12222,311,501 - 22,337,220 (-)NCBICHM1_1
T2T-CHM13v2.02222,370,556 - 22,396,320 (-)NCBIT2T-CHM13v2.0
Top3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,601,223 - 97,629,678 (-)NCBIGRCr8
mRatBN7.21184,097,018 - 84,125,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,821,137 - 92,849,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,482,270 - 85,510,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,535,862 - 84,564,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,346,305 - 88,374,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,401,389 - 91,429,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,116,936 - 86,145,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,157,538 - 86,185,850 (-)NCBI
Celera1182,851,647 - 82,880,025 (-)NCBICelera
Cytogenetic Map11q23NCBI
Top3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,200,453 - 17,225,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,201,079 - 17,223,824 (+)NCBIChiLan1.0ChiLan1.0
TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,498,751 - 31,524,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,047,630 - 34,073,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,076,295 - 4,102,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,557,248 - 20,583,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,557,248 - 20,583,464 (-)Ensemblpanpan1.1panPan2
TOP3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,198,371 - 31,223,133 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,198,382 - 31,215,134 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2631,154,388 - 31,178,817 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,604,302 - 32,628,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,604,310 - 32,628,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,652,585 - 30,677,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,276,606 - 30,301,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,367,160 - 31,391,836 (-)NCBIUU_Cfam_GSD_1.0
Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,971,807 - 140,997,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,756,791 - 1,785,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,756,829 - 1,782,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,020,509 - 50,037,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,020,412 - 50,037,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,462,935 - 53,480,381 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,137,823 - 4,163,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Top3b
738 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2707
Count of miRNA genes:813
Interacting mature miRNAs:1031
Transcripts:ENSMUST00000023465, ENSMUST00000118424, ENSMUST00000119787, ENSMUST00000124185, ENSMUST00000124960, ENSMUST00000125202, ENSMUST00000128407, ENSMUST00000128497, ENSMUST00000129969, ENSMUST00000130650, ENSMUST00000131063, ENSMUST00000135597, ENSMUST00000138618, ENSMUST00000139740, ENSMUST00000144513, ENSMUST00000147531, ENSMUST00000150424, ENSMUST00000151271, ENSMUST00000156502, ENSMUST00000156951
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
UniSTS:237446  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381616,892,133 - 16,892,219UniSTSGRCm38
MGSCv371616,892,226 - 16,892,312UniSTSGRCm37
Celera1617,464,124 - 17,464,210UniSTS
Cytogenetic Map16B1UniSTS
Top3b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
cM Map16 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001326576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001781810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003951778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB013603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB045324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ852426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW122701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY035336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000023465   ⟹   ENSMUSP00000023465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,645 - 16,710,854 (+)Ensembl
GRCm38.p6 Ensembl1616,870,781 - 16,892,990 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,681 - 16,710,854 (+)Ensembl
GRCm38.p6 Ensembl1616,870,817 - 16,892,990 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,709,366 - 16,710,283 (+)Ensembl
GRCm38.p6 Ensembl1616,891,502 - 16,892,419 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,705,703 - 16,710,839 (+)Ensembl
GRCm38.p6 Ensembl1616,887,839 - 16,892,975 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231576
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,664 - 16,697,204 (+)Ensembl
GRCm38.p6 Ensembl1616,870,800 - 16,879,340 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231812   ⟹   ENSMUSP00000156369
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,631 - 16,697,189 (+)Ensembl
GRCm38.p6 Ensembl1616,870,767 - 16,879,325 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231834
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,704,508 - 16,705,574 (+)Ensembl
GRCm38.p6 Ensembl1616,886,644 - 16,887,710 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231966   ⟹   ENSMUSP00000156239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,708,090 - 16,710,364 (+)Ensembl
GRCm38.p6 Ensembl1616,890,226 - 16,892,500 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232017   ⟹   ENSMUSP00000155905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,638 - 16,701,390 (+)Ensembl
GRCm38.p6 Ensembl1616,870,774 - 16,883,526 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232080   ⟹   ENSMUSP00000155903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,600 - 16,703,713 (+)Ensembl
GRCm38.p6 Ensembl1616,870,736 - 16,885,849 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232117   ⟹   ENSMUSP00000156322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,701,306 - 16,710,837 (+)Ensembl
GRCm38.p6 Ensembl1616,883,442 - 16,892,973 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,704,774 - 16,705,751 (+)Ensembl
GRCm38.p6 Ensembl1616,886,910 - 16,887,887 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232200   ⟹   ENSMUSP00000155870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,671 - 16,696,916 (+)Ensembl
GRCm38.p6 Ensembl1616,870,807 - 16,879,052 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232231   ⟹   ENSMUSP00000155935
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,651 - 16,698,513 (+)Ensembl
GRCm38.p6 Ensembl1616,870,787 - 16,880,649 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,829 - 16,697,331 (+)Ensembl
GRCm38.p6 Ensembl1616,870,965 - 16,879,467 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,702,076 - 16,710,854 (+)Ensembl
GRCm38.p6 Ensembl1616,884,212 - 16,892,990 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232531
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,650 - 16,703,329 (+)Ensembl
GRCm38.p6 Ensembl1616,870,786 - 16,885,465 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232547   ⟹   ENSMUSP00000156017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,704 - 16,696,851 (+)Ensembl
GRCm38.p6 Ensembl1616,870,840 - 16,878,987 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232581   ⟹   ENSMUSP00000156132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,688,621 - 16,710,849 (+)Ensembl
GRCm38.p6 Ensembl1616,870,757 - 16,892,985 (+)Ensembl
Ensembl Acc Id: ENSMUST00000232656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1616,703,213 - 16,704,611 (+)Ensembl
GRCm38.p6 Ensembl1616,885,349 - 16,886,747 (+)Ensembl
RefSeq Acc Id: NM_001326576   ⟹   NP_001313505
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,600 - 16,710,850 (+)NCBI
GRCm381616,870,736 - 16,892,986 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011624   ⟹   NP_035754
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,600 - 16,710,850 (+)NCBI
GRCm381616,870,736 - 16,892,986 (+)NCBI
MGSCv371616,870,984 - 16,893,079 (+)RGD
Celera1617,442,801 - 17,464,977 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521991   ⟹   XP_006522054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,588 - 16,710,850 (+)NCBI
GRCm381616,870,728 - 16,892,986 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521992   ⟹   XP_006522055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,606 - 16,710,850 (+)NCBI
GRCm381616,870,741 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521994   ⟹   XP_006522057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,643 - 16,710,850 (+)NCBI
GRCm381616,870,779 - 16,892,986 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521995   ⟹   XP_006522058
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,663 - 16,710,850 (+)NCBI
GRCm381616,870,799 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521997   ⟹   XP_006522060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,592 - 16,710,283 (+)NCBI
GRCm381616,870,728 - 16,892,419 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316937   ⟹   XP_017172426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,667 - 16,710,850 (+)NCBI
GRCm381616,870,803 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030249043   ⟹   XP_030104903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,588 - 16,710,850 (+)NCBI
GRCm381616,870,724 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030249044   ⟹   XP_030104904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,633 - 16,710,850 (+)NCBI
GRCm381616,870,768 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030249045   ⟹   XP_030104905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,607 - 16,710,850 (+)NCBI
GRCm381616,870,744 - 16,892,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159873   ⟹   XP_036015766
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,638 - 16,710,850 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159874   ⟹   XP_036015767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,643 - 16,710,850 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001781810
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,587 - 16,710,850 (+)NCBI
GRCm381616,870,722 - 16,892,986 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003951778
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391616,688,633 - 16,710,850 (+)NCBI
GRCm381616,870,754 - 16,892,976 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001313505 (Get FASTA)   NCBI Sequence Viewer  
  NP_035754 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522054 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522055 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522057 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522058 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522060 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172426 (Get FASTA)   NCBI Sequence Viewer  
  XP_030104903 (Get FASTA)   NCBI Sequence Viewer  
  XP_030104904 (Get FASTA)   NCBI Sequence Viewer  
  XP_030104905 (Get FASTA)   NCBI Sequence Viewer  
  XP_036015766 (Get FASTA)   NCBI Sequence Viewer  
  XP_036015767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH31723 (Get FASTA)   NCBI Sequence Viewer  
  BAA34227 (Get FASTA)   NCBI Sequence Viewer  
  BAA97984 (Get FASTA)   NCBI Sequence Viewer  
  BAE26026 (Get FASTA)   NCBI Sequence Viewer  
  BAE27200 (Get FASTA)   NCBI Sequence Viewer  
  EDK97430 (Get FASTA)   NCBI Sequence Viewer  
  EDK97431 (Get FASTA)   NCBI Sequence Viewer  
  EDK97432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000023465
  ENSMUSP00000023465.8
  ENSMUSP00000155870.2
  ENSMUSP00000155903.2
  ENSMUSP00000155905.2
  ENSMUSP00000155935.2
  ENSMUSP00000156017.2
  ENSMUSP00000156132
  ENSMUSP00000156132.2
  ENSMUSP00000156239.2
  ENSMUSP00000156322.2
  ENSMUSP00000156369.2
GenBank Protein Q9Z321 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035754   ⟸   NM_011624
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522057   ⟸   XM_006521994
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522055   ⟸   XM_006521992
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522054   ⟸   XM_006521991
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522060   ⟸   XM_006521997
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006522058   ⟸   XM_006521995
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172426   ⟸   XM_017316937
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001313505   ⟸   NM_001326576
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030104903   ⟸   XM_030249043
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030104905   ⟸   XM_030249045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030104904   ⟸   XM_030249044
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000156239   ⟸   ENSMUST00000231966
Ensembl Acc Id: ENSMUSP00000156369   ⟸   ENSMUST00000231812
Ensembl Acc Id: ENSMUSP00000155935   ⟸   ENSMUST00000232231
Ensembl Acc Id: ENSMUSP00000155870   ⟸   ENSMUST00000232200
Ensembl Acc Id: ENSMUSP00000156322   ⟸   ENSMUST00000232117
Ensembl Acc Id: ENSMUSP00000155903   ⟸   ENSMUST00000232080
Ensembl Acc Id: ENSMUSP00000155905   ⟸   ENSMUST00000232017
Ensembl Acc Id: ENSMUSP00000156132   ⟸   ENSMUST00000232581
Ensembl Acc Id: ENSMUSP00000156017   ⟸   ENSMUST00000232547
Ensembl Acc Id: ENSMUSP00000023465   ⟸   ENSMUST00000023465
RefSeq Acc Id: XP_036015766   ⟸   XM_036159873
- Peptide Label: isoform X1
- UniProtKB: Q9Z321 (UniProtKB/Swiss-Prot),   Q3UJF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036015767   ⟸   XM_036159874
- Peptide Label: isoform X4
Protein Domains
DNA topoisomerase type IA DNA-binding   Topo IA-type catalytic   Toprim

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z321-F1-model_v2 AlphaFold Q9Z321 1-862 view protein structure

Promoters
RGD ID:6827601
Promoter ID:MM_KWN:20257
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000067954,   OTTMUST00000067955,   OTTMUST00000067958,   OTTMUST00000067959,   OTTMUST00000068205,   OTTMUST00000068208,   OTTMUST00000068209,   OTTMUST00000068210,   OTTMUST00000068211,   UC007YJH.1,   UC007YJI.1,   UC007YJJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,870,714 - 16,871,214 (+)MPROMDB
RGD ID:8685566
Promoter ID:EPDNEW_M20814
Type:initiation region
Name:Top3b_1
Description:Mus musculus topoisomerase III beta , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381616,870,769 - 16,870,829EPDNEW
RGD ID:6827585
Promoter ID:MM_KWN:20258
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000084919
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,882,336 - 16,882,836 (+)MPROMDB
RGD ID:6827582
Promoter ID:MM_KWN:20259
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000067961
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,883,836 - 16,884,336 (+)MPROMDB
RGD ID:6827583
Promoter ID:MM_KWN:20260
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000067962
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,884,831 - 16,885,987 (+)MPROMDB
RGD ID:6827599
Promoter ID:MM_KWN:20261
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000067963,   UC007YJM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,886,141 - 16,886,732 (+)MPROMDB
RGD ID:6827584
Promoter ID:MM_KWN:20263
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   Spleen
Transcripts:OTTMUST00000067965
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,889,636 - 16,890,582 (+)MPROMDB
RGD ID:6827586
Promoter ID:MM_KWN:20264
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000068204
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361616,891,659 - 16,892,159 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333803 AgrOrtholog
Ensembl Genes ENSMUSG00000022779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023465 ENTREZGENE
  ENSMUST00000023465.16 UniProtKB/Swiss-Prot
  ENSMUST00000231278 ENTREZGENE
  ENSMUST00000231812.2 UniProtKB/TrEMBL
  ENSMUST00000231966.2 UniProtKB/TrEMBL
  ENSMUST00000232017.2 UniProtKB/TrEMBL
  ENSMUST00000232080.2 UniProtKB/TrEMBL
  ENSMUST00000232117.2 UniProtKB/TrEMBL
  ENSMUST00000232200.2 UniProtKB/TrEMBL
  ENSMUST00000232231.2 UniProtKB/TrEMBL
  ENSMUST00000232547.2 UniProtKB/TrEMBL
  ENSMUST00000232581 ENTREZGENE
  ENSMUST00000232581.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Multihaem_cyt_sf UniProtKB/TrEMBL
  Topo_IA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_cen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_cen_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_cen_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_cen_sub3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_core_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IA_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_TopoIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21976 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333803 ENTREZGENE
NCBI Gene 21976 ENTREZGENE
PANTHER DNA TOPOISOMERASE 3-BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Topoisom_bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toprim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Top3b PhenoGen
PRINTS PRTPISMRASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TOPO_IA_2 UniProtKB/Swiss-Prot
  TOPOISOMERASE_I_PROK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TOP1Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOP1Bc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48695 UniProtKB/TrEMBL
  SSF56712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P6A6_MOUSE UniProtKB/TrEMBL
  A0A338P6C0_MOUSE UniProtKB/TrEMBL
  A0A338P6F5_MOUSE UniProtKB/TrEMBL
  A0A338P6J7_MOUSE UniProtKB/TrEMBL
  A0A338P6M7_MOUSE UniProtKB/TrEMBL
  A0A338P753_MOUSE UniProtKB/TrEMBL
  A0A338P7C6_MOUSE UniProtKB/TrEMBL
  A0A338P7E0_MOUSE UniProtKB/TrEMBL
  Q3UJF5 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJ62_MOUSE UniProtKB/TrEMBL
  Q9Z321 ENTREZGENE, UniProtKB/Swiss-Prot