Top3b (DNA topoisomerase III beta) - Rat Genome Database

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Gene: Top3b (DNA topoisomerase III beta) Heterocephalus glaber
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Symbol: Top3b
Name: DNA topoisomerase III beta
RGD ID: 18923259
Description: ENCODES a protein that exhibits RNA topoisomerase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); FOUND IN DNA topoisomerase III-beta-TDRD3 complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 3-beta-1; topoisomerase (DNA) III beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Top3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TOP3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,957,025 - 21,982,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,957,025 - 21,982,813 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,311,397 - 22,337,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,641,403 - 20,667,147 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,635,957 - 20,661,701NCBI
Celera226,128,944 - 6,154,663 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,268,479 - 5,294,196 (-)NCBIHuRef
CHM1_12222,311,501 - 22,337,220 (-)NCBICHM1_1
T2T-CHM13v2.02222,370,556 - 22,396,320 (-)NCBIT2T-CHM13v2.0
Top3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,688,587 - 16,710,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,688,600 - 16,710,854 (+)EnsemblGRCm39 Ensembl
GRCm381616,870,722 - 16,892,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,870,736 - 16,892,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,870,984 - 16,893,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,784,454 - 16,806,549 (+)NCBIMGSCv36mm8
Celera1617,442,801 - 17,464,977 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.46NCBI
Top3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,601,223 - 97,629,678 (-)NCBIGRCr8
mRatBN7.21184,097,018 - 84,125,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,821,137 - 92,849,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,482,270 - 85,510,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,535,862 - 84,564,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,346,305 - 88,374,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,401,389 - 91,429,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,116,936 - 86,145,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,157,538 - 86,185,850 (-)NCBI
Celera1182,851,647 - 82,880,025 (-)NCBICelera
Cytogenetic Map11q23NCBI
Top3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,200,453 - 17,225,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,201,079 - 17,223,824 (+)NCBIChiLan1.0ChiLan1.0
TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,498,751 - 31,524,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,047,630 - 34,073,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,076,295 - 4,102,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,557,248 - 20,583,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,557,248 - 20,583,464 (-)Ensemblpanpan1.1panPan2
TOP3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,198,371 - 31,223,133 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,198,382 - 31,215,134 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2631,154,388 - 31,178,817 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,604,302 - 32,628,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,604,310 - 32,628,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,652,585 - 30,677,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,276,606 - 30,301,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,367,160 - 31,391,836 (-)NCBIUU_Cfam_GSD_1.0
Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,971,807 - 140,997,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,756,791 - 1,785,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,756,829 - 1,782,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,020,509 - 50,037,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,020,412 - 50,037,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,462,935 - 53,480,381 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,137,823 - 4,163,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026284   ⟹   ENSHGLP00000026054
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)Ensembl
RefSeq Acc Id: XM_004843327   ⟹   XP_004843384
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,450,236 - 1,473,464 (-)NCBI
RefSeq Acc Id: XM_021257123   ⟹   XP_021112782
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,450,338 - 1,470,325 (-)NCBI
RefSeq Acc Id: XM_021257124   ⟹   XP_021112783
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBI
RefSeq Acc Id: XM_021257125   ⟹   XP_021112784
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,450,236 - 1,473,464 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004843384 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112782 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112783 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112784 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09770 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026054
  ENSHGLP00100039023
GenBank Protein JAO02547 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021112783   ⟸   XM_021257124
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021112784   ⟸   XM_021257125
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004843384   ⟸   XM_004843327
- Peptide Label: isoform X1
- UniProtKB: G5BKF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112782   ⟸   XM_021257123
- Peptide Label: isoform X1
- UniProtKB: G5BKF9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026054   ⟸   ENSHGLT00000026284


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018551 Ensembl, ENTREZGENE
  ENSHGLG00100000523 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026284 ENTREZGENE
  ENSHGLT00100077570 UniProtKB/TrEMBL
Gene3D-CATH 1.10.290.10 UniProtKB/TrEMBL
  1.10.460.10 UniProtKB/TrEMBL
  2.70.20.10 UniProtKB/TrEMBL
  3.40.50.140 UniProtKB/TrEMBL
InterPro Topo_IA UniProtKB/TrEMBL
  Topo_IA_2 UniProtKB/TrEMBL
  Topo_IA_AS UniProtKB/TrEMBL
  Topo_IA_cen UniProtKB/TrEMBL
  Topo_IA_cen_sub1 UniProtKB/TrEMBL
  Topo_IA_cen_sub2 UniProtKB/TrEMBL
  Topo_IA_cen_sub3 UniProtKB/TrEMBL
  Topo_IA_core_domain UniProtKB/TrEMBL
  Topo_IA_DNA-bd_dom UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoIII UniProtKB/TrEMBL
KEGG Report hgl:101708161 UniProtKB/TrEMBL
NCBI Gene Top3b ENTREZGENE
PANTHER DNA TOPOISOMERASE 3-BETA-1 UniProtKB/TrEMBL
  PTHR11390 UniProtKB/TrEMBL
Pfam Topoisom_bac UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
PRINTS PRTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_PROK UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
SMART TOP1Ac UniProtKB/TrEMBL
  TOP1Bc UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
Superfamily-SCOP SSF56712 UniProtKB/TrEMBL
UniProt A0AAX6SWB5_HETGA UniProtKB/TrEMBL
  A0AAX6SYD2_HETGA UniProtKB/TrEMBL
  G5BKF9 ENTREZGENE, UniProtKB/TrEMBL