TOP3B (DNA topoisomerase III beta)

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Gene: TOP3B (DNA topoisomerase III beta) Pan paniscus

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Symbol:

TOP3B

Name:

DNA topoisomerase III beta

RGD ID:

12018757

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN chromosome segregation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); FOUND IN condensed chromosome (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 3-beta-1; topoisomerase (DNA) III beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,557 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	34,047,630 - 34,073,423 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

DiGeorge syndrome (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome segregation (ISO)

DNA recombination (IEA)

DNA repair (IEA)

DNA topological change (IEA)

Cellular Component

condensed chromosome (ISO)

DNA topoisomerase III-beta-TDRD3 complex (IEA)

nucleus (IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IEA)

protein binding (ISO)

RNA topoisomerase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,557 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	34,047,630 - 34,073,423 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl	panpan1.1		panPan2

TOP3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,957,025 - 21,982,787 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,957,025 - 21,982,813 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,311,397 - 22,337,184 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,641,403 - 20,667,147 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,635,957 - 20,661,701	NCBI
Celera	22	6,128,944 - 6,154,663 (-)	NCBI		Celera
Cytogenetic Map	22	q11.22	NCBI
HuRef	22	5,268,479 - 5,294,196 (-)	NCBI		HuRef
CHM1_1	22	22,311,501 - 22,337,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,370,556 - 22,396,320 (-)	NCBI		T2T-CHM13v2.0

Top3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,688,587 - 16,710,850 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,688,600 - 16,710,854 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	16,870,722 - 16,892,986 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	16,870,736 - 16,892,990 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	16,870,984 - 16,893,079 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	16,784,454 - 16,806,549 (+)	NCBI		MGSCv36	mm8
Celera	16	17,442,801 - 17,464,977 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.46	NCBI

Top3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,601,223 - 97,629,678 (-)	NCBI		GRCr8
mRatBN7.2	11	84,097,018 - 84,125,474 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	84,097,026 - 84,125,392 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,821,137 - 92,849,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,482,270 - 85,510,510 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,535,862 - 84,564,108 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,346,305 - 88,374,896 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,346,313 - 88,374,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,401,389 - 91,429,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	86,116,936 - 86,145,314 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,157,538 - 86,185,850 (-)	NCBI
Celera	11	82,851,647 - 82,880,025 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Top3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,200,453 - 17,225,335 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,201,079 - 17,223,824 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOP3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,198,371 - 31,223,133 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,604,302 - 32,628,806 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,604,310 - 32,628,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,652,585 - 30,677,122 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,276,606 - 30,301,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,836 (-)	NCBI		UU_Cfam_GSD_1.0

Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,971,807 - 140,997,296 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,756,791 - 1,785,953 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,756,829 - 1,782,063 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,020,509 - 50,037,856 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,020,412 - 50,037,854 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,462,935 - 53,480,381 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,137,823 - 4,163,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,137,862 - 4,166,436 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,836,805 - 2,865,520 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,446,412 - 1,473,600 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,450,236 - 1,473,467 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003807737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034948749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055105533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055105534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055105535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063603242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063603243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063603244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063603245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000052254 ⟹ ENSPPAP00000029405

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000052261 ⟹ ENSPPAP00000029412

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000052266 ⟹ ENSPPAP00000029417

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	22	20,557,248 - 20,576,978 (-)	Ensembl

RefSeq Acc Id:

XM_003807737 ⟹ XP_003807785

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,546 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,416 (-)	NCBI
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI

Sequence:

show sequence

AGACGCTGGCACACCGGACGCGGGGACGCCAGAAGCGGCTGGACCCGGAAATAGGGGTTGTCGG
TAGCCGCCCCGGGAACAAGGACCGGAGCTGGATCCGCGGTGAGGCTGTGGGAGTCAGCATTGGT
AATAGTGCTGTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGAAACTGGA
GTGTGAAGGACCGAGACAAGATGAAGACCGTGCTCATGGTTGCTGAAAAGCCGTCCTTGGCACA
GTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACACAAAGGGCTGAACGGGGCCTGC
TCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCT
GTGGTCACGTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAAGTGGACCCCGC
AGAACTGTTCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGAACATGGTGAAG
TTCCTGCAGGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTGCGACAAGGAGG
GGGAGAACATCTGCTTTGAGGTTCTTGATGTTGTTCTGCCCGTCATGAACAAGGCCCATGGTGG
CGAGAAGACCGTGTTTCGGGCCAGGTTTAGCTCCATCACGGACACAGACATCTGTAATGCCATG
GCCTGCCTGGGCGAGCCTGACCACAACGAGGCGCTCTCAGTGGATGCTCGCCAGGAGCTGGACC
TGCGAATCGGCTGTGCGTTCACCAGGTTTCAGACTAAATATTTCCAGGGGAAATACGGTGATTT
AGACAGCTCTCTCATCTCCTTTGGGCCATGTCAGACTCCAACCCTGGGATTCTGTGTGGAGAGA
CATGATAAAATCCAGTCCTTCAAACCAGAGACCTACTGGGTGCTGCAGGCCAAGGTTAACACTG
ACAAAGACAGGTCTCTCCTTTTGGACTGGGACCGAGTAAGAGTGTTCGACCGGGAGATCGCACA
GATGTTTTTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAA
AAGGCCAAGCAGAGGCCCCTGGCCCTGAACACTGTGGAGATGCTGCGTGTGGCCAGCTCTTCTC
TGGGCATGGGGCCGCAGCACGCCATGCAGACGGCTGAGCGGCTCTACACGCAAGGCTACATCAG
CTACCCACGGACAGAGACCACCCACTACCCTGAGAACTTTGACCTGAAGGGCTCTCTGCGGCAG
CAGGCCAACCACCCCTACTGGGCCGACACGGTGAAACGGTTGTTAGCAGAAGGTATCAACCGCC
CGCGGAAAGGCCATGACGCCGGCGACCATCCCCCCATCACCCCCATGAAGTCTGCCACAGAGGC
CGAATTAGGGGGTGACGCGTGGCGGCTCTATGAGTACATCACCAGACACTTCATCGCCACGGTC
AGCCATGACTGCAAGTACCTGCAGAGCACCATCTCCTTCAGAATTGGGCCCGAGCTCTTCACCT
GCTCCGGGAAGACCGTCCTCTCACCAGGCTTCACGGAGGTCATGCCCTGGCAGAGCGTGCCCCT
GGAGGAGAGCCTGCCCACTTGCCAGCGGGGTGACGCCTTCCCTGTGGGCGAGGTGAAGATGCTG
GAGAAGCAGACGAACCCACCCGACTACCTGACGGAGGCCGAGCTCATCACGCTCATGGAGAAGC
ATGGCATCGGCACAGATGCCAGCATCCCTGTGCATATCAACAACATCTGCCAGCGCAACTATGT
CACGGTGGAGAGCGGGCGCCGGCTCAAGCCCACCAACCTCGGCATTGTCCTGGTGCACGGCTAC
TATAAGATTGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAGAAGCAGCTGAACC
TGATCGCCCAGGGCAAGGCCGACTACCGCCAGGTCCTTGGCCACACCCTGGACGTGTTCAAGAG
GAAGTTCCACTACTTTGTCGACTCCATTGCTGGCATGGATGAGTTGATGGAGGTGTCTTTCTCG
CCCCTGGCGGCCACAGGCAAGCCCCTCTCACGCTGTGGGAAGTGCCACCGCTTCATGAAGTACA
TCCAGGCCAAGCCAAGCCGCCTGCACTGCTCCCACTGCGATGAGACCTACACGCTCCCCCAGAA
CGGCACCATCAAGCTCTACAAGGAGCTCCGCTGCCCTCTGGATGACTTCGAGCTGGTCCTGTGG
TCATCAGGCTCTCGGGGCAAGAGCTACCCGCTGTGCCCCTACTGCTACAACCACCCACCCTTCC
GAGACATGAAGAAAGGCATGGGCTGCAACGAGTGTACGCACCCCTCCTGCCAGCACTCGCTGAG
CATGCTGGGCATCGGCCAGTGCGTGGAATGTGAGAGCGGGGTGCTGGTGCTGGACCCCACCTCG
GGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCAATGTGGTAGCGCACTGCTTCGAGAACGCCC
ACCGCGTGCGGGTGTCCGCCGACACCTGCAGTGTCTGTGAGGCCGCCTTGCTTGATGTGGACTT
CAACAAGGCCAAGTCCCCACTCCCGGGCGATGAGACGCAGCACATGGGCTGCGTCTTTTGTGAC
CCCGTCTTCCAGGAGCTGGTGGAGCTGAAGCATGCGGCCTCCTGCCACCCCATGCACCGCGGTG
GACCAGGGAGAAGGCAGGGTCGAGGGCGGGGCCGGGCCAGGAGGCCCCCTGGGAAGCCCAACCC
CAGACGGCCCAAGGACAAGATGTCAGCCCTGGCCGCCTACTTTGTATGATGACCCTGTCCTCCC
TCACCCAGGCTGCAGTGCCATGCAGACACCTCATGGCACTTCAAACTATTAAAATGCATTTTAC
CTTATCCAGA

hide sequence

RefSeq Acc Id:

XM_008959874 ⟹ XP_008958122

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,553 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,423 (-)	NCBI
Mhudiblu_PPA_v0	22	4,076,301 - 4,102,065 (-)	NCBI
PanPan1.1	22	20,557,248 - 20,583,262 (-)	NCBI

Sequence:

show sequence

CGGAAATAGGGGTTGTCGGTAGCCGCCCCGGGAACAAGGACCGGAGCTGGATCCGCGGAGTCAG
CATTGGTAATAGTGCTGTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGA
AACTGGAGTGTGAAGGACCGAGACAAGATGAAGACCGTGCTCATGGTTGCTGAAAAGCCGTCCT
TGGCACAGTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACACAAAGGGCTGAACGG
GGCCTGCTCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACG
TCTGTCTGTGGTCACGTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAAGTGG
ACCCCGCAGAACTGTTCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGAACAT
GGTGAAGTTCCTGCAGGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTGCGAC
AAGGAGGGGGAGAACATCTGCTTTGAGGTTCTTGATGTTGTTCTGCCCGTCATGAACAAGGCCC
ATGGTGGCGAGAAGACCGTGTTTCGGGCCAGGTTTAGCTCCATCACGGACACAGACATCTGTAA
TGCCATGGCCTGCCTGGGCGAGCCTGACCACAACGAGGCGCTCTCAGTGGATGCTCGCCAGGAG
CTGGACCTGCGAATCGGCTGTGCGTTCACCAGGTTTCAGACTAAATATTTCCAGGGGAAATACG
GTGATTTAGACAGCTCTCTCATCTCCTTTGGGCCATGTCAGACTCCAACCCTGGGATTCTGTGT
GGAGAGACATGATAAAATCCAGTCCTTCAAACCAGAGACCTACTGGGTGCTGCAGGCCAAGGTT
AACACTGACAAAGACAGGTCTCTCCTTTTGGACTGGGACCGAGTAAGAGTGTTCGACCGGGAGA
TCGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAG
GAAAGAAAAGGCCAAGCAGAGGCCCCTGGCCCTGAACACTGTGGAGATGCTGCGTGTGGCCAGC
TCTTCTCTGGGCATGGGGCCGCAGCACGCCATGCAGACGGCTGAGCGGCTCTACACGCAAGGCT
ACATCAGCTACCCACGGACAGAGACCACCCACTACCCTGAGAACTTTGACCTGAAGGGCTCTCT
GCGGCAGCAGGCCAACCACCCCTACTGGGCCGACACGGTGAAACGGTTGTTAGCAGAAGGTATC
AACCGCCCGCGGAAAGGCCATGACGCCGGCGACCATCCCCCCATCACCCCCATGAAGTCTGCCA
CAGAGGCCGAATTAGGGGGTGACGCGTGGCGGCTCTATGAGTACATCACCAGACACTTCATCGC
CACGGTCAGCCATGACTGCAAGTACCTGCAGAGCACCATCTCCTTCAGAATTGGGCCCGAGCTC
TTCACCTGCTCCGGGAAGACCGTCCTCTCACCAGGCTTCACGGAGGTCATGCCCTGGCAGAGCG
TGCCCCTGGAGGAGAGCCTGCCCACTTGCCAGCGGGGTGACGCCTTCCCTGTGGGCGAGGTGAA
GATGCTGGAGAAGCAGACGAACCCACCCGACTACCTGACGGAGGCCGAGCTCATCACGCTCATG
GAGAAGCATGGCATCGGCACAGATGCCAGCATCCCTGTGCATATCAACAACATCTGCCAGCGCA
ACTATGTCACGGTGGAGAGCGGGCGCCGGCTCAAGCCCACCAACCTCGGCATTGTCCTGGTGCA
CGGCTACTATAAGATTGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAGAAGCAG
CTGAACCTGATCGCCCAGGGCAAGGCCGACTACCGCCAGGTCCTTGGCCACACCCTGGACGTGT
TCAAGAGGAAGTTCCACTACTTTGTCGACTCCATTGCTGGCATGGATGAGTTGATGGAGGTGTC
TTTCTCGCCCCTGGCGGCCACAGGCAAGCCCCTCTCACGCTGTGGGAAGTGCCACCGCTTCATG
AAGTACATCCAGGCCAAGCCAAGCCGCCTGCACTGCTCCCACTGCGATGAGACCTACACGCTCC
CCCAGAACGGCACCATCAAGCTCTACAAGGAGCTCCGCTGCCCTCTGGATGACTTCGAGCTGGT
CCTGTGGTCATCAGGCTCTCGGGGCAAGAGCTACCCGCTGTGCCCCTACTGCTACAACCACCCA
CCCTTCCGAGACATGAAGAAAGGCATGGGCTGCAACGAGTGTACGCACCCCTCCTGCCAGCACT
CGCTGAGCATGCTGGGCATCGGCCAGTGCGTGGAATGTGAGAGCGGGGTGCTGGTGCTGGACCC
CACCTCGGGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCAATGTGGTAGCGCACTGCTTCGAG
AACGCCCACCGCGTGCGGGTGTCCGCCGACACCTGCAGTGTCTGTGAGGCCGCCTTGCTTGATG
TGGACTTCAACAAGGCCAAGTCCCCACTCCCGGGCGATGAGACGCAGCACATGGGCTGCGTCTT
TTGTGACCCCGTCTTCCAGGAGCTGGTGGAGCTGAAGCATGCGGCCTCCTGCCACCCCATGCAC
CGCGGTGGACCAGGGAGAAGGCAGGGTCGAGGGCGGGGCCGGGCCAGGAGGCCCCCTGGGAAGC
CCAACCCCAGACGGCCCAAGGACAAGATGTCAGCCCTGGCCGCCTACTTTGTATGATGACCCTG
TCCTCCCTCACCCAGGCTGCAGTGCCATGCAGACACCTCATGGCACTTCAAACTATTAAAATGC
ATTTTACCTTATCCAGA

hide sequence

RefSeq Acc Id:

XM_008959877 ⟹ XP_008958125

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,546 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,416 (-)	NCBI
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI

Sequence:

show sequence

AGACGCTGGCACACCGGACGCGGGGACGCCAGAAGCGGCTGGACCCGGAAATAGGGGTTGTCGG
TAGCCGCCCCGGGAACAAGGACCGGAGCTGGATCCGCGGTGAGGCTGTGGGAGTCAGCATTGGT
AATAGTGCTGTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGAAACTGGA
GTGTGAAGGACCGAGACAAGATGAAGACCGTGCTCATGGTTGCTGAAAAGCCGTCCTTGGCACA
GTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACACAAAGGGCTGAACGGGGCCTGC
TCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCT
GTGGTCACGTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAAGTGGACCCCGC
AGAACTGTTCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGAACATGGTGAAG
TTCCTGCAGGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTGCGACAAGGAGG
GGGAGAACATCTGCTTTGAGGTTAACACTGACAAAGACAGGTCTCTCCTTTTGGACTGGGACCG
AGTAAGAGTGTTCGACCGGGAGATCGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAA
GCCCAGGTGGAGGCCACAAGCAGGAAAGAAAAGGCCAAGCAGAGGCCCCTGGCCCTGAACACTG
TGGAGATGCTGCGTGTGGCCAGCTCTTCTCTGGGCATGGGGCCGCAGCACGCCATGCAGACGGC
TGAGCGGCTCTACACGCAAGGCTACATCAGCTACCCACGGACAGAGACCACCCACTACCCTGAG
AACTTTGACCTGAAGGGCTCTCTGCGGCAGCAGGCCAACCACCCCTACTGGGCCGACACGGTGA
AACGGTTGTTAGCAGAAGGTATCAACCGCCCGCGGAAAGGCCATGACGCCGGCGACCATCCCCC
CATCACCCCCATGAAGTCTGCCACAGAGGCCGAATTAGGGGGTGACGCGTGGCGGCTCTATGAG
TACATCACCAGACACTTCATCGCCACGGTCAGCCATGACTGCAAGTACCTGCAGAGCACCATCT
CCTTCAGAATTGGGCCCGAGCTCTTCACCTGCTCCGGGAAGACCGTCCTCTCACCAGGCTTCAC
GGAGGTCATGCCCTGGCAGAGCGTGCCCCTGGAGGAGAGCCTGCCCACTTGCCAGCGGGGTGAC
GCCTTCCCTGTGGGCGAGGTGAAGATGCTGGAGAAGCAGACGAACCCACCCGACTACCTGACGG
AGGCCGAGCTCATCACGCTCATGGAGAAGCATGGCATCGGCACAGATGCCAGCATCCCTGTGCA
TATCAACAACATCTGCCAGCGCAACTATGTCACGGTGGAGAGCGGGCGCCGGCTCAAGCCCACC
AACCTCGGCATTGTCCTGGTGCACGGCTACTATAAGATTGATGCAGAGCTGGTGCTCCCCACCA
TCCGCAGTGCAGTGGAGAAGCAGCTGAACCTGATCGCCCAGGGCAAGGCCGACTACCGCCAGGT
CCTTGGCCACACCCTGGACGTGTTCAAGAGGAAGTTCCACTACTTTGTCGACTCCATTGCTGGC
ATGGATGAGTTGATGGAGGTGTCTTTCTCGCCCCTGGCGGCCACAGGCAAGCCCCTCTCACGCT
GTGGGAAGTGCCACCGCTTCATGAAGTACATCCAGGCCAAGCCAAGCCGCCTGCACTGCTCCCA
CTGCGATGAGACCTACACGCTCCCCCAGAACGGCACCATCAAGCTCTACAAGGAGCTCCGCTGC
CCTCTGGATGACTTCGAGCTGGTCCTGTGGTCATCAGGCTCTCGGGGCAAGAGCTACCCGCTGT
GCCCCTACTGCTACAACCACCCACCCTTCCGAGACATGAAGAAAGGCATGGGCTGCAACGAGTG
TACGCACCCCTCCTGCCAGCACTCGCTGAGCATGCTGGGCATCGGCCAGTGCGTGGAATGTGAG
AGCGGGGTGCTGGTGCTGGACCCCACCTCGGGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCA
ATGTGGTAGCGCACTGCTTCGAGAACGCCCACCGCGTGCGGGTGTCCGCCGACACCTGCAGTGT
CTGTGAGGCCGCCTTGCTTGATGTGGACTTCAACAAGGCCAAGTCCCCACTCCCGGGCGATGAG
ACGCAGCACATGGGCTGCGTCTTTTGTGACCCCGTCTTCCAGGAGCTGGTGGAGCTGAAGCATG
CGGCCTCCTGCCACCCCATGCACCGCGGTGGACCAGGGAGAAGGCAGGGTCGAGGGCGGGGCCG
GGCCAGGAGGCCCCCTGGGAAGCCCAACCCCAGACGGCCCAAGGACAAGATGTCAGCCCTGGCC
GCCTACTTTGTATGATGACCCTGTCCTCCCTCACCCAGGCTGCAGTGCCATGCAGACACCTCAT
GGCACTTCAAACTATTAAAATGCATTTTACCTTATCCAGA

hide sequence

RefSeq Acc Id:

XM_034948749 ⟹ XP_034804640

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,546 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,416 (-)	NCBI
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI

RefSeq Acc Id:

XM_055105533 ⟹ XP_054961508

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,525 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,393 (-)	NCBI

RefSeq Acc Id:

XM_055105534 ⟹ XP_054961509

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,557 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,073,393 (-)	NCBI

RefSeq Acc Id:

XM_055105535 ⟹ XP_054961510

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,513,631 (-)	NCBI
NHGRI_mPanPan1	22	34,047,630 - 34,062,510 (-)	NCBI

RefSeq Acc Id:

XM_063603242 ⟹ XP_063459312

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,546 (-)	NCBI

RefSeq Acc Id:

XM_063603243 ⟹ XP_063459313

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,523 (-)	NCBI

RefSeq Acc Id:

XM_063603244 ⟹ XP_063459314

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,546 (-)	NCBI

RefSeq Acc Id:

XM_063603245 ⟹ XP_063459315

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,524 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003807785	(Get FASTA)	NCBI Sequence Viewer
	XP_008958122	(Get FASTA)	NCBI Sequence Viewer
	XP_008958125	(Get FASTA)	NCBI Sequence Viewer
	XP_034804640	(Get FASTA)	NCBI Sequence Viewer
	XP_054961508	(Get FASTA)	NCBI Sequence Viewer
	XP_054961509	(Get FASTA)	NCBI Sequence Viewer
	XP_054961510	(Get FASTA)	NCBI Sequence Viewer
	XP_063459312	(Get FASTA)	NCBI Sequence Viewer
	XP_063459313	(Get FASTA)	NCBI Sequence Viewer
	XP_063459314	(Get FASTA)	NCBI Sequence Viewer
	XP_063459315	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000029405
	ENSPPAP00000029405.1
	ENSPPAP00000029412
	ENSPPAP00000029412.1
	ENSPPAP00000029417.1

RefSeq Acc Id:	XP_008958125 ⟸ XM_008959877
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9BLW1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFE VNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVA SSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEG INRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPE LFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITL MEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRF MKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNH PPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCF ENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPM HRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_003807785 ⟸ XM_003807737
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BLW2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFE VLDVVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAF TRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLL LDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH AMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDA GDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVL SPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDA SIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKA DYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR LHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGM GCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSA DTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQG RGRGRARRPPGKPNPRRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_008958122 ⟸ XM_008959874
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BLW2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTL DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFE VLDVVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAF TRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLL LDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH AMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDA GDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVL SPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDA SIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKA DYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR LHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGM GCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSA DTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQG RGRGRARRPPGKPNPRRPKDKMSALAAYFV hide sequence

RefSeq Acc Id:	XP_034804640 ⟸ XM_034948749
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSPPAP00000029412 ⟸ ENSPPAT00000052261

Ensembl Acc Id:

ENSPPAP00000029417 ⟸ ENSPPAT00000052266

Ensembl Acc Id:

ENSPPAP00000029405 ⟸ ENSPPAT00000052254

RefSeq Acc Id:	XP_054961509 ⟸ XM_055105534
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9BLW1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054961508 ⟸ XM_055105533
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_054961510 ⟸ XM_055105535
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063459314 ⟸ XM_063603244
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063459312 ⟸ XM_063603242
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063459315 ⟸ XM_063603245
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063459313 ⟸ XM_063603243
- Peptide Label:	isoform X5

Protein Domains

Toprim

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037703	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000052254.1	UniProtKB/TrEMBL
	ENSPPAT00000052261.1	UniProtKB/TrEMBL
	ENSPPAT00000052266.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.290.10	UniProtKB/TrEMBL
	1.10.460.10	UniProtKB/TrEMBL
	2.70.20.10	UniProtKB/TrEMBL
	3.40.50.140	UniProtKB/TrEMBL
InterPro	Topo_IA	UniProtKB/TrEMBL
	Topo_IA_2	UniProtKB/TrEMBL
	Topo_IA_AS	UniProtKB/TrEMBL
	Topo_IA_cen	UniProtKB/TrEMBL
	Topo_IA_cen_sub1	UniProtKB/TrEMBL
	Topo_IA_cen_sub2	UniProtKB/TrEMBL
	Topo_IA_cen_sub3	UniProtKB/TrEMBL
	Topo_IA_core_domain	UniProtKB/TrEMBL
	Topo_IA_DNA-bd_dom	UniProtKB/TrEMBL
	TOPRIM_domain	UniProtKB/TrEMBL
	TOPRIM_TopoIII	UniProtKB/TrEMBL
KEGG Report	pps:100986932	UniProtKB/TrEMBL
NCBI Gene	TOP3B	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 3-BETA-1	UniProtKB/TrEMBL
	PTHR11390	UniProtKB/TrEMBL
Pfam	Topoisom_bac	UniProtKB/TrEMBL
	Toprim	UniProtKB/TrEMBL
PRINTS	PRTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_PROK	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
SMART	TOP1Ac	UniProtKB/TrEMBL
	TOP1Bc	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56712	UniProtKB/TrEMBL
UniProt	A0A2R9BLW1	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BLW2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-08	TOP3B	DNA topoisomerase III beta		topoisomerase (DNA) III beta	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar