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Gene: TOP3B (DNA topoisomerase III beta) Homo sapiens
Symbol: TOP3B
Name: DNA topoisomerase III beta
Description: Exhibits RNA binding activity. Predicted to be involved in DNA topological change. Predicted to localize to nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1; FLJ39376; TOP3B1; topoisomerase (DNA) III beta; topoisomerase III beta
Mus musculus (house mouse) : Top3b (topoisomerase (DNA) III beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Top3b (DNA topoisomerase III beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top3b (DNA topoisomerase III beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP3B (DNA topoisomerase III beta)
Canis lupus familiaris (dog) : TOP3B (DNA topoisomerase III beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top3b (DNA topoisomerase III beta)
Sus scrofa (pig) : TOP3B (DNA topoisomerase III beta)
Chlorocebus sabaeus (African green monkey) : TOP3B (DNA topoisomerase III beta)
Heterocephalus glaber (naked mole-rat) : Top3b (DNA topoisomerase III beta)
more info ...
Related Pseudogenes: TOP3BP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2221,957,025 - 21,982,816 (-)EnsemblGRCh38hg38GRCh38
GRCh382221,957,025 - 21,982,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,311,397 - 22,337,219 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,641,403 - 20,667,147 (-)NCBINCBI36hg18NCBI36
Build 342220,635,957 - 20,661,701NCBI
Celera226,128,944 - 6,154,663 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,268,479 - 5,294,196 (-)NCBIHuRef
CHM1_12222,311,495 - 22,337,313 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TOP3B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319825
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.