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Gene: MSH6 (mutS homolog 6) Chlorocebus sabaeus

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Symbol:

MSH6

Name:

mutS homolog 6

RGD ID:

18717408

Description:

ENCODES a protein that exhibits guanine/thymine mispair binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN determination of adult lifespan (ortholog); intrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2B (ortholog); B-lymphoblastic leukemia/lymphoma with BCR-ABL1 (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); MutSalpha complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA mismatch repair protein Msh6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSH6 (mutS homolog 6)	NCBI	Ortholog
Mus musculus (house mouse):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSH6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSH6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSH6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Msh6 (mutS homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	59,375,602 - 59,400,252 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	59,375,691 - 59,400,174 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	52,443,508 - 52,468,664 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (ISO)

autosomal recessive limb-girdle muscular dystrophy type 2B (ISO)

B-lymphoblastic leukemia/lymphoma with BCR-ABL1 (ISO)

bilateral breast cancer (ISO)

breast cancer (ISO)

Breast Cancer, Familial (ISO)

breast carcinoma (ISO)

cerebellar medulloblastoma (ISO)

colon adenocarcinoma (ISO)

colon carcinoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

Digestive System Neoplasms (ISO)

endometrial cancer (ISO)

endometrial carcinoma (ISO)

Endometrial Neoplasms (ISO)

endometrial serous adenocarcinoma (ISO)

Familial Prostate Cancer (ISO)

Gaucher's disease (ISO)

Gaucher's disease type I (ISO)

Genetic Predisposition to Disease (ISO)

GM1 gangliosidosis type 1 (ISO)

hepatoblastoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

hereditary nonpolyposis colorectal cancer type 4 (ISO)

hereditary nonpolyposis colorectal cancer type 5 (ISO)

lung adenocarcinoma (ISO)

lung sarcomatoid carcinoma (ISO)

Lynch syndrome (ISO)

Lynch syndrome 1 (ISO)

Microsatellite Instability (ISO)

mismatch repair cancer syndrome (ISO)

Mismatch Repair Cancer Syndrome 1 (ISO)

Mismatch Repair Cancer Syndrome 3 (ISO)

multiple acyl-CoA dehydrogenase deficiency (ISO)

osteosarcoma (ISO)

ovarian cancer (ISO)

ovarian carcinoma (ISO)

Ovarian Neoplasms (ISO)

prostate cancer (ISO)

rhabdomyosarcoma (ISO)

stomach cancer (ISO)

Thyroid Neoplasms (ISO)

urinary bladder cancer (ISO)

Urogenital Neoplasms (ISO)

uterine corpus cancer (ISO)

xeroderma pigmentosum group D (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin organization (IEA)

determination of adult lifespan (ISO)

DNA damage response (IEA)

DNA repair (IEA)

intrinsic apoptotic signaling pathway (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

isotype switching (ISO)

maintenance of DNA repeat elements (ISO)

mismatch repair (IEA,ISO)

negative regulation of DNA recombination (IEA,ISO)

response to UV (ISO)

somatic hypermutation of immunoglobulin genes (ISO)

somatic recombination of immunoglobulin gene segments (ISO)

spermatogenesis (ISO)

Cellular Component

chromatin (IEA)

chromosome (IEA)

MutSalpha complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

ADP binding (IEA)

ATP binding (IEA)

ATP-dependent activity, acting on DNA (IEA)

ATP-dependent DNA damage sensor activity (IEA)

chromatin binding (IEA)

damaged DNA binding (IEA)

DNA binding (IEA)

double-stranded DNA binding (IEA)

enzyme binding (IEA)

four-way junction DNA binding (IEA)

guanine/thymine mispair binding (IEA,ISO)

histone H3K36me3 reader activity (IEA)

magnesium ion binding (IEA)

mismatched DNA binding (IEA)

MutLalpha complex binding (IEA)

nucleotide binding (IEA)

oxidized purine DNA binding (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

single guanine insertion binding (IEA)

single thymine insertion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered mismatch repair pathway (ISO)

colorectal cancer pathway (ISO)

endometrial cancer pathway (ISO)

mismatch repair pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MSH6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	59,375,602 - 59,400,252 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	59,375,691 - 59,400,174 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	52,443,508 - 52,468,664 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MSH6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	47,783,145 - 47,810,101 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	47,695,530 - 47,810,109 (+)	Ensembl			hg38	GRCh38
GRCh37	2	48,010,284 - 48,037,240 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	47,863,725 - 47,887,596 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	47,921,936 - 47,945,743	NCBI
Celera	2	47,849,755 - 47,873,614 (+)	NCBI		Celera
Cytogenetic Map	2	p16.3	NCBI
HuRef	2	47,746,516 - 47,770,575 (+)	NCBI		HuRef
CHM1_1	2	47,940,665 - 47,964,487 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	47,789,083 - 47,816,050 (+)	NCBI		T2T-CHM13v2.0

Msh6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	88,282,478 - 88,298,320 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	88,282,490 - 88,298,320 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	87,975,050 - 87,990,892 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	87,975,062 - 87,990,892 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	88,374,390 - 88,390,232 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	87,883,410 - 87,899,389 (+)	NCBI		MGSCv36	mm8
Celera	17	92,385,348 - 92,401,193 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	57.87	NCBI

Msh6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	12,316,190 - 12,333,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	12,316,198 - 12,333,844 (-)	Ensembl				GRCr8
mRatBN7.2	6	6,562,631 - 6,579,995 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	6,562,632 - 6,579,956 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	6,844,774 - 6,862,085 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	7,154,179 - 7,171,490 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	6,681,324 - 6,698,635 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	6	13,741,705 - 13,759,018 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	6	13,187,510 - 13,204,823 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	6	10,993,544 - 11,010,857 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	6	10,135,273 - 10,152,426 (-)	NCBI		F344_StmMcwi
Rnor_6.0	6	11,644,565 - 11,662,389 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	11,644,578 - 11,662,499 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	21,616,672 - 21,634,338 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	11,525,292 - 11,542,592 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	6,326,162 - 6,343,370 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

Msh6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	14,451,307 - 14,471,227 (+)	Ensembl
ChiLan1.0	NW_004955441	14,451,207 - 14,471,316 (+)	NCBI	ChiLan1.0	ChiLan1.0

MSH6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	78,578,235 - 78,603,381 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	78,582,203 - 78,607,350 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	47,901,591 - 47,926,662 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	48,824,469 - 48,849,779 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	48,824,350 - 48,849,779 (+)	Ensembl			panPan2	panpan1.1

MSH6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	49,825,330 - 49,838,036 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	49,803,898 - 49,838,028 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	49,669,446 - 49,693,588 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	50,687,723 - 50,711,873 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	50,687,741 - 50,711,873 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	50,394,939 - 50,419,090 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	50,681,795 - 50,705,920 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	50,869,560 - 50,893,685 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Msh6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	33,280,052 - 33,300,065 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	4,708,661 - 4,728,787 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	4,708,661 - 4,728,671 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSH6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	92,785,664 - 92,814,238 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	92,792,590 - 92,814,154 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	98,710,956 - 98,732,503 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Msh6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	29,083,692 - 29,108,792 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	29,083,696 - 29,108,792 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Msh6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	5,010,975 - 5,027,614 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in MSH6
369 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007970705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007970706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007970707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038006901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_073022954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011679 ⟹ ENSCSAP00000009745

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	59,375,691 - 59,400,174 (-)	Ensembl

RefSeq Acc Id:

XM_007970706 ⟹ XP_007968897

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	59,375,602 - 59,400,252 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	52,443,508 - 52,468,664 (+)	NCBI

Sequence:

show sequence

GGCGCCTGTTGATTGGCCACTGGGGCCCGGGTTCCTCCCGCGGAGCGCGCCTCCCCCCAGGTTT
CCCGCCAGCAGGAGCCGCGCGGTAGGTGCGGTGCGTTTCGGCGCTCCGTCCGACAGAACGGTTG
GGCCTTGTCAGCTGTCGCTATGTCGCGACAGAGCACCCTGTACAGCTTCTTCCCCAAGTCTCCG
GCGCTGAGTGATTCCAACAAGGCCTCGGCCAGGGCCTCTCGCGAAGGCGGCCGTGCCGCCGCTG
TCCCCGGGGCCTCTCCTTCCCTAGGCGAGGATGCGGCCTGGAGCGAGGCTGGGCCTGGGCCCAG
GCCCTCGGCGCGCTCCGCGTCGCCACCTAAGGCGAAGAACCTCAACGGAGGGCTGCGGAGATCC
GCAGCGCCTGCGGCCCCCACCAGTTGTGACTTCTCACCAGGAGATTTGGTTTGGGCCAAGATGG
AGGGTTACCCCTGGTGGCCTTGTCTGGTTTACAACCACCCCTTTGATGGAACATTCATCCGCGA
GAAAGGGAAATCAGTCCGTGTTCATGTACAGTTTTTTGATGACAGCCCAACAAGGGGCTGGGTT
AGCAAAAGACTTTTAAAGCCATATACAGGTTCAAAATCAAAGGAAGCCCAGAAGGGAGGTCATT
TTTACAGTGCAAAGCCTGAAATACTGAGAGCAATGCAACGTGCAGATGAAGCCTTAAATAAAGA
CAAGATTAAGAGGCTTGAATTGGCAGTTTGTGATGAGCCCTCAGAGCCAGAAGAGGAAGAAGAG
ATGGAGGTAGGCACAACTTATGTAACAGATAAGAGTGAAGAAGATAATGAAATTGAGAGTGAAG
AGGAAGTACAGCCTAAGACACAAGGATCTAGGCGAAGTAGCCGCCAAATAAAAAAACGAAGGGT
CATATCAGACTCTGAGAGTGACATTGGTGGCTCTGATGTGGAATTTAAGCCAGACACTAAGGAG
GAAGGAAGCAGTGATGAAATAAGCAGTGGAGTGGGGGATAGTGAGAGTGAAGGCCCGAACAGCC
CTGTCAAAGTTGCTCGAAAGCGGAAGAGAGTGGTCACTGGAAATGGCTCTCTTAAAAGGAAAAG
TTCTAGGAAGGAAATGCCCTCAGCCACCAAACGAGCAACTGGCATTTCATCAGAAACCAAGAAT
ACTTTGAGTGCTTTCTCTGCCCCTCAAAATTCTGAATCCCAAGCCCACGTTAGTGGAGGTGGTG
ATGACAGTAGTCGCCCTACTGTTTGGTATCATGAAACTTTAGAATGGCTTAAGGAGGAAAAGAG
AAGAGATGAGCACAGGAGGCGGCCTGATCACCCCGATTTTAATGCATCTACACTCTATGTGCCT
GAGGATTTCCTCAATTCCTGTACTCCTGGGATGAGGAAGTGGTGGCAGATTAAGTCTCAGAACT
TTGATCTTGTCATCTGTTATAAGGTGGGGAAATTTTATGAACTGTACCACATGGATGCTCTTAT
TGGAGTCAGTGAACTGGGGCTGGTATTCATGAAAGGCAACTGGGCCCATTCTGGCTTTCCTGAA
ATTGCATTTGGCCGTTATTCAGACTCCTTGGTGCAGAAGGGCTATAAAGTAGCACGAGTGGAAC
AGACTGAGACTCCGGAAATGATGGAGGCACGATGCCGAAAGATGGCACATATATCCAAGTATGA
TAGAGTGGTGAGGAGGGAGATCTGTAGGATCATTACCAAGGGTACACAGACTTACAGTGTGCTG
GAAGGTGATCCCTCTGAGAACTACAGTAAGTATCTTCTTAGCCTCAAAGAAAAAGAGGAAGATT
CTTCTGGCCATACTCGTGCATATGGTGTGTGCTTTGTTGATACTTCACTGGGAAAGTTTTTCAT
AGGTCAGTTTTCAGATGATCGCCATTGTTCGAGATTTAGGACTCTAGTGGCACACTATCCCCCA
GTACAAGTCTTATTTGAAAAAGGAAATCTCTCAAAGGAAACGAAAACAATTTTAAAGAGTTCAT
TGTCCTCTTCTCTTCAGGAAGGTCTGATACCTGGCTCCCAGTTTTGGGATGCATCCAAAACTTT
GAGAACTCTCCTTGAGGAAGGATATTTTCGGGAAAAGCTAAGTGATGACATTGGGGTGATGTTA
CCCCAGGTGCTTAAAGGTATGACTTCAGAGTCAGATTCCATTGGGTTGACACCAGGAGAGAAAA
GTGAATTGGCCCTCTCTGCTCTAGGTGGTTGTATCTTCTACCTCAAAAAATGCCTTATTGATCA
GGAGCTTTTATCAATGGCTAATTTTGAAGAATATATTCCCTTGGATTCTGACATAGTCAGCACT
ACAAGATCTGGTGCTATCTTCACCAAAGCCTATCAACGAATGGTGCTAGATGCAGTAACATTAA
ACAACTTGGAGATTTTTCTGAATGGAACAAACGGTTCTACTGAAGGAACCCTGCTAGAGAGGGT
TGATACTTGCCATACTCCCTTTGGTAAGCGGCTCCTAAAGCAATGGCTTTGTGCCCCACTCTGT
AGCCCTTATGCTATCAATGATCGTCTAGATGCCATAGAAGACCTCATGGTTGTGCCTGACAAAA
TCTCCGAAGTTGTAGAGCTTCTAAAGAAGCTTCCAGATCTTGAGAGACTACTCAGTAAAATTCA
TAATGTTGGGTCTCCCCTGAAGAGTCAGAACCATCCAGATAGCAGGGCTATAATGTATGAAGAA
ACTACATACAGCAAAAAAAAGATCATTGATTTTCTTTCTGCTCTGGAAGGATTCAAAGTAATGT
GTAAAATTATAGGGATCATGGAAGAAGTCATTGATGGTTTTAAGTCTAAAATCCTTAAGCAGGT
CATCTCTCTGCAGACAAAAAATCCTGAAGGCCGTTTTCCTGATTTGACTACAGAACTGAACCGA
TGGGATACAGCCTTTGACCATGAAAAGGCTCGAAAGACTGGACTTATTACTCCCAAAGCAGGCT
TTGACTCTGATTATGACCAAGCTCTTGCTGACATAAGAGAAAATGAACAGAGCCTCCTGGACTA
CCTAGAGAAACAGCGCAACAGAATTGGCTGTAGGACCATAGTCTATTGGGGGATTGGTAGGAAC
CGTTACCAGTTGGAAATTCCTGAGAATTTCACCACTCGCAATTTGCCAGAAGAATACGAATTGA
AATCTACCAAGAAGGGCTGTAAACGATACTGGACCAAAACTATTGAGAAGAAGTTGGCTAATCT
CATAAATGCCGAAGAACGGAGAGATGTATCATTGAAGGACTGCATGCGGCGACTGTTCTATAAC
TTTGATAAAAATTACAAGGACTGGCAGTCTGCTGTAGAGTGTATCGCAGTGTTGGATGTCTTAC
TGTGCCTGGCTAACTACAGTCGAGGAGGTGATGGTCCTATGTGTCGCCCAGTAATTCTCTTGCC
AGAAGATACCCCCCCCTTCTTAGAGCTTAAAGGATCACGCCATCCTTGCATTACGAAGACTTTT
TTTGGAGATGATTTTATTCCTAATGACATTCTAATAGGCTGTGAGGAAGAGGAGCAGGAAAATG
GCAAAGCCTATTGTGTGCTTGTTACTGGACCAAATATGGGGGGCAAGTCTACACTCATGAGACA
GGCTGGCTTATTAGCTGTAATGGCCCAGATGGGTTGTTATGTCCCCGCTGAAGTGTGCAGGCTC
ACACCGATTGATAGAGTGTTTACTAGACTTGGTGCCTCAGATAGAATAATGTCAGGTGAAAGTA
CATTTTTTGTTGAATTAAGTGAAACTGCCAGCATACTTATGCATGCAACAGCACATTCTCTGGT
GCTTGTGGATGAATTAGGAAGAGGTACTGCAACATTTGATGGGACAGCAATAGCAAATGCAGTT
GTTAAAGAACTTGCTGAGACTATAAAATGTCGTACATTATTTTCAACTCACTACCATTCATTAG
TAGAAGATTACTCTCAAAATGTTGCTGTGCGCTTAGGACATATGGCATGCATGGTAGAAAATGA
ATGTGAAGACCCCAGCCAGGAGACTATTACCTTCCTCTATAAATTCATTAAGGGAGCTTGTCCT
AAAAGCTATGGCTTTAATGCAGCAAGGCTTGCTAATCTCCCAGAGGAAGTTATTCAAAAGGGAC
ATAGAAAAGCAAGAGAATTTGAGAAGATGAATCAGTCTCTACGATTATTTCGGGAAGTTTGCCT
GGCTAGTGAAAGGTCAACTGTAGATGCTGAAGCTGTCCATAAATTGCTGACTTTGATTAAGGAA
TTATAGACTACATTGGAAGCTTTGAGTTGACTTCTGACAAACTTGGTAAATTCAGACAACATTA
TGATCTAATAAACTTTATTTTTTAAAAATGA

hide sequence

RefSeq Acc Id:

XM_038006901 ⟹ XP_037862829

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666045	52,451,772 - 52,468,664 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007968897	(Get FASTA)	NCBI Sequence Viewer
	XP_072879055	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009745
	ENSCSAP00000009745.1

RefSeq Acc Id:	XP_007968897 ⟸ XM_007970706
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RMA6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009745 ⟸ ENSCSAT00000011679

RefSeq Acc Id:	XP_037862829 ⟸ XM_038006901
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013583	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011679.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1420.10	UniProtKB/TrEMBL
	2.30.30.140	UniProtKB/TrEMBL
	3.30.420.110	UniProtKB/TrEMBL
	3.40.1170.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	DNA_mismatch_repair_MutS-lik_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS/MSH	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_C	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_clamp	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_core	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_sf	UniProtKB/TrEMBL
	DNA_mmatch_repair_MutS_con_dom	UniProtKB/TrEMBL
	MutS_con_dom_sf	UniProtKB/TrEMBL
	MutS_family	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PWWP_dom	UniProtKB/TrEMBL
NCBI Gene	MSH6	ENTREZGENE
PANTHER	DNA MISMATCH REPAIR PROTEIN MSH6	UniProtKB/TrEMBL
	PTHR11361	UniProtKB/TrEMBL
Pfam	MutS_I	UniProtKB/TrEMBL
	MutS_II	UniProtKB/TrEMBL
	MutS_III	UniProtKB/TrEMBL
	MutS_IV	UniProtKB/TrEMBL
	MutS_V	UniProtKB/TrEMBL
	PWWP	UniProtKB/TrEMBL
PIRSF	DNA_mis_repair_Msh6	UniProtKB/TrEMBL
PROSITE	DNA_MISMATCH_REPAIR_2	UniProtKB/TrEMBL
	PWWP	UniProtKB/TrEMBL
SMART	MUTSac	UniProtKB/TrEMBL
	MUTSd	UniProtKB/TrEMBL
	PWWP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48334	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
	SSF55271	UniProtKB/TrEMBL
	Tudor/PWWP/MBT	UniProtKB/TrEMBL
UniProt	A0A0D9RMA6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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