MSH6 (mutS homolog 6) - Rat Genome Database

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Gene: MSH6 (mutS homolog 6) Canis lupus familiaris
Analyze
Symbol: MSH6
Name: mutS homolog 6
RGD ID: 12141324
Description: ENCODES a protein that exhibits ADP binding (ortholog); ATP binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN determination of adult lifespan (ortholog); intrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2B (ortholog); autosomal recessive progressive external ophthalmoplegia 1 (ortholog); FOUND IN chromatin (inferred); cytosol (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA mismatch repair protein Msh6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,825,330 - 49,838,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,803,898 - 49,838,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,669,446 - 49,693,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01050,687,723 - 50,711,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,687,741 - 50,711,873 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,394,939 - 50,419,090 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,681,795 - 50,705,920 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,869,560 - 50,893,685 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ataxia telangiectasia  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
B-lymphoblastic leukemia/lymphoma with BCR-ABL1  (ISO)
bilateral breast cancer  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
CEREBELLAR ATAXIA INFANTILE WITH PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA  (ISO)
cerebellar medulloblastoma  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Digestive System Neoplasms  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
endometrial serous adenocarcinoma  (ISO)
Familial Prostate Cancer  (ISO)
Gaucher's disease  (ISO)
Gaucher's disease type I  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hereditary nonpolyposis colorectal cancer type 5  (ISO)
INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES  (ISO)
lung adenocarcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
Lynch syndrome  (ISO)
Lynch syndrome 1  (ISO)
Microsatellite Instability  (ISO)
mismatch repair cancer syndrome  (ISO)
Mismatch Repair Cancer Syndrome 1  (ISO)
Mismatch Repair Cancer Syndrome 3  (ISO)
Neurodevelopmental Disorders  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Pitt-Hopkins-like syndrome 2  (ISO)
progressive myoclonus epilepsy 5  (ISO)
prostate cancer  (ISO)
rhabdomyosarcoma  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
stomach cancer  (ISO)
Thyroid Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urogenital Neoplasms  (ISO)
uterine corpus cancer  (ISO)
xeroderma pigmentosum group D  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MSH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,825,330 - 49,838,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,803,898 - 49,838,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,669,446 - 49,693,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01050,687,723 - 50,711,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,687,741 - 50,711,873 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,394,939 - 50,419,090 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,681,795 - 50,705,920 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,869,560 - 50,893,685 (+)NCBIUU_Cfam_GSD_1.0
MSH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,783,145 - 47,810,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,695,530 - 47,810,063 (+)EnsemblGRCh38hg38GRCh38
GRCh37248,010,284 - 48,037,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,863,725 - 47,887,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34247,921,936 - 47,945,743NCBI
Celera247,849,755 - 47,873,614 (+)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef247,746,516 - 47,770,575 (+)NCBIHuRef
CHM1_1247,940,665 - 47,964,487 (+)NCBICHM1_1
T2T-CHM13v2.0247,789,083 - 47,816,050 (+)NCBIT2T-CHM13v2.0
Msh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,282,478 - 88,298,320 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,282,490 - 88,298,320 (+)EnsemblGRCm39 Ensembl
GRCm381787,975,050 - 87,990,892 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,975,062 - 87,990,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,374,390 - 88,390,232 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,883,410 - 87,899,389 (+)NCBIMGSCv36mm8
Celera1792,385,348 - 92,401,193 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
Msh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,316,190 - 12,333,505 (-)NCBIGRCr8
mRatBN7.266,562,631 - 6,579,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,562,632 - 6,579,956 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,844,774 - 6,862,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,154,179 - 7,171,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,681,324 - 6,698,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,644,565 - 11,662,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,644,578 - 11,662,499 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,616,672 - 21,634,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,525,292 - 11,542,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera66,326,162 - 6,343,370 (-)NCBICelera
Cytogenetic Map6q12NCBI
Msh6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,451,307 - 14,471,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544114,451,207 - 14,471,316 (+)NCBIChiLan1.0ChiLan1.0
MSH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,578,235 - 78,603,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,582,203 - 78,607,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,901,591 - 47,926,662 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,824,469 - 48,849,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,824,350 - 48,849,779 (+)Ensemblpanpan1.1panPan2
Msh6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,280,052 - 33,300,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,708,661 - 4,728,787 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,708,661 - 4,728,671 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,785,664 - 92,814,238 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1392,792,590 - 92,814,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2398,710,956 - 98,732,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSH6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,375,602 - 59,400,252 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,375,691 - 59,400,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604552,443,508 - 52,468,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,083,692 - 29,108,792 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473829,083,696 - 29,108,792 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MSH6
99 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000004197   ⟹   ENSCAFP00000003882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1049,814,859 - 49,838,028 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000043509   ⟹   ENSCAFP00000040899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1049,803,898 - 49,838,028 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000074068   ⟹   ENSCAFP00000054924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1049,825,120 - 49,832,908 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009790   ⟹   ENSCAFP00845007653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1050,687,741 - 50,711,870 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009798   ⟹   ENSCAFP00845007660
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1050,687,741 - 50,711,864 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009822   ⟹   ENSCAFP00845007679
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1050,687,792 - 50,711,873 (+)Ensembl
RefSeq Acc Id: XM_038489232   ⟹   XP_038345160
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11050,394,939 - 50,419,090 (+)NCBI
RefSeq Acc Id: XM_038551236   ⟹   XP_038407164
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01050,869,560 - 50,893,685 (+)NCBI
RefSeq Acc Id: XM_038615132   ⟹   XP_038471060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01050,681,795 - 50,705,920 (+)NCBI
RefSeq Acc Id: XM_038646908   ⟹   XP_038502836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1049,669,446 - 49,693,588 (+)NCBI
RefSeq Acc Id: XM_038680515   ⟹   XP_038536443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01050,687,723 - 50,711,873 (+)NCBI
Ensembl Acc Id: ENSCAFP00000054924   ⟸   ENSCAFT00000074068
Ensembl Acc Id: ENSCAFP00000003882   ⟸   ENSCAFT00000004197
Ensembl Acc Id: ENSCAFP00000040899   ⟸   ENSCAFT00000043509
RefSeq Acc Id: XP_038345160   ⟸   XM_038489232
RefSeq Acc Id: XP_038471060   ⟸   XM_038615132
RefSeq Acc Id: XP_038536443   ⟸   XM_038680515
RefSeq Acc Id: XP_038502836   ⟸   XM_038646908
RefSeq Acc Id: XP_038407164   ⟸   XM_038551236
- UniProtKB: A0A8C0LSJ2 (UniProtKB/TrEMBL),   A0A8C0N1R0 (UniProtKB/TrEMBL),   A0A8I3RSQ0 (UniProtKB/TrEMBL),   A0A8P0P4A2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845007660   ⟸   ENSCAFT00845009798
Ensembl Acc Id: ENSCAFP00845007653   ⟸   ENSCAFT00845009790
Ensembl Acc Id: ENSCAFP00845007679   ⟸   ENSCAFT00845009822
Protein Domains
DNA mismatch repair proteins mutS family   PWWP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002664 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008935 UniProtKB/TrEMBL
  ENSCAFG00040012249 UniProtKB/TrEMBL
  ENSCAFG00845005493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004197.6 UniProtKB/TrEMBL
  ENSCAFT00000043509.3 UniProtKB/TrEMBL
  ENSCAFT00000074068.2 UniProtKB/TrEMBL
  ENSCAFT00030016690.1 UniProtKB/TrEMBL
  ENSCAFT00030016725.1 UniProtKB/TrEMBL
  ENSCAFT00030016764.1 UniProtKB/TrEMBL
  ENSCAFT00040022717.1 UniProtKB/TrEMBL
  ENSCAFT00040022798.1 UniProtKB/TrEMBL
  ENSCAFT00845009790 ENTREZGENE
  ENSCAFT00845009790.1 UniProtKB/TrEMBL
  ENSCAFT00845009798.1 UniProtKB/TrEMBL
  ENSCAFT00845009822.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/TrEMBL
  3.40.1170.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS-lik_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS/MSH UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_clamp UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/TrEMBL
  MutS_family UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PWWP_dom UniProtKB/TrEMBL
NCBI Gene MSH6 ENTREZGENE
PANTHER DNA MISMATCH REPAIR PROTEIN MSH6 UniProtKB/TrEMBL
  PTHR11361 UniProtKB/TrEMBL
Pfam MutS_I UniProtKB/TrEMBL
  MutS_II UniProtKB/TrEMBL
  MutS_III UniProtKB/TrEMBL
  MutS_IV UniProtKB/TrEMBL
  MutS_V UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
PIRSF DNA_mis_repair_Msh6 UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
SMART MUTSac UniProtKB/TrEMBL
  MUTSd UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF55271 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8C0LSJ2 ENTREZGENE
  A0A8C0MVN9_CANLF UniProtKB/TrEMBL
  A0A8C0N1R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SDJ2_CANLF UniProtKB/TrEMBL
  A0A8C0SDX2_CANLF UniProtKB/TrEMBL
  A0A8I3MPE7_CANLF UniProtKB/TrEMBL
  A0A8I3MR87_CANLF UniProtKB/TrEMBL
  A0A8I3RSQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P4A2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43441 ENTREZGENE