Fam220a (family with sequence similarity 220, member A) - Rat Genome Database

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Gene: Fam220a (family with sequence similarity 220, member A) Rattus norvegicus
Analyze
Symbol: Fam220a
Name: family with sequence similarity 220, member A
RGD ID: 1561923
Description: Predicted to enable STAT family protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in acrosomal vesicle. Predicted to be active in nucleus. Orthologous to several human genes including FAM220A (family with sequence similarity 220 member A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498145; similar to RIKEN cDNA 2810453I06; Sipar; STAT3-interacting protein as a repressor
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,111,593 - 16,127,584 (-)NCBIGRCr8
mRatBN7.21210,997,969 - 11,013,962 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,997,740 - 11,016,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,805,254 - 11,821,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,428,542 - 12,444,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,453,553 - 11,469,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,043,038 - 13,067,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,043,038 - 13,067,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,088,130 - 15,110,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,341,686 - 11,343,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1212,792,738 - 12,808,579 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
acrosomal vesicle  (ISO,ISS)
cytoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:25943107   PMID:26026268  


Genomics

Comparative Map Data
Fam220a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,111,593 - 16,127,584 (-)NCBIGRCr8
mRatBN7.21210,997,969 - 11,013,962 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,997,740 - 11,016,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,805,254 - 11,821,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,428,542 - 12,444,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,453,553 - 11,469,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,043,038 - 13,067,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,043,038 - 13,067,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,088,130 - 15,110,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,341,686 - 11,343,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1212,792,738 - 12,808,579 (-)NCBICelera
Cytogenetic Map12p11NCBI
FAM220A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,329,411 - 6,348,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,329,411 - 6,348,981 (-)EnsemblGRCh38hg38GRCh38
GRCh3776,369,042 - 6,388,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,335,565 - 6,355,115 (-)NCBINCBI36Build 36hg18NCBI36
Celera76,346,541 - 6,366,073 (+)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,240,692 - 6,260,128 (-)NCBIHuRef
CHM1_176,368,638 - 6,388,157 (-)NCBICHM1_1
T2T-CHM13v2.076,448,805 - 6,468,359 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,415,393 - 6,434,949 (-)NCBI
Fam220a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,534,475 - 143,550,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,534,463 - 143,550,286 (+)EnsemblGRCm39 Ensembl
GRCm385143,548,720 - 143,564,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,548,706 - 143,564,531 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,548,708 - 143,564,531 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,309,574 - 144,325,393 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,804,343 - 143,820,144 (+)NCBIMGSCv36mm8
Celera5140,595,338 - 140,611,144 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.27NCBI
Fam220a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546013,329,417 - 13,335,986 (+)NCBIChiLan1.0ChiLan1.0
LOC100683001
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,692,532 - 11,711,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,317,709 - 13,336,687 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,693,112 - 11,712,092 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1611,569,420 - 11,588,404 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,548,525 - 11,567,497 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,775,631 - 11,795,213 (-)NCBIUU_Cfam_GSD_1.0
Fam220a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,778,284 - 139,792,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750152,827 - 165,171 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936750165,233 - 166,026 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750152,866 - 166,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110260073
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.134,821,544 - 4,848,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FAM220A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,538,085 - 15,560,278 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,539,047 - 15,539,826 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102516,560 - 537,110 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam220a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474031,009,409 - 31,010,170 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam220a
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:114
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000029692
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
RH134487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21210,997,907 - 10,998,097 (+)MAPPERmRatBN7.2
Rnor_6.01213,042,977 - 13,043,165NCBIRnor6.0
Rnor_5.01215,088,069 - 15,088,257UniSTSRnor5.0
RGSC_v3.41211,341,625 - 11,341,813UniSTSRGSC3.4
Celera1212,792,675 - 12,792,865UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000029692   ⟹   ENSRNOP00000059765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1210,997,807 - 11,000,259 (-)Ensembl
Rnor_6.0 Ensembl1213,043,038 - 13,067,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102797   ⟹   ENSRNOP00000078852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1210,997,740 - 11,016,501 (-)Ensembl
RefSeq Acc Id: NM_001017485   ⟹   NP_001017485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,111,593 - 16,127,584 (-)NCBI
mRatBN7.21210,997,969 - 11,013,962 (-)NCBI
Rnor_6.01213,043,038 - 13,067,043 (-)NCBI
Rnor_5.01215,088,130 - 15,110,348 (-)NCBI
RGSC_v3.41211,341,686 - 11,343,288 (-)RGD
Celera1212,792,738 - 12,808,579 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001017485 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH76392 (Get FASTA)   NCBI Sequence Viewer  
  EDL89662 (Get FASTA)   NCBI Sequence Viewer  
  EDL89663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059765.1
  ENSRNOP00000078852.1
  ENSRNOP00065000167
  ENSRNOP00065000168
GenBank Protein Q6DGF6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017485   ⟸   NM_001017485
- UniProtKB: Q6DGF6 (UniProtKB/Swiss-Prot),   A6K1K4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059765   ⟸   ENSRNOT00000029692
Ensembl Acc Id: ENSRNOP00000078852   ⟸   ENSRNOT00000102797
Protein Domains
SIPAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6DGF6-F1-model_v2 AlphaFold Q6DGF6 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698436
Promoter ID:EPDNEW_R8961
Type:initiation region
Name:Fam220a_1
Description:family with sequence similarity 220, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,067,349 - 13,067,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561923 AgrOrtholog
BioCyc Gene G2FUF-20009 BioCyc
Ensembl Genes ENSRNOG00000024605 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00065000102 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029692.7 UniProtKB/Swiss-Prot
  ENSRNOT00000102797.1 UniProtKB/Swiss-Prot
  ENSRNOT00065000168 UniProtKB/Swiss-Prot
  ENSRNOT00065000169 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107018 IMAGE-MGC_LOAD
InterPro FAM220A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIPAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:498145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94793 IMAGE-MGC_LOAD
NCBI Gene 498145 ENTREZGENE
PANTHER PROTEIN FAM220A UniProtKB/Swiss-Prot
  PROTEIN FAM220A UniProtKB/TrEMBL
  PROTEIN FAM220A UniProtKB/TrEMBL
  PTHR31980 UniProtKB/Swiss-Prot
Pfam FAM220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fam220a PhenoGen
RatGTEx ENSRNOG00000024605 RatGTEx
  ENSRNOG00065000102 RatGTEx
UniProt A6K1K4 ENTREZGENE, UniProtKB/TrEMBL
  F220A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-18 Fam220a  family with sequence similarity 220, member A  LOC498145  similar to RIKEN cDNA 2810453I06  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498145  similar to RIKEN cDNA 2810453I06      Symbol and Name status set to provisional 70820 PROVISIONAL