Etaa1 (ETAA1 activator of ATR kinase) - Rat Genome Database

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Gene: Etaa1 (ETAA1 activator of ATR kinase) Rattus norvegicus
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Symbol: Etaa1 (Ensembl: Etaa1l1)
Name: ETAA1 activator of ATR kinase (Ensembl:Ewing tumor-associated antigen 1-like 1)
RGD ID: 1560957
Description: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Predicted to be located in cytosol; nuclear replication fork; and nucleoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Etaa1l1; Ewing tumor-associated antigen 1; Ewing tumor-associated antigen 1-like 1; Ewing's tumor-associated antigen 1; ewing's tumor-associated antigen 1 homolog; LOC103693794; LOC498420; RGD1560957; similar to ETAA16 protein; similar to RIKEN cDNA 5730466H23
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Etaa1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81496,500,899 - 96,515,617 (-)NCBIGRCr8
mRatBN7.21492,298,461 - 92,314,044 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1492,299,553 - 92,314,104 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1496,598,264 - 96,612,991 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,842,571 - 97,857,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01494,307,596 - 94,322,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01497,196,079 - 97,199,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014100,886,177 - 100,886,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01496,994,880 - 96,997,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,807,365 - 98,822,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1491,335,388 - 91,349,568 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nuclear replication fork  (IBA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Etaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81496,500,899 - 96,515,617 (-)NCBIGRCr8
mRatBN7.21492,298,461 - 92,314,044 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1492,299,553 - 92,314,104 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1496,598,264 - 96,612,991 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,842,571 - 97,857,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01494,307,596 - 94,322,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01497,196,079 - 97,199,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014100,886,177 - 100,886,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01496,994,880 - 96,997,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,807,365 - 98,822,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1491,335,388 - 91,349,568 (-)NCBICelera
Cytogenetic Map14q22NCBI
ETAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38267,397,333 - 67,412,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl267,397,322 - 67,412,089 (+)EnsemblGRCh38hg38GRCh38
GRCh37267,624,465 - 67,639,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36267,477,946 - 67,491,037 (+)NCBINCBI36Build 36hg18NCBI36
Celera267,473,171 - 67,486,260 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef267,362,342 - 67,375,379 (+)NCBIHuRef
CHM1_1267,555,586 - 67,568,671 (+)NCBICHM1_1
T2T-CHM13v2.0267,407,046 - 67,421,800 (+)NCBIT2T-CHM13v2.0
Etaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,888,753 - 17,903,875 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,888,756 - 17,903,875 (-)EnsemblGRCm39 Ensembl
GRCm381117,938,753 - 17,953,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,938,756 - 17,953,875 (-)EnsemblGRCm38mm10GRCm38
MGSCv371117,838,752 - 17,853,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,839,895 - 17,853,851 (-)NCBIMGSCv36mm8
Celera1120,118,628 - 20,133,382 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1110.44NCBI

Variants

.
Variants in Etaa1
107 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000008135   ⟹   ENSRNOP00000008135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1492,299,553 - 92,314,104 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097260   ⟹   ENSRNOP00000093008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1492,299,553 - 92,313,696 (-)Ensembl
RefSeq Acc Id: NM_001109094   ⟹   NP_001102564
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,500,899 - 96,515,617 (-)NCBI
mRatBN7.21492,299,314 - 92,314,032 (-)NCBI
Rnor_6.01497,196,079 - 97,199,067 (-)NCBI
Rnor_5.014100,886,177 - 100,886,881 (-)NCBI
RGSC_v3.41498,807,365 - 98,822,369 (-)RGD
Celera1491,335,388 - 91,349,568 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092321   ⟹   XP_038948249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,501,136 - 96,515,441 (-)NCBI
mRatBN7.21492,298,461 - 92,313,866 (-)NCBI
RefSeq Acc Id: XM_039092323   ⟹   XP_038948251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,501,136 - 96,515,441 (-)NCBI
mRatBN7.21492,298,461 - 92,313,866 (-)NCBI
RefSeq Acc Id: XM_039092324   ⟹   XP_038948252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,501,136 - 96,510,032 (-)NCBI
mRatBN7.21492,298,461 - 92,313,910 (-)NCBI
RefSeq Acc Id: XM_063273495   ⟹   XP_063129565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,501,136 - 96,515,453 (-)NCBI
RefSeq Acc Id: XM_063273496   ⟹   XP_063129566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81496,501,136 - 96,515,453 (-)NCBI
RefSeq Acc Id: NP_001102564   ⟸   NM_001109094
- UniProtKB: D3ZQ67 (UniProtKB/TrEMBL),   A6JQ01 (UniProtKB/TrEMBL),   A0A8I6AIP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038948252   ⟸   XM_039092324
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AIP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948251   ⟸   XM_039092323
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948249   ⟸   XM_039092321
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIP4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000008135   ⟸   ENSRNOT00000008135
Ensembl Acc Id: ENSRNOP00000093008   ⟸   ENSRNOT00000097260
RefSeq Acc Id: XP_063129566   ⟸   XM_063273496
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063129565   ⟸   XM_063273495
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-14920 BioCyc
Ensembl Genes ENSRNOG00000006185 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008135.7 UniProtKB/TrEMBL
  ENSRNOT00000097260.1 UniProtKB/TrEMBL
InterPro ETAA1 UniProtKB/TrEMBL
KEGG Report rno:498420 UniProtKB/TrEMBL
NCBI Gene 498420 ENTREZGENE
PANTHER EWING'S TUMOR-ASSOCIATED ANTIGEN 1 UniProtKB/TrEMBL
  PTHR16434 UniProtKB/TrEMBL
Pfam ETAA1 UniProtKB/TrEMBL
PhenoGen Etaa1 PhenoGen
RatGTEx ENSRNOG00000006185 RatGTEx
UniProt A0A8I6AIP4 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ01 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQ67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-10 Etaa1  ETAA1 activator of ATR kinase  Etaa1  Ewing tumor-associated antigen 1  Name changed 629549 APPROVED
2023-08-10 Etaa1  Ewing tumor-associated antigen 1  Etaa1l1  Ewing tumor-associated antigen 1-like 1  Name and Symbol changed 629549 APPROVED
2021-03-09 Etaa1l1  Ewing tumor-associated antigen 1-like 1  LOC103693794  ewing's tumor-associated antigen 1 homolog  Data merged from RGD:9426181 737654 PROVISIONAL
2014-08-25 LOC103693794  ewing's tumor-associated antigen 1 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-18 Etaa1l1  Ewing tumor-associated antigen 1-like 1  Etaa1  Ewing tumor-associated antigen 1  Name and Symbol changed 629549 APPROVED
2013-05-24 Etaa1  Ewing tumor-associated antigen 1  LOC680614  similar to ETAA16 protein  Data merged from RGD:1589462 1643240 APPROVED
2008-10-23 Etaa1  Ewing tumor-associated antigen 1  Etaa1  Ewing's tumor-associated antigen 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Etaa1  Ewing's tumor-associated antigen 1  RGD1560957_predicted  similar to RIKEN cDNA 5730466H23 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC680614  similar to ETAA16 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1560957_predicted  similar to RIKEN cDNA 5730466H23 (predicted)  LOC498420  similar to RIKEN cDNA 5730466H23  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498420  similar to RIKEN cDNA 5730466H23      Symbol and Name status set to provisional 70820 PROVISIONAL