Tm4sf19 (transmembrane 4 L six family member 19) - Rat Genome Database

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Gene: Tm4sf19 (transmembrane 4 L six family member 19) Rattus norvegicus
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Symbol: Tm4sf19
Name: transmembrane 4 L six family member 19
RGD ID: 1560486
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in actin cytoskeleton and filopodium. Predicted to be active in membrane. Orthologous to human TM4SF19 (transmembrane 4 L six family member 19); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC288044; RGD1560486; similar to hypothetical protein BC013113; transmembrane 4 L6 family member 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,876,714 - 81,899,603 (-)NCBIGRCr8
mRatBN7.21168,372,945 - 68,386,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,210,434 - 77,221,651 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,875,160 - 69,886,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,899,548 - 68,910,766 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,607,735 - 71,619,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,692,458 - 74,703,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,189,725 - 70,201,499 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1167,805,997 - 67,817,558 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tm4sf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,876,714 - 81,899,603 (-)NCBIGRCr8
mRatBN7.21168,372,945 - 68,386,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,210,434 - 77,221,651 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,875,160 - 69,886,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,899,548 - 68,910,766 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,607,735 - 71,619,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,692,458 - 74,703,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,189,725 - 70,201,499 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1167,805,997 - 67,817,558 (-)NCBICelera
Cytogenetic Map11q22NCBI
TM4SF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,323,547 - 196,338,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,319,342 - 196,338,503 (-)EnsemblGRCh38hg38GRCh38
GRCh373196,050,418 - 196,065,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,534,816 - 197,549,655 (-)NCBINCBI36Build 36hg18NCBI36
Celera3194,630,617 - 194,645,455 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,347,379 - 193,362,525 (-)NCBIHuRef
CHM1_13196,021,242 - 196,036,106 (-)NCBICHM1_1
T2T-CHM13v2.03199,043,086 - 199,057,713 (-)NCBIT2T-CHM13v2.0
Tm4sf19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,218,823 - 32,227,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,219,324 - 32,227,045 (+)EnsemblGRCm39 Ensembl
GRCm381632,400,012 - 32,409,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,400,506 - 32,408,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,400,592 - 32,408,313 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,189,634 - 32,197,108 (+)NCBIMGSCv36mm8
MGSCv361632,320,526 - 32,327,762 (+)NCBIMGSCv36mm8
Celera1632,884,981 - 32,892,660 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1622.66NCBI
Tm4sf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,531,012 - 12,537,156 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,532,435 - 12,558,861 (-)NCBIChiLan1.0ChiLan1.0
TM4SF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,194,558 - 194,200,254 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,201,166 - 194,208,276 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,670,511 - 193,674,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,612,836 - 203,617,267 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,608,788 - 203,616,808 (-)Ensemblpanpan1.1panPan2
Tm4sf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,921,081 - 124,929,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784959,921 - 964,175 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784959,924 - 964,175 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TM4SF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,759,539 - 133,767,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,759,122 - 133,770,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TM4SF19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,858,641 - 90,878,981 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,875,041 - 90,878,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,669,013 - 64,685,085 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tm4sf19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,484,712 - 61,487,335 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,484,511 - 61,487,458 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tm4sf19
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000002396
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 79 78 47 25 47 6 206 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002396   ⟹   ENSRNOP00000002396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)Ensembl
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)Ensembl
RefSeq Acc Id: NM_001105873   ⟹   NP_001099343
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,878,436 - 81,889,646 (-)NCBI
mRatBN7.21168,373,380 - 68,384,591 (-)NCBI
Rnor_6.01171,607,735 - 71,619,108 (-)NCBI
Rnor_5.01174,692,458 - 74,703,220 (-)NCBI
RGSC_v3.41170,189,725 - 70,201,499 (-)RGD
Celera1167,805,997 - 67,817,558 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088111   ⟹   XP_038944039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,888,317 (-)NCBI
mRatBN7.21168,372,945 - 68,383,236 (-)NCBI
RefSeq Acc Id: XM_039088113   ⟹   XP_038944041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,899,603 (-)NCBI
mRatBN7.21168,372,945 - 68,386,192 (-)NCBI
RefSeq Acc Id: XM_039088115   ⟹   XP_038944043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,888,516 (-)NCBI
mRatBN7.21168,372,945 - 68,383,224 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099343 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944039 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944041 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002396.4
RefSeq Acc Id: NP_001099343   ⟸   NM_001105873
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002396   ⟸   ENSRNOT00000002396
RefSeq Acc Id: XP_038944041   ⟸   XM_039088113
- Peptide Label: isoform X1
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944039   ⟸   XM_039088111
- Peptide Label: isoform X1
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944043   ⟸   XM_039088115
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADI7-F1-model_v2 AlphaFold D4ADI7 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560486 AgrOrtholog
BioCyc Gene G2FUF-21092 BioCyc
Ensembl Genes ENSRNOG00000001757 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002396.6 UniProtKB/TrEMBL
InterPro L6_membrane UniProtKB/TrEMBL
KEGG Report rno:288044 UniProtKB/TrEMBL
NCBI Gene 288044 ENTREZGENE
PANTHER PTHR14198 UniProtKB/TrEMBL
  TRANSMEMBRANE 4 L6 FAMILY MEMBER 19 UniProtKB/TrEMBL
Pfam L6_membrane UniProtKB/TrEMBL
PhenoGen Tm4sf19 PhenoGen
RatGTEx ENSRNOG00000001757 RatGTEx
UniProt A6IRS1 ENTREZGENE, UniProtKB/TrEMBL
  D4ADI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Tm4sf19  transmembrane 4 L six family member 19  RGD1560486_predicted  similar to hypothetical protein BC013113 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560486_predicted  similar to hypothetical protein BC013113 (predicted)  LOC288044  similar to hypothetical protein BC013113  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC288044  similar to hypothetical protein BC013113      Symbol and Name status set to provisional 70820 PROVISIONAL