TGFB1 (transforming growth factor beta 1) - Rat Genome Database

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Gene: TGFB1 (transforming growth factor beta 1) Sus scrofa
Analyze
Symbol: TGFB1
Name: transforming growth factor beta 1
RGD ID: 14121243
Description: ENCODES a protein that exhibits identical protein binding; protein-containing complex binding (ortholog); type I transforming growth factor beta receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic process (ortholog); ATP biosynthetic process (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; ASSOCIATED WITH acromicric dysplasia (ortholog); actinic keratosis (ortholog); acute kidney failure (ortholog); FOUND IN axon (ortholog); blood microparticle (ortholog); cell surface (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; arecoline; cadmium atom
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TGF-BETA-1; Transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor, beta 1 (Camurati-Engelmann disease)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,332,173 - 49,349,046 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,332,169 - 49,348,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,127,027 - 45,141,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q11-q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acromicric dysplasia  (ISO)
actinic keratosis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Anetoderma  (ISO)
anogenital venereal wart  (ISO)
aortic valve insufficiency  (ISO)
aphthous stomatitis  (ISO)
aplastic anemia  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
biliary atresia  (ISO)
brain disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Camurati-Engelmann disease  (ISO)
Camurati-Engelmann disease 1  (ISO)
carcinoma  (ISO)
carcinosarcoma  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholangiocarcinoma  (ISO)
chorioamnionitis  (ISO)
Chronic Experimental Pancreatitis  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis B  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
cleft palate  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Copper-Overload Cirrhosis  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Diaphragmatic Hernia  (ISO)
Dilatation, Pathologic  (ISO)
dry eye syndrome  (ISO)
Duchenne muscular dystrophy  (ISO)
duodenal ulcer  (ISO)
Ehlers-Danlos syndrome  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
eosinophilic esophagitis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
factor VIII deficiency  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
gout  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
Heart Injuries  (ISO)
Hemorrhagic Shock  (ISO)
hepatic encephalopathy  (ISO)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Infant, Newborn, Diseases  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY  (ISO)
insulinoma  (ISO)
interstitial lung disease  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
Lymphomatoid Papulosis  (ISO)
Meckel Syndrome 10  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
muscular disease  (ISO)
myelofibrosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrolithiasis  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
nephrotoxicity  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
occupational asthma  (ISO)
Occupational Diseases  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
Paraquat Lung  (ISO)
Peritoneal Fibrosis  (ISO)
Peyronie's disease  (ISO)
pleural disease  (ISO)
pneumonia  (ISO)
Posterior Leukoencephalopathy Syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
Progressive Diaphyseal Dysplasia 1  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
rhinitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Neoplasm Regression  (ISO)
squamous cell carcinoma  (ISO)
stroke  (ISO)
thrombocytopenia  (ISO)
tracheal stenosis  (ISO)
traumatic brain injury  (ISO)
Tubulointerstitial Fibrosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
urticaria  (ISO)
uveitis  (ISO)
Ventricular Remodeling  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  (IEA)
animal organ regeneration  (ISO)
aortic valve morphogenesis  (IEA)
apoptotic process  (ISO)
ATP biosynthetic process  (IEA,ISS)
branch elongation involved in mammary gland duct branching  (ISO)
canonical Wnt signaling pathway  (ISO)
cell activation  (ISO)
cell differentiation  (IBA)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell junction organization  (IEA,ISS)
cellular response to acetaldehyde  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IEA)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO,ISS)
cellular response to virus  (IEA)
chondrocyte differentiation  (IEA,ISS)
columnar/cuboidal epithelial cell maturation  (ISO)
connective tissue development  (ISO)
defense response to fungus  (ISO)
digestive tract development  (ISO)
embryonic liver development  (IEA)
endoderm development  (ISO)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
extracellular matrix assembly  (IEA,ISS)
extrinsic apoptotic signaling pathway  (IEA,ISS)
face morphogenesis  (IEA)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
gene expression  (ISO)
germ cell migration  (ISO)
heart development  (IBA,IEA)
heart valve morphogenesis  (IEA)
hematopoietic progenitor cell differentiation  (IEA,ISS)
hyaluronan catabolic process  (IEA,ISS)
inflammatory response  (ISO,ISS)
inner ear development  (ISO)
intracellular calcium ion homeostasis  (ISO)
lens fiber cell differentiation  (ISO)
liver regeneration  (ISO)
lung alveolus development  (ISO)
lymph node development  (ISO,ISS)
mammary gland branching involved in thelarche  (ISO)
mammary gland development  (ISO)
membrane protein intracellular domain proteolysis  (IEA,ISS)
mononuclear cell proliferation  (ISO)
morphogenesis of a branching structure  (ISO)
muscle cell cellular homeostasis  (ISO)
myelination  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of biomineral tissue development  (IEA)
negative regulation of blood vessel endothelial cell migration  (IEA,ISS)
negative regulation of cell cycle  (IEA,ISS)
negative regulation of cell differentiation  (IEA)
negative regulation of cell growth  (IEA,ISS)
negative regulation of cell population proliferation  (IEA,ISS)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA,ISS)
negative regulation of DNA-templated transcription  (IEA,ISS)
negative regulation of epithelial cell proliferation  (IEA,ISO,ISS)
negative regulation of fat cell differentiation  (IEA,ISS)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of hyaluronan biosynthetic process  (IEA,ISS)
negative regulation of interleukin-17 production  (IEA)
negative regulation of macrophage cytokine production  (IEA,ISS)
negative regulation of miRNA transcription  (IEA)
negative regulation of myoblast differentiation  (IEA,ISS)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IEA)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of ossification  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of protein localization to plasma membrane  (IEA)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
negative regulation of skeletal muscle tissue development  (IEA,ISS)
negative regulation of T cell activation  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube closure  (IEA)
neural tube development  (IEA)
neuron apoptotic process  (ISO)
Notch signaling pathway  (ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (ISO)
odontoblast differentiation  (IEA,ISS)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte development  (IEA)
osteoclast differentiation  (ISO)
phosphate-containing compound metabolic process  (IEA,ISS)
phospholipid homeostasis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell differentiation  (IEA)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IEA,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of chemotaxis  (IEA,ISS)
positive regulation of collagen biosynthetic process  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of endothelial cell apoptotic process  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (ISS)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISS)
positive regulation of exit from mitosis  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of fibroblast migration  (IEA,ISO,ISS)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-17 production  (IEA,ISS)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of isotype switching to IgA isotypes  (ISO,ISS)
positive regulation of MAPK cascade  (IEA)
positive regulation of mesenchymal stem cell proliferation  (IEA)
positive regulation of microglia differentiation  (IEA,ISS)
positive regulation of miRNA transcription  (IEA)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of primary miRNA processing  (IEA)
positive regulation of protein import into nucleus  (IEA,ISS)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISS)
positive regulation of protein secretion  (IEA,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISS)
positive regulation of receptor signaling pathway via STAT  (IEA)
positive regulation of regulatory T cell differentiation  (IEA)
positive regulation of SMAD protein signal transduction  (IEA,ISS)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of superoxide anion generation  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of vascular permeability  (IEA)
positive regulation of vasculature development  (IEA)
protein export from nucleus  (IEA)
protein phosphorylation  (ISO)
receptor catabolic process  (IEA,ISS)
regulation of actin cytoskeleton organization  (ISO)
regulation of branching involved in mammary gland duct morphogenesis  (ISO)
regulation of cartilage development  (ISO)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (IBA,ISO)
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
regulation of gene expression  (ISO)
regulation of interleukin-23 production  (IEA)
regulation of miRNA transcription  (ISO)
regulation of protein import into nucleus  (ISO,ISS)
regulation of regulatory T cell differentiation  (ISO)
regulation of sodium ion transport  (ISO)
regulation of striated muscle tissue development  (ISO,ISS)
regulatory T cell differentiation  (IEA,ISO)
response to cholesterol  (IEA,ISS)
response to estradiol  (IEA,ISO,ISS)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to laminar fluid shear stress  (ISO)
response to progesterone  (IEA,ISS)
response to salt  (ISO)
response to vitamin D  (ISO)
response to wounding  (IEA,ISS)
response to xenobiotic stimulus  (ISO)
retina vasculature development in camera-type eye  (ISO)
salivary gland morphogenesis  (IEA,ISS)
signal transduction  (IEA)
sprouting angiogenesis  (ISO)
surfactant homeostasis  (ISO)
T cell activation  (ISO)
T cell differentiation  (ISO)
T cell homeostasis  (ISO)
tolerance induction to self antigen  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISO,ISS)
ureteric bud development  (IEA)
vasculogenesis  (IEA)
ventricular cardiac muscle tissue morphogenesis  (IEA)

Cellular Component
axon  (ISO)
blood microparticle  (ISS)
cell surface  (IEA,ISS)
cytoplasm  (IEA,ISS)
extracellular matrix  (IEA,ISO,ISS)
extracellular region  (IEA)
extracellular space  (IBA,IEA,ISO,ISS)
microvillus  (IEA,ISS)
neuronal cell body  (ISO)
nucleus  (IEA,ISS)
secretory granule  (ISO)

References
Additional References at PubMed
PMID:2090012   PMID:2461367   PMID:2879635   PMID:3166520   PMID:3470708   PMID:8104872   PMID:8242742   PMID:9250869   PMID:9872992   PMID:14681463   PMID:15961561   PMID:16530041  
PMID:16978608   PMID:17145712   PMID:17651407   PMID:17694440   PMID:18160996   PMID:18218921   PMID:18387002   PMID:18832581   PMID:19023092   PMID:19188658   PMID:19645615   PMID:19716643  
PMID:19840848   PMID:19920116   PMID:20088852   PMID:20378284   PMID:20432454   PMID:20511416   PMID:21106882   PMID:21127288   PMID:21677751   PMID:21739142   PMID:21851806   PMID:22251543  
PMID:22301074   PMID:22482797   PMID:22927042   PMID:23602250   PMID:23903699   PMID:24020676   PMID:24042214   PMID:25170924   PMID:27189428   PMID:27633089   PMID:27882941   PMID:28142299  
PMID:28360109   PMID:30032202   PMID:30541630   PMID:32661265  


Genomics

Comparative Map Data
TGFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,332,173 - 49,349,046 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,332,169 - 49,348,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,127,027 - 45,141,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q11-q21NCBI
TGFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,330,323 - 41,353,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,301,587 - 41,353,961 (-)Ensemblhg38GRCh38
GRCh371941,836,228 - 41,859,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,528,491 - 46,551,656 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341946,528,658 - 46,551,158NCBI
Celera1938,636,964 - 38,659,992 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,268,902 - 38,291,920 (-)NCBIHuRef
CHM1_11941,836,504 - 41,859,495 (-)NCBICHM1_1
T2T-CHM13v2.01944,151,181 - 44,174,790 (-)NCBIT2T-CHM13v2.0
Tgfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,386,406 - 25,404,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,386,427 - 25,404,502 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,687,002 - 25,705,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,687,002 - 25,705,077 (+)Ensemblmm10GRCm38
MGSCv37726,472,021 - 26,490,015 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36725,395,762 - 25,413,756 (+)NCBIMGSCv36mm8
Celera720,295,914 - 20,313,908 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.98NCBI
Tgfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,324,312 - 90,340,627 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,324,046 - 90,340,899 (+)EnsemblGRCr8
mRatBN7.2181,196,532 - 81,212,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,196,532 - 81,212,847 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,588,717 - 86,605,032 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,140,207 - 95,156,569 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,344,513 - 88,360,828 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd188,944,249 - 88,960,564 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive194,081,083 - 94,097,398 (+)NCBILyon_Normotensive
Lyon_Hypertensive190,624,611 - 90,640,951 (+)NCBILyon_Hypertensive
F344_StmMcwi189,069,578 - 89,085,893 (+)NCBIF344_StmMcwi
Rnor_6.0182,480,875 - 82,497,196 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,480,195 - 82,497,199 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,742,151 - 83,758,472 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,894,705 - 80,911,020 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,636,001 - 75,652,315 (+)NCBICelera
RGSC_v3.1180,972,549 - 80,988,992 (+)NCBI
Cytogenetic Map1q21NCBI
Tgfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555270,652 - 288,441 (-)Ensembl
ChiLan1.0NW_004955555274,405 - 288,441 (-)NCBIChiLan1.0ChiLan1.0
TGFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,541,048 - 47,564,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,409,816 - 49,432,810 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,324,009 - 38,347,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,831,659 - 46,852,973 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,831,659 - 46,852,973 (-)EnsemblpanPan2panpan1.1
B9D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,621,832 - 112,627,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,621,633 - 112,643,885 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,025,951 - 112,032,055 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,219,930 - 113,226,035 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,219,701 - 113,241,694 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,781,179 - 112,787,278 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,413,522 - 112,419,614 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,406,803 - 113,412,909 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tgfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,314,010 - 15,330,197 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,742,066 - 3,758,272 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,742,080 - 3,758,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,651,583 - 35,674,387 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,648,677 - 35,674,365 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607313,886,646 - 13,908,666 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907161,569 - 176,605 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907162,567 - 175,696 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tgfb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,090,515 - 169,108,146 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in TGFB1
219 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000036469   ⟹   ENSSSCP00000030317
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl649,332,173 - 49,349,046 (-)Ensembl
RefSeq Acc Id: NM_214015   ⟹   NP_999180
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1649,332,171 - 49,348,601 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093503   ⟹   XP_020949162
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1649,332,169 - 49,348,642 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020949162   ⟸   XM_021093503
- Peptide Label: isoform X1
- UniProtKB: P08832 (UniProtKB/Swiss-Prot),   P07200 (UniProtKB/Swiss-Prot),   K7GQZ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_999180   ⟸   NM_214015
- Peptide Label: precursor
- UniProtKB: P08832 (UniProtKB/Swiss-Prot),   K7GQZ2 (UniProtKB/Swiss-Prot),   P07200 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSSSCP00000030317   ⟸   ENSSSCT00000036469
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015080792 UniProtKB/Swiss-Prot
  ENSSSCG00025019487 UniProtKB/Swiss-Prot
  ENSSSCG00030021126 UniProtKB/Swiss-Prot
  ENSSSCG00035038894 UniProtKB/Swiss-Prot
  ENSSSCG00040068791 UniProtKB/Swiss-Prot
  ENSSSCG00045032593 UniProtKB/Swiss-Prot
  ENSSSCG00050023190 UniProtKB/Swiss-Prot
  ENSSSCG00055009042 UniProtKB/Swiss-Prot
  ENSSSCG00060070125 UniProtKB/Swiss-Prot
  ENSSSCG00065012270 UniProtKB/Swiss-Prot
  ENSSSCG00070001924 UniProtKB/Swiss-Prot
  ENSSSCG00105033465 UniProtKB/Swiss-Prot
  ENSSSCG00110035834 UniProtKB/Swiss-Prot
  ENSSSCG00115013672 UniProtKB/Swiss-Prot
  ENSSSCG00130027410 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000036469 ENTREZGENE
  ENSSSCT00000036469.4 UniProtKB/Swiss-Prot
  ENSSSCT00015109974.1 UniProtKB/Swiss-Prot
  ENSSSCT00025026430.1 UniProtKB/Swiss-Prot
  ENSSSCT00030029290.1 UniProtKB/Swiss-Prot
  ENSSSCT00035051620.1 UniProtKB/Swiss-Prot
  ENSSSCT00040094188.1 UniProtKB/Swiss-Prot
  ENSSSCT00045055664.1 UniProtKB/Swiss-Prot
  ENSSSCT00050031315.1 UniProtKB/Swiss-Prot
  ENSSSCT00055017714.1 UniProtKB/Swiss-Prot
  ENSSSCT00060095738.1 UniProtKB/Swiss-Prot
  ENSSSCT00065016364.1 UniProtKB/Swiss-Prot
  ENSSSCT00070003600.1 UniProtKB/Swiss-Prot
  ENSSSCT00105063742 UniProtKB/Swiss-Prot
  ENSSSCT00110068157 UniProtKB/Swiss-Prot
  ENSSSCT00115023833 UniProtKB/Swiss-Prot
  ENSSSCT00130053360 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb1 UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report ssc:397078 UniProtKB/Swiss-Prot
NCBI Gene TGFB1 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PIRSF TGF-beta UniProtKB/Swiss-Prot
PRINTS TGFBETA UniProtKB/Swiss-Prot
  TGFBETA1 UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt K7GQZ2 ENTREZGENE
  P07200 ENTREZGENE
  P08832 ENTREZGENE
  Q703I6_PIG UniProtKB/TrEMBL
  TGFB1_PIG UniProtKB/Swiss-Prot
UniProt Secondary K7GQZ2 UniProtKB/Swiss-Prot
  P08832 UniProtKB/Swiss-Prot
VGNC ID VGNC:98656 ENTREZGENE