Trap1 (TNF receptor-associated protein 1)

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Gene: Trap1 (TNF receptor-associated protein 1) Rattus norvegicus

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Symbol:

Trap1

Name:

TNF receptor-associated protein 1

RGD ID:

1359733

Description:

Enables protein kinase binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Orthologous to human TRAP1 (TNF receptor associated protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

heat shock protein 75 kDa, mitochondrial; HSP 75; MGC95278; TNFR-associated protein 1; TRAP-1; tumor necrosis factor type 1 receptor associated protein; tumor necrosis factor type 1 receptor-associated protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRAP1 (TNF receptor associated protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Trap1 (TNF receptor-associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trap1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRAP1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRAP1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trap1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRAP1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRAP1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trap1 (TNF receptor associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TRAP1 (TNF receptor associated protein 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trap1 (TNF receptor-associated protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trap1 (TNF receptor-associated protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hsp-75	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Trap1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Alc5 Alc9

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	11,971,259 - 12,005,306 (+)	NCBI		GRCr8
mRatBN7.2	10	11,464,882 - 11,498,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,464,821 - 11,498,981 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,172,885 - 16,206,519 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,661,716 - 15,695,348 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,330,648 - 11,364,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	11,724,032 - 11,757,682 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	11,724,032 - 11,757,681 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,478,499 - 10,512,149 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	11,728,524 - 11,762,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	11,728,523 - 11,762,570 (+)	NCBI
Celera	10	10,421,446 - 10,455,484 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast carcinoma (ISO)

CAKUT (ISO)

CAKUT1 (ISO)

Disease Progression (ISO)

epilepsy (ISO)

hereditary renal cell carcinoma (ISO)

idiopathic generalized epilepsy (ISO)

osteoarthritis (ISO)

Rubinstein-Taybi syndrome (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

Stomach Neoplasms (ISO)

VACTERL association (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

cannabidiol (ISO)

captan (ISO)

carbon nanotube (ISO)

casticin (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

desferrioxamine B (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

diethyl maleate (ISO)

dopamine (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

fenvalerate (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

fructose (EXP)

fulvestrant (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

indometacin (ISO)

inulin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lithocholic acid (ISO)

Mesaconitine (EXP)

methapyrilene (EXP,ISO)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

microcystin-LR (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

nimesulide (EXP)

Nutlin-3 (ISO)

ochratoxin A (ISO)

oleanolic acid (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorododecanoic acid (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pinostrobin (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propiconazole (EXP)

quercetin (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

SB 431542 (ISO)

SNX-2112 (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sulfadimethoxine (EXP)

T-2 toxin (EXP)

temozolomide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cellular respiration (IEA,ISO,ISS)

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide (IMP)

protein folding (IBA,IEA)

translational attenuation (IEA,ISO)

Cellular Component

cell periphery (IEA,ISO)

mitochondrial inner membrane (IBA,IDA,IEA,ISO,ISS)

mitochondrial intermembrane space (IDA)

mitochondrial matrix (IEA,ISO,ISS)

mitochondrion (IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

ATP binding (IBA,IEA)

ATP hydrolysis activity (IBA,IEA)

ATP-dependent protein folding chaperone (IEA)

protein binding (IPI,ISO)

protein kinase binding (IBA,IEA,IPI,ISO)

RNA binding (ISS)

unfolded protein binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.	Chen CF, etal., Mol Cell Biol 1996 Sep;16(9):4691-9.
2.	The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.	Felts SJ, etal., J Biol Chem 2000 Feb 4;275(5):3305-12.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.	Masuda Y, etal., J Biol Chem 2004 Oct 8;279(41):42503-15. Epub 2004 Jul 28.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.	Pridgeon JW, etal., PLoS Biol. 2007 Jul;5(7):e172. Epub 2007 Jun 19.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14651853	PMID:15489334	PMID:18614015	PMID:19946888	PMID:22658674	PMID:23376485	PMID:23564345	PMID:24113185	PMID:27592455	PMID:32215175

Genomics

Comparative Map Data

Trap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	11,971,259 - 12,005,306 (+)	NCBI		GRCr8
mRatBN7.2	10	11,464,882 - 11,498,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,464,821 - 11,498,981 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,172,885 - 16,206,519 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,661,716 - 15,695,348 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,330,648 - 11,364,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	11,724,032 - 11,757,682 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	11,724,032 - 11,757,681 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,478,499 - 10,512,149 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	11,728,524 - 11,762,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	11,728,523 - 11,762,570 (+)	NCBI
Celera	10	10,421,446 - 10,455,484 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

TRAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	3,658,037 - 3,717,524 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	3,651,639 - 3,717,553 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	3,708,038 - 3,767,525 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	3,648,039 - 3,707,599 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	3,648,039 - 3,707,514	NCBI
Celera	16	3,914,746 - 3,974,292 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	3,677,147 - 3,736,537 (-)	NCBI		HuRef
CHM1_1	16	3,708,058 - 3,767,598 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	3,685,304 - 3,744,794 (-)	NCBI		T2T-CHM13v2.0

Trap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	3,857,835 - 3,895,704 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	3,857,835 - 3,895,691 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	4,039,971 - 4,077,840 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	4,039,971 - 4,077,827 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	4,039,977 - 4,077,810 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	3,955,205 - 3,993,038 (-)	NCBI		MGSCv36	mm8
Celera	16	4,672,290 - 4,710,127 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.38	NCBI

Trap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	13,696,810 - 13,733,161 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	13,697,471 - 13,733,161 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	4,182,860 - 4,242,611 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	7,966,432 - 8,025,977 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	2,578,483 - 2,637,996 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	3,753,707 - 3,786,580 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	3,753,799 - 3,786,429 (-)	Ensembl	panpan1.1		panPan2

TRAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	37,544,929 - 37,596,789 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	37,544,580 - 37,597,427 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	38,873,867 - 38,925,736 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	37,760,017 - 37,811,929 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	37,759,669 - 37,812,558 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	37,543,278 - 37,595,139 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	37,436,377 - 37,488,256 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	37,847,123 - 37,898,963 (+)	NCBI		UU_Cfam_GSD_1.0

Trap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	106,004,468 - 106,041,800 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	667,691 - 704,994 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	667,687 - 704,994 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRAP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	38,536,668 - 38,603,015 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	38,536,710 - 38,595,273 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	39,804,652 - 39,862,836 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	3,339,954 - 3,405,218 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	3,340,040 - 3,405,166 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	27,405,950 - 27,475,869 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	1,446,827 - 1,511,225 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	1,446,827 - 1,511,062 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trap1
165 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	38
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000008966
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat

Markers in Region

RH129035

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	11,498,936 - 11,499,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	11,757,688 - 11,757,868	NCBI	Rnor6.0
Rnor_5.0	10	10,512,155 - 10,512,335	UniSTS	Rnor5.0
RGSC_v3.4	10	11,762,577 - 11,762,757	UniSTS	RGSC3.4
Celera	10	10,455,490 - 10,455,670	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH94863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	11,498,754 - 11,498,992 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	11,757,506 - 11,757,743	NCBI	Rnor6.0
Rnor_5.0	10	10,511,973 - 10,512,210	UniSTS	Rnor5.0
RGSC_v3.4	10	11,762,395 - 11,762,632	UniSTS	RGSC3.4
Celera	10	10,455,308 - 10,455,545	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH140196

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	11,498,541 - 11,498,883 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	11,757,293 - 11,757,634	NCBI	Rnor6.0
Rnor_5.0	10	10,511,760 - 10,512,101	UniSTS	Rnor5.0
RGSC_v3.4	10	11,762,182 - 11,762,523	UniSTS	RGSC3.4
Celera	10	10,455,095 - 10,455,436	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008966 ⟹ ENSRNOP00000008966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	11,464,821 - 11,498,981 (+)	Ensembl
Rnor_6.0 Ensembl	10	11,724,032 - 11,757,681 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107479 ⟹ ENSRNOP00000093880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	11,472,027 - 11,498,981 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118800 ⟹ ENSRNOP00000091021

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	11,464,821 - 11,498,981 (+)	Ensembl

RefSeq Acc Id:

NM_001039001 ⟹ NP_001034090

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	11,971,259 - 12,005,306 (+)	NCBI
mRatBN7.2	10	11,464,882 - 11,498,931 (+)	NCBI
Rnor_6.0	10	11,724,032 - 11,757,682 (+)	NCBI
Rnor_5.0	10	10,478,499 - 10,512,149 (+)	NCBI
RGSC_v3.4	10	11,728,524 - 11,762,571 (+)	RGD
Celera	10	10,421,446 - 10,455,484 (+)	RGD

Sequence:

show sequence

GTTCTAAGGAACAGAAGCATGGCGCGAGAGCTGCGAGCTCTGCTGCTGTGGGGCCGCGGGCTGC
AGTCTGCACTGAGGGCTCCCGCGCTGGCGGGAGTCCGGCGAGGAAAGCCAGTTCTGCACCTTCA
GAAGACCACAGTCCACTTTAGGGACCCCACACAAAGTCTGGCTTCAGGGATCTCTGCAGGACAG
TTATATAGCACACAGGCAGCTGAGGACAAGAAGGAGGAGGCCCTGCACTCCATAATCAGCAACA
CTGAGGCTGTGCAAGGTTCTGTCTCCAAACATGAGTTCCAGGCAGAGACAAAGAAGCTTTTGGA
CATTGTAGCCCGTTCACTGTACTCGGAAAAAGAGGTATTCATACGAGAGCTCATCTCCAACGCC
AGCGATGCCTTGGAGAAACTGCGGCACAAGCGGGTGTGTGAAGGCCAGGTGCTGCCAGAAATGG
AGATTCACCTTCAGACGGATGCCGAGAAGGGCACCATCACCATCCAGGACACTGGGATTGGGAT
GACCAAGGAGGAGCTGGTGTCCAACCTTGGCACAATCGCCAGATCAGGGTCAAAGGCTTTCCTG
GAAGCACTGCAGCACCAGGCAGAGACCAGCAGCAGGATCATCGGCCAGTTTGGAGTGGGCTTCT
ATTCTGCCTTCATGGTGGCTGACAAAGTTGAAGTCTATTCTCGACCGGCAGCCCCAGAGAGCCC
AGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATTGCTGAAGCTTCAGGAGTTAGA
CCTGGGACCAAAATAATCATCCACCTCAAGTCAGACTGCAAAGATTTCGCCAACGAGTCCCGGG
TGCAAGATGTGGTAACAAAGTACAGTAACTTTGTCAGCTTCCCCCTGTACCTTAACGGAAGGCG
GATTAACACTTTGCAGGCCATCTGGATGATGGACCCAAAGGACATCAGTGAATTTCAGCACGAG
GAATTCTACCGTTACATCGCACAGGCTTACGATAAGCCTCGCTTCATTTTGCACTACAAGACGG
ACGCCCCACTCAATATCCGCAGCATCTTCTATGTGCCAGAGATGAAACCATCCATGTTTGACGT
GAGCAGGGAGCTGGGCTCCAGTGTGGCACTGTATAGCCGCAAGGTGCTCATCCAGACCAAGGCT
ACGGATATCCTGCCCAAGTGGCTGCGCTTCGTTCGAGGTGTGGTGGACAGTGAGGACATCCCCC
TGAACCTCAGCCGAGAGCTCCTGCAGGAGAGCGCCCTCATCCGGAAACTCCGGGACGTTCTACA
ACAGAGATTGATCAAATTCTTCATTGACCAGAGTAAAAAAGATGCTGAAAAATATGCCAAGTTT
TTTGAAGATTATGGCTTGTTCATGAGGGAGGGCATTGTGACCACCGCTGAGCAAGACATCAAGG
AGGATATTGCAAAGCTGCTACGGTATGAGTCCTCAGCCCTGCCTGCTGGGCAGCTGACCAGCTT
ATCAGACTACGCCAGCCGAATGCAGGCTGGCACCCGCAACATCTATTACCTGTGTGCCCCTAAC
CGTCACCTGGCTGAACATTCACCCTATTATGAAGCCATGAAGCAGAAACAGACTGAGGTGCTCT
TCTGCTACGAGCAGTTCGACGAGCTCACTCTGCTGCACCTGCGGGAGTTTGACAAGAAGAAGCT
GATCTCTGTGGAGACGGACATCGTCGTTGATCACTACAAGGAGGAAAAGTTTGAGGACACATCT
CCAGCTGGTGAGCGCCTCTCTGAGAAAGAAACAGAAGAGCTAATGGCATGGATGAGAAATGCAC
TGGGGTCCCGTGTCACCAATGTGAAGGTGACTTTCCGCCTGGACACCCACCCTGCCATGGTGAC
CGTGCTAGAGATGGGGGCTGCTCGACATTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAG
GAGCGTGCTCAGTTGCTACAGCCCACACTGGAGATCAACCCCAGGCACACACTAATAAAGAAAC
TCAACCAGCTGAGGGAGCGTGAGCCGGAGCTAGCCCAGCTGCTAGTGGATCAGATCTATGAGAA
CGCCATGATAGCAGCAGGACTCGTTGATGATCCCCGGGCCATGGTAGGCCGCCTGAATGACCTT
CTGGTCAAGGCCCTGGAGAGACACTGACAGCCAAGAAACTGGATCTAGTGTCAGCCCACATCTT
CTCAGGTGACAGATGGACCTGCCTGGGGAGGAAGGACTTAATACACAGTCAGTACCACTAAAAA
AAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001034090	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83909	(Get FASTA)	NCBI Sequence Viewer
	EDL96307	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008966.4
	ENSRNOP00000091021.1
	ENSRNOP00000093880.1
GenBank Protein	Q5XHZ0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001034090 ⟸ NM_001039001
- Peptide Label:	precursor
- UniProtKB:	Q5XHZ0 (UniProtKB/Swiss-Prot), A6K4T5 (UniProtKB/TrEMBL), A0A8I6AFD9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARELRALLLWGRGLQSALRAPALAGVRRGKPVLHLQKTTVHFRDPTQSLASGISAGQLYSTQA AEDKKEEALHSIISNTEAVQGSVSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEK LRHKRVCEGQVLPEMEIHLQTDAEKGTITIQDTGIGMTKEELVSNLGTIARSGSKAFLEALQHQ AETSSRIIGQFGVGFYSAFMVADKVEVYSRPAAPESPGYQWLSDGSGVFEIAEASGVRPGTKII IHLKSDCKDFANESRVQDVVTKYSNFVSFPLYLNGRRINTLQAIWMMDPKDISEFQHEEFYRYI AQAYDKPRFILHYKTDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPK WLRFVRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGL FMREGIVTTAEQDIKEDIAKLLRYESSALPAGQLTSLSDYASRMQAGTRNIYYLCAPNRHLAEH SPYYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPAGERL SEKETEELMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLL QPTLEINPRHTLIKKLNQLREREPELAQLLVDQIYENAMIAAGLVDDPRAMVGRLNDLLVKALE RH hide sequence

Ensembl Acc Id:

ENSRNOP00000008966 ⟸ ENSRNOT00000008966

Ensembl Acc Id:

ENSRNOP00000093880 ⟸ ENSRNOT00000107479

Ensembl Acc Id:

ENSRNOP00000091021 ⟸ ENSRNOT00000118800

Protein Domains

Histidine kinase/HSP90-like ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XHZ0-F1-model_v2	AlphaFold	Q5XHZ0	1-706	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696980

Promoter ID:

EPDNEW_R7505

Type:

initiation region

Name:

Trap1_1

Description:

TNF receptor-associated protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	11,724,018 - 11,724,078	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359733	AgrOrtholog
BioCyc Gene	G2FUF-26001	BioCyc
Ensembl Genes	ENSRNOG00000005418	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008966.5	UniProtKB/TrEMBL
	ENSRNOT00000107479.1	UniProtKB/TrEMBL
	ENSRNOT00000118800.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.790	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.230.80	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.565.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.11260	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7134204	IMAGE-MGC_LOAD
InterPro	HATPase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HATPase_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HSP90_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hsp90_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hsp90_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:287069	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:95278	IMAGE-MGC_LOAD
NCBI Gene	287069	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11528	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HATPase_c_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HSP90	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Trap1	PhenoGen
PIRSF	Hsp90	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	HEATSHOCK90	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005418	RatGTEx
SMART	HATPase_c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF110942	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54211	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55874	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AFD9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GKV1_RAT	UniProtKB/TrEMBL
	A0A8L2UI37_RAT	UniProtKB/TrEMBL
	A6K4T5	ENTREZGENE, UniProtKB/TrEMBL
	Q5XHZ0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Trap1	TNF receptor-associated protein 1		tumor necrosis factor type 1 receptor associated protein	Name updated	1299863	APPROVED
2005-07-29	Trap1	tumor necrosis factor type 1 receptor associated protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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