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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359733
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trap1
Name: TNF receptor-associated protein 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trap1decreases expressionISOTRAP1 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of TRAP1 proteinPMID:33465424
Trap1multiple interactionsISOTRAP1 (Homo sapiens)6480464CTDOleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]; TRAP1 protein affects the reaction [ochratoxin A results in decreased expression of BCL2 protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of CYCS protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of DDIT3 protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]]PMID:33465424
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