Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Ik (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of IK mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Ik (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IK mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ik (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of IK mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of IK mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of IK mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | IK (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of IK mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Ik (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of IK mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Ik (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of IK promoter | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Ik (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of IK mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IK mRNA | CTD | PMID:36041667 | aristolochic acid A | multiple interactions | EXP | | 6480464 | [aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of IK mRNA | CTD | PMID:23912714 | Aroclor 1254 | decreases expression | ISO | Ik (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of IK mRNA | CTD | PMID:23650126 | arsenous acid | increases expression | ISO | IK (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of IK mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | ISO | Ik (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of IK mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | ISO | IK (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of IK mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IK mRNA | CTD | PMID:36041667 | bisphenol A | decreases expression | ISO | Ik (Mus musculus) | 6480464 | bisphenol A results in decreased expression of IK mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of IK mRNA | CTD | PMID:34947998 | bisphenol A | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IK mRNA | CTD | PMID:36041667 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of IK protein | CTD | PMID:28903499 | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of IK mRNA | CTD | PMID:24136188 | carbamazepine | affects expression | ISO | IK (Homo sapiens) | 6480464 | Carbamazepine affects the expression of IK mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Ik (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of IK mRNA | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to IK gene] | CTD | PMID:28238834 | chrysene | increases expression | ISO | Ik (Mus musculus) | 6480464 | chrysene results in increased expression of IK mRNA | CTD | PMID:26377693 | dexamethasone | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | IK (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of IK mRNA | CTD | PMID:20458559 | diethylstilbestrol | decreases expression | ISO | IK (Homo sapiens) | 6480464 | Diethylstilbestrol results in decreased expression of IK mRNA | CTD | PMID:36621641 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of IK mRNA | CTD | PMID:25152437 | doxorubicin | increases expression | ISO | IK (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of IK mRNA | CTD | PMID:29803840 | elemental selenium | increases expression | ISO | IK (Homo sapiens) | 6480464 | Selenium results in increased expression of IK mRNA | CTD | PMID:19244175 | enzyme inhibitor | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IK protein | CTD | PMID:23301498 | ethanol | affects splicing | ISO | Ik (Mus musculus) | 6480464 | Ethanol affects the splicing of IK mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of IK mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of IK mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Ik (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IK mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | IK (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of IK protein | CTD | PMID:37730182 | hydrogen peroxide | affects expression | ISO | IK (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of IK mRNA | CTD | PMID:20044591 | indometacin | multiple interactions | ISO | IK (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | IK (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of IK protein | CTD | PMID:32959892 | methyl methanesulfonate | increases expression | ISO | IK (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of IK mRNA | CTD | PMID:23649840 | paracetamol | increases expression | ISO | IK (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of IK mRNA | CTD | PMID:26690555 | pentachlorophenol | increases expression | ISO | Ik (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of IK mRNA | CTD | PMID:23892564 | poly(propylene imine) macromolecule | decreases expression | ISO | IK (Homo sapiens) | 6480464 | poly(propyleneimine) analog results in decreased expression of IK mRNA | CTD | PMID:16308212 | resveratrol | decreases expression | ISO | Ik (Mus musculus) | 6480464 | resveratrol results in decreased expression of IK protein | CTD | PMID:25505154 | selenium atom | increases expression | ISO | IK (Homo sapiens) | 6480464 | Selenium results in increased expression of IK mRNA | CTD | PMID:19244175 | sunitinib | decreases expression | ISO | IK (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of IK mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | Ik (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of IK mRNA | CTD | PMID:31919559 | tungsten | decreases expression | ISO | Ik (Mus musculus) | 6480464 | Tungsten results in decreased expression of IK mRNA | CTD | PMID:30912803 | uranium atom | affects expression | ISO | IK (Homo sapiens) | 6480464 | Uranium affects the expression of IK mRNA | CTD | PMID:15672453 | urethane | increases expression | ISO | IK (Homo sapiens) | 6480464 | Urethane results in increased expression of IK mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | Ik (Mus musculus) | 6480464 | Valproic Acid affects the expression of IK mRNA | CTD | PMID:17292431 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of IK mRNA | CTD | PMID:23034163 | vitamin E | increases expression | ISO | IK (Homo sapiens) | 6480464 | Vitamin E results in increased expression of IK mRNA | CTD | PMID:19244175 | |