Pus1 (pseudouridine synthase 1) - Rat Genome Database

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Gene: Pus1 (pseudouridine synthase 1) Rattus norvegicus
Analyze
Symbol: Pus1
Name: pseudouridine synthase 1
RGD ID: 1311871
Description: Predicted to enable several functions, including RNA binding activity; nuclear receptor coactivator activity; and tRNA pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304567; MGC112655; pseudouridylate synthase 1; pseudouridylate synthase 1 homolog; tRNA pseudouridine synthase 1; tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,539,659 - 51,548,975 (+)NCBIGRCr8
mRatBN7.21245,880,364 - 45,889,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,880,440 - 45,889,196 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,055,896 - 47,064,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,661,351 - 47,670,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,721,879 - 46,730,643 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,936,721 - 51,945,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,675,092 - 53,684,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,024,978 - 46,033,733 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,889,104 - 45,897,858 (+)NCBI
Celera1247,439,849 - 47,448,604 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10094309   PMID:11027153   PMID:11085940   PMID:12477932   PMID:15327771   PMID:15489334   PMID:15772074   PMID:22102571   PMID:22658674   PMID:22681889   PMID:23707380   PMID:24722331  


Genomics

Comparative Map Data
Pus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,539,659 - 51,548,975 (+)NCBIGRCr8
mRatBN7.21245,880,364 - 45,889,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,880,440 - 45,889,196 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,055,896 - 47,064,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,661,351 - 47,670,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,721,879 - 46,730,643 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,936,721 - 51,945,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,675,092 - 53,684,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,024,978 - 46,033,733 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,889,104 - 45,897,858 (+)NCBI
Celera1247,439,849 - 47,448,604 (+)NCBICelera
Cytogenetic Map12q16NCBI
PUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,929,276 - 131,945,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,929,200 - 131,945,896 (+)EnsemblGRCh38hg38GRCh38
GRCh3712132,413,821 - 132,430,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,979,742 - 130,994,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412131,080,271 - 131,094,632NCBI
Celera12132,032,281 - 132,046,846 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,299,517 - 129,314,189 (+)NCBIHuRef
CHM1_112132,234,704 - 132,249,366 (+)NCBICHM1_1
T2T-CHM13v2.012131,977,320 - 131,993,946 (+)NCBIT2T-CHM13v2.0
Pus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,921,533 - 110,928,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,921,533 - 110,928,525 (-)EnsemblGRCm39 Ensembl
GRCm385110,773,667 - 110,780,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,773,667 - 110,780,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv375111,202,686 - 111,209,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365111,013,969 - 111,020,917 (-)NCBIMGSCv36mm8
Celera5107,905,692 - 107,912,636 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.7NCBI
Pus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482748,394 - 756,747 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482749,265 - 756,964 (-)NCBIChiLan1.0ChiLan1.0
PUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210140,020,955 - 140,036,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112140,017,411 - 140,032,719 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,583,040 - 129,598,328 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112134,011,927 - 134,027,160 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12134,011,932 - 134,027,160 (+)Ensemblpanpan1.1panPan2
PUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126955,413 - 965,561 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26955,462 - 966,155 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26999,050 - 1,009,405 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,017,083 - 1,027,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,017,131 - 1,027,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126954,195 - 964,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,050,823 - 1,061,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026973,978 - 984,323 (-)NCBIUU_Cfam_GSD_1.0
Pus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,521,435 - 122,532,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,192,651 - 2,199,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,192,583 - 2,199,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,400,584 - 23,418,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11423,400,575 - 23,418,470 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,852,142 - 24,870,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,307,955 - 127,327,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,308,053 - 127,328,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037117,632,671 - 117,650,593 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,698,816 - 27,709,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,699,397 - 27,707,592 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pus1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:54
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000056780
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000056780   ⟹   ENSRNOP00000053623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,880,440 - 45,889,194 (+)Ensembl
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102180   ⟹   ENSRNOP00000090656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,880,877 - 45,889,196 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106367   ⟹   ENSRNOP00000087894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,880,572 - 45,889,196 (+)Ensembl
RefSeq Acc Id: NM_001025563   ⟹   NP_001020734
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,540,219 - 51,548,975 (+)NCBI
mRatBN7.21245,880,440 - 45,889,196 (+)NCBI
Rnor_6.01251,937,175 - 51,945,930 (+)NCBI
Rnor_5.01253,675,092 - 53,684,281 (+)NCBI
RGSC_v3.41246,024,978 - 46,033,733 (+)RGD
Celera1247,439,849 - 47,448,604 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249547   ⟹   XP_006249609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,539,659 - 51,548,975 (+)NCBI
mRatBN7.21245,880,364 - 45,889,196 (+)NCBI
Rnor_6.01251,936,725 - 51,945,930 (+)NCBI
Rnor_5.01253,675,092 - 53,684,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598352   ⟹   XP_017453841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,540,216 - 51,548,975 (+)NCBI
mRatBN7.21245,880,633 - 45,889,196 (+)NCBI
Rnor_6.01251,936,721 - 51,945,930 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271365   ⟹   XP_063127435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,539,659 - 51,548,975 (+)NCBI
RefSeq Acc Id: NP_001020734   ⟸   NM_001025563
- UniProtKB: Q4KM92 (UniProtKB/Swiss-Prot),   B1WBN5 (UniProtKB/TrEMBL),   A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249609   ⟸   XM_006249547
- Peptide Label: isoform X1
- UniProtKB: A6J293 (UniProtKB/TrEMBL),   A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453841   ⟸   XM_017598352
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053623   ⟸   ENSRNOT00000056780
Ensembl Acc Id: ENSRNOP00000087894   ⟸   ENSRNOT00000106367
Ensembl Acc Id: ENSRNOP00000090656   ⟸   ENSRNOT00000102180
RefSeq Acc Id: XP_063127435   ⟸   XM_063271365
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANT6 (UniProtKB/TrEMBL)
Protein Domains
Pseudouridine synthase I TruA alpha/beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KM92-F1-model_v2 AlphaFold Q4KM92 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698734
Promoter ID:EPDNEW_R9258
Type:initiation region
Name:Pus1_1
Description:pseudouridylate synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01251,937,167 - 51,937,227EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311871 AgrOrtholog
BioCyc Gene G2FUF-18818 BioCyc
Ensembl Genes ENSRNOG00000037500 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055001822 UniProtKB/Swiss-Prot
  ENSRNOG00060004370 UniProtKB/Swiss-Prot
  ENSRNOG00065006419 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056780.2 UniProtKB/Swiss-Prot
  ENSRNOT00000102180.1 UniProtKB/TrEMBL
  ENSRNOT00000106367.1 UniProtKB/TrEMBL
  ENSRNOT00055002963 UniProtKB/Swiss-Prot
  ENSRNOT00060007352 UniProtKB/Swiss-Prot
  ENSRNOT00065009886 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.580 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9027947 IMAGE-MGC_LOAD
InterPro PsdUridine_synth_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PsdUridine_synth_TruA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PsdUridine_synth_TruA_a/b_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PsdUridine_synth_TruA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PUS1/PUS2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TruA/RsuA/RluB/E/F_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304567 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187275 IMAGE-MGC_LOAD
NCBI Gene 304567 ENTREZGENE
PANTHER PTHR11142 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRNA PSEUDOURIDINE SYNTHASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PseudoU_synth_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pus1 PhenoGen
RatGTEx ENSRNOG00000037500 RatGTEx
  ENSRNOG00055001822 RatGTEx
  ENSRNOG00060004370 RatGTEx
  ENSRNOG00065006419 RatGTEx
Superfamily-SCOP SSF55120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A863 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANT6 ENTREZGENE, UniProtKB/TrEMBL
  A6J292 ENTREZGENE, UniProtKB/TrEMBL
  A6J293 ENTREZGENE, UniProtKB/TrEMBL
  B1WBN5 ENTREZGENE, UniProtKB/TrEMBL
  Q4KM92 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-21 Pus1  pseudouridine synthase 1  Pus1  pseudouridylate synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Pus1  pseudouridylate synthase 1  Pus1  pseudouridine synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Pus1  pseudouridine synthase 1  Pus1_predicted  pseudouridine synthase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pus1_predicted  pseudouridine synthase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED