Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tmem176a | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TMEM176A mRNA] | CTD | PMID:31150632 | Tmem176a | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TMEM176A mRNA | CTD | PMID:36331819 | Tmem176a | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of TMEM176A mRNA | CTD | PMID:22206623 | Tmem176a | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of TMEM176A mRNA] | CTD | PMID:22206623 | Tmem176a | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of TMEM176A mRNA | CTD | PMID:17108234 | Tmem176a | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TMEM176A mRNA | CTD | PMID:32741896 | Tmem176a | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of TMEM176A mRNA | CTD | PMID:32145629 | Tmem176a | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TMEM176A mRNA | CTD | PMID:32741896 | Tmem176a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TMEM176A mRNA | CTD | PMID:15328365 | Tmem176a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TMEM176A mRNA | CTD | PMID:34747641 | Tmem176a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tmem176a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TMEM176A mRNA | CTD | PMID:21570461 | Tmem176a | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Tmem176a (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Tmem176a | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Fenretinide results in increased expression of TMEM176A mRNA | CTD | PMID:28973697 | Tmem176a | Rat | aflatoxin B1 | affects expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of TMEM176A protein | CTD | PMID:20106945 | Tmem176a | Rat | aflatoxin B1 | decreases methylation | ISO | TMEM176A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of TMEM176A gene | CTD | PMID:27153756 | Tmem176a | Rat | aflatoxin B1 | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of TMEM176A mRNA | CTD | PMID:22100608 | Tmem176a | Rat | all-trans-retinoic acid | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of TMEM176A mRNA | CTD | PMID:30951980 | Tmem176a | Rat | antirheumatic drug | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of TMEM176A mRNA | CTD | PMID:24449571 | Tmem176a | Rat | atrazine | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Atrazine results in increased expression of TMEM176A mRNA | CTD | PMID:22378314 | Tmem176a | Rat | benzo[a]pyrene | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TMEM176A mRNA | CTD | PMID:20106945 and PMID:32234424 | Tmem176a | Rat | beta-lapachone | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of TMEM176A mRNA | CTD | PMID:38218311 | Tmem176a | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TMEM176A mRNA | CTD | PMID:25181051 | Tmem176a | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TMEM176A mRNA | CTD | PMID:30903817 | Tmem176a | Rat | bisphenol A | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of TMEM176A mRNA | CTD | PMID:30951980 | Tmem176a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TMEM176A mRNA | CTD | PMID:30816183 more ... | Tmem176a | Rat | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of TMEM176A gene | CTD | PMID:28505145 | Tmem176a | Rat | bisphenol F | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | bisphenol F results in decreased expression of TMEM176A mRNA | CTD | PMID:38685157 | Tmem176a | Rat | calcitriol | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of TMEM176A mRNA | CTD | PMID:26485663 | Tmem176a | Rat | carbon nanotube | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Tmem176a | Rat | clofibrate | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Clofibrate results in decreased expression of TMEM176A mRNA | CTD | PMID:17585979 | Tmem176a | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of TMEM176A mRNA | CTD | PMID:24386269 | Tmem176a | Rat | crocidolite asbestos | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of TMEM176A mRNA | CTD | PMID:23917077 | Tmem176a | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of TMEM176A mRNA | CTD | PMID:27523638 | Tmem176a | Rat | cyclosporin A | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TMEM176A mRNA | CTD | PMID:20106945 and PMID:27989131 | Tmem176a | Rat | cyproconazole | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | cyproconazole results in increased expression of TMEM176A mRNA | CTD | PMID:22334560 | Tmem176a | Rat | dibutyl phthalate | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of TMEM176A mRNA | CTD | PMID:21266533 | Tmem176a | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TMEM176A mRNA | CTD | PMID:21266533 | Tmem176a | Rat | diclofenac | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Diclofenac results in increased expression of TMEM176A mRNA | CTD | PMID:26934552 | Tmem176a | Rat | diclofenac | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Diclofenac results in decreased expression of TMEM176A mRNA | CTD | PMID:26934552 | Tmem176a | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of TMEM176A mRNA | CTD | PMID:25152437 | Tmem176a | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of TMEM176A mRNA | CTD | PMID:29391264 | Tmem176a | Rat | epoxiconazole | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | epoxiconazole results in increased expression of TMEM176A mRNA | CTD | PMID:22334560 | Tmem176a | Rat | ethanol | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Ethanol results in increased expression of TMEM176A mRNA | CTD | PMID:30319688 | Tmem176a | Rat | ferric oxide | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | ferric oxide analog results in decreased expression of TMEM176A mRNA | CTD | PMID:25086211 | Tmem176a | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of TMEM176A mRNA | CTD | PMID:24136188 | Tmem176a | Rat | folic acid | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TMEM176A mRNA | CTD | PMID:25629700 | Tmem176a | Rat | folic acid | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of TMEM176A mRNA] | CTD | PMID:22206623 | Tmem176a | Rat | fonofos | increases methylation | ISO | TMEM176A (Homo sapiens) | 6480464 | Fonofos results in increased methylation of TMEM176A promoter | CTD | PMID:22847954 | Tmem176a | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of TMEM176A mRNA | CTD | PMID:25539665 and PMID:26194646 | Tmem176a | Rat | genistein | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Genistein results in decreased expression of TMEM176A mRNA | CTD | PMID:32186404 | Tmem176a | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TMEM176A mRNA | CTD | PMID:33387578 | Tmem176a | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of TMEM176A mRNA | CTD | PMID:24136188 | Tmem176a | Rat | inulin | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of TMEM176A mRNA | CTD | PMID:36331819 | Tmem176a | Rat | isoprenaline | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Isoproterenol results in increased expression of TMEM176A mRNA | CTD | PMID:20003209 | Tmem176a | Rat | lead diacetate | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | lead acetate results in increased expression of TMEM176A mRNA | CTD | PMID:21829687 | Tmem176a | Rat | lipopolysaccharide | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of TMEM176A mRNA | CTD | PMID:27339419 | Tmem176a | Rat | lipopolysaccharide | multiple interactions | ISO | TMEM176A (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of TMEM176A mRNA | CTD | PMID:35811015 | Tmem176a | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of TMEM176A mRNA | CTD | PMID:22484513 | Tmem176a | Rat | methidathion | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | methidathion results in increased expression of TMEM176A mRNA | CTD | PMID:34813904 | Tmem176a | Rat | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TMEM176A mRNA | CTD | PMID:25566086 | Tmem176a | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of TMEM176A mRNA | CTD | PMID:24810058 | Tmem176a | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of TMEM176A mRNA | CTD | PMID:24136188 | Tmem176a | Rat | nickel atom | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Nickel results in increased expression of TMEM176A mRNA | CTD | PMID:25583101 | Tmem176a | Rat | O-methyleugenol | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of TMEM176A mRNA | CTD | PMID:32234424 | Tmem176a | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TMEM176A mRNA | CTD | PMID:25729387 | Tmem176a | Rat | ozone | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TMEM176A mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of TMEM176A mRNA | CTD | PMID:34911549 | Tmem176a | Rat | paclitaxel | decreases expression | EXP | | 6480464 | Paclitaxel analog results in decreased expression of TMEM176A mRNA and Paclitaxel results in decreased expression of TMEM176A mRNA | CTD | PMID:15585946 | Tmem176a | Rat | paracetamol | affects expression | ISO | Tmem176a (Mus musculus) | 6480464 | Acetaminophen affects the expression of TMEM176A mRNA | CTD | PMID:17562736 | Tmem176a | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of TMEM176A mRNA | CTD | PMID:33387578 | Tmem176a | Rat | paracetamol | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TMEM176A mRNA | CTD | PMID:29067470 | Tmem176a | Rat | paracetamol | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of TMEM176A mRNA] | CTD | PMID:29246445 | Tmem176a | Rat | paracetamol | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Acetaminophen results in increased expression of TMEM176A mRNA | CTD | PMID:29246445 | Tmem176a | Rat | parathion | increases methylation | ISO | TMEM176A (Homo sapiens) | 6480464 | Parathion results in increased methylation of TMEM176A promoter | CTD | PMID:22847954 | Tmem176a | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of TMEM176A mRNA | CTD | PMID:37995155 | Tmem176a | Rat | perfluorononanoic acid | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of TMEM176A mRNA | CTD | PMID:32588087 | Tmem176a | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Tmem176a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TMEM176A mRNA more ... | CTD | PMID:36331819 | Tmem176a | Rat | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of TMEM176A mRNA | CTD | PMID:22484513 | Tmem176a | Rat | propiconazole | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | propiconazole results in increased expression of TMEM176A mRNA | CTD | PMID:22334560 | Tmem176a | Rat | pyrazinecarboxamide | increases expression | EXP | | 6480464 | Pyrazinamide results in increased expression of TMEM176A mRNA | CTD | PMID:22431067 | Tmem176a | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of TMEM176A mRNA | CTD | PMID:28374803 | Tmem176a | Rat | rotenone | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Rotenone results in increased expression of TMEM176A mRNA | CTD | PMID:29955902 | Tmem176a | Rat | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of TMEM176A mRNA | CTD | PMID:35811015 | Tmem176a | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | TMEM176A (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of TMEM176A mRNA | CTD | PMID:35811015 | Tmem176a | Rat | senecionine | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | senecionine results in decreased expression of TMEM176A protein | CTD | PMID:35357534 | Tmem176a | Rat | sodium arsenite | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of TMEM176A mRNA | CTD | PMID:37682722 | Tmem176a | Rat | terbufos | increases methylation | ISO | TMEM176A (Homo sapiens) | 6480464 | terbufos results in increased methylation of TMEM176A promoter | CTD | PMID:22847954 | Tmem176a | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TMEM176A mRNA | CTD | PMID:32741896 | Tmem176a | Rat | tetrachloromethane | affects expression | ISO | Tmem176a (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of TMEM176A mRNA | CTD | PMID:17484886 and PMID:31919559 | Tmem176a | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TMEM176A mRNA | CTD | PMID:31150632 | Tmem176a | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TMEM176A mRNA] | CTD | PMID:31150632 | Tmem176a | Rat | tetrachloromethane | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of TMEM176A mRNA | CTD | PMID:27339419 | Tmem176a | Rat | thalidomide | decreases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Thalidomide results in decreased expression of TMEM176A mRNA | CTD | PMID:26217789 | Tmem176a | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TMEM176A mRNA | CTD | PMID:34492290 | Tmem176a | Rat | titanium dioxide | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | titanium dioxide results in increased expression of TMEM176A mRNA | CTD | PMID:23557971 and PMID:27760801 | Tmem176a | Rat | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of TMEM176A mRNA | CTD | PMID:25729387 | Tmem176a | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TMEM176A mRNA | CTD | PMID:25729387 | Tmem176a | Rat | trichloroethene | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of TMEM176A mRNA | CTD | PMID:19254012 | Tmem176a | Rat | triclosan | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Triclosan results in increased expression of TMEM176A mRNA | CTD | PMID:30510588 | Tmem176a | Rat | triphenyl phosphate | affects expression | ISO | TMEM176A (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of TMEM176A mRNA | CTD | PMID:37042841 | Tmem176a | Rat | troglitazone | increases expression | ISO | Tmem176a (Mus musculus) | 6480464 | troglitazone results in increased expression of TMEM176A mRNA | CTD | PMID:28973697 | Tmem176a | Rat | valproic acid | decreases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TMEM176A mRNA | CTD | PMID:29154799 | Tmem176a | Rat | valproic acid | decreases methylation | ISO | TMEM176A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of TMEM176A gene | CTD | PMID:29154799 | Tmem176a | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of TMEM176A mRNA | CTD | PMID:23034163 | Tmem176a | Rat | vitamin E | increases expression | ISO | TMEM176A (Homo sapiens) | 6480464 | Vitamin E results in increased expression of TMEM176A mRNA | CTD | PMID:19244175 | |