TMEM176A (transmembrane protein 176A) - Rat Genome Database

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Gene: TMEM176A (transmembrane protein 176A) Canis lupus familiaris
Analyze
Symbol: TMEM176A
Name: transmembrane protein 176A
RGD ID: 12399621
Description: INVOLVED IN negative regulation of dendritic cell differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); long QT syndrome (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,927,031 - 14,931,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,926,805 - 14,931,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,535,289 - 15,539,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,642,520 - 16,646,838 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11615,021,512 - 15,025,830 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,603,025 - 15,607,343 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,653,561 - 15,657,879 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TMEM176A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,927,031 - 14,931,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,926,805 - 14,931,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,535,289 - 15,539,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,642,520 - 16,646,838 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11615,021,512 - 15,025,830 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,603,025 - 15,607,343 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,653,561 - 15,657,879 (+)NCBIUU_Cfam_GSD_1.0
TMEM176A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,800,769 - 150,805,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,800,403 - 150,805,118 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,497,857 - 150,502,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,128,787 - 150,133,141 (+)NCBINCBI36Build 36hg18NCBI36
Celera7145,054,882 - 145,059,236 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,309,934 - 144,314,288 (+)NCBIHuRef
CHM1_17150,506,066 - 150,510,420 (+)NCBICHM1_1
T2T-CHM13v2.07151,973,144 - 151,977,889 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,827,144 - 149,831,498 (+)NCBI
Tmem176a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,818,417 - 48,822,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,817,853 - 48,824,005 (+)EnsemblGRCm39 Ensembl
GRCm38648,841,483 - 48,845,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,840,919 - 48,847,071 (+)EnsemblGRCm38mm10GRCm38
MGSCv37648,791,482 - 48,795,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,771,108 - 48,776,634 (+)NCBIMGSCv36mm8
Celera649,351,236 - 49,355,117 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.75NCBI
Tmem176a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,101,946 - 79,109,499 (+)NCBIGRCr8
mRatBN7.2477,774,940 - 77,778,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,774,843 - 77,778,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,982,347 - 82,986,027 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,757,819 - 78,761,499 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,198,109 - 77,201,789 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,458,735 - 78,462,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,458,625 - 78,462,423 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,146,378 - 143,150,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,919,918 - 76,923,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,195,665 - 77,200,002 (+)NCBI
Celera472,712,007 - 72,715,688 (+)NCBICelera
Cytogenetic Map4q24NCBI
Tmem176a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,209,923 - 5,213,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,209,426 - 5,213,194 (+)NCBIChiLan1.0ChiLan1.0
TMEM176A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,216,094 - 187,220,502 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,226,358 - 39,230,767 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,383,001 - 142,387,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,535,019 - 154,539,613 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,535,019 - 154,539,613 (+)Ensemblpanpan1.1panPan2
Tmem176a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,632,165 - 6,636,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,267,877 - 6,271,290 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,267,135 - 6,271,275 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM176A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,337,837 - 6,342,555 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,337,835 - 6,342,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,647,757 - 6,650,861 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM176A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121118,992,217 - 118,996,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21118,991,363 - 118,996,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607214,964,082 - 14,968,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem176a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,821,826 - 5,833,217 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,822,702 - 5,833,752 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM176A
39 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 17 6 6 6 6 5 5
Low 3 5 6 2 6 8 5 1
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038452636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038452637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038452638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000045768   ⟹   ENSCAFP00000041127
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1614,926,805 - 14,931,238 (+)Ensembl
RefSeq Acc Id: XM_038452636   ⟹   XP_038308564
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1615,535,472 - 15,539,607 (+)NCBI
RefSeq Acc Id: XM_038452637   ⟹   XP_038308565
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1615,535,289 - 15,539,607 (+)NCBI
RefSeq Acc Id: XM_038452638   ⟹   XP_038308566
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1615,535,614 - 15,539,607 (+)NCBI
RefSeq Acc Id: XM_038497283   ⟹   XP_038353211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11615,021,695 - 15,025,830 (+)NCBI
RefSeq Acc Id: XM_038497284   ⟹   XP_038353212
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11615,022,395 - 15,025,830 (+)NCBI
RefSeq Acc Id: XM_038497285   ⟹   XP_038353213
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11615,021,512 - 15,025,830 (+)NCBI
RefSeq Acc Id: XM_038497286   ⟹   XP_038353214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11615,021,837 - 15,025,830 (+)NCBI
RefSeq Acc Id: XM_038559708   ⟹   XP_038415636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01615,653,744 - 15,657,879 (+)NCBI
RefSeq Acc Id: XM_038559709   ⟹   XP_038415637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01615,654,444 - 15,657,879 (+)NCBI
RefSeq Acc Id: XM_038559710   ⟹   XP_038415638
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01615,653,561 - 15,657,879 (+)NCBI
RefSeq Acc Id: XM_038559711   ⟹   XP_038415639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01615,653,886 - 15,657,879 (+)NCBI
RefSeq Acc Id: XM_038623705   ⟹   XP_038479633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01615,603,208 - 15,607,343 (+)NCBI
RefSeq Acc Id: XM_038623706   ⟹   XP_038479634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01615,603,908 - 15,607,343 (+)NCBI
RefSeq Acc Id: XM_038623707   ⟹   XP_038479635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01615,603,025 - 15,607,343 (+)NCBI
RefSeq Acc Id: XM_038623709   ⟹   XP_038479637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01615,603,350 - 15,607,343 (+)NCBI
RefSeq Acc Id: XM_038689469   ⟹   XP_038545397
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01616,642,703 - 16,646,838 (+)NCBI
RefSeq Acc Id: XM_038689470   ⟹   XP_038545398
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01616,643,403 - 16,646,838 (+)NCBI
RefSeq Acc Id: XM_038689471   ⟹   XP_038545399
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01616,642,520 - 16,646,838 (+)NCBI
RefSeq Acc Id: XM_038689473   ⟹   XP_038545401
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01616,642,845 - 16,646,838 (+)NCBI
RefSeq Acc Id: XM_532758   ⟹   XP_532758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11614,927,031 - 14,931,350 (+)NCBI
Dog10K_Boxer_Tasha1615,536,172 - 15,539,607 (+)NCBI
Sequence:
RefSeq Acc Id: XP_532758   ⟸   XM_532758
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM27 (UniProtKB/TrEMBL),   A0A8P0NS61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041127   ⟸   ENSCAFT00000045768
RefSeq Acc Id: XP_038353213   ⟸   XM_038497285
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038353211   ⟸   XM_038497283
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038353214   ⟸   XM_038497286
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038353212   ⟸   XM_038497284
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038479635   ⟸   XM_038623707
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038479633   ⟸   XM_038623705
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479637   ⟸   XM_038623709
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038479634   ⟸   XM_038623706
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038545399   ⟸   XM_038689471
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038545397   ⟸   XM_038689469
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038545401   ⟸   XM_038689473
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038545398   ⟸   XM_038689470
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM27 (UniProtKB/TrEMBL),   A0A8P0NS61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308565   ⟸   XM_038452637
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038308564   ⟸   XM_038452636
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038308566   ⟸   XM_038452638
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038415638   ⟸   XM_038559710
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038415636   ⟸   XM_038559708
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038415639   ⟸   XM_038559711
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038415637   ⟸   XM_038559709
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM27 (UniProtKB/TrEMBL),   A0A8P0NS61 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031409 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024963 UniProtKB/TrEMBL
  ENSCAFG00040020150 UniProtKB/TrEMBL
  ENSCAFG00845009739 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045768.3 UniProtKB/TrEMBL
  ENSCAFT00030046018.1 UniProtKB/TrEMBL
  ENSCAFT00040037236.1 UniProtKB/TrEMBL
  ENSCAFT00845017159.1 UniProtKB/TrEMBL
InterPro CD20-like UniProtKB/TrEMBL
  TMEM176A/TMEM176B UniProtKB/TrEMBL
NCBI Gene TMEM176A ENTREZGENE
PANTHER PTHR15756 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 176A UniProtKB/TrEMBL
Pfam CD20 UniProtKB/TrEMBL
UniProt A0A8C0PM27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N3C7_CANLF UniProtKB/TrEMBL
  A0A8P0NS61 ENTREZGENE
UniProt Secondary A0A8P0NS61 UniProtKB/TrEMBL
VGNC ID VGNC:47501 ENTREZGENE