Sox4 (SRY-box transcription factor 4) - Rat Genome Database

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Gene: Sox4 (SRY-box transcription factor 4) Rattus norvegicus
Analyze
Symbol: Sox4
Name: SRY-box transcription factor 4
RGD ID: 1309488
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and miRNA binding activity. Involved in response to hypoxia. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 10 and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC364712; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box containing gene 4; transcription factor SOX-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81735,876,298 - 35,881,004 (+)NCBIGRCr8
mRatBN7.21735,667,809 - 35,672,515 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1735,667,537 - 35,673,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1735,492,341 - 35,497,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01737,096,302 - 37,100,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01735,490,340 - 35,495,039 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01737,615,022 - 37,619,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01739,476,956 - 39,481,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41742,172,863 - 42,177,590 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11742,175,727 - 42,178,618 (+)NCBI
Celera1735,186,015 - 35,190,495 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
anthracen-2-amine  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ascending aorta morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
brain development  (IBA)
camera-type eye morphogenesis  (IBA)
cardiac right ventricle morphogenesis  (ISO)
cellular response to glucose stimulus  (ISO)
endocrine pancreas development  (ISO)
gene expression  (ISO)
glial cell development  (ISO)
glial cell proliferation  (ISO)
glucose homeostasis  (ISO)
heart development  (ISO)
hematopoietic stem cell homeostasis  (ISO)
kidney morphogenesis  (ISO)
mesenchyme development  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
nervous system development  (ISO)
neuroepithelial cell differentiation  (ISO)
neuron differentiation  (IBA)
noradrenergic neuron differentiation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
pro-B cell differentiation  (ISO)
protein stabilization  (ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of DNA-templated transcription  (ISO)
response to hypoxia  (IDA)
somatic stem cell population maintenance  (ISO)
spinal cord development  (ISO)
sympathetic nervous system development  (ISO)
T cell differentiation  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Aaboe M, etal., Cancer Res. 2006 Apr 1;66(7):3434-42.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of transcription factors in the brain of rats with perinatal asphyxia. Lubec B, etal., Biol Neonate. 2002;81(4):266-78.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. Ohtsuka T, etal., Int J Cancer. 2006 Jan 15;118(2):263-73. doi: 10.1002/ijc.21324.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas. Sasaki A, etal., Pathol Int. 2018 Jun 7. doi: 10.1111/pin.12685.
8. High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Shin MS, etal., Cancer Res. 2004 Jul 1;64(13):4419-27.
9. Sox4-deficiency syndrome in mice is an animal model for common trunk. Ya J, etal., Circ Res. 1998 Nov 16;83(10):986-94.
Additional References at PubMed
PMID:7706298   PMID:8614465   PMID:9174623   PMID:15522200   PMID:15645444   PMID:16109771   PMID:16306355   PMID:16631117   PMID:17875931   PMID:18403418   PMID:18477811   PMID:18505825  
PMID:19147588   PMID:19234109   PMID:19379700   PMID:20049565   PMID:20147379   PMID:20596238   PMID:20646169   PMID:21527504   PMID:22344693   PMID:23562159   PMID:26802803   PMID:29039454  
PMID:30661772   PMID:37741429  


Genomics

Comparative Map Data
Sox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81735,876,298 - 35,881,004 (+)NCBIGRCr8
mRatBN7.21735,667,809 - 35,672,515 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1735,667,537 - 35,673,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1735,492,341 - 35,497,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01737,096,302 - 37,100,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01735,490,340 - 35,495,039 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01737,615,022 - 37,619,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01739,476,956 - 39,481,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41742,172,863 - 42,177,590 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11742,175,727 - 42,178,618 (+)NCBI
Celera1735,186,015 - 35,190,495 (+)NCBICelera
Cytogenetic Map17p12NCBI
SOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38621,593,751 - 21,598,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl621,593,751 - 21,598,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37621,593,982 - 21,598,850 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36621,701,951 - 21,706,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 34621,701,950 - 21,706,826NCBI
Celera622,827,304 - 22,832,182 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef621,537,779 - 21,542,257 (+)NCBIHuRef
CHM1_1621,596,072 - 21,600,948 (+)NCBICHM1_1
T2T-CHM13v2.0621,466,412 - 21,471,279 (+)NCBIT2T-CHM13v2.0
Sox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391329,132,902 - 29,137,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1329,132,902 - 29,137,696 (-)EnsemblGRCm39 Ensembl
GRCm381328,948,919 - 28,953,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1328,948,919 - 28,953,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv371329,042,585 - 29,045,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361328,958,181 - 28,961,147 (-)NCBIMGSCv36mm8
Celera1329,175,127 - 29,178,093 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.87NCBI
Sox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554835,076,664 - 5,077,059 (-)NCBIChiLan1.0ChiLan1.0
SOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,226,734 - 36,239,186 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,233,423 - 32,238,717 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0621,422,846 - 21,427,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1621,765,921 - 21,771,728 (+)NCBIpanpan1.1PanPan1.1panPan2
SOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,098,783 - 20,101,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3520,099,773 - 20,101,154 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,057,136 - 20,059,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03520,209,623 - 20,212,209 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3520,210,531 - 20,211,991 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13520,010,721 - 20,014,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03520,075,381 - 20,077,956 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03521,494,787 - 21,497,360 (+)NCBIUU_Cfam_GSD_1.0
SOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl716,891,319 - 16,892,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1716,886,834 - 16,895,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2717,852,748 - 17,857,158 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247565,128,848 - 5,156,174 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sox4
16 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
RH134585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,670,561 - 35,670,749 (+)MAPPERmRatBN7.2
Rnor_6.01737,617,775 - 37,617,962NCBIRnor6.0
Rnor_5.01739,479,709 - 39,479,896UniSTSRnor5.0
RGSC_v3.41742,175,637 - 42,175,824UniSTSRGSC3.4
Celera1735,188,541 - 35,188,728UniSTS
RH 3.4 Map17406.6UniSTS
Cytogenetic Map17p12UniSTS
Sox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,669,624 - 35,669,834 (+)MAPPERmRatBN7.2
Rnor_6.01737,616,838 - 37,617,047NCBIRnor6.0
Rnor_5.01739,478,772 - 39,478,981UniSTSRnor5.0
RGSC_v3.41742,174,700 - 42,174,909UniSTSRGSC3.4
Cytogenetic Map17p12UniSTS
RH79983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,671,384 - 35,671,586 (+)MAPPERmRatBN7.2
Rnor_6.01737,618,598 - 37,618,799NCBIRnor6.0
Rnor_5.01739,480,532 - 39,480,733UniSTSRnor5.0
RGSC_v3.41742,176,460 - 42,176,661UniSTSRGSC3.4
Celera1735,189,364 - 35,189,565UniSTS
Cytogenetic Map17p12UniSTS
MARC_10647-10648:1000474126:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,671,958 - 35,672,449 (+)MAPPERmRatBN7.2
Rnor_6.01737,619,172 - 37,619,662NCBIRnor6.0
Rnor_5.01739,481,106 - 39,481,596UniSTSRnor5.0
RGSC_v3.41742,177,034 - 42,177,524UniSTSRGSC3.4
Celera1735,189,938 - 35,190,429UniSTS
Cytogenetic Map17p12UniSTS
UniSTS:496745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21735,669,612 - 35,669,703 (+)MAPPERmRatBN7.2
Rnor_6.01737,616,826 - 37,616,916NCBIRnor6.0
Rnor_5.01739,478,760 - 39,478,850UniSTSRnor5.0
RGSC_v3.41742,174,688 - 42,174,778UniSTSRGSC3.4
Celera1735,187,751 - 35,187,841UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000115501   ⟹   ENSRNOP00000080737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1735,667,537 - 35,673,665 (+)Ensembl
RefSeq Acc Id: NM_001271205   ⟹   NP_001258134
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81735,876,298 - 35,881,004 (+)NCBI
mRatBN7.21735,667,809 - 35,672,515 (+)NCBI
Rnor_6.01737,615,022 - 37,619,728 (+)NCBI
Rnor_5.01739,476,956 - 39,481,662 (+)NCBI
Celera1735,186,015 - 35,190,495 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080737.1
RefSeq Acc Id: NP_001258134   ⟸   NM_001271205
- UniProtKB: A0A8I5ZQY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000080737   ⟸   ENSRNOT00000115501
Protein Domains
HMG box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309488 AgrOrtholog
BioCyc Gene G2FUF-9490 BioCyc
Ensembl Genes ENSRNOG00000065643 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115501.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  SOX-12/11/4 UniProtKB/TrEMBL
  SRY-related_HMG-box_TFs UniProtKB/TrEMBL
KEGG Report rno:364712 UniProtKB/TrEMBL
NCBI Gene 364712 ENTREZGENE
PANTHER SOX TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SOX-4 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
PhenoGen Sox4 PhenoGen
PIRSF SOX-12/11/4a UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065643 RatGTEx
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A8I5ZQY6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Sox4  SRY-box transcription factor 4  Sox4  SRY box 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Sox4  SRY box 4  Sox4  SRY (sex determining region Y)-box 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sox4  SRY (sex determining region Y)-box 4  Sox4  SRY-box containing gene 4   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sox4  SRY-box containing gene 4   Sox4_predicted  SRY-box containing gene 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sox4_predicted  SRY-box containing gene 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED