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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309488
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox4
Name: SRY-box transcription factor 4
Acc ID: CHEBI:50673
Term: methimazole
Definition: A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.
Chemical ID: MESH:D008713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox4decreases expressionEXP 6480464CTDMethimazole results in decreased expression of SOX4 mRNAPMID:30047161
Sox4increases expressionEXP 6480464CTDMethimazole results in increased expression of SOX4 mRNAPMID:22504374
Sox4multiple interactionsISOSox4 (Mus musculus)6480464CTD[Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 proteinPMID:27421576
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