Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase) - Rat Genome Database

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Gene: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase) Rattus norvegicus
Analyze
Symbol: Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
RGD ID: 1308671
Description: Predicted to enable NADPH-hemoprotein reductase activity; [methionine synthase] reductase (NADPH) activity; and nucleotide binding activity. Predicted to be involved in several processes, including folic acid metabolic process; negative regulation of cystathionine beta-synthase activity; and sulfur amino acid metabolic process. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aqCbl reductase; aquacobalamin reductase; LOC290947; methionine synthase reductase; MGC112912; MSR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,695,376 - 36,727,341 (+)NCBIGRCr8
mRatBN7.2134,866,991 - 34,899,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,867,089 - 34,899,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,728,420 - 34,760,302 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,719,274 - 40,751,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,893,978 - 34,925,845 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,743,089 - 37,774,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,743,147 - 37,774,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,124,730 - 39,156,109 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,086,219 - 5,118,086 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1175,087,203 - 5,117,405 (+)NCBI
Celera133,436,562 - 33,468,429 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. Aneiros-Guerrero A, etal., BMC Med Genet. 2011 May 26;12:75.
2. Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma. Bethke L, etal., Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1195-202.
3. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
4. Functional variant in methionine synthase reductase intron-1 is associated with pleiotropic congenital malformations. Cheng H, etal., Mol Cell Biochem. 2015 Sep;407(1-2):51-6. doi: 10.1007/s11010-015-2453-8. Epub 2015 Jun 5.
5. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Doolin MT, etal., Am J Hum Genet 2002 Nov;71(5):1222-6. Epub 2002 Oct 09.
6. Association of MTHFR, MTR, and MTRR polymorphisms with Parkinson's disease among ethnic Chinese in Taiwan. Fong CS, etal., Clin Chim Acta. 2011 Jan 30;412(3-4):332-8. Epub 2010 Nov 8.
7. Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study. Gast A, etal., Leukemia. 2007 Feb;21(2):320-5. Epub 2006 Nov 30.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Gemmati D, etal., Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):787-94.
10. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Gueant-Rodriguez RM, etal., Neurosci Lett 2003 Jul 3;344(3):189-92.
13. Hyperhomocysteinemia and Related Genetic Polymorphisms Correlate with Ulcerative Colitis in Southeast China. Jiang Y, etal., Cell Biochem Biophys. 2011 Sep 24.
14. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Kim HN, etal., Leuk Res. 2009 Jan;33(1):82-7. doi: 10.1016/j.leukres.2008.07.026. Epub 2008 Sep 6.
15. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population. Kwak SY, etal., Anticancer Res. 2008 Sep-Oct;28(5A):2807-11.
16. Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis. Lautner-Csorba O, etal., PLoS One. 2013 Aug 5;8(8):e69843. doi: 10.1371/journal.pone.0069843. Print 2013.
17. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk. Lima CS, etal., Leuk Res. 2008 Mar;32(3):401-5. Epub 2007 Jul 25.
18. Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients. Miriuka SG, etal., Transpl Int. 2005 Jan;18(1):29-35.
19. Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association. O'leary VB, etal., Mol Genet Metab 2005 Jul;85(3):220-7. Epub 2005 Mar 17.
20. His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk. Ohnami S, etal., Gastroenterology. 2008 Aug;135(2):477-88. Epub 2008 Apr 18.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida. Pietrzyk JJ, etal., J Appl Genet. 2003;44(1):111-3.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk. Suzuki T, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2742-7.
28. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
29. Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. Wiltshire EJ, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):348-53.
30. cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression. Zavadakova P, etal., Hum Mutat. 2005 Mar;25(3):239-47.
31. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Zhao JY, etal., Circulation. 2012 Jan 24;125(3):482-90. doi: 10.1161/CIRCULATIONAHA.111.050245. Epub 2011 Dec 16.
Additional References at PubMed
PMID:11466310   PMID:12477932   PMID:16769880   PMID:17369066   PMID:17892308   PMID:24074862   PMID:24416422  


Genomics

Comparative Map Data
Mtrr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,695,376 - 36,727,341 (+)NCBIGRCr8
mRatBN7.2134,866,991 - 34,899,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,867,089 - 34,899,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,728,420 - 34,760,302 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,719,274 - 40,751,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,893,978 - 34,925,845 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,743,089 - 37,774,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,743,147 - 37,774,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,124,730 - 39,156,109 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,086,219 - 5,118,086 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1175,087,203 - 5,117,405 (+)NCBI
Celera133,436,562 - 33,468,429 (+)NCBICelera
Cytogenetic Map1p11NCBI
MTRR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3857,850,859 - 7,901,113 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl57,851,186 - 7,906,025 (+)EnsemblGRCh38hg38GRCh38
GRCh3757,869,261 - 7,901,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3657,922,217 - 7,954,237 (+)NCBINCBI36Build 36hg18NCBI36
Build 3457,922,216 - 7,954,233NCBI
Celera57,910,259 - 7,942,243 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef57,850,954 - 7,882,932 (+)NCBIHuRef
CHM1_157,869,302 - 7,901,279 (+)NCBICHM1_1
T2T-CHM13v2.057,789,841 - 7,840,236 (+)NCBIT2T-CHM13v2.0
Mtrr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391368,708,897 - 68,730,273 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1368,708,899 - 68,730,268 (-)EnsemblGRCm39 Ensembl
GRCm381368,560,780 - 68,582,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1368,560,780 - 68,582,149 (-)EnsemblGRCm38mm10GRCm38
MGSCv371368,699,657 - 68,720,998 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361369,028,151 - 69,049,492 (-)NCBIMGSCv36mm8
Celera1370,920,592 - 70,941,889 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.54NCBI
Mtrr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555045,413,586 - 5,435,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555045,412,290 - 5,435,409 (+)NCBIChiLan1.0ChiLan1.0
MTRR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v248,106,696 - 8,156,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan156,260,305 - 6,310,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v058,195,868 - 8,228,071 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.158,017,373 - 8,049,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl58,017,403 - 8,049,322 (+)Ensemblpanpan1.1panPan2
MTRR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,068,572 - 6,119,580 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,070,046 - 6,098,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3410,576,595 - 10,608,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0345,974,025 - 6,005,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl345,974,050 - 6,005,641 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,023,818 - 6,055,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,004,603 - 6,036,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0346,217,429 - 6,249,109 (-)NCBIUU_Cfam_GSD_1.0
Mtrr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213238,993,011 - 239,023,047 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936643380,968 - 409,464 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936643379,790 - 410,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTRR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1674,245,228 - 74,270,783 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11674,245,214 - 74,270,828 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21680,297,640 - 80,323,444 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTRR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.147,461,521 - 7,493,032 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl47,461,526 - 7,493,840 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606421,124,251 - 21,155,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtrr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247515,445,241 - 5,469,657 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247515,445,274 - 5,469,386 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtrr
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:144
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000024041, ENSRNOT00000061790
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024041   ⟹   ENSRNOP00000024041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl134,867,091 - 34,898,956 (+)Ensembl
Rnor_6.0 Ensembl137,744,097 - 37,773,448 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061790   ⟹   ENSRNOP00000058505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl134,867,089 - 34,898,955 (+)Ensembl
Rnor_6.0 Ensembl137,743,147 - 37,774,015 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094903   ⟹   ENSRNOP00000078665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl134,867,095 - 34,899,425 (+)Ensembl
RefSeq Acc Id: NM_001039003   ⟹   NP_001034092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,695,474 - 36,727,341 (+)NCBI
mRatBN7.2134,867,089 - 34,898,956 (+)NCBI
Rnor_6.0137,743,147 - 37,774,016 (+)NCBI
Rnor_5.0139,124,730 - 39,156,109 (+)NCBI
RGSC_v3.4175,086,219 - 5,118,086 (+)RGD
Celera133,436,562 - 33,468,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227813   ⟹   XP_006227875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,695,376 - 36,727,341 (+)NCBI
mRatBN7.2134,866,991 - 34,899,425 (+)NCBI
Rnor_6.0137,743,089 - 37,774,485 (+)NCBI
Rnor_5.0139,124,730 - 39,156,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227814   ⟹   XP_006227876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,697,971 - 36,727,341 (+)NCBI
mRatBN7.2134,869,588 - 34,899,425 (+)NCBI
Rnor_6.0137,745,697 - 37,774,485 (+)NCBI
Rnor_5.0139,124,730 - 39,156,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102881   ⟹   XP_038958809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,696,472 - 36,727,341 (+)NCBI
mRatBN7.2134,868,076 - 34,899,425 (+)NCBI
RefSeq Acc Id: XM_039102907   ⟹   XP_038958835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,697,971 - 36,727,341 (+)NCBI
mRatBN7.2134,869,588 - 34,899,425 (+)NCBI
RefSeq Acc Id: XM_063282710   ⟹   XP_063138780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,695,876 - 36,727,341 (+)NCBI
RefSeq Acc Id: XM_063282712   ⟹   XP_063138782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,695,376 - 36,724,307 (+)NCBI
RefSeq Acc Id: XM_063282713   ⟹   XP_063138783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,696,450 - 36,727,341 (+)NCBI
RefSeq Acc Id: NP_001034092   ⟸   NM_001039003
- UniProtKB: Q498R1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006227875   ⟸   XM_006227813
- Peptide Label: isoform X1
- UniProtKB: D3ZDG8 (UniProtKB/Swiss-Prot),   Q498R1 (UniProtKB/Swiss-Prot),   A0A8L2QCU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227876   ⟸   XM_006227814
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QCU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024041   ⟸   ENSRNOT00000024041
Ensembl Acc Id: ENSRNOP00000058505   ⟸   ENSRNOT00000061790
RefSeq Acc Id: XP_038958809   ⟸   XM_039102881
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QCU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958835   ⟸   XM_039102907
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QCU1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078665   ⟸   ENSRNOT00000094903
RefSeq Acc Id: XP_063138782   ⟸   XM_063282712
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138780   ⟸   XM_063282710
- Peptide Label: isoform X1
- UniProtKB: Q498R1 (UniProtKB/Swiss-Prot),   D3ZDG8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138783   ⟸   XM_063282713
- Peptide Label: isoform X5
Protein Domains
FAD-binding FR-type   Flavodoxin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498R1-F1-model_v2 AlphaFold Q498R1 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689578
Promoter ID:EPDNEW_R103
Type:multiple initiation site
Name:Mtrr_1
Description:5-methyltetrahydrofolate-homocysteine methyltransferase reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0137,743,138 - 37,743,198EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308671 AgrOrtholog
BioCyc Gene G2FUF-61850 BioCyc
BioCyc Pathway PWY-7974 [cobalamin salvage (eukaryotic)] BioCyc
BioCyc Pathway Image PWY-7974 BioCyc
Ensembl Genes ENSRNOG00000017826 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021272 UniProtKB/Swiss-Prot
  ENSRNOG00060000685 UniProtKB/Swiss-Prot
  ENSRNOG00065002580 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024041.6 UniProtKB/TrEMBL
  ENSRNOT00000061790.4 UniProtKB/Swiss-Prot
  ENSRNOT00000094903.1 UniProtKB/Swiss-Prot
  ENSRNOT00055036349 UniProtKB/Swiss-Prot
  ENSRNOT00060000768 UniProtKB/Swiss-Prot
  ENSRNOT00065003414 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379770 IMAGE-MGC_LOAD
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290947 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112912 IMAGE-MGC_LOAD
NCBI Gene 290947 ENTREZGENE
PANTHER METHIONINE SYNTHASE REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MTRR RGD
PhenoGen Mtrr PhenoGen
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017826 RatGTEx
  ENSRNOG00055021272 RatGTEx
  ENSRNOG00060000685 RatGTEx
  ENSRNOG00065002580 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QCU1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDG8 ENTREZGENE
  MTRR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3ZDG8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mtrr  5-methyltetrahydrofolate-homocysteine methyltransferase reductase  Mtrr_predicted  5-methyltetrahydrofolate-homocysteine methyltransferase reductase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mtrr_predicted  5-methyltetrahydrofolate-homocysteine methyltransferase reductase (predicted)      Symbol and Name status set to approved 70820 APPROVED