C9h2orf69 (similar to human chromosome 2 open reading frame 69) - Rat Genome Database

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Gene: C9h2orf69 (similar to human chromosome 2 open reading frame 69) Rattus norvegicus
Analyze
Symbol: C9h2orf69
Name: similar to human chromosome 2 open reading frame 69
RGD ID: 1306941
Description: Predicted to be involved in oxidative phosphorylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 53. Orthologous to human C2orf69 (chromosome 2 open reading frame 69); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC316406; LOC316406; mitochondrial protein C2orf69 homolog; RGD1306941; similar to CG31122-PA; uncharacterized protein LOC316406; UPF0565 protein C2orf69 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8966,444,084 - 66,452,720 (+)NCBIGRCr8
mRatBN7.2958,949,821 - 58,958,456 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl958,949,846 - 58,958,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx967,450,931 - 67,459,449 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0972,566,852 - 72,575,370 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0970,884,913 - 70,893,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,066,579 - 64,075,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,066,579 - 64,075,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0963,871,338 - 63,881,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4956,272,657 - 56,281,182 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1956,419,695 - 56,426,405 (+)NCBI
Celera956,396,183 - 56,404,793 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
C9h2orf69
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8966,444,084 - 66,452,720 (+)NCBIGRCr8
mRatBN7.2958,949,821 - 58,958,456 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl958,949,846 - 58,958,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx967,450,931 - 67,459,449 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0972,566,852 - 72,575,370 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0970,884,913 - 70,893,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,066,579 - 64,075,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,066,579 - 64,075,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0963,871,338 - 63,881,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4956,272,657 - 56,281,182 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1956,419,695 - 56,426,405 (+)NCBI
Celera956,396,183 - 56,404,793 (+)NCBICelera
Cytogenetic Map9q31NCBI
C2orf69
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382199,911,293 - 199,928,273 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2199,911,293 - 199,955,935 (+)EnsemblGRCh38hg38GRCh38
GRCh372200,776,016 - 200,792,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362200,484,274 - 200,501,241 (+)NCBINCBI36Build 36hg18NCBI36
Celera2194,531,108 - 194,547,696 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2192,628,617 - 192,645,678 (+)NCBIHuRef
CHM1_12200,782,113 - 200,799,121 (+)NCBICHM1_1
T2T-CHM13v2.02200,394,882 - 200,411,904 (+)NCBIT2T-CHM13v2.0
1700066M21Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,416,755 - 57,424,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl157,416,779 - 57,424,582 (+)EnsemblGRCm39 Ensembl
GRCm38157,377,596 - 57,385,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,377,620 - 57,385,423 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,434,464 - 57,442,267 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36157,322,172 - 57,328,503 (+)NCBIMGSCv36mm8
Celera157,892,076 - 57,899,879 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.78NCBI
CUNH2orf69
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554031,349,489 - 1,352,541 (-)NCBIChiLan1.0ChiLan1.0
C13H2orf69
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213102,529,719 - 102,546,620 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B102,544,721 - 102,561,622 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B87,160,309 - 87,177,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B205,319,042 - 205,335,744 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B205,319,094 - 205,333,361 (+)Ensemblpanpan1.1panPan2
C37H2orf69
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1379,092,569 - 9,106,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl379,092,658 - 9,104,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha379,979,641 - 9,997,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0378,991,929 - 9,010,096 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl378,991,463 - 9,003,625 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1378,981,914 - 9,000,014 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0378,953,790 - 8,971,871 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0378,950,956 - 8,969,122 (+)NCBIUU_Cfam_GSD_1.0
CUNH2orf69
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303157,079,449 - 157,087,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936825942,471 - 947,999 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936825936,690 - 948,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUNH2orf69
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11085,412,119 - 85,428,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1085,412,287 - 85,425,998 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040114,011,588 - 114,027,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH2orf69
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248891,001,585 - 1,008,350 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624889999,433 - 1,008,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C9h2orf69
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:154
Interacting mature miRNAs:196
Transcripts:ENSRNOT00000013511
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013511   ⟹   ENSRNOP00000013512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl958,949,846 - 58,958,561 (+)Ensembl
Rnor_6.0 Ensembl964,066,579 - 64,075,197 (+)Ensembl
RefSeq Acc Id: NM_001108219   ⟹   NP_001101689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8966,444,110 - 66,452,720 (+)NCBI
mRatBN7.2958,949,845 - 58,958,456 (+)NCBI
Rnor_6.0964,066,579 - 64,075,197 (+)NCBI
Rnor_5.0963,871,338 - 63,881,044 (+)NCBI
RGSC_v3.4956,272,657 - 56,281,182 (+)RGD
Celera956,396,183 - 56,404,793 (+)RGD
Sequence:
RefSeq Acc Id: XR_005488908
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8966,444,084 - 66,450,228 (+)NCBI
mRatBN7.2958,949,821 - 58,955,958 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66506 (Get FASTA)   NCBI Sequence Viewer  
  EDL99025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013512.4
RefSeq Acc Id: NP_001101689   ⟸   NM_001108219
- Peptide Label: precursor
- UniProtKB: G3V7A7 (UniProtKB/TrEMBL),   A6IP35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013512   ⟸   ENSRNOT00000013511

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7A7-F1-model_v2 AlphaFold G3V7A7 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696674
Promoter ID:EPDNEW_R7199
Type:multiple initiation site
Name:RGD1306941_1
Description:similar to CG31122-PA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0964,066,588 - 64,066,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306941 AgrOrtholog
BioCyc Gene G2FUF-27486 BioCyc
Ensembl Genes ENSRNOG00000010185 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013511.6 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123565 IMAGE-MGC_LOAD
InterPro UPF0565 UniProtKB/TrEMBL
KEGG Report rno:316406 UniProtKB/TrEMBL
MGC_CLONE MGC:188073 IMAGE-MGC_LOAD
NCBI Gene 316406 ENTREZGENE
PANTHER PTHR31296 UniProtKB/TrEMBL
  UPF0565 PROTEIN C2ORF69 UniProtKB/TrEMBL
Pfam UPF0565 UniProtKB/TrEMBL
PhenoGen C9h2orf69 PhenoGen
RatGTEx ENSRNOG00000010185 RatGTEx
UniProt A6IP35 ENTREZGENE, UniProtKB/TrEMBL
  G3V7A7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C9h2orf69  similar to human chromosome 2 open reading frame 69  RGD1306941  similar to CG31122-PA  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1306941  similar to CG31122-PA   RGD1306941_predicted  similar to CG31122-PA (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306941_predicted  similar to CG31122-PA (predicted)  LOC316406_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316406_predicted  similar to CG31122-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL