Dot1l (DOT1 like histone lysine methyltransferase) - Rat Genome Database

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Gene: Dot1l (DOT1 like histone lysine methyltransferase) Rattus norvegicus
Analyze
Symbol: Dot1l
Name: DOT1 like histone lysine methyltransferase
RGD ID: 1306644
Description: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; histone H3K79 methyltransferase activity; and transcription coactivator activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin formation. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DOT1-like histone H3K79 methyltransferase; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; LOC362831
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,569,439 - 9,607,095 (-)NCBIGRCr8
mRatBN7.278,918,764 - 8,959,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,917,786 - 8,956,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,797,442 - 11,834,651 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,672,947 - 13,710,156 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,539,407 - 11,576,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,786,105 - 11,824,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,953,820 - 11,992,519 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,428,275 - 10,466,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,431,054 - 10,466,674 (-)NCBI
Celera77,100,524 - 7,139,150 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
inulin  (ISO)
methimazole  (EXP)
nitrofen  (EXP)
Oleacein  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Daigle SR, etal., Blood. 2013 Aug 8;122(6):1017-25. doi: 10.1182/blood-2013-04-497644. Epub 2013 Jun 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Targeting protein lysine methylation and demethylation in cancers. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Min J, etal., Cell 2003 Mar 7;112(5):711-23.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14572310   PMID:15851025   PMID:17707234   PMID:22002246   PMID:32799103  


Genomics

Comparative Map Data
Dot1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,569,439 - 9,607,095 (-)NCBIGRCr8
mRatBN7.278,918,764 - 8,959,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,917,786 - 8,956,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,797,442 - 11,834,651 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,672,947 - 13,710,156 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,539,407 - 11,576,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,786,105 - 11,824,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,953,820 - 11,992,519 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,428,275 - 10,466,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,431,054 - 10,466,674 (-)NCBI
Celera77,100,524 - 7,139,150 (-)NCBICelera
Cytogenetic Map7q11NCBI
DOT1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,163,933 - 2,232,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,163,933 - 2,232,578 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,163,932 - 2,232,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,115,148 - 2,181,015 (+)NCBINCBI36Build 36hg18NCBI36
Build 34192,115,147 - 2,181,014NCBI
Celera192,098,311 - 2,166,754 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,935,055 - 2,003,614 (+)NCBIHuRef
CHM1_1192,163,729 - 2,232,081 (+)NCBICHM1_1
T2T-CHM13v2.0192,137,178 - 2,206,142 (+)NCBIT2T-CHM13v2.0
Dot1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,590,935 - 80,631,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,591,040 - 80,631,295 (+)EnsemblGRCm39 Ensembl
GRCm381080,755,101 - 80,795,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,755,206 - 80,795,461 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,217,951 - 80,257,092 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,158,335 - 80,197,476 (+)NCBIMGSCv36mm8
Celera1081,773,573 - 81,812,716 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Dot1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,909,880 - 5,959,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,907,486 - 5,958,241 (-)NCBIChiLan1.0ChiLan1.0
DOT1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,545,662 - 6,617,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,777,073 - 5,843,976 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,173,915 - 1,243,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,147,008 - 2,215,262 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,147,031 - 2,210,039 (+)Ensemblpanpan1.1panPan2
DOT1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,805,030 - 56,868,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,803,242 - 56,852,539 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,598,283 - 56,663,359 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,536,083 - 57,601,163 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,536,089 - 57,601,126 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,588,099 - 56,653,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,073,218 - 57,138,276 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,273,728 - 57,338,765 (-)NCBIUU_Cfam_GSD_1.0
Dot1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,502,294 - 216,560,162 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,288,392 - 1,330,297 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,288,447 - 1,332,489 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOT1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,339,470 - 76,401,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,339,452 - 76,401,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,053,227 - 77,070,556 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOT1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,962,077 - 2,030,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,962,279 - 2,026,455 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,693,681 - 6,765,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dot1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,650,762 - 6,697,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,648,403 - 6,697,617 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dot1l
119 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:211
Interacting mature miRNAs:247
Transcripts:ENSRNOT00000051467
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
AW907654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,919,899 - 8,920,042 (+)MAPPERmRatBN7.2
Rnor_6.0711,788,219 - 11,788,361NCBIRnor6.0
Rnor_5.0711,955,934 - 11,956,076UniSTSRnor5.0
RGSC_v3.4710,430,389 - 10,430,532UniSTSRGSC3.4
Celera77,102,638 - 7,102,780UniSTS
Cytogenetic Map7q11UniSTS
RH127906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,918,829 - 8,919,018 (+)MAPPERmRatBN7.2
Rnor_6.0711,787,149 - 11,787,337NCBIRnor6.0
Rnor_5.0711,954,864 - 11,955,052UniSTSRnor5.0
RGSC_v3.4710,429,319 - 10,429,507UniSTSRGSC3.4
Celera77,101,568 - 7,101,756UniSTS
RH 3.4 Map716.4UniSTS
Cytogenetic Map7q11UniSTS
RH134554  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,917,818 - 8,918,017 (+)MAPPERmRatBN7.2
Rnor_6.0711,786,138 - 11,786,336NCBIRnor6.0
Rnor_5.0711,953,853 - 11,954,051UniSTSRnor5.0
RGSC_v3.4710,428,308 - 10,428,506UniSTSRGSC3.4
Celera77,100,557 - 7,100,755UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000051467   ⟹   ENSRNOP00000043691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,917,786 - 8,956,475 (-)Ensembl
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116154   ⟹   ENSRNOP00000095270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,922,266 - 8,956,184 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118608   ⟹   ENSRNOP00000081362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,918,757 - 8,956,475 (-)Ensembl
RefSeq Acc Id: NM_001108733   ⟹   NP_001102203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,569,439 - 9,607,095 (-)NCBI
mRatBN7.278,918,764 - 8,956,420 (-)NCBI
Rnor_6.0711,786,105 - 11,824,742 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
RGSC_v3.4710,428,275 - 10,466,913 (-)RGD
Celera77,100,524 - 7,139,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240959   ⟹   XP_006241021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,569,439 - 9,607,073 (-)NCBI
mRatBN7.278,918,764 - 8,956,418 (-)NCBI
Rnor_6.0711,787,083 - 11,824,737 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079392   ⟹   XP_038935320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,569,439 - 9,605,634 (-)NCBI
mRatBN7.278,918,764 - 8,954,098 (-)NCBI
RefSeq Acc Id: XM_063263742   ⟹   XP_063119812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,572,591 - 9,607,072 (-)NCBI
RefSeq Acc Id: XR_010052992
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,572,607 - 9,607,072 (-)NCBI
RefSeq Acc Id: NP_001102203   ⟸   NM_001108733
- UniProtKB: D3ZCP0 (UniProtKB/TrEMBL),   A6K8G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241021   ⟸   XM_006240959
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZRT2 (UniProtKB/TrEMBL),   A6K8H0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043691   ⟸   ENSRNOT00000051467
RefSeq Acc Id: XP_038935320   ⟸   XM_039079392
- Peptide Label: isoform X2
- UniProtKB: A6K8H0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081362   ⟸   ENSRNOT00000118608
Ensembl Acc Id: ENSRNOP00000095270   ⟸   ENSRNOT00000116154
RefSeq Acc Id: XP_063119812   ⟸   XM_063263742
- Peptide Label: isoform X3
Protein Domains
DOT1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCP0-F1-model_v2 AlphaFold D3ZCP0 1-1549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695006
Promoter ID:EPDNEW_R5531
Type:multiple initiation site
Name:Dot1l_1
Description:DOT1 like histone lysine methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,824,739 - 11,824,799EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306644 AgrOrtholog
BioCyc Gene G2FUF-34965 BioCyc
Ensembl Genes ENSRNOG00000032546 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051467.5 UniProtKB/TrEMBL
  ENSRNOT00000116154.1 UniProtKB/TrEMBL
  ENSRNOT00000118608.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.60 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
InterPro H3-K79_meTrfase UniProtKB/TrEMBL
  Histone_H3-K79_MeTrfase UniProtKB/TrEMBL
  Histone_H3-K79_MeTrfase_met UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:362831 UniProtKB/TrEMBL
NCBI Gene 362831 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC UniProtKB/TrEMBL
  PTHR21451 UniProtKB/TrEMBL
Pfam DOT1 UniProtKB/TrEMBL
PhenoGen Dot1l PhenoGen
PIRSF Histone_H3-K79_MeTrfase_met UniProtKB/TrEMBL
PROSITE DOT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032546 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I5ZRT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMR2_RAT UniProtKB/TrEMBL
  A6K8G9 ENTREZGENE, UniProtKB/TrEMBL
  A6K8H0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCP0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Dot1l  DOT1 like histone lysine methyltransferase  Dot1l  DOT1-like histone H3K79 methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Dot1l  DOT1-like histone H3K79 methyltransferase  Dot1l  DOT1-like, histone H3 methyltransferase (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dot1l  DOT1-like, histone H3 methyltransferase (S. cerevisiae)   Dot1l_predicted  DOT1-like, histone H3 methyltransferase (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dot1l_predicted  DOT1-like, histone H3 methyltransferase (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED