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Gene: Dot1l (DOT1-like, histone H3 methyltransferase (S. cerevisiae)) Mus musculus
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Symbol: Dot1l
Name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Description: Exhibits histone methyltransferase activity. Predicted to be involved in several processes, including DNA damage checkpoint; histone H3-K79 methylation; and regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and protein-containing complex. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A630076O07; AW907654; Dot1; DOT1-like histone H3 methyltransferase; histone H3 methyltransferase DOT1; histone methyltransferase DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific; KMT4; mDot1
Orthologs:
Homo sapiens (human) : DOT1L (DOT1 like histone lysine methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dot1l (DOT1 like histone lysine methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dot1l (DOT1 like histone lysine methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DOT1L (DOT1 like histone lysine methyltransferase)
Canis lupus familiaris (dog) : DOT1L (DOT1 like histone lysine methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dot1l (DOT1 like histone lysine methyltransferase)
Sus scrofa (pig) : DOT1L (DOT1 like histone lysine methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381080,755,101 - 80,795,461 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371080,217,951 - 80,257,092 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,158,335 - 80,197,476 (+)NCBImm8
Celera1081,773,573 - 81,812,716 (+)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dot1l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315377
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.