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Gene: Dot1l (DOT1-like, histone H3 methyltransferase (S. cerevisiae)) Mus musculus
Symbol: Dot1l
Name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Description: Exhibits histone methyltransferase activity. Predicted to be involved in several processes, including DNA damage checkpoint; histone H3-K79 methylation; and regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and protein-containing complex. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A630076O07; AW907654; Dot1; DOT1-like histone H3 methyltransferase; histone H3 methyltransferase DOT1; histone methyltransferase DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific; KMT4; mDot1
Homo sapiens (human) : DOT1L (DOT1 like histone lysine methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dot1l (DOT1 like histone lysine methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dot1l (DOT1 like histone lysine methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DOT1L (DOT1 like histone lysine methyltransferase)
Canis lupus familiaris (dog) : DOT1L (DOT1 like histone lysine methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dot1l (DOT1 like histone lysine methyltransferase)
Sus scrofa (pig) : DOT1L (DOT1 like histone lysine methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381080,755,101 - 80,795,461 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371080,217,951 - 80,257,092 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,158,335 - 80,197,476 (+)NCBImm8
Celera1081,773,573 - 81,812,716 (+)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dot1l
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315377
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.