Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Mdn1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDN1 mRNA] | CTD | PMID:31150632 | Mdn1 | Rat | (-)-alpha-phellandrene | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of MDN1 mRNA | CTD | PMID:25075043 | Mdn1 | Rat | (-)-demecolcine | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Demecolcine results in increased expression of MDN1 mRNA | CTD | PMID:23649840 | Mdn1 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of MDN1 mRNA | CTD | PMID:22206623 | Mdn1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Mdn1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of MDN1 mRNA | CTD | PMID:17555576 | Mdn1 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDN1 mRNA | CTD | PMID:17942748 | Mdn1 | Rat | 17beta-estradiol | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of MDN1 mRNA | CTD | PMID:23019147 and PMID:31614463 | Mdn1 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | decreases expression | ISO | Mdn1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | Mdn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDN1 mRNA | CTD | PMID:17942748 | Mdn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MDN1 mRNA | CTD | PMID:32109520 and PMID:33387578 | Mdn1 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Mdn1 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of MDN1 mRNA | CTD | PMID:30851411 | Mdn1 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MDN1 mRNA | CTD | PMID:28628672 | Mdn1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MDN1 mRNA | CTD | PMID:28628672 | Mdn1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [bisphenol S co-treated with LIF protein] results in decreased expression of MDN1 mRNA | CTD | PMID:30951980 | Mdn1 | Rat | acrolein | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of MDN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of MDN1 mRNA | CTD | PMID:32699268 | Mdn1 | Rat | aflatoxin B1 | increases methylation | ISO | MDN1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of MDN1 exon | CTD | PMID:30157460 | Mdn1 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | MDN1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of MDN1 exon and aflatoxin B2 results in decreased methylation of MDN1 intron | CTD | PMID:30157460 | Mdn1 | Rat | all-trans-retinoic acid | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of MDN1 mRNA | CTD | PMID:15498508 and PMID:33167477 | Mdn1 | Rat | alpha-phellandrene | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of MDN1 mRNA | CTD | PMID:25075043 | Mdn1 | Rat | alpha-pinene | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of MDN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of MDN1 mRNA | CTD | PMID:32699268 | Mdn1 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of MDN1 mRNA | CTD | PMID:30779732 | Mdn1 | Rat | atrazine | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of MDN1 mRNA | CTD | PMID:22378314 | Mdn1 | Rat | benzo[a]pyrene | affects methylation | ISO | MDN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of MDN1 exon | CTD | PMID:30157460 | Mdn1 | Rat | benzo[a]pyrene | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA | CTD | PMID:27858113 | Mdn1 | Rat | benzo[a]pyrene | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of MDN1 mRNA | CTD | PMID:22228805 | Mdn1 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Mdn1 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA | CTD | PMID:27858113 | Mdn1 | Rat | benzo[e]pyrene | decreases methylation | ISO | MDN1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of MDN1 exon and benzo(e)pyrene results in decreased methylation of MDN1 intron | CTD | PMID:30157460 | Mdn1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of MDN1 mRNA | CTD | PMID:25181051 | Mdn1 | Rat | bisphenol A | decreases expression | ISO | Mdn1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of MDN1 mRNA | CTD | PMID:32156529 | Mdn1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MDN1 mRNA | CTD | PMID:32145629 | Mdn1 | Rat | bisphenol A | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [bisphenol A co-treated with LIF protein] results in decreased expression of MDN1 mRNA | CTD | PMID:30951980 | Mdn1 | Rat | bisphenol F | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA | CTD | PMID:28628672 | Mdn1 | Rat | butanal | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of MDN1 mRNA | CTD | PMID:26079696 | Mdn1 | Rat | cadmium atom | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MDN1 mRNA | CTD | PMID:35301059 | Mdn1 | Rat | cadmium dichloride | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of MDN1 mRNA | CTD | PMID:38568856 | Mdn1 | Rat | cadmium dichloride | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MDN1 mRNA | CTD | PMID:35301059 | Mdn1 | Rat | caffeine | decreases phosphorylation | ISO | MDN1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of MDN1 protein | CTD | PMID:35688186 | Mdn1 | Rat | carbon nanotube | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of MDN1 mRNA | CTD | PMID:25554681 | Mdn1 | Rat | chlorpyrifos | decreases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of MDN1 mRNA | CTD | PMID:37019170 | Mdn1 | Rat | chrysene | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA | CTD | PMID:27858113 | Mdn1 | Rat | cisplatin | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of MDN1 mRNA | CTD | PMID:27594783 | Mdn1 | Rat | clobetasol | decreases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of MDN1 mRNA | CTD | PMID:27462272 | Mdn1 | Rat | cobalt dichloride | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of MDN1 mRNA | CTD | PMID:19320972 | Mdn1 | Rat | coumarin | increases phosphorylation | ISO | MDN1 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of MDN1 protein | CTD | PMID:35688186 | Mdn1 | Rat | DDE | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of MDN1 mRNA | CTD | PMID:38568856 | Mdn1 | Rat | dexamethasone | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MDN1 mRNA | CTD | PMID:28628672 | Mdn1 | Rat | dicrotophos | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of MDN1 mRNA | CTD | PMID:28302478 | Mdn1 | Rat | diuron | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Diuron results in decreased expression of MDN1 mRNA | CTD | PMID:35967413 | Mdn1 | Rat | doxorubicin | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of MDN1 mRNA | CTD | PMID:29803840 | Mdn1 | Rat | ethyl methanesulfonate | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of MDN1 mRNA | CTD | PMID:23649840 | Mdn1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of MDN1 mRNA | CTD | PMID:24136188 | Mdn1 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of MDN1 mRNA | CTD | PMID:24793618 | Mdn1 | Rat | formaldehyde | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MDN1 mRNA | CTD | PMID:20655997 and PMID:23649840 | Mdn1 | Rat | FR900359 | increases phosphorylation | ISO | MDN1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of MDN1 protein | CTD | PMID:37730182 | Mdn1 | Rat | genistein | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Genistein results in increased expression of MDN1 mRNA | CTD | PMID:32186404 | Mdn1 | Rat | hexadecanoic acid | decreases phosphorylation | ISO | MDN1 (Homo sapiens) | 6480464 | Palmitic Acid results in decreased phosphorylation of MDN1 protein | CTD | PMID:28073184 | Mdn1 | Rat | indometacin | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MDN1 mRNA | CTD | PMID:28628672 | Mdn1 | Rat | irinotecan | affects expression | ISO | MDN1 (Homo sapiens) | 6480464 | Irinotecan analog affects the expression of MDN1 mRNA | CTD | PMID:18927307 | Mdn1 | Rat | methapyrilene | decreases methylation | ISO | MDN1 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of MDN1 exon and Methapyrilene results in decreased methylation of MDN1 intron | CTD | PMID:30157460 | Mdn1 | Rat | methyl methanesulfonate | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of MDN1 mRNA | CTD | PMID:23649840 | Mdn1 | Rat | methylmercury chloride | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of MDN1 mRNA | CTD | PMID:26272509 | Mdn1 | Rat | ozone | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of MDN1 mRNA more ... | CTD | PMID:32699268 | Mdn1 | Rat | paracetamol | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of MDN1 mRNA | CTD | PMID:21420995 | Mdn1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MDN1 mRNA | CTD | PMID:33387578 | Mdn1 | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of MDN1 mRNA | CTD | PMID:32680482 | Mdn1 | Rat | pirinixic acid | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MDN1 mRNA | CTD | PMID:19710929 | Mdn1 | Rat | pirinixic acid | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of MDN1 mRNA | CTD | PMID:18301758 and PMID:23811191 | Mdn1 | Rat | progesterone | affects expression | ISO | Mdn1 (Mus musculus) | 6480464 | Progesterone affects the expression of MDN1 mRNA | CTD | PMID:17251523 | Mdn1 | Rat | quercetin | decreases phosphorylation | ISO | MDN1 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of MDN1 protein | CTD | PMID:35688186 | Mdn1 | Rat | rac-lactic acid | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of MDN1 mRNA | CTD | PMID:30851411 | Mdn1 | Rat | SB 431542 | multiple interactions | ISO | MDN1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of MDN1 protein | CTD | PMID:37664457 | Mdn1 | Rat | sodium arsenite | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of MDN1 mRNA | CTD | PMID:38568856 | Mdn1 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of MDN1 mRNA | CTD | PMID:19281266 | Mdn1 | Rat | sunitinib | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of MDN1 mRNA | CTD | PMID:31533062 | Mdn1 | Rat | tamibarotene | affects expression | ISO | MDN1 (Homo sapiens) | 6480464 | tamibarotene affects the expression of MDN1 mRNA | CTD | PMID:15498508 | Mdn1 | Rat | tamoxifen | affects expression | ISO | Mdn1 (Mus musculus) | 6480464 | Tamoxifen affects the expression of MDN1 mRNA | CTD | PMID:17555576 | Mdn1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDN1 mRNA] | CTD | PMID:31150632 | Mdn1 | Rat | tetrachloromethane | increases expression | ISO | Mdn1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of MDN1 mRNA | CTD | PMID:31919559 | Mdn1 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of MDN1 mRNA | CTD | PMID:31150632 | Mdn1 | Rat | tetraphene | multiple interactions | ISO | Mdn1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA | CTD | PMID:27858113 | Mdn1 | Rat | titanium dioxide | decreases methylation | ISO | Mdn1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of MDN1 gene | CTD | PMID:35295148 | Mdn1 | Rat | trichostatin A | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of MDN1 mRNA | CTD | PMID:24935251 and PMID:26272509 | Mdn1 | Rat | triphenyl phosphate | decreases expression | EXP | | 6480464 | triphenyl phosphate results in decreased expression of MDN1 mRNA | CTD | PMID:30589522 | Mdn1 | Rat | triphenyl phosphate | affects expression | ISO | MDN1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of MDN1 mRNA | CTD | PMID:37042841 | Mdn1 | Rat | urethane | decreases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of MDN1 mRNA | CTD | PMID:28818685 | Mdn1 | Rat | valproic acid | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MDN1 mRNA | CTD | PMID:23179753 | Mdn1 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of MDN1 mRNA | CTD | PMID:29427782 | Mdn1 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of MDN1 mRNA | CTD | PMID:20566332 | Mdn1 | Rat | vincristine | increases expression | ISO | MDN1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of MDN1 mRNA | CTD | PMID:23649840 | |