IHH (Indian hedgehog signaling molecule) - Rat Genome Database

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Gene: IHH (Indian hedgehog signaling molecule) Canis lupus familiaris
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Symbol: IHH
Name: Indian hedgehog signaling molecule
RGD ID: 12323558
Description: ENCODES a protein that exhibits very-low-density lipoprotein particle binding (ortholog); INVOLVED IN bone resorption (ortholog); branching involved in blood vessel morphogenesis (ortholog); camera-type eye development (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH acrocapitofemoral dysplasia (ortholog); annular pancreas (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); extracellular matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: indian hedgehog; Indian hedgehog homolog; indian hedgehog protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,616,942 - 25,622,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,633,157 - 25,638,407 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone resorption  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
camera-type eye photoreceptor cell fate commitment  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cell fate specification  (IBA,ISO)
cell maturation  (ISO)
cell-cell signaling  (IEA)
chondrocyte differentiation involved in endochondral bone morphogenesis  (ISO)
chondrocyte proliferation  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic pattern specification  (ISO)
embryonic skeletal joint development  (ISO)
epithelial cell morphogenesis  (ISO)
epithelial cell-cell adhesion  (ISO)
head morphogenesis  (ISO)
heart looping  (IEA)
in utero embryonic development  (ISO)
intein-mediated protein splicing  (IEA)
liver regeneration  (ISO)
maternal process involved in female pregnancy  (ISO)
morphogenesis of a branching structure  (ISO)
multicellular organism growth  (ISO)
negative regulation of alpha-beta T cell differentiation  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of eye pigmentation  (ISO)
negative regulation of immature T cell proliferation in thymus  (IEA)
negative regulation of T cell differentiation in thymus  (IEA)
neuron development  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
pancreas development  (ISO)
pattern specification process  (ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of smoothened signaling pathway  (IEA)
positive regulation of T cell differentiation in thymus  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
protein autoprocessing  (IEA)
proteoglycan metabolic process  (ISO)
proteolysis  (IEA)
regulation of gene expression  (IBA)
regulation of growth  (ISO)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
retinal pigment epithelium development  (ISO)
skeletal system development  (IEA,ISO)
smooth muscle tissue development  (ISO)
smoothened signaling pathway  (IBA,IEA,ISO)
somite development  (IEA)
system development  (IEA)
vasculature development  (ISO)
vitelline membrane formation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IHH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,616,942 - 25,622,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,633,157 - 25,638,407 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
IHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,054,424 - 219,060,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,054,424 - 219,060,921 (-)Ensemblhg38GRCh38
GRCh372219,919,146 - 219,925,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,627,390 - 219,633,433 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2213,688,833 - 213,694,930 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,773,140 - 211,779,240 (-)NCBIHuRef
CHM1_12219,926,506 - 219,932,606 (-)NCBICHM1_1
T2T-CHM13v2.02219,542,768 - 219,549,269 (-)NCBIT2T-CHM13v2.0
Ihh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,984,474 - 74,990,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,984,474 - 74,990,831 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,945,315 - 74,951,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)Ensemblmm10GRCm38
MGSCv37174,991,892 - 74,998,225 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36174,878,525 - 74,884,858 (-)NCBIMGSCv36mm8
Celera175,500,289 - 75,506,631 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.55NCBI
Ihh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,952,986 - 83,959,203 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,952,986 - 83,959,203 (-)EnsemblGRCr8
mRatBN7.2976,504,315 - 76,510,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,504,315 - 76,510,532 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,948,807 - 84,955,041 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,077,709 - 90,083,943 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,463,912 - 88,470,146 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,208,223 - 82,214,440 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,208,223 - 82,214,440 (-)Ensemblrn6Rnor6.0
Rnor_5.0981,977,484 - 81,983,701 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,287,115 - 74,293,332 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,074,990 - 74,081,207 (-)NCBICelera
RGSC_v3.1974,435,304 - 74,439,783 (-)NCBI
Cytogenetic Map9q33NCBI
Ihh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,376,718 - 14,381,747 (+)Ensembl
ChiLan1.0NW_00495545314,376,665 - 14,382,536 (+)NCBIChiLan1.0ChiLan1.0
IHH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,685,363 - 121,691,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,700,328 - 121,706,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,905,488 - 224,917,887 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)EnsemblpanPan2panpan1.1
Ihh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,131,886 - 175,137,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,474,665 - 1,480,568 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,474,693 - 1,480,562 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IHH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,122,714 - 134,129,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IHH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,960,296 - 104,966,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,960,120 - 104,966,585 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,431,690 - 94,438,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ihh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,959,448 - 5,964,769 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248235,959,329 - 5,965,584 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ihh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,366,302 - 148,372,415 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in IHH
104 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845051230   ⟹   ENSCAFP00845040178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3725,633,157 - 25,638,407 (-)Ensembl
RefSeq Acc Id: XM_038447983   ⟹   XP_038303911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBI
RefSeq Acc Id: XM_038521966   ⟹   XP_038377894
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBI
RefSeq Acc Id: XM_038585773   ⟹   XP_038441701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBI
RefSeq Acc Id: XM_038650155   ⟹   XP_038506083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBI
RefSeq Acc Id: XM_545653   ⟹   XP_545653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13725,616,942 - 25,622,989 (-)NCBI
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBI
Sequence:
RefSeq Acc Id: XP_545653   ⟸   XM_545653
- UniProtKB: A0A8C0MU20 (UniProtKB/TrEMBL),   A0A8C0R8T9 (UniProtKB/TrEMBL),   A0A8I3PZB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038377894   ⟸   XM_038521966
RefSeq Acc Id: XP_038506083   ⟸   XM_038650155
RefSeq Acc Id: XP_038303911   ⟸   XM_038447983
- UniProtKB: A0A8C0MU20 (UniProtKB/TrEMBL),   A0A8C0R8T9 (UniProtKB/TrEMBL),   A0A8I3PZB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441701   ⟸   XM_038585773
- UniProtKB: A0A8C0MU20 (UniProtKB/TrEMBL),   A0A8C0R8T9 (UniProtKB/TrEMBL),   A0A8I3PZB1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845040178   ⟸   ENSCAFT00845051230
Protein Domains
Hint


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000056276 UniProtKB/TrEMBL
  ENSCAFG00030008228 UniProtKB/TrEMBL
  ENSCAFG00040024061 UniProtKB/TrEMBL
  ENSCAFG00845028975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000071716.2 UniProtKB/TrEMBL
  ENSCAFT00030015086.1 UniProtKB/TrEMBL
  ENSCAFT00040044843.1 UniProtKB/TrEMBL
  ENSCAFT00845051230 ENTREZGENE
  ENSCAFT00845051230.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1380.10 UniProtKB/TrEMBL
  Hedgehog/Intein (Hint) domain UniProtKB/TrEMBL
InterPro Hedgehog UniProtKB/TrEMBL
  Hedgehog_Hint UniProtKB/TrEMBL
  Hedgehog_sig/DD-Pept_Zn-bd_sf UniProtKB/TrEMBL
  Hedgehog_Signaling UniProtKB/TrEMBL
  Hedgehog_signalling_dom UniProtKB/TrEMBL
  Hint_dom_C UniProtKB/TrEMBL
  Hint_dom_N UniProtKB/TrEMBL
  Hint_dom_sf UniProtKB/TrEMBL
  Intein_N UniProtKB/TrEMBL
NCBI Gene IHH ENTREZGENE
PANTHER HEDGEHOG UniProtKB/TrEMBL
  PTHR11889:SF39 UniProtKB/TrEMBL
Pfam HH_signal UniProtKB/TrEMBL
  Hint UniProtKB/TrEMBL
PIRSF Peptidase_C46 UniProtKB/TrEMBL
PRINTS SONICHHOG UniProtKB/TrEMBL
PROSITE INTEIN_N_TER UniProtKB/TrEMBL
SMART HintC UniProtKB/TrEMBL
  HintN UniProtKB/TrEMBL
Superfamily-SCOP SSF51294 UniProtKB/TrEMBL
  SSF55166 UniProtKB/TrEMBL
UniProt A0A8C0MU20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R8T9 ENTREZGENE
  A0A8I3PZB1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-29 IHH  Indian hedgehog signaling molecule    indian hedgehog  Symbol and/or name change 5135510 APPROVED