IHH (Indian hedgehog signaling molecule) - Rat Genome Database

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Gene: IHH (Indian hedgehog signaling molecule) Sus scrofa
Analyze
Symbol: IHH
Name: Indian hedgehog signaling molecule
RGD ID: 14053021
Description: ENCODES a protein that exhibits very-low-density lipoprotein particle binding (ortholog); INVOLVED IN bone resorption (ortholog); branching involved in blood vessel morphogenesis (ortholog); camera-type eye development (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH acrocapitofemoral dysplasia (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); autism spectrum disorder (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: indian hedgehog protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,122,714 - 134,129,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
bone resorption  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
camera-type eye development  (IEA,ISO)
camera-type eye photoreceptor cell fate commitment  (IEA,ISO)
cartilage development  (IEA,ISO)
cell fate specification  (IEA,ISO)
cell maturation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (IEA)
chondrocyte differentiation  (IEA,ISO)
chondrocyte differentiation involved in endochondral bone morphogenesis  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
embryonic camera-type eye morphogenesis  (IEA,ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
embryonic skeletal joint development  (IEA,ISO)
endochondral bone morphogenesis  (ISO)
epithelial cell morphogenesis  (IEA,ISO)
epithelial cell-cell adhesion  (IEA,ISO)
head morphogenesis  (IEA,ISO)
heart looping  (IEA)
in utero embryonic development  (IEA,ISO)
intein-mediated protein splicing  (IEA)
liver regeneration  (ISO)
maternal process involved in female pregnancy  (ISO)
morphogenesis of a branching structure  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of alpha-beta T cell differentiation  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of eye pigmentation  (IEA,ISO)
negative regulation of immature T cell proliferation in thymus  (IEA)
negative regulation of T cell differentiation in thymus  (IEA)
neuron development  (IEA,ISO)
ossification  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
pancreas development  (IEA,ISO)
pattern specification process  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IEA)
positive regulation of T cell differentiation in thymus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein autoprocessing  (IEA)
proteoglycan metabolic process  (IEA,ISO)
proteolysis  (IEA)
regulation of growth  (IEA,ISO)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
retinal pigment epithelium development  (IEA,ISO)
skeletal system development  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
somite development  (IEA)
system development  (IEA)
vasculature development  (IEA,ISO)
vitelline membrane formation  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
IHH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,122,714 - 134,129,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,054,424 - 219,060,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,054,424 - 219,060,921 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,919,146 - 219,925,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,627,390 - 219,633,433 (-)NCBINCBI36hg18NCBI36
Celera2213,688,833 - 213,694,930 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2211,773,140 - 211,779,240 (-)NCBIHuRef
CHM1_12219,926,506 - 219,932,606 (-)NCBICHM1_1
T2T-CHM13v2.02219,542,768 - 219,549,269 (-)NCBI
Ihh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,984,474 - 74,990,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl174,984,474 - 74,990,831 (-)Ensembl
GRCm38174,945,315 - 74,951,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,991,892 - 74,998,225 (-)NCBIGRCm37mm9NCBIm37
MGSCv36174,878,525 - 74,884,858 (-)NCBImm8
Celera175,500,289 - 75,506,631 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.55NCBI
Ihh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,504,315 - 76,510,532 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl976,504,315 - 76,510,532 (-)Ensembl
Rnor_6.0982,208,223 - 82,214,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,208,223 - 82,214,440 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,977,484 - 81,983,701 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,287,115 - 74,293,332 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,435,304 - 74,439,783 (-)NCBI
Celera974,074,990 - 74,081,207 (-)NCBICelera
Cytogenetic Map9q33NCBI
Ihh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,376,718 - 14,381,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,376,665 - 14,382,536 (+)NCBIChiLan1.0ChiLan1.0
IHH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B224,905,488 - 224,917,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBIMhudiblu_PPA_v0panPan3
IHH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,616,942 - 25,622,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBI
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBI
ROS_Cfam_1.0 Ensembl3725,633,157 - 25,638,407 (-)Ensembl
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBI
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBI
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBI
Ihh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,131,886 - 175,137,781 (-)NCBI
SpeTri2.0NW_0049365691,474,693 - 1,480,562 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IHH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,960,296 - 104,966,596 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,960,120 - 104,966,585 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604094,431,690 - 94,438,180 (+)NCBIVero_WHO_p1.0
Ihh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,959,448 - 5,964,769 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248235,959,329 - 5,965,584 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system renal system reproductive system
High
Medium
Low 7 1
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000017645   ⟹   ENSSSCP00000017167
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)Ensembl
RefSeq Acc Id: NM_001244470   ⟹   NP_001231399
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115121,083,750 - 121,090,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021074681   ⟹   XP_020930340
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231399 (Get FASTA)   NCBI Sequence Viewer  
  XP_020930340 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV31782 (Get FASTA)   NCBI Sequence Viewer  
  CAD60251 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020930340   ⟸   XM_021074681
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001231399   ⟸   NM_001244470
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSSSCP00000017167   ⟸   ENSSSCT00000017645
Protein Domains
Hint   HintC   HintN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016204 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025017840 UniProtKB/TrEMBL
  ENSSSCG00030011724 UniProtKB/TrEMBL
  ENSSSCG00035024752 UniProtKB/TrEMBL
  ENSSSCG00040014983 UniProtKB/TrEMBL
  ENSSSCG00045036417 UniProtKB/TrEMBL
  ENSSSCG00050045550 UniProtKB/TrEMBL
  ENSSSCG00055000296 UniProtKB/TrEMBL
  ENSSSCG00060023093 UniProtKB/TrEMBL
  ENSSSCG00065051714 UniProtKB/TrEMBL
  ENSSSCG00070016835 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000017167 ENTREZGENE
  ENSSSCP00000017167.4 UniProtKB/TrEMBL
  ENSSSCP00025010240.1 UniProtKB/TrEMBL
  ENSSSCP00030007202.1 UniProtKB/TrEMBL
  ENSSSCP00035012814.1 UniProtKB/TrEMBL
  ENSSSCP00040008403.1 UniProtKB/TrEMBL
  ENSSSCP00045044168.1 UniProtKB/TrEMBL
  ENSSSCP00050026638.1 UniProtKB/TrEMBL
  ENSSSCP00055000354.1 UniProtKB/TrEMBL
  ENSSSCP00060013455.1 UniProtKB/TrEMBL
  ENSSSCP00065030871.1 UniProtKB/TrEMBL
  ENSSSCP00070027693.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017645 ENTREZGENE
  ENSSSCT00000017645.4 UniProtKB/TrEMBL
  ENSSSCT00025024202.1 UniProtKB/TrEMBL
  ENSSSCT00030016073.1 UniProtKB/TrEMBL
  ENSSSCT00035032551.1 UniProtKB/TrEMBL
  ENSSSCT00040020132.1 UniProtKB/TrEMBL
  ENSSSCT00045062680.1 UniProtKB/TrEMBL
  ENSSSCT00050061998.1 UniProtKB/TrEMBL
  ENSSSCT00055000507.1 UniProtKB/TrEMBL
  ENSSSCT00060031345.1 UniProtKB/TrEMBL
  ENSSSCT00065070814.1 UniProtKB/TrEMBL
  ENSSSCT00070033157.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1380.10 UniProtKB/TrEMBL
InterPro Hedgehog UniProtKB/TrEMBL
  Hedgehog_Hint UniProtKB/TrEMBL
  Hedgehog_sig/DD-Pept_Zn-bd_sf UniProtKB/TrEMBL
  Hedgehog_signalling_dom UniProtKB/TrEMBL
  Hint_dom_C UniProtKB/TrEMBL
  Hint_dom_N UniProtKB/TrEMBL
  Hint_dom_sf UniProtKB/TrEMBL
  IHH UniProtKB/TrEMBL
  Intein_N UniProtKB/TrEMBL
KEGG Report ssc:397174 UniProtKB/TrEMBL
NCBI Gene IHH ENTREZGENE
PANTHER PTHR11889:SF39 UniProtKB/TrEMBL
Pfam HH_signal UniProtKB/TrEMBL
  Hint UniProtKB/TrEMBL
PIRSF Peptidase_C46 UniProtKB/TrEMBL
PRINTS SONICHHOG UniProtKB/TrEMBL
PROSITE INTEIN_N_TER UniProtKB/TrEMBL
SMART HintC UniProtKB/TrEMBL
  HintN UniProtKB/TrEMBL
Superfamily-SCOP SSF51294 UniProtKB/TrEMBL
  SSF55166 UniProtKB/TrEMBL
UniProt A0A4X1UI09_PIG UniProtKB/TrEMBL
  A0A8D1J7X5_PIG UniProtKB/TrEMBL
  F1SRW6_PIG UniProtKB/TrEMBL
  Q866A4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96370 ENTREZGENE