IHH (Indian hedgehog signaling molecule) - Rat Genome Database

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Gene: IHH (Indian hedgehog signaling molecule) Pan paniscus
Analyze
Symbol: IHH
Name: Indian hedgehog signaling molecule
RGD ID: 11889356
Description: ENCODES a protein that exhibits very-low-density lipoprotein particle binding (ortholog); INVOLVED IN bone resorption (ortholog); branching involved in blood vessel morphogenesis (ortholog); camera-type eye development (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH acrocapitofemoral dysplasia (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); annular pancreas (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); extracellular matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: indian hedgehog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B224,905,488 - 224,917,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
bone resorption  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
camera-type eye development  (IEA,ISO)
camera-type eye photoreceptor cell fate commitment  (IEA,ISO)
cartilage development  (IEA,ISO)
cell fate specification  (IEA,ISO)
cell maturation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (IEA)
chondrocyte differentiation  (IEA,ISO)
chondrocyte differentiation involved in endochondral bone morphogenesis  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
embryonic camera-type eye morphogenesis  (IEA,ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
embryonic skeletal joint development  (IEA,ISO)
endochondral bone morphogenesis  (ISO)
epithelial cell morphogenesis  (IEA,ISO)
epithelial cell-cell adhesion  (IEA,ISO)
head morphogenesis  (IEA,ISO)
heart looping  (IEA)
in utero embryonic development  (IEA,ISO)
intein-mediated protein splicing  (IEA)
liver regeneration  (ISO)
maternal process involved in female pregnancy  (ISO)
morphogenesis of a branching structure  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of alpha-beta T cell differentiation  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of eye pigmentation  (IEA,ISO)
negative regulation of immature T cell proliferation in thymus  (IEA)
negative regulation of T cell differentiation in thymus  (IEA)
neuron development  (IEA,ISO)
ossification  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
pancreas development  (IEA,ISO)
pattern specification process  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IEA)
positive regulation of T cell differentiation in thymus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein autoprocessing  (IEA)
proteoglycan metabolic process  (IEA,ISO)
proteolysis  (IEA)
regulation of growth  (IEA,ISO)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
retinal pigment epithelium development  (IEA,ISO)
skeletal system development  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
somite development  (IEA)
system development  (IEA)
vasculature development  (IEA,ISO)
vitelline membrane formation  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
IHH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B224,905,488 - 224,917,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,054,424 - 219,060,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,054,424 - 219,060,921 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,919,146 - 219,925,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,627,390 - 219,633,433 (-)NCBINCBI36Build 36hg18NCBI36
Celera2213,688,833 - 213,694,930 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,773,140 - 211,779,240 (-)NCBIHuRef
CHM1_12219,926,506 - 219,932,606 (-)NCBICHM1_1
T2T-CHM13v2.02219,542,768 - 219,549,269 (-)NCBIT2T-CHM13v2.0
Ihh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,984,474 - 74,990,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,984,474 - 74,990,831 (-)EnsemblGRCm39 Ensembl
GRCm38174,945,315 - 74,951,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,945,315 - 74,951,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv37174,991,892 - 74,998,225 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,878,525 - 74,884,858 (-)NCBIMGSCv36mm8
Celera175,500,289 - 75,506,631 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.55NCBI
Ihh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,504,315 - 76,510,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,504,315 - 76,510,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,948,807 - 84,955,041 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0990,077,709 - 90,083,943 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0988,463,912 - 88,470,146 (-)NCBIRnor_WKY
Rnor_6.0982,208,223 - 82,214,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,208,223 - 82,214,440 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,977,484 - 81,983,701 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,287,115 - 74,293,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,435,304 - 74,439,783 (-)NCBI
Celera974,074,990 - 74,081,207 (-)NCBICelera
Cytogenetic Map9q33NCBI
Ihh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,376,718 - 14,381,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,376,665 - 14,382,536 (+)NCBIChiLan1.0ChiLan1.0
IHH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,616,942 - 25,622,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,443,433 - 26,449,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,632,373 - 25,638,422 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,633,157 - 25,638,407 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,536,946 - 25,542,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,472,029 - 25,478,078 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,492,880 - 25,498,929 (-)NCBIUU_Cfam_GSD_1.0
Ihh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,131,886 - 175,137,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,474,665 - 1,480,568 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365691,474,693 - 1,480,562 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IHH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,083,753 - 121,090,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,083,750 - 121,090,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,122,714 - 134,129,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IHH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,960,296 - 104,966,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,960,120 - 104,966,585 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,431,690 - 94,438,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ihh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,959,448 - 5,964,769 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,959,329 - 5,965,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034955183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000044601   ⟹   ENSPPAP00000021798
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B224,906,271 - 224,911,506 (-)Ensembl
RefSeq Acc Id: XM_034955183   ⟹   XP_034811074
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v02B106,312,472 - 106,319,124 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034811074 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034811074   ⟸   XM_034955183
RefSeq Acc Id: ENSPPAP00000021798   ⟸   ENSPPAT00000044601
Protein Domains
HintC   HintN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034087 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000021798.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044601.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1380.10 UniProtKB/TrEMBL
InterPro Hedgehog UniProtKB/TrEMBL
  Hedgehog_Hint UniProtKB/TrEMBL
  Hedgehog_sig/DD-Pept_Zn-bd_sf UniProtKB/TrEMBL
  Hedgehog_signalling_dom UniProtKB/TrEMBL
  Hint_dom_C UniProtKB/TrEMBL
  Hint_dom_N UniProtKB/TrEMBL
  Hint_dom_sf UniProtKB/TrEMBL
  IHH UniProtKB/TrEMBL
  Intein_N UniProtKB/TrEMBL
NCBI Gene IHH ENTREZGENE
PANTHER PTHR11889:SF39 UniProtKB/TrEMBL
Pfam HH_signal UniProtKB/TrEMBL
  Hint UniProtKB/TrEMBL
PIRSF Peptidase_C46 UniProtKB/TrEMBL
PRINTS SONICHHOG UniProtKB/TrEMBL
PROSITE INTEIN_N_TER UniProtKB/TrEMBL
SMART HintC UniProtKB/TrEMBL
  HintN UniProtKB/TrEMBL
Superfamily-SCOP SSF51294 UniProtKB/TrEMBL
  SSF55166 UniProtKB/TrEMBL
UniProt A0A2R9AWY9_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-29 IHH  Indian hedgehog signaling molecule    indian hedgehog  Symbol and/or name change 5135510 APPROVED