PPP1CB (protein phosphatase 1 catalytic subunit beta) - Rat Genome Database

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Pathways
Gene: PPP1CB (protein phosphatase 1 catalytic subunit beta) Canis lupus familiaris
Analyze
Symbol: PPP1CB
Name: protein phosphatase 1 catalytic subunit beta
RGD ID: 12319210
Description: ENCODES a protein that exhibits myosin phosphatase activity (ortholog); myosin-light-chain-phosphatase activity (ortholog); phosphatase activity (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; dopamine signaling pathway; glycogen biosynthetic pathway; ASSOCIATED WITH Dandy-Walker syndrome (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN glycogen granule (ortholog); protein phosphatase type 1 complex (ortholog); PTW/PP1 phosphatase complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PP-1B; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase type 1 beta isoform; protein phosphatase type 1 catalytic subunit delta isoform; serine/threonine-protein phosphatase PP1-beta catalytic subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,680,691 - 22,699,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,679,783 - 22,699,999 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1722,457,238 - 22,494,559 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01723,225,044 - 23,264,565 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,225,011 - 23,268,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,524,746 - 22,562,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,577,001 - 22,614,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,693,483 - 22,730,878 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PPP1CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,680,691 - 22,699,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,679,783 - 22,699,999 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1722,457,238 - 22,494,559 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01723,225,044 - 23,264,565 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,225,011 - 23,268,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,524,746 - 22,562,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,577,001 - 22,614,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,693,483 - 22,730,878 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PPP1CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38228,751,604 - 28,802,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,751,562 - 28,802,940 (+)Ensemblhg38GRCh38
GRCh37228,974,470 - 29,025,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,828,118 - 28,879,310 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34228,886,264 - 28,937,456NCBI
Celera228,820,144 - 28,871,300 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,716,532 - 28,767,764 (+)NCBIHuRef
CHM1_1228,904,700 - 28,955,863 (+)NCBICHM1_1
T2T-CHM13v2.0228,795,220 - 28,846,552 (+)NCBIT2T-CHM13v2.0
Ppp1cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,616,192 - 32,651,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,616,187 - 32,674,777 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38532,458,848 - 32,493,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,458,843 - 32,517,433 (+)Ensemblmm10GRCm38
MGSCv37532,761,343 - 32,796,085 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36532,735,841 - 32,769,335 (+)NCBIMGSCv36mm8
Celera529,932,959 - 29,967,634 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Ppp1cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8629,681,099 - 29,712,835 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl629,681,100 - 29,712,924 (-)EnsemblGRCr8
mRatBN7.2623,958,813 - 23,992,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl623,960,998 - 23,992,824 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx624,260,597 - 24,292,337 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,576,477 - 24,608,213 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,065,465 - 24,097,720 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd631,128,757 - 31,160,493 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive630,565,323 - 30,597,058 (-)NCBILyon_Normotensive
Lyon_Hypertensive628,361,162 - 28,392,898 (-)NCBILyon_Hypertensive
F344_StmMcwi627,573,217 - 27,604,958 (-)NCBIF344_StmMcwi
Rnor_6.0623,548,507 - 23,581,136 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)Ensemblrn6Rnor6.0
Rnor_5.0633,416,540 - 33,448,276 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4624,067,544 - 24,099,280 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera623,460,146 - 23,491,883 (-)NCBICelera
RGSC_v3.1624,070,497 - 24,102,233 (-)NCBI
Cytogenetic Map6q14NCBI
Ppp1cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546910,662,032 - 10,682,398 (+)Ensembl
ChiLan1.0NW_00495546910,657,029 - 10,682,398 (+)NCBIChiLan1.0ChiLan1.0
PPP1CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21297,705,718 - 97,757,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A97,709,065 - 97,761,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,758,176 - 28,809,561 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,863,650 - 28,889,401 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,862,083 - 28,889,401 (+)EnsemblpanPan2panpan1.1
Ppp1cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629266,837,482 - 66,858,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,981,370 - 4,002,667 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,981,364 - 4,002,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3110,437,688 - 110,474,891 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13110,437,681 - 110,474,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,257,014 - 117,275,122 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11478,802,295 - 78,852,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1478,804,548 - 78,852,682 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604533,280,709 - 33,332,417 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,689,152 - 10,730,171 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473810,689,395 - 10,730,171 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1cb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1721,671,817 - 21,704,192 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PPP1CB
204 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000008467   ⟹   ENSCAFP00000007848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1722,680,019 - 22,699,999 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000074645   ⟹   ENSCAFP00000054843
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1722,679,783 - 22,696,887 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000083509   ⟹   ENSCAFP00000050877
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1722,680,610 - 22,699,999 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000086763   ⟹   ENSCAFP00000063144
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1722,680,481 - 22,696,494 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845018787   ⟹   ENSCAFP00845014669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,225,011 - 23,264,547 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845018826   ⟹   ENSCAFP00845014699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,225,145 - 23,264,145 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845018886   ⟹   ENSCAFP00845014754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,225,153 - 23,268,387 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845018937   ⟹   ENSCAFP00845014798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,242,612 - 23,259,720 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845019123   ⟹   ENSCAFP00845014939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,242,937 - 23,268,395 (+)Ensembl
RefSeq Acc Id: NM_001003034   ⟹   NP_001003034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11722,680,691 - 22,699,999 (+)NCBI
Dog10K_Boxer_Tasha1722,457,238 - 22,494,559 (+)NCBI
ROS_Cfam_1.01723,225,434 - 23,262,840 (+)NCBI
UMICH_Zoey_3.11722,524,746 - 22,562,152 (+)NCBI
UNSW_CanFamBas_1.01722,577,001 - 22,614,723 (+)NCBI
UU_Cfam_GSD_1.01722,693,483 - 22,730,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038690429   ⟹   XP_038546357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01723,225,112 - 23,264,565 (+)NCBI
RefSeq Acc Id: XM_038690430   ⟹   XP_038546358
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01723,225,044 - 23,264,565 (+)NCBI
RefSeq Acc Id: XM_038690431   ⟹   XP_038546359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01723,225,175 - 23,264,565 (+)NCBI
RefSeq Acc Id: NP_001003034   ⟸   NM_001003034
- UniProtKB: A0A8I3NEG9 (UniProtKB/TrEMBL),   A0A8P0P0P3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000054843   ⟸   ENSCAFT00000074645
Ensembl Acc Id: ENSCAFP00000050877   ⟸   ENSCAFT00000083509
Ensembl Acc Id: ENSCAFP00000063144   ⟸   ENSCAFT00000086763
Ensembl Acc Id: ENSCAFP00000007848   ⟸   ENSCAFT00000008467
RefSeq Acc Id: XP_038546358   ⟸   XM_038690430
- Peptide Label: isoform X1
- UniProtKB: Q8MJ47 (UniProtKB/Swiss-Prot),   Q8MJ45 (UniProtKB/Swiss-Prot),   A0A8C0LJS5 (UniProtKB/TrEMBL),   A0A8I3NEG9 (UniProtKB/TrEMBL),   A0A8P0P0P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038546357   ⟸   XM_038690429
- Peptide Label: isoform X1
- UniProtKB: Q8MJ47 (UniProtKB/Swiss-Prot),   Q8MJ45 (UniProtKB/Swiss-Prot),   A0A8C0LJS5 (UniProtKB/TrEMBL),   A0A8I3NEG9 (UniProtKB/TrEMBL),   A0A8P0P0P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038546359   ⟸   XM_038690431
- Peptide Label: isoform X1
- UniProtKB: Q8MJ47 (UniProtKB/Swiss-Prot),   Q8MJ45 (UniProtKB/Swiss-Prot),   A0A8C0LJS5 (UniProtKB/TrEMBL),   A0A8I3NEG9 (UniProtKB/TrEMBL),   A0A8P0P0P3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845014669   ⟸   ENSCAFT00845018787
Ensembl Acc Id: ENSCAFP00845014699   ⟸   ENSCAFT00845018826
Ensembl Acc Id: ENSCAFP00845014798   ⟸   ENSCAFT00845018937
Ensembl Acc Id: ENSCAFP00845014754   ⟸   ENSCAFT00845018886
Ensembl Acc Id: ENSCAFP00845014939   ⟸   ENSCAFT00845019123

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005238 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00845010629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000094747.1 UniProtKB/Swiss-Prot
  ENSCAFT00845018787 ENTREZGENE
  ENSCAFT00845018826 ENTREZGENE
  ENSCAFT00845018886 ENTREZGENE
  ENSCAFT00845018886.1 UniProtKB/Swiss-Prot
  ENSCAFT00845019123 ENTREZGENE
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  PP1_catalytic_subunit UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
  STPPase_N UniProtKB/Swiss-Prot
KEGG Report cfa:403558 UniProtKB/Swiss-Prot
NCBI Gene PPP1CB ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
  STPPase_N UniProtKB/Swiss-Prot
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
SMART PP2Ac UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A8C0LJS5 ENTREZGENE
  A0A8C0N6E4_CANLF UniProtKB/TrEMBL
  A0A8C0NB89_CANLF UniProtKB/TrEMBL
  A0A8C0NDQ4_CANLF UniProtKB/TrEMBL
  A0A8C0NG06_CANLF UniProtKB/TrEMBL
  A0A8I3NEG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NG05_CANLF UniProtKB/TrEMBL
  A0A8I3NGF5_CANLF UniProtKB/TrEMBL
  A0A8I3NS10_CANLF UniProtKB/TrEMBL
  A0A8P0P0P3 ENTREZGENE, UniProtKB/TrEMBL
  PP1B_CANLF UniProtKB/Swiss-Prot
  Q8MJ45 ENTREZGENE
  Q8MJ47 ENTREZGENE
UniProt Secondary Q8MJ45 UniProtKB/Swiss-Prot
VGNC ID VGNC:44875 ENTREZGENE