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Gene: CYP7A1 (cytochrome P450 family 7 subfamily A member 1) Canis lupus familiaris

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Symbol:

CYP7A1

Name:

cytochrome P450 family 7 subfamily A member 1

RGD ID:

12142723

Description:

ENCODES a protein that exhibits cholesterol 7-alpha-monooxygenase activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); cellular response to cholesterol (ortholog); cholesterol catabolic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); autism spectrum disorder (ortholog); cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	9,285,315 - 9,295,895 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	9,286,181 - 9,332,310 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	9,598,242 - 9,625,248 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	9,370,713 - 9,397,915 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,417,428 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	9,368,643 - 9,395,863 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	9,494,537 - 9,521,733 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	9,773,555 - 9,801,001 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic hepatitis (ISO)

autism spectrum disorder (ISO)

cholestasis (ISO)

Experimental Liver Cirrhosis (ISO)

extrahepatic cholestasis (ISO)

Hypercholesterolemia (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

Metabolic Syndrome (ISO)

morbid obesity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IBA,IEA)

bile acid metabolic process (ISO)

cellular response to cholesterol (ISO)

cellular response to glucose stimulus (IEA)

cholesterol catabolic process (IEA,ISO)

cholesterol homeostasis (IBA,IEA)

cholesterol metabolic process (IEA)

lipid metabolic process (IEA)

negative regulation of collagen biosynthetic process (ISO)

negative regulation of fatty acid biosynthetic process (ISO)

positive regulation of cholesterol biosynthetic process (ISO)

regulation of bile acid biosynthetic process (IEA)

response to ethanol (ISO)

small molecule metabolic process (IEA)

steroid metabolic process (IEA)

sterol metabolic process (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA)

Molecular Function

cholesterol 7-alpha-monooxygenase activity (IBA,IEA,ISO)

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (ISO)

bile acid signaling pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

Zellweger syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP7A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	9,285,315 - 9,295,895 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	9,286,181 - 9,332,310 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	9,598,242 - 9,625,248 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	9,370,713 - 9,397,915 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,417,428 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	9,368,643 - 9,395,863 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	9,494,537 - 9,521,733 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	9,773,555 - 9,801,001 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

CYP7A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	58,490,178 - 58,500,163 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	58,490,178 - 58,500,163 (-)	Ensembl			hg38	GRCh38
GRCh37	8	59,402,737 - 59,412,722 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	59,565,292 - 59,575,275 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	59,565,291 - 59,575,275	NCBI
Celera	8	55,395,751 - 55,405,734 (-)	NCBI		Celera
Cytogenetic Map	8	q12.1	NCBI
HuRef	8	54,889,962 - 54,899,885 (-)	NCBI		HuRef
CHM1_1	8	59,454,626 - 59,464,609 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	58,911,316 - 58,921,301 (-)	NCBI		T2T-CHM13v2.0

Cyp7a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	6,265,612 - 6,275,632 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	6,265,612 - 6,275,633 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	6,265,612 - 6,275,632 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	6,265,612 - 6,275,633 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	6,192,759 - 6,202,778 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	6,192,759 - 6,202,778 (-)	NCBI		MGSCv36	mm8
Celera	4	6,185,007 - 6,195,027 (-)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	2.91	NCBI

Cyp7a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	24,174,505 - 24,184,202 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	24,174,505 - 24,184,202 (-)	Ensembl				GRCr8
mRatBN7.2	5	19,376,979 - 19,386,676 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	19,376,974 - 19,386,688 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	21,584,097 - 21,593,795 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	23,169,474 - 23,179,158 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	22,949,785 - 22,959,469 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	19,358,734 - 19,368,431 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	19,358,734 - 19,368,431 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	24,143,589 - 24,153,286 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	19,707,159 - 19,716,856 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	18,677,267 - 18,686,964 (-)	NCBI		Celera
RGSC_v3.1	5	19,707,158 - 19,716,856 (-)	NCBI
Cytogenetic Map	5	q12	NCBI

LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	17,036,204 - 17,042,756 (-)	Ensembl
ChiLan1.0	NW_004955454	17,035,105 - 17,078,854 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	74,184,135 - 74,194,121 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	49,837,992 - 49,847,979 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	54,942,509 - 54,952,500 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	56,593,799 - 56,603,933 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	56,593,799 - 56,604,037 (-)	Ensembl			panPan2	panpan1.1

Cyp7a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	70,179,849 - 70,187,118 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	4,599,138 - 4,605,653 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936496	4,599,138 - 4,605,653 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP7A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	74,343,123 - 74,372,621 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	74,343,101 - 74,372,628 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	81,137,378 - 81,166,790 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP7A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	54,475,801 - 54,489,329 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	54,477,105 - 54,485,649 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666039	87,237,971 - 87,247,876 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101701685
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	33,612,901 - 33,619,869 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624744	33,563,564 - 33,619,851 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

LOC116889445
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	136,703,307 - 136,710,694 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in CYP7A1
130 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	31	20	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038441216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038441217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038441218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038460856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038460857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038515792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038515793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038515794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038579361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038579362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038579363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038643602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038643603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038643604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_544091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000011373 ⟹ ENSCAFP00000010535

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	29	9,286,181 - 9,295,983 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000049960 ⟹ ENSCAFP00000041493

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	29	9,286,181 - 9,332,310 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000071215 ⟹ ENSCAFP00000045160

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	29	9,286,181 - 9,332,310 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845048901 ⟹ ENSCAFP00845038359

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,417,428 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845048943 ⟹ ENSCAFP00845038394

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,417,428 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845048983 ⟹ ENSCAFP00845038555

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,382,099 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845049191 ⟹ ENSCAFP00845038599

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	29	9,371,580 - 9,381,318 (-)	Ensembl

RefSeq Acc Id:

XM_038441216 ⟹ XP_038297144

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	29	9,370,713 - 9,381,298 (-)	NCBI

RefSeq Acc Id:

XM_038441217 ⟹ XP_038297145

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	29	9,370,713 - 9,381,944 (-)	NCBI

RefSeq Acc Id:

XM_038441218 ⟹ XP_038297146

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	29	9,370,713 - 9,397,915 (-)	NCBI

RefSeq Acc Id:

XM_038460856 ⟹ XP_038316784

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	29	9,598,242 - 9,609,270 (-)	NCBI

RefSeq Acc Id:

XM_038460857 ⟹ XP_038316785

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	29	9,598,242 - 9,625,248 (-)	NCBI

RefSeq Acc Id:

XM_038515792 ⟹ XP_038371720

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	29	9,368,643 - 9,379,228 (-)	NCBI

RefSeq Acc Id:

XM_038515793 ⟹ XP_038371721

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	29	9,368,643 - 9,379,874 (-)	NCBI

RefSeq Acc Id:

XM_038515794 ⟹ XP_038371722

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	29	9,368,643 - 9,395,863 (-)	NCBI

RefSeq Acc Id:

XM_038579361 ⟹ XP_038435289

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	29	9,773,555 - 9,784,367 (-)	NCBI

RefSeq Acc Id:

XM_038579362 ⟹ XP_038435290

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	29	9,773,555 - 9,785,013 (-)	NCBI

RefSeq Acc Id:

XM_038579363 ⟹ XP_038435291

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	29	9,773,555 - 9,801,001 (-)	NCBI

RefSeq Acc Id:

XM_038643602 ⟹ XP_038499530

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	29	9,494,537 - 9,505,134 (-)	NCBI

RefSeq Acc Id:

XM_038643603 ⟹ XP_038499531

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	29	9,494,537 - 9,505,780 (-)	NCBI

RefSeq Acc Id:

XM_038643604 ⟹ XP_038499532

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	29	9,494,537 - 9,521,733 (-)	NCBI

RefSeq Acc Id:

XM_544091 ⟹ XP_544091

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	29	9,285,315 - 9,295,895 (-)	NCBI
Dog10K_Boxer_Tasha	29	9,598,242 - 9,608,622 (-)	NCBI

Sequence:

show sequence

AGTCTCTCTTCAGTGATATCTTTACCTCTCTATTCAGAGATTCTCTTCTTTAAAAGTTTTGCAT
TAGATTTGCAAAATGATGACCATATCTTTGATCTGGGGGATTGTTGTAGCAGTATGCTGTTGTT
TATGGCTTATTTTTGGAATGAGGAGAAGACAAATGGGTGAACCACCGCTGGAGAATGGGTTGAT
TCCATACCTGGGATGTGCTTTGAAATTTGGTGCCAATCCTCTCGAGTTCCTGAGAGCAAATCAA
AGGAAATATGGTCATGTTTTTACCTGCAGATTGATGGGAAACTATGTCCACTTCATCACAAATC
CCTTGTCATACCAGAAAGTGTTGTGCCATGGAAAATACTTGGATTGGAAAAAGTTTCACTTTAC
TACTTCTGCAAAGGCATTTGGGCACAGAAGCATTGACCCAAGTGATGGAAATACCACTGAAAAT
ATAAATAAAACTTTCATCAAAACCCTGCAGGGCGATGCCTTGAATTCCCTCACAGAAGCCATGA
TGGAAAACCTCCAACTTGTCATGAGATGTCCCCTGGTATCTAAATCAAAGACTCCTGCCTGGGT
GACGGAAGGGATGTATTCCTTCTGTTACCGAGTGATGTTTGAAGCTGGGTATTTAACTCTCTTT
GGCAAAGATCTTACAGGGCAAGATGCACAAAAAGGACTTATTCTGAATAACCTTGACCACTTCA
AGGAATTTGACAAAATCTTTCCTGCTCTGGTAGCAGGCCTCCCCATTCATGTGTTCAAGACGGC
ACACCACGCTAGGGAAAAGCTGGCAGAGGGCTTGAGGCATGAGAACCTTGGAAAGAGAGACCAC
ATCTCGGAACTGGTCAGGTTTCTGAATGACATGCTTTCCACCTTAGATGACATGGATAAGGCTA
AGACGCACCTCGCTATCCTCTGGGCATCACAAGCAAACACTATTCCAGCGACCTTCTGGAGCTT
ATTTCAAATGATTAGGAGCCCTGAAGCAATGAAAGCAGCTACTGAAGAAGTGAATAAAACACTA
GAGAATGCTGGCCAAAAAATCAGCCTTGATGGCAGTCCTATTTGTCTGAATCAAATGCAACTGA
ATGACATGCCAGTGCTAGATAGCCTCATCAAGGAGTCTCTGAGGCTTTCCAGTGCCTCCCTGAA
CATCCGGACTGCTACAGAGGATTTTACTTTGCACCTCCAGGACAGTTCCTATAACATCCGCAAA
GATGACATCATAGCTTTTTATCCGCAGTTAGTGCATTTAGATCCAGAAATCTACCCAGACCCTT
TGACTTTTAAATATGATCGGTATCTTGATGAAAATGGGAAGACAAAGACCACCTTCTATAGTAA
CGGAATCAAGTTAAAGTATTACTACATGCCTTTTGGGTCAGGAGCGACAATGTGTCCTGGAAGA
TTATTTGCTGTCCAGGAAATCAAGCAGTTTTTGATTCTGATGCTTTCCTATTTTGAACTAGAGC
TTGTAGAGAGCCAAGTCAAATGTCCCCCTTTGGACCAGTCCCGTGCAGGCTTAGGCATTTTACC
ACCATTAAATGATATCGAGTTTAAATATAAATTCAAACATTTGTGAACATATAATTGGAAGCAG
AGGACATGAGATGATGTTACCAGTCTGCAGAACACCATCATGTATCTGTCCCTTTGGACAGTGG
CCTTTGGTGGTGGTGGCACTGAGTTACCAGGGGTCCAGCTCTACACATGGATGCTTGCTTCTGA
ATCTTAACATTTTGGTGACTGTTTCCAGATGCTATCTCAGACTGTGCTAGTGAAAAAAACCTAG
ATTCTAGAAGCACAATAATTTCTTTTCATTTGAATAAGTCCATGAATGTTCATCTAACCAGGCA
GCGAAGTTCATTATTTTCAGAGGAAAAATTCTTTGTTTTTTTTTTCCCCACAGTGAAGATATTC
TGATTGGCAAAAGTTTTTATTTTTTTTCCTAAGGAAACAGCTTTATTTTTATAAAAACCACCCA
TTAATTATGAAAAAGGTAAAAATTCACGTTTTAGTGAAACCATATGAGTTTTTTTTGAATAGAT
ATATCTTTTTTTTTCTTTTTTAGAACATAGCCCTCTTATTGTCCAGCACCTGTGACAGTTTCAT
GTCTCTCTAAAGAAGGCAGGAAGCTTAGAGCACTATTAGCCCTTTCAAAGGAAAAGGAGTGGGT
AGGCACACCCAGAAGTCAGTGACTCTCTTAACACTTGGGAATGTGCTACTAGTACAACCAAGCC
CACGCCCAACATACTCCCTACCAGTCAAATGTAGATATATATTATAAAGGATGTTTTAAATGAT
TTTTATCATGCTTTTTAATAAAAAGAAAATGTTTTTCAGCTTTCCCTATATGTGGTATTTAGGG
CTTTTCAAATGGTGACATTTATGTTCTGAAAATATTAAAGATGGTTTTAATATATTCTCTTTAT
CCTTTAATGTATTTTTGCTGGAAACTCTAATGTCTACATCAGGTTGCAACTATCTTACCTATAT
TTTCATAAGATTCTATATTAATGAGAAGATTTTTTTCAGACAATGCGGTTTTTTTCTGGTACTA
CGAAACATGCATCAATAAAGAGAACATAGCTCTTGTGTGATATCTTTTAAAATGAAAATGACCA
TTTGAAAGCCTTGGATATGAAACATACAAAGAGTTTGTTAAATGGAGCTAGAATTGCCTTATTT
AAATACTTTTTATCTTTAAATGACTTGTAGATGAAGGAAATATAATTGAAGGCTATATAGTAGT
GTTTAACCACTATGCATAACAGTGCTTTGGTAAAATATTTTAAACATTGGAGTTATCAGCTATA
CTATTTTTATTGATATTTCTGTATGTATATATATATATATTTTTTTTTTTTTTGAGAGAGAGAG
AGAGAGAGAGAGAGGGACAGAGCAAGCACACATTGCGGGTGGGGAGGAAGAGTAGAGGGAAAAG
GAAAGAAAGAATCTCAAGCAGTCTCCACACCCAGTGTGGAGCCTCACACGGGGCTTGATCTCAT
GACCCCGAGATCACAACCTGAGCTGAAATCAAGAGTCCAACTGTTGACTGAGCCACCAGGAACC
TCTTATGTATGTATTTATATGTAAATTATCTTTTCCTTTTTCCTTGTATACAAATACTAAGAAA
ATATTGTAACATTTGATAATTTTGAAATGATTCACATTTCAGAAATAAAAATATAAATGTGTAT
ATTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038297144	(Get FASTA)	NCBI Sequence Viewer
	XP_038297145	(Get FASTA)	NCBI Sequence Viewer
	XP_038297146	(Get FASTA)	NCBI Sequence Viewer
	XP_038316784	(Get FASTA)	NCBI Sequence Viewer
	XP_038316785	(Get FASTA)	NCBI Sequence Viewer
	XP_038371720	(Get FASTA)	NCBI Sequence Viewer
	XP_038371721	(Get FASTA)	NCBI Sequence Viewer
	XP_038371722	(Get FASTA)	NCBI Sequence Viewer
	XP_038435289	(Get FASTA)	NCBI Sequence Viewer
	XP_038435290	(Get FASTA)	NCBI Sequence Viewer
	XP_038435291	(Get FASTA)	NCBI Sequence Viewer
	XP_038499530	(Get FASTA)	NCBI Sequence Viewer
	XP_038499531	(Get FASTA)	NCBI Sequence Viewer
	XP_038499532	(Get FASTA)	NCBI Sequence Viewer
	XP_544091	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000010535.1
	ENSCAFP00000041493.1
	ENSCAFP00000045160.1
	ENSCAFP00000067374.1
	ENSCAFP00030029036.1
	ENSCAFP00030029052.1
	ENSCAFP00040025936.1
	ENSCAFP00040025963.1
	ENSCAFP00040026000.1
	ENSCAFP00845038359.1
	ENSCAFP00845038394
	ENSCAFP00845038394.1
	ENSCAFP00845038555
	ENSCAFP00845038555.1
	ENSCAFP00845038599
	ENSCAFP00845038599.1

RefSeq Acc Id:	XP_544091 ⟸ XM_544091
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KSE1 (UniProtKB/TrEMBL), A0A8C0SS44 (UniProtKB/TrEMBL), A0A8I3PVJ4 (UniProtKB/TrEMBL), A0A8C0NRH2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMTISLIWGIVVAVCCCLWLIFGMRRRQMGEPPLENGLIPYLGCALKFGANPLEFLRANQRKYG HVFTCRLMGNYVHFITNPLSYQKVLCHGKYLDWKKFHFTTSAKAFGHRSIDPSDGNTTENINKT FIKTLQGDALNSLTEAMMENLQLVMRCPLVSKSKTPAWVTEGMYSFCYRVMFEAGYLTLFGKDL TGQDAQKGLILNNLDHFKEFDKIFPALVAGLPIHVFKTAHHAREKLAEGLRHENLGKRDHISEL VRFLNDMLSTLDDMDKAKTHLAILWASQANTIPATFWSLFQMIRSPEAMKAATEEVNKTLENAG QKISLDGSPICLNQMQLNDMPVLDSLIKESLRLSSASLNIRTATEDFTLHLQDSSYNIRKDDII AFYPQLVHLDPEIYPDPLTFKYDRYLDENGKTKTTFYSNGIKLKYYYMPFGSGATMCPGRLFAV QEIKQFLILMLSYFELELVESQVKCPPLDQSRAGLGILPPLNDIEFKYKFKHL hide sequence

Ensembl Acc Id:

ENSCAFP00000041493 ⟸ ENSCAFT00000049960

Ensembl Acc Id:

ENSCAFP00000010535 ⟸ ENSCAFT00000011373

Ensembl Acc Id:

ENSCAFP00000045160 ⟸ ENSCAFT00000071215

RefSeq Acc Id:	XP_038371722 ⟸ XM_038515794
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038371721 ⟸ XM_038515793
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038371720 ⟸ XM_038515792
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038499532 ⟸ XM_038643604
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038499531 ⟸ XM_038643603
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038499530 ⟸ XM_038643602
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038297146 ⟸ XM_038441218
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SRX9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038297145 ⟸ XM_038441217
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0SU05 (UniProtKB/TrEMBL), A0A8I3PV16 (UniProtKB/TrEMBL), A0A8C0NML0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038297144 ⟸ XM_038441216
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KSE1 (UniProtKB/TrEMBL), A0A8C0SS44 (UniProtKB/TrEMBL), A0A8I3PVJ4 (UniProtKB/TrEMBL), A0A8C0NRH2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038316785 ⟸ XM_038460857
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SRX9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038316784 ⟸ XM_038460856
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0SU05 (UniProtKB/TrEMBL), A0A8I3PV16 (UniProtKB/TrEMBL), A0A8C0NML0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038435291 ⟸ XM_038579363
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SRX9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038435290 ⟸ XM_038579362
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NML0 (UniProtKB/TrEMBL), A0A8C0SU05 (UniProtKB/TrEMBL), A0A8I3PV16 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038435289 ⟸ XM_038579361
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KSE1 (UniProtKB/TrEMBL), A0A8C0NRH2 (UniProtKB/TrEMBL), A0A8C0SS44 (UniProtKB/TrEMBL), A0A8I3PVJ4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845038555 ⟸ ENSCAFT00845048983

Ensembl Acc Id:

ENSCAFP00845038599 ⟸ ENSCAFT00845049191

Ensembl Acc Id:

ENSCAFP00845038394 ⟸ ENSCAFT00845048943

Ensembl Acc Id:

ENSCAFP00845038359 ⟸ ENSCAFT00845048901

Promoters

RGD ID:

13688404

Promoter ID:

EPDNEW_C6470

Type:

multiple initiation site

Name:

CYP7A1_1

Description:

cytochrome P450 family 7 subfamily A member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	29	9,295,884 - 9,295,944	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000007098	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030018071	UniProtKB/TrEMBL
	ENSCAFG00040016219	UniProtKB/TrEMBL
	ENSCAFG00845027730	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011373.3	UniProtKB/TrEMBL
	ENSCAFT00000049960.4	UniProtKB/TrEMBL
	ENSCAFT00000071215.2	UniProtKB/TrEMBL
	ENSCAFT00000094820.1	UniProtKB/TrEMBL
	ENSCAFT00030033282.1	UniProtKB/TrEMBL
	ENSCAFT00030033300.1	UniProtKB/TrEMBL
	ENSCAFT00040029857.1	UniProtKB/TrEMBL
	ENSCAFT00040029887.1	UniProtKB/TrEMBL
	ENSCAFT00040029928.1	UniProtKB/TrEMBL
	ENSCAFT00845048901.1	UniProtKB/TrEMBL
	ENSCAFT00845048943	ENTREZGENE
	ENSCAFT00845048943.1	UniProtKB/TrEMBL
	ENSCAFT00845048983	ENTREZGENE
	ENSCAFT00845048983.1	UniProtKB/TrEMBL
	ENSCAFT00845049191	ENTREZGENE
	ENSCAFT00845049191.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cholesterol_7a_monooxygenase	UniProtKB/TrEMBL
	CYP450_sterol_14alpha_dmase	UniProtKB/TrEMBL
	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_CYP7A1-type	UniProtKB/TrEMBL
	Cyt_P450_E_grp-IV	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
NCBI Gene	CYP7A1	ENTREZGENE
PANTHER	CYTOCHROME P450 FAMILY 7	UniProtKB/TrEMBL
	PTHR24304:SF1	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PIRSF	Cytochrome_CYP7A1	UniProtKB/TrEMBL
	Cytochrome_CYPVIIA1	UniProtKB/TrEMBL
PRINTS	EP450IV	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A8C0KSE1	ENTREZGENE
	A0A8C0NML0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0NRH2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SRX9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SS44	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SU05	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PV16	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PVJ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3QEK8_CANLF	UniProtKB/TrEMBL
	A0A8I3SAZ3_CANLF	UniProtKB/TrEMBL
	A0A8P0NVG0_CANLF	UniProtKB/TrEMBL
	A0A8P0SVC3_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:50378	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-09	CYP7A1	cytochrome P450 family 7 subfamily A member 1		cytochrome P450, family 7, subfamily A, polypeptide 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB