GGT1 (gamma-glutamyltransferase 1) - Rat Genome Database

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Gene: GGT1 (gamma-glutamyltransferase 1) Canis lupus familiaris
Analyze
Symbol: GGT1
Name: gamma-glutamyltransferase 1
RGD ID: 12114548
Description: ENCODES a protein that exhibits aminoacyltransferase activity (ortholog); leukotriene-C(4) hydrolase activity (ortholog); peptidyltransferase activity (ortholog); INVOLVED IN amino acid metabolic process (ortholog); cellular response to oxidative stress (ortholog); fatty acid metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH aflatoxins-related hepatocellular carcinoma (ortholog); Albuminuria (ortholog); alcohol dependence (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gamma-glutamyltranspeptidase 1; glutathione hydrolase 1 proenzyme; LOC486400
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,301,455 - 28,315,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,360,247 - 27,389,912 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02629,689,666 - 29,719,314 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,692,972 - 29,719,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,773,590 - 27,803,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,390,370 - 27,420,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,380,459 - 28,410,164 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GGT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,301,455 - 28,315,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,360,247 - 27,389,912 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02629,689,666 - 29,719,314 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,692,972 - 29,719,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,773,590 - 27,803,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,390,370 - 27,420,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,380,459 - 28,410,164 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GGT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,583,750 - 24,628,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,594,684 - 24,629,011 (+)Ensemblhg38GRCh38
GRCh372224,979,718 - 25,024,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,309,718 - 23,354,972 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342223,304,271 - 23,349,489NCBI
Celera228,779,459 - 8,824,717 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,929,404 - 7,974,708 (+)NCBIHuRef
CHM1_12224,938,527 - 24,983,991 (+)NCBICHM1_1
T2T-CHM13v2.02225,045,351 - 25,090,447 (+)NCBIT2T-CHM13v2.0
Ggt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,396,910 - 75,422,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,397,438 - 75,422,034 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381075,561,076 - 75,586,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,561,604 - 75,586,200 (+)Ensemblmm10GRCm38
MGSCv371075,036,338 - 75,048,927 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361075,017,309 - 75,029,898 (+)NCBIMGSCv36mm8
Celera1076,618,288 - 76,630,876 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.55NCBI
Ggt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,074,141 - 13,103,551 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2013,074,141 - 13,088,050 (-)EnsemblGRCr8
mRatBN7.22013,074,695 - 13,104,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,074,700 - 13,108,442 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,781,279 - 13,802,241 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,142,223 - 13,163,185 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,614,726 - 13,635,690 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,019,723 - 14,045,781 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,019,723 - 14,025,068 (-)Ensemblrn6Rnor6.0
Rnor_5.02016,209,337 - 16,231,303 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera2014,560,916 - 14,581,414 (-)NCBICelera
Cytogenetic Map20p12NCBI
Ggt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,068,710 - 8,099,584 (+)Ensembl
ChiLan1.0NW_0049554558,082,578 - 8,099,523 (+)NCBIChiLan1.0ChiLan1.0
GGT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,377,966 - 34,418,498 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,108,395 - 37,149,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,424,334 - 5,469,705 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Ggt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,962,444 - 141,979,185 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619762,102 - 791,631 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936619762,278 - 791,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103223058
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,353,922 - 7,406,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236661001,521 - 6,868 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ggt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,030,034 - 10,048,554 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ggt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11811,858,956 - 11,869,227 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in GGT1
197 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00845040543   ⟹   ENSCAFP00845031741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2629,692,972 - 29,719,310 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845040641   ⟹   ENSCAFP00845031812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2629,698,197 - 29,719,310 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845040754   ⟹   ENSCAFP00845031906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2629,705,067 - 29,719,303 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845040844   ⟹   ENSCAFP00845031981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2629,705,067 - 29,719,303 (+)Ensembl
RefSeq Acc Id: XM_038437427   ⟹   XP_038293355
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02629,689,666 - 29,719,314 (+)NCBI
RefSeq Acc Id: XM_038458824   ⟹   XP_038314752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2627,360,247 - 27,389,912 (+)NCBI
RefSeq Acc Id: XM_038512298   ⟹   XP_038368226
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12627,773,590 - 27,803,271 (+)NCBI
RefSeq Acc Id: XM_038575798   ⟹   XP_038431726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02628,380,459 - 28,410,164 (+)NCBI
RefSeq Acc Id: XM_038640010   ⟹   XP_038495938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02627,390,370 - 27,420,073 (+)NCBI
RefSeq Acc Id: XP_038368226   ⟸   XM_038512298
RefSeq Acc Id: XP_038495938   ⟸   XM_038640010
RefSeq Acc Id: XP_038293355   ⟸   XM_038437427
- UniProtKB: A0A8C0K2D8 (UniProtKB/TrEMBL),   A0A8C0T3V0 (UniProtKB/TrEMBL),   A0A8I3PLS6 (UniProtKB/TrEMBL),   A0A8C0P8J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038314752   ⟸   XM_038458824
- UniProtKB: A0A8P0NFJ8 (UniProtKB/TrEMBL),   A0A8C0P8J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431726   ⟸   XM_038575798
- UniProtKB: A0A8C0P8J9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845031741   ⟸   ENSCAFT00845040543
Ensembl Acc Id: ENSCAFP00845031906   ⟸   ENSCAFT00845040754
Ensembl Acc Id: ENSCAFP00845031981   ⟸   ENSCAFT00845040844
Ensembl Acc Id: ENSCAFP00845031812   ⟸   ENSCAFT00845040641


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013899 UniProtKB/TrEMBL
  ENSCAFG00030022118 UniProtKB/TrEMBL
  ENSCAFG00040018650 UniProtKB/TrEMBL
  ENSCAFG00845022970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022055.5 UniProtKB/TrEMBL
  ENSCAFT00000064927.2 UniProtKB/TrEMBL
  ENSCAFT00000078714.2 UniProtKB/TrEMBL
  ENSCAFT00030040601.1 UniProtKB/TrEMBL
  ENSCAFT00030040668.1 UniProtKB/TrEMBL
  ENSCAFT00030040767.1 UniProtKB/TrEMBL
  ENSCAFT00040034469.1 UniProtKB/TrEMBL
  ENSCAFT00040034545.1 UniProtKB/TrEMBL
  ENSCAFT00040034689.1 UniProtKB/TrEMBL
  ENSCAFT00040034842.1 UniProtKB/TrEMBL
  ENSCAFT00845040543.1 UniProtKB/TrEMBL
  ENSCAFT00845040641 ENTREZGENE
  ENSCAFT00845040641.1 UniProtKB/TrEMBL
  ENSCAFT00845040754.1 UniProtKB/TrEMBL
  ENSCAFT00845040844.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.130 UniProtKB/TrEMBL
  3.60.20.40 UniProtKB/TrEMBL
InterPro GGT_CS UniProtKB/TrEMBL
  GGT_lsub_C UniProtKB/TrEMBL
  GGT_peptidase UniProtKB/TrEMBL
  GGT_ssub UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/TrEMBL
NCBI Gene LOC486400 ENTREZGENE
PANTHER GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED UniProtKB/TrEMBL
  PTHR11686 UniProtKB/TrEMBL
Pfam G_glu_transpept UniProtKB/TrEMBL
PRINTS GGTRANSPTASE UniProtKB/TrEMBL
PROSITE G_GLU_TRANSPEPTIDASE UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/TrEMBL
UniProt A0A8C0K2D8 ENTREZGENE
  A0A8C0P3S9_CANLF UniProtKB/TrEMBL
  A0A8C0P8J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RQW1_CANLF UniProtKB/TrEMBL
  A0A8C0T1S5_CANLF UniProtKB/TrEMBL
  A0A8C0T3V0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T4C2_CANLF UniProtKB/TrEMBL
  A0A8C0Z1K5_CANLF UniProtKB/TrEMBL
  A0A8I3PH96_CANLF UniProtKB/TrEMBL
  A0A8I3PHP8_CANLF UniProtKB/TrEMBL
  A0A8I3PLS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PM79_CANLF UniProtKB/TrEMBL
  A0A8P0NFJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NU17_CANLF UniProtKB/TrEMBL
  A0A8P0P4U8_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 GGT1  gamma-glutamyltransferase 1  LOC486400  gamma-glutamyltranspeptidase 1  Symbol and/or name change 5135510 APPROVED