Erbb2 Gene Search Result

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11 records found for search term Erbb2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
10533	Erbb2	erb-b2 receptor tyrosine kinase 2	Enables coreceptor activity and protein tyrosine kinase activity. Involved in several processes, including ERBB2 signaling pathway; nervous system development; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of o ... (more) r within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Part of semaphorin receptor complex. Is active in neuromuscular junction and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]	11	98303310	98328542	Mouse	888	symbol , old_gene_name , PhenoGen , description , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1321970	Pds5b	PDS5 cohesin associated factor B	Predicted to enable DNA binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid syste ... (more) m; nervous system; and sensory organ. Orthologous to human PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Apr 2025]	5	150597178	150734174	Mouse	205	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1550938	Tob2	transducer of ERBB2, 2	Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed ... (more) in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Jul 2025]	15	81732471	81744742	Mouse	127	name , description	gene, protein-coding, VALIDATED [RefSeq]
1558339	Erbin	Erbb2 interacting protein	Predicted to enable signaling receptor binding activity. Involved in negative regulation of monocyte chemotactic protein-1 production; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of postsynaptic membrane neurotransmitter re ... (more) ceptor levels. Acts upstream of or within protein targeting. Located in basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in cerebral cortex and retina nuclear layer. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]	13	103955294	104057094	Mouse	143	old_gene_name , name , description , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
731920	Tob1	transducer of ErbB-2.1	Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in several structur ... (more) es, including 1st branchial arch; back skin; genitourinary system; limb; and sensory organ. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Jul 2025]	11	94100668	94106321	Mouse	177	old_gene_name , description	gene, protein-coding, VALIDATED [RefSeq]
1552554	Memo1	mediator of cell motility 1	Predicted to enable peptide binding activity. Predicted to be involved in regulation of microtubule-based process. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MEMO1 (mediator of ce ... (more) ll motility 1). [provided by Alliance of Genome Resources, Jul 2025]	17	74493759	74602677	Mouse	74	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]
10511	Egfr	epidermal growth factor receptor	Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within se ... (more) veral processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025]	11	16700153	16868158	Mouse	1900	description	gene, protein-coding, VALIDATED [RefSeq]
736142	Erbb3	erb-b2 receptor tyrosine kinase 3	Enables neuregulin receptor activity. Involved in ERBB2-ERBB3 signaling pathway; Schwann cell development; and myelination. Acts upstream of or within several processes, including negative regulation of motor neuron apoptotic process; nervous system development; ... (more) and positive regulation of calcineurin-NFAT signaling cascade. Located in apical plasma membrane and lateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]	10	128403392	128425504	Mouse	524	description	gene, protein-coding, VALIDATED [RefSeq]
1552258	Hbegf	heparin-binding EGF-like growth factor	Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, sp ... (more) reading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025]	18	36637980	36648858	Mouse	488	description	gene, protein-coding, VALIDATED [RefSeq]
734341	Myoc	myocilin	Enables receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; an ... (more) d node of Ranvier. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Jul 2025]	1	162466719	162477263	Mouse	208	description	gene, protein-coding, VALIDATED [RefSeq]
1612360	Nrg2	neuregulin 2	Enables receptor ligand activity. Involved in ERBB2-ERBB3 signaling pathway and ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to huma ... (more) n NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Jul 2025]	18	36147634	36332754	Mouse	132	description	gene, protein-coding, VALIDATED [RefSeq]