| 631351 | Tlr5 | toll-like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide; male gonad development; positive regulation of nitric oxide biosynthetic process; PARTICIPATES IN Toll-like receptor signa ling pathway; ASSOCIATED WITH perinatal necrotizing enterocolitis; Salmonella Infections, Animal; adult respiratory distress syndrome (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 13 | 97166430 | 97190642 | Rat | 150 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1331979 | Tlr5 | toll-like receptor 5 | Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Predicted to be involved in inflammatory response; pattern recognition receptor signaling pathway; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; sensory organ; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 182782317 | 182804010 | Mouse | 200 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348706 | TLR5 | toll like receptor 5 | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] | 1 | 223109404 | 223143248 | Human | 154 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9010445 | Tlr5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-li ke receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955520 | 1544840 | 1562081 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11776166 | TLR5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 1 | 198787046 | 198819537 | Bonobo | 54 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12316177 | TLR5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN extracellular region (inferred); membrane (inferred); plasma membrane (inferred) | 38 | 23700323 | 23705628 | Dog | 52 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12641487 | Tlr5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936526 | 383490 | 387007 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246642 | tlr5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18606148 | TLR5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 596934228 | tlr5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625893883 | Tlr5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-li ke receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14246979 | TLR5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH cadmium nitrate | | | | Pig | 54 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18899806 | Tlr5 | toll like receptor 5 | ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-li ke receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); alcohol use disorder (ortholog); ankylosing spondylitis (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 596935682 | tlr5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155259115 | tlr5.L | | | | | | African Clawed Frog | | symbol | gene, null |
