| 1317896 | RORC | RAR related orphan receptor C | The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogen esis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 151806071 | 151831802 | Human | 297 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317897 | Rorc | RAR-related orphan receptor gamma | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including circadian regulation of gene expression; hematopoietic or lymphoid organ development; and regulation of primary metabolic process. Ac ts upstream of or within several processes, including T cell differentiation; mucosa-associated lymphoid tissue development; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; hemolymphoid system; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 94280106 | 94305583 | Mouse | 331 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1595785 | Rorc | RAR-related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN circadian rhythm; adipose tissue de velopment (ortholog); alpha-beta T cell differentiation (ortholog); ASSOCIATED WITH Dysbiosis; Experimental Autoimmune Myocarditis; advanced sleep phase syndrome (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 2 | 184698779 | 184723942 | Rat | 279 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9008811 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adipose tissue development (ortholo g); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog); nucleus (ortholog) | NW_004955589 | 590653 | 616784 | Chinchilla | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12028797 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | 1 | 127164725 | 127190479 | Bonobo | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12421811 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | 17 | 60821498 | 60842485 | Dog | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12632877 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | NW_004936580 | 1997640 | 2020649 | Squirrel | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18342812 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Green Monkey | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249548 | rorc | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626048651 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adipose tissue development (ortholo g); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog); nucleus (ortholog) | | | | Black Rat | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13982454 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931540 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); ligand-modulated transcription factor activity (ortholog); INVOLVED IN adipose tissue development (or tholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249547 | rorc.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257733 | rorc.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 10054442 | Rorcem3Mcwi | RAR-related orphan receptor C; CRISPR/Cas9 system induced mutant 3, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 8-bp deletion in the Rorc gene | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 10054445 | Rorcem5Mcwi | RAR-related orphan receptor C; CRISPR/Cas9 system induced mutant 5, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 69-bp deletion in the genome and a 9-bp insertion at the deletion site, net 60-bp deletion in the Rorc gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |