| 3281 | Pde4d | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding; cyclic-nucleotide phosphodiesterase activity; enzyme binding; INVOLVED IN adrenergic receptor signaling pathway; establishment of endothelial barrier; lung development; PARTICIPATES IN protein kinase A (PKA) signaling pathway; adeni ne phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Brain Injuries; depressive disorder; Spinal Cord Injuries; FOUND IN centrosome; myofibril; protein-containing complex; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 41748337 | 43262567 | Rat | 320 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11066 | Pde4d | phosphodiesterase 4D, cAMP specific | Enables several functions, including ATPase binding activity; calcium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cAMP/PKA signal transduction; regulation of calcium ion transmembrane transport; and regulation of heart contract ion. Acts upstream of or within several processes, including cellular response to follicle-stimulating hormone stimulus; neutrophil chemotaxis; and ovulation from ovarian follicle. Located in centrosome. Part of potassium channel complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 108790711 | 110092503 | Mouse | 333 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736102 | PDE4D | phosphodiesterase 4D | This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alte rnatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] | 5 | 58969038 | 60522128 | Human | 476 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8784150 | Pde4d | phosphodiesterase 4D | ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-nucleotide phosphodiesterase activity (ortholog); ATPase binding (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular response t o cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN calcium channel complex (ortholog); centrosome (ortholog); cytosol (ortholog) | NW_004955446 | 7914326 | 9252527 | Chinchilla | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11701420 | PDE4D | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); calcium channel regulator activity (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular respo nse to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); membrane (ortholog) | 5 | 53510287 | 55039181 | Bonobo | 123 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12364109 | PDE4D | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); calcium channel regulator activity (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular respo nse to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); membrane (ortholog) | 2 | 45843767 | 47245263 | Dog | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12720761 | Pde4d | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); calcium channel regulator activity (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular respo nse to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); membrane (ortholog) | NW_004936480 | 8123437 | 9235586 | Squirrel | 121 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14144877 | PDE4D | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); calcium channel regulator activity (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular respo nse to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH resveratrol | | | | Pig | 126 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18346925 | PDE4D | phosphodiesterase 4D | ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); calcium channel regulator activity (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular respo nse to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); membrane (ortholog) | | | | Green Monkey | 123 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258384 | pde4d | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626131706 | Pde4d | phosphodiesterase 4D | ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-nucleotide phosphodiesterase activity (ortholog); ATPase binding (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular response t o cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN calcium channel complex (ortholog); centrosome (ortholog); cytosol (ortholog) | | | | Black Rat | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626468824 | pde4d.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183046 | pde4d.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 597538566 | PDE4D-AS1 | PDE4D antisense RNA 1 | | 5 | 59039766 | 59063510 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 2302644 | Pde4dTn(sb-T2/Bart3)2.285Mcwi | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); transposon insertion 2.285, Medical College of Wisconsin | this mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Pde4d gene | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 18932826 | LOC101705115 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | | | | | Naked Mole-Rat | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 708410 | Pde4dip | phosphodiesterase 4D interacting protein | ENCODES a protein that exhibits enzyme binding; molecular adaptor activity (ortholog); INVOLVED IN protein-containing complex assembly; astral microtubule organization (ortholog); positive regulation of microtubule nucleation (ortholog); FOUND IN centrosome; myofibril; cortical microtubule plus-end (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 187982002 | 188178937 | Rat | 187 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1352019 | PDE4DIP | phosphodiesterase 4D interacting protein | The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this g ene. [provided by RefSeq, Aug 2010] | 1 | 148808434 | 149033016 | Human | 205 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1620696 | Pde4dip | phosphodiesterase 4D interacting protein (myomegalin) | Predicted to enable enzyme binding activity and molecular adaptor activity. Predicted to be involved in microtubule cytoskeleton organization; protein-containing complex assembly; and regulation of organelle organization. Predicted to be located in myofibril and nucleus. Predicted to be active in Go lgi apparatus and centrosome. Predicted to colocalize with cortical microtubule plus-end. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 97597144 | 97796023 | Mouse | 201 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8971807 | Pde4dip | phosphodiesterase 4D interacting protein | ENCODES a protein that exhibits enzyme binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN astral microtubule organization (ortholog); positive regulation of microtubule nucleation (ortholog); protein-containing complex assembly (ortholog); FOUND IN centrosome (ortholog); cortical microtubule plus-end (ortholog); cytoplasm (ortholog) | NW_004955568 | 1321053 | 1546351 | Chinchilla | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12103287 | PDE4DIP | phosphodiesterase 4D interacting protein | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN astral microtubule organization (ortholog); positive regulation of microtubule nucleation (ortholog); protein-containing complex assembly (ortholog); FOUND IN centrosome (ortholog); cortical microtubule plus-end (ortholog); cytop lasm (ortholog) | 17 | 57135716 | 57359348 | Dog | 35 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18651865 | PDE4DIP | phosphodiesterase 4D interacting protein | ENCODES a protein that exhibits enzyme binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN astral microtubule organization (ortholog); positive regulation of microtubule nucleation (ortholog); protein-containing complex assembly (ortholog); FOUND IN centrosome (ortholog); cortical microtubule plus-end (ortholog); cytoplasm (ortholog) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865741 | PDE4DIP | phosphodiesterase 4D interacting protein | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155258285 | pde4dip | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858757 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859908 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864290 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865205 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468250 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468276 | pde4dip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858202 | pde4dip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861312 | pde4dip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862519 | pde4dip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863384 | pde4dip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188424 | pde4dip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 8694007 | PDE4DIPP1 | PDE4DIP pseudogene 1 | INTERACTS WITH benzo[a]pyrene | 1 | 148049302 | 148094777 | Human | 1 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 30310094 | PDE4DIPP2 | PDE4DIP pseudogene 2 | INTERACTS WITH acrylamide | 1 | 120469628 | 120665436 | Human | 1 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 16555621 | PDE4DIPP3 | PDE4DIP pseudogene 3 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, unprocessed_pseudogene |
| 30310021 | PDE4DIPP3 | PDE4DIP pseudogene 3 | | 1 | 143811402 | 143840303 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 16567609 | PDE4DIPP4 | PDE4DIP pseudogene 4 | | 1 | 120985692 | 121052167 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 16567431 | PDE4DIPP5 | PDE4DIP pseudogene 5 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, unprocessed_pseudogene |
| 30310005 | PDE4DIPP5 | PDE4DIP pseudogene 5 | | 1 | 145506385 | 145567501 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 32716554 | PDE4DIPP6 | PDE4DIP pseudogene 6 | | 1 | 148402506 | 148432546 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 16555864 | PDE4DIPP7 | PDE4DIP pseudogene 7 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, transcribed_unprocessed_pseudogene |
| 32716582 | PDE4DIPP7 | PDE4DIP pseudogene 7 | | 1 | 149719677 | 149748834 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 32716622 | PDE4DIPP8 | PDE4DIP pseudogene 8 | | 1 | 16548651 | 16551230 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16554669 | PDE4DIPP9 | PDE4DIP pseudogene 9 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, unprocessed_pseudogene |
| 32716487 | PDE4DIPP9 | PDE4DIP pseudogene 9 | | 1 | 16856711 | 16859284 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16554237 | PDE4DIPP10 | PDE4DIP pseudogene 10 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, unprocessed_pseudogene |
| 32716533 | PDE4DIPP10 | PDE4DIP pseudogene 10 | | 1 | 21411456 | 21411990 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11853855 | LOC100977296 | myomegalin | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN protein-containing complex assembly (ortholog); FOUND IN centrosome (ortholog); myofibril (ortholog) | 1 | 122445609 | 122452842 | Bonobo | 5 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11944169 | LOC100988482 | myomegalin | ENCODES a protein that exhibits molecular adaptor activity (inferred); zinc ion binding (inferred); INVOLVED IN astral microtubule organization (ortholog); FOUND IN cortical microtubule plus-end (ortholog); cytoplasm (ortholog) | 1 | 120522499 | 120693837 | Bonobo | 26 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908929 | LOC101715007 | myomegalin | ENCODES a protein that exhibits molecular adaptor activity (inferred); zinc ion binding (inferred); INVOLVED IN centrosome cycle (inferred); positive regulation of microtubule nucleation (inferred); regulation of Golgi organization (inferred); FOUND IN centrosome (inferred); Golgi apparatus (inferre d); microtubule organizing center (inferred) | | | | Naked Mole-Rat | 11 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14267841 | LOC100624559 | myomegalin | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN astral microtubule organization (ortholog); positive regulation of microtubule nucleation (ortholog); protein-containing complex assembly (ortholog); FOUND IN centrosome (ortholog); cortical microtubule plus-end (ortholog); cytop lasm (ortholog) | | | | Pig | 35 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16568478 | AC239860.1 | phosphodiesterase 4D interacting protein (PDE4DIP) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16570348 | AC241585.3 | phosphodiesterase 4D interacting protein (PDE4DIP) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16567283 | AC244669.2 | phosphodiesterase 4D interacting protein (PDE4DIP) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16551534 | AC239859.1 | phosphodiesterase 4D interacting protein (myomegalin) (PDE4DIP) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16552225 | AC245297.1 | phosphodiesterase 4D interacting protein (myomegalin) (PDE4DIP) pseudogene | | | | | Human | | name | gene, transcribed_unprocessed_pseudogene |
| 16569628 | AL021920.2 | phosphodiesterase 4D interacting protein (myomegalin) (PDE4DIP) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16552690 | AC239800.1 | novel pseudogene, similar to phosphodiesterase 4D interacting protein PDE4DIP | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16570664 | AC241377.3 | novel pseudogene, similar to phosphodiesterase 4D interacting protein PDE4DIP | | | | | Human | | name | gene, transcribed_unprocessed_pseudogene |