| 1316061 | Pan3 | PAN3 poly(A) specific ribonuclease subunit | Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 147363018 | 147485310 | Mouse | 91 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1590880 | Pan3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (orth olog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; FOUND IN P-body (ortholog); PAN complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene | 12 | 12512835 | 12637066 | Rat | 82 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603874 | PAN3 | poly(A) specific ribonuclease subunit PAN3 | Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 28138193 | 28295335 | Human | 86 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8916232 | Pan3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (orth olog); PARTICIPATES IN microRNA pathway; FOUND IN P-body (ortholog); PAN complex (ortholog) | NW_004955497 | 7500478 | 7646541 | Chinchilla | 14 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11707837 | PAN3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits ATP binding (inferred); metal ion binding (inferred); nucleotide binding (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (o rtholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 13 | 9420405 | 9579859 | Bonobo | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12229209 | PAN3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits ATP binding (inferred); metal ion binding (inferred); nucleotide binding (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (o rtholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 25 | 11416321 | 11550830 | Dog | 38 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12689149 | Pan3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits ATP binding (inferred); metal ion binding (inferred); nucleotide binding (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (o rtholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | NW_004936472 | 23297679 | 23434107 | Squirrel | 37 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14372916 | PAN3 | | | | | | Yeast | | symbol | gene, null |
| 18905815 | Pan3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | | | | Naked Mole-Rat | 36 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626143081 | Pan3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (orth olog); PARTICIPATES IN microRNA pathway; FOUND IN P-body (ortholog); PAN complex (ortholog) | | | | Black Rat | 14 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18713388 | PAN3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits ATP binding (inferred); metal ion binding (inferred); nucleotide binding (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (o rtholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | | | | Green Monkey | 37 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14063339 | PAN3 | poly(A) specific ribonuclease subunit PAN3 | ENCODES a protein that exhibits ATP binding (inferred); metal ion binding (inferred); nucleotide binding (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (o rtholog); PARTICIPATES IN microRNA pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | | | | Pig | 38 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155236972 | pan3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155236454 | pan3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236971 | pan3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5131763 | PAN3-AS1 | PAN3 antisense RNA 1 | INTERACTS WITH beta-lapachone; dorsomorphin; melatonin | 13 | 28136843 | 28139174 | Human | 9 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1350327 | NLRP6 | NLR family pyrin domain containing 6 | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] | 11 | 278407 | 285388 | Human | 125 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737618 | Pcsk1n | proprotein convertase subtilisin/kexin type 1 inhibitor | Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space; secretory granule; and trans-Golgi network. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Jul 2025] | X | 7786061 | 7790649 | Mouse | 103 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18908130 | LOC106010801 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1303301 | Pan2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN P-body (ortholog); PAN complex (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium atom | 7 | 1313654 | 1332252 | Rat | 127 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1348496 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 12 | 56316936 | 56334000 | Human | 121 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1553696 | Pan2 | PAN2 poly(A) specific ribonuclease subunit | Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process. Located in P-body. I s expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128135106 | 128157227 | Mouse | 128 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 11863860 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) ta il shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 12 | 32581728 | 32598445 | Bonobo | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12274827 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) ta il shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 10 | 621286 | 636899 | Dog | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12575465 | Pan2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) ta il shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN nucleus (inferred); P-body (inferred); PAN complex (inferred) | NW_004936646 | 719821 | 737284 | Squirrel | 34 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18529448 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) ta il shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | | | | Green Monkey | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625944029 | Pan2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN P-body (ortholog); PAN complex (ortholog) | | | | Black Rat | 12 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
