| 1309329 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN response to peptide hormone; retina vasculature morphogenesis in camera-type eye; adipose tissue development (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern; ASSOCIATED WITH autosomal dominant polycystic kidney disease; Femur Head Necrosis; osteoporosis; FOUND IN plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 210243499 | 210346886 | Rat | 322 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319617 | LRP5 | LDL receptor related protein 5 | This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on th e basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] | 11 | 68298412 | 68449275 | Human | 1309 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319618 | Lrp5 | low density lipoprotein receptor-related protein 5 | Enables Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; osteoblast development; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including embryonic morphogen esis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease (multiple). Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 3634825 | 3736574 | Mouse | 525 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9040848 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regression (ortholog); PARTICIPATES IN alter ed Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | NW_004955422 | 17394371 | 17475244 | Chinchilla | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11858708 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | 11 | 63396511 | 63534471 | Bonobo | 153 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12365689 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | 18 | 49439494 | 49555375 | Dog | 157 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12545303 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); receptor complex (inferred) | NW_004936599 | 1746309 | 1814471 | Squirrel | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251846 | lrp5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14030019 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 151 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626149741 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regression (ortholog); PARTICIPATES IN alter ed Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | | | | Black Rat | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18789018 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin sign aling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 154 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899907 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regression (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathwa y; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN receptor complex (ortholog) | | | | Naked Mole-Rat | 154 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239325 | lrp5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 41404647 | Lrp5em1Vari | LDL receptor related protein 5;CRISPR/Cas9 induced mutant 1, Vari | ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern | | | | Rat | 7 | symbol , description | gene, allele |
| 41404650 | Lrp5em2Vari | LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari | ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern | | | | Rat | 6 | symbol , description | gene, allele |
| 41404652 | Lrp5em3Vari | LDL receptor related protein 5; CRISPR/Cas9 induced mutant 3, Vari | ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern | | | | Rat | 7 | symbol , description | gene, allele |
| 1606195 | LRP5L | LDL receptor related protein 5 like (pseudogene) | INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methylcholine | 22 | 25351418 | 25405408 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 11943432 | LOC100983183 | low-density lipoprotein receptor-related protein 5 | | 22 | 6293669 | 6358052 | Bonobo | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1558526 | Fzd8 | frizzled class receptor 8 | Enables several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in Wnt signaling pathway. Acts upstream of or within several processes, including T cell differentiation in thymus; canonical Wnt signaling pathway; and positive regula tion of JUN kinase activity. Located in plasma membrane. Part of Wnt-Frizzled-LRP5/6 complex. Is active in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 9212856 | 9216201 | Mouse | 195 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560525 | Fzd8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; basal cell carcinoma pathway; Wnt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); plasma membrane (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 17 | 62007849 | 62015485 | Rat | 174 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8823096 | Fzd8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); plasma membrane (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | NW_004955462 | 5870410 | 5873714 | Chinchilla | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12161270 | FZD8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | 2 | 1319179 | 1322103 | Dog | 40 | description | gene, protein-coding, MODEL [RefSeq] |
| 32733190 | FZD8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); plasma membrane (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | 10 | 35766112 | 35770154 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18398058 | FZD8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); plasma membrane (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | | | | Green Monkey | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 626155440 | Fzd8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); plasma membrane (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | | | | Black Rat | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 13870731 | FZD8 | frizzled class receptor 8 | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN Wnt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog ); FOUND IN neuronal dense core vesicle (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | | | | Pig | 41 | description | gene, protein-coding, MODEL [RefSeq] |
| 18901458 | Fzd8 | frizzled class receptor 8 | ENCODES a protein that exhibits PDZ domain binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN angiogenesis (ortholog); canonical Wnt signaling pathway (ortholog); positive regulation of JUN kinase activity (ortholog); PARTICIPATES IN W nt signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN neuronal dense core vesicle (ortholog); Wnt-Frizzled-LRP5/6 complex (ortholog) | | | | Naked Mole-Rat | 40 | description | gene, protein-coding, MODEL [RefSeq] |
| 1319984 | Wnt9b | wingless-type MMTV integration site family, member 9B | Enables co-receptor binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and kidney development. Predicted to be located in extracellular region. Predicted to be part of Wnt-Frizzled-< span style='font-weight:700;'>LRP5/6 complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; epithelium; genitourinary system; heart; and surface ectoderm. Orthologous to human WNT9B (Wnt family member 9B). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 103618188 | 103666098 | Mouse | 140 | description | gene, protein-coding, VALIDATED [RefSeq] |