Lrp5<sup>em2Vari</sup> (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lrp5em2Vari (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari) Rattus norvegicus
Analyze
Symbol: Lrp5em2Vari
Name: LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari
RGD ID: 41404650
Description: CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos.
ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern
Type: allele  of Lrp5  
Previously known as: LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari; Lrp5^[em2Vari]
Is Marker For: Strains:   SD-Lrp5em2Vari   SD-Lrp5em2Vari/Rrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature. Ubels JL, etal., CRISPR J. 2020 Aug;3(4):284-298. doi: 10.1089/crispr.2020.0009.

Genomics


Related Rat Strains
The following Strains have been annotated to Lrp5em2Vari
SD-Lrp5em2Vari     SD-Lrp5em2Vari/Rrrc    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-29 Lrp5em2Vari  LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari  Lrp5em2Vari  LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari  Name changed 629549 APPROVED