| 2613 | Fgg | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding; cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to interleukin-1; cellular response to interleukin-6; platelet maturation; PARTICIPATES IN acenocoumarol pharmacodynamics pathway ; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; Inflammation; Kidney Reperfusion Injury; FOUND IN blood microparticle; cell cortex (ortholog); cell surface (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 170652929 | 170660372 | Rat | 314 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10586 | Fgg | fibrinogen gamma chain | This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene i s located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] | 3 | 82915031 | 82922363 | Mouse | 354 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 731481 | FGG | fibrinogen gamma chain | The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] | 4 | 154604136 | 154612656 | Human | 429 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8740878 | Fgg | fibrinogen gamma chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN blood coagulation, fibrin clot formation (ortholog); cell-matrix adhesion (ortholog); cellular response to interleukin-1 (ortholog); PAR TICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | NW_004955471 | 8786910 | 8794947 | Chinchilla | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11999017 | FGG | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to interleukin-6 (ortholog); platelet maturation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); synapse (ortholog) | 4 | 146970671 | 146979348 | Bonobo | 110 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12333033 | FGG | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to interleukin-6 (ortholog); platelet maturation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); synapse (ortholog) | 15 | 52261215 | 52270077 | Dog | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12611915 | Fgg | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to interleukin-6 (ortholog); platelet maturation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); synapse (ortholog) | NW_004936576 | 1343657 | 1352085 | Squirrel | 98 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13976603 | FGG | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to interleukin-6 (ortholog); platelet maturation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); synapse (ortholog); INTERACTS WITH ammonia | | | | Pig | 97 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18609661 | FGG | fibrinogen gamma chain | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to interleukin-6 (ortholog); platelet maturation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); synapse (ortholog) | | | | Green Monkey | 110 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919403 | Fgg | fibrinogen gamma chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); identical protein binding (ortholog); structural molecule activity (ortholog); INVOLVED IN blood coagulation, fibrin clot formation (ortholog); cell-matrix adhesion (ortholog); cellular response to interleukin-1 (ortholog); P ARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254628 | fgg | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625887494 | Fgg | fibrinogen gamma chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN blood coagulation, fibrin clot formation (ortholog); cell-matrix adhesion (ortholog); cellular response to interleukin-1 (ortholog); PAR TICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); brain small vessel disease (ortholog); congenital afibrinogenemia (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | | | | Black Rat | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258222 | fgg.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243380 | fgg.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572842 | AC107385.2 | fibrinogen gamma chain (FGG) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 1359429 | Fggy | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate phosphorylation (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH obesity (ortholog); Weight G ain (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 115514573 | 115901713 | Rat | 120 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1558424 | Fggy | FGGY carbohydrate kinase domain containing | Predicted to enable D-ribulokinase activity. Predicted to be involved in carbohydrate phosphorylation; neuron cellular homeostasis; and pentose metabolic process. Predicted to be active in cytoplasm. Is expressed in liver lobe; metanephros; and olfactory epithelium. Orthologous to human FGG 'font-weight:700;'>FGGY (FGGY carbohydrate kinase domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 95445717 | 95815176 | Mouse | 121 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605365 | FGGY | FGGY carbohydrate kinase domain containing | This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations hav e not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] | 1 | 59296378 | 59762730 | Human | 119 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8926776 | Fggy | FGGY carbohydrate kinase domain containing | INVOLVED IN carbohydrate phosphorylation (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH obesity (ortholog); Weight Gain (ortholog) | NW_004955464 | 188037 | 683230 | Chinchilla | 4 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12029837 | FGGY | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); neuron cellular homeostasis (inferred); A SSOCIATED WITH obesity (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred) | 1 | 58561066 | 59020520 | Bonobo | 14 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12051886 | FGGY | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); neuron cellular homeostasis (inferred); A SSOCIATED WITH obesity (ortholog); Weight Gain (ortholog) | 5 | 50109660 | 50523896 | Dog | 14 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12625017 | Fggy | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); neuron cellular homeostasis (inferred); A SSOCIATED WITH obesity (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred) | NW_004936522 | 2196664 | 2589311 | Squirrel | 14 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14107861 | FGGY | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); neuron cellular homeostasis (inferred); A SSOCIATED WITH obesity (ortholog); Weight Gain (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18606476 | FGGY | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); neuron cellular homeostasis (inferred); A SSOCIATED WITH obesity (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 14 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18933550 | Fggy | FGGY carbohydrate kinase domain containing | ENCODES a protein that exhibits D-ribulokinase activity (inferred); kinase activity (inferred); phosphotransferase activity, alcohol group as acceptor (inferred); INVOLVED IN neuron cellular homeostasis (ortholog); ASSOCIATED WITH obesity (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (infer red) | | | | Naked Mole-Rat | 13 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155241154 | fggy | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626137985 | Fggy | FGGY carbohydrate kinase domain containing | INVOLVED IN carbohydrate phosphorylation (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH obesity (ortholog); Weight Gain (ortholog) | | | | Black Rat | 4 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155241153 | fggy.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861388 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861930 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863636 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865275 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181221 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182706 | fggy.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16552940 | FGGY-DT | FGGY divergent transcript | INTERACTS WITH benzo[a]pyrene; bisphenol A; permethrin | 1 | 59131936 | 59146807 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, PREDICTED [RefSeq] |
| 38632281 | FGGY-DT | FGGY divergent transcript | | 1 | 59289296 | 59296550 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1603635 | ITFG2 | integrin alpha FG-GAP repeat containing 2 | Involved in cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Located in Golgi apparatus and lysosomal membrane. Part of KICSTOR complex. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 2812668 | 2859791 | Human | 69 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1344759 | GK | glycerol kinase | The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this ge ne are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] | X | 30653423 | 30731462 | Human | 327 | description | gene, protein-coding, REVIEWED [RefSeq] |