| 70908 | Crot | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity; INVOLVED IN response to xenobiotic stimulus; carnitine metabolic process (ortholog); coenzyme A metabolic process (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN peroxisome; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-naphthyl isothiocyanate | 4 | 26031729 | 26088057 | Rat | 251 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732197 | CROT | carnitine O-octanoyltransferase | This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009] | 7 | 87345664 | 87399794 | Human | 237 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732198 | Crot | carnitine O-octanoyltransferase | Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 9016033 | 9047926 | Mouse | 245 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8861992 | Crot | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN carnitine metabolic process (ortholog); cellular response to norepinephrine stimulus (ortholog); coenzyme A metabolic process (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarni tine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | NW_004955607 | 379121 | 413394 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11774588 | CROT | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); fatty acid transport (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | 7 | 79339498 | 79393676 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12331923 | CROT | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); fatty acid transport (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | 14 | 13475130 | 13532536 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12572867 | Crot | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); fatty acid transport (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | NW_004936763 | 1425394 | 1462638 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14087595 | CROT | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); fatty acid transport (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | | | | Pig | 33 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18720746 | CROT | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); fatty acid transport (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251906 | crot | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625843932 | Crot | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN carnitine metabolic process (ortholog); cellular response to norepinephrine stimulus (ortholog); coenzyme A metabolic process (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarni tine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915138 | Crot | carnitine O-octanoyltransferase | ENCODES a protein that exhibits carnitine O-octanoyltransferase activity (ortholog); INVOLVED IN carnitine metabolic process (ortholog); cellular response to norepinephrine stimulus (ortholog); coenzyme A metabolic process (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarni tine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN peroxisome (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257229 | crot.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 10026221 | Gm40264 | predicted gene, 40264 | Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 9084746 | 9088592 | Mouse | | old_gene_symbol | gene, ncrna, MODEL [RefSeq] |
| 1602719 | DRICH1 | aspartate rich 1 | INTERACTS WITH benzo[a]pyrene; crotonaldehyde; silicon dioxide | 22 | 23580880 | 23632816 | Human | 7 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1549745 | Cdyl | chromodomain Y-like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (ortholog); chromatin binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); random inactivation of X chromosome (ortholog); spermatid development (ortholog); ASSOCIATED WITH epilepsy (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (ortholog); cytoplasm (ortholog); nuclear speck (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 17 | 29188697 | 29409805 | Rat | 137 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1556912 | Cdyl | chromodomain protein, Y chromosome-like | Enables chromatin binding activity. Involved in negative regulation of peptidyl-lysine crotonylation; random inactivation of X chromosome; and spermatid development. Located in chromosome; cytoplasm; and nucleus. Is expressed in 2-cell stage embryo; 4-cell stage embryo; cap mesenchyme; and ureteric tip. Used to study epilepsy. Orthologous to human CDYL (chromodomain Y like). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 35843801 | 36058047 | Mouse | 127 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606325 | CDYL | chromodomain Y like | Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] | 6 | 4706138 | 4955544 | Human | 120 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1348463 | EP300 | EP300 lysine acetyltransferase | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regul ation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] | 22 | 41092592 | 41180077 | Human | 1195 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1552027 | Ep300 | E1A binding protein p300 | Enables several functions, including N-acyltransferase activity; p53 binding activity; and transcription coactivator activity. Involved in several processes, including face morphogenesis; protein acylation; and protein stabilization. Acts upstream of or within several processes, including hemopoiesi s; regulation of gene expression; and somitogenesis. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including early conceptus; eye; heart; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 81470329 | 81536273 | Mouse | 955 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8931103 | Cdyl | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (ortholog); chromatin binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); random inactivation of X chromosome (ortholog); spermatid development (ortholog); ASSOCIATED WITH epilepsy (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (ortholog); cytoplasm (ortholog); nuclear speck (ortholog) | NW_004955465 | 8570197 | 8780551 | Chinchilla | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12024398 | CDYL | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (inferred); chromatin binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); ASSOCIATED WITH epileps y (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nuclear speck (inferred) | 6 | 4607088 | 4790742 | Bonobo | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12651897 | Cdyl | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (inferred); chromatin binding (inferred); lyase activity (inferred); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); ASSOCIATED WITH epilepsy (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nuclear speck (inferred) | NW_004936534 | 7525618 | 7601184 | Squirrel | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 18736622 | CDYL | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (inferred); chromatin binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); ASSOCIATED WITH epileps y (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nuclear speck (inferred) | | | | Green Monkey | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 626078890 | Cdyl | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (ortholog); chromatin binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); random inactivation of X chromosome (ortholog); spermatid development (ortholog); ASSOCIATED WITH epilepsy (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (ortholog); cytoplasm (ortholog); nuclear speck (ortholog) | | | | Black Rat | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18921569 | Cdyl | chromodomain Y like | ENCODES a protein that exhibits (2E)-butenoyl-CoA hydratase activity (ortholog); chromatin binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN negative regulation of peptidyl-lysine crotonylation (ortholog); random inactivation of X chromosome (ortholog); spermatid development (ortholog); ASSOCIATED WITH epilepsy (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (ortholog); cytoplasm (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 1318826 | GCDH | glutaryl-CoA dehydrogenase | The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses elec tron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013] | 19 | 12891129 | 12899999 | Human | 494 | description | gene, protein-coding, REVIEWED [RefSeq] |
