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Gene: GCDH (glutaryl-CoA dehydrogenase) Homo sapiens
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Symbol: GCDH
Name: glutaryl-CoA dehydrogenase
Description: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACAD5; GCD; glutaryl-CoA dehydrogenase, mitochondrial; glutaryl-Coenzyme A dehydrogenase; truncated GCDH; truncated glutaryl-CoA dehydrogenase
Orthologs:
Mus musculus (house mouse) : Gcdh (glutaryl-Coenzyme A dehydrogenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gcdh (glutaryl-CoA dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gcdh (glutaryl-CoA dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : GCDH (glutaryl-CoA dehydrogenase)
Canis lupus familiaris (dog) : GCDH (glutaryl-CoA dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gcdh (glutaryl-CoA dehydrogenase)
Sus scrofa (pig) : GCDH (glutaryl-CoA dehydrogenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,891,129 - 12,915,345 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,001,943 - 13,010,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,862,974 - 12,871,783 (+)NCBINCBI36hg18NCBI36
Build 341912,862,973 - 12,871,782NCBI
Celera1912,891,682 - 12,900,491 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,573,809 - 12,582,680 (+)NCBIHuRef
CHM1_11913,002,442 - 13,011,310 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GCDH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318826
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.