| 2200 | Bcl2l1 | Bcl2-like 1 | ENCODES a protein that exhibits BH domain binding; clathrin binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; INVOLVED IN cellular response to astaxanthin; cellular response to cAMP; cellular response to dexamethasone stimulus; PARTICIPATES IN intrinsic apoptotic pathway; erythropoietin signaling pathway; interleukin-3 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis; acute kidney failure; amyotrophic lateral sclerosis; FOUND IN clathrin-coated pit; cytosol; mitochondrial membrane; INTERACTS WITH (R)-carnitine; (R)-lipoic acid; (R)-noradrenaline | 3 | 161713777 | 161764844 | Rat | 1413 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735516 | BCL2L1 | BCL2 like 1 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial memb rane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015] | 20 | 31664452 | 31723963 | Human | 1467 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552009 | Bcl2l1 | BCL2-like 1 | This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014] | 2 | 152600652 | 152673632 | Mouse | 1498 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9056618 | Bcl2l1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); clathrin binding (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular response to alkaloid (ortholog); PARTICIPATES IN erythropoietin s ignaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); centrosome (ortholog); clathrin-coated pit (ortholog) | NW_004955422 | 29254440 | 29307104 | Chinchilla | 289 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11762647 | BCL2L1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular respons e to alkaloid (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN clathrin-coated pit (ortholog); cytosol (ortholog); mitochondrial outer membrane (ortholog) | 20 | 27955688 | 28015950 | Bonobo | 304 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12261823 | BCL2L1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular respons e to alkaloid (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN clathrin-coated pit (ortholog); cytosol (ortholog); mitochondrial outer membrane (ortholog) | 24 | 21145214 | 21209425 | Dog | 303 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12586429 | Bcl2l1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); clathrin binding (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular response to alkaloid (ortholog); PARTICIPATES IN erythropoietin s ignaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); clathrin-coated pit (ortholog); cytoplasm (ortholog) | NW_004936485 | 18654046 | 18707324 | Squirrel | 302 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14155681 | BCL2L1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular respons e to alkaloid (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN centrosome (ortholog); clathrin-coated pit (ortholog); cytoplasm (ortholog); INTERACTS WITH 4-phenylbutyric acid; benzo[a]pyrene; bisphenol A | | | | Pig | 325 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18506319 | BCL2L1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular respons e to alkaloid (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN clathrin-coated pit (ortholog); cytosol (ortholog); mitochondrial outer membrane (ortholog) | | | | Green Monkey | 304 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907961 | Bcl2l1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular respons e to alkaloid (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN clathrin-coated pit (ortholog); cytosol (ortholog); mitochondrial outer membrane (ortholog) | | | | Naked Mole-Rat | 305 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856967 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405856969 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858106 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858486 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858577 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405860455 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405861533 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405861756 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863050 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405864187 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626118839 | Bcl2l1 | BCL2 like 1 | ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); clathrin binding (ortholog); INVOLVED IN apoptotic process in bone marrow cell (ortholog); cell population proliferation (ortholog); cellular response to alkaloid (ortholog); PARTICIPATES IN erythropoietin s ignaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); centrosome (ortholog); clathrin-coated pit (ortholog) | | | | Black Rat | 289 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626171581 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626174295 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179197 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626182411 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626188195 | bcl2l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14700612 | BCL2L1-AS1 | BCL2L1 antisense RNA 1 | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | 20 | 31675108 | 31716844 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1593913 | Bcl2l1-ps1 | Bcl2-like 1, pseudogene 1 | INTERACTS WITH paracetamol | 1 | 166454234 | 166456342 | Rat | 1 | symbol , PhenoGen | gene, protein-coding |
| 621015 | Bcl2l10 | Bcl2-like 10 | ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); identical protein binding (ortholog); INVOLVED IN oligodendrocyte differentiation; apoptotic process (ortholog); microtubule organizing center organization (ortholog); PARTICIPATES IN intrinsic apoptotic path way; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; ammonium chloride; arsenous acid | 8 | 84987833 | 84993878 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731990 | Bcl2l10 | Bcl2-like 10 | Enables identical protein binding activity. Involved in microtubule organizing center organization. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; and positive regulation of a poptotic process. Located in membrane and spindle. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; liver; and meninges. Human ortholog(s) of this gene implicated in multiple myeloma; myelodysplastic syndrome; and stomach carcinoma. Orthologous to human BCL2L10 (BCL2 like 10). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 75255040 | 75258922 | Mouse | 117 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1353095 | BCL2L10 | BCL2 like 10 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008] | 15 | 52109263 | 52112775 | Human | 122 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 12029361 | BCL2L10 | BCL2 like 10 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule organizing center organization (ortholog); negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); negative regulation of intrinsic apoptotic signaling pathway (ortholo g); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN membrane (ortholog) | 15 | 31049509 | 31057273 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12477567 | Bcl2l10 | BCL2 like 10 | ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); identical protein binding (ortholog); INVOLVED IN apoptotic process (ortholog); microtubule organizing center organization (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN intr insic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | NW_004936471 | 13943600 | 13946085 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13961619 | BCL2L10 | BCL2 like 10 | ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); identical protein binding (ortholog); INVOLVED IN microtubule organizing center organization (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of extrinsic apoptotic signali ng pathway in absence of ligand (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog) | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18778677 | BCL2L10 | BCL2 like 10 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule organizing center organization (ortholog); negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); negative regulation of intrinsic apoptotic signaling pathway (ortholo g); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN membrane (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907984 | Bcl2l10 | BCL2 like 10 | ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); identical protein binding (ortholog); INVOLVED IN microtubule organizing center organization (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of extrinsic apoptotic signali ng pathway in absence of ligand (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285113697 | bcl2l10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626046509 | Bcl2l10 | BCL2 like 10 | ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); identical protein binding (ortholog); INVOLVED IN apoptotic process (ortholog); microtubule organizing center organization (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN intr insic apoptotic pathway; ASSOCIATED WITH breast carcinoma (ortholog); multiple myeloma (ortholog); myelodysplastic syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 628774 | Bcl2l11 | Bcl2-like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to amyloid-beta; cellular response to estradiol stimulus; cellular response to nerve growth factor stimulus; PARTICIPATES IN intrinsic a poptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 135820042 | 135857330 | Rat | 526 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 734299 | BCL2L11 | BCL2 like 11 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] | 2 | 111120914 | 111168445 | Human | 554 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734300 | Bcl2l11 | BCL2 like 11 | Enables microtubule binding activity and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including apoptotic signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Located in mem brane and mitochondrion. Part of Bcl-2 family protein complex. Is expressed in several structures, including hair outer root sheath; hemolymphoid system gland; metanephros; neural tube; and trunk mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 127967958 | 128004467 | Mouse | 725 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8759575 | Bcl2l11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN in trinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog) | NW_004955470 | 2740682 | 2780225 | Chinchilla | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11800429 | BCL2L11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIAT ED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog); cytosol (ortholog) | 2A | 90862070 | 90909833 | Bonobo | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12179015 | BCL2L11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN in trinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog) | 17 | 35619804 | 35665782 | Dog | 116 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12510312 | Bcl2l11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIAT ED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog); cytosol (ortholog) | NW_004936783 | 15493 | 50959 | Squirrel | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14228752 | BCL2L11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIAT ED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog); cytosol (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride | | | | Pig | 117 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18358319 | BCL2L11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN in trinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog) | | | | Green Monkey | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917884 | Bcl2l11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN in trinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog) | | | | Naked Mole-Rat | 115 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867319 | BCL2L11 | BCL2 like 11 | INVOLVED IN meiosis I (inferred); positive regulation of apoptotic process (inferred); positive regulation of fibroblast apoptotic process (inferred); FOUND IN mitochondrion (inferred) | | | | Green Monkey | 8 | symbol | gene, protein-coding |
| 155243707 | bcl2l11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625884910 | Bcl2l11 | BCL2 like 11 | ENCODES a protein that exhibits dynein complex binding (ortholog); microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN in trinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog) | | | | Black Rat | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307361 | Bcl2l12 | Bcl2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride | 1 | 104608753 | 104617472 | Rat | 82 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316515 | Bcl2l12 | BCL2 like 12 | Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adre nal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 44640646 | 44647011 | Mouse | 88 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606211 | BCL2L12 | BCL2 like 12 | This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] | 19 | 49665142 | 49673916 | Human | 79 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8817316 | Bcl2l12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | NW_004955559 | 1217797 | 1224875 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832552 | BCL2L12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | 19 | 46679749 | 46688539 | Bonobo | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12366984 | BCL2L12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (inferred); INVOLVED IN negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN nucleus (inferred) | 1 | 106865346 | 106873329 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12534807 | Bcl2l12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (inferred); INVOLVED IN negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN nucleus (inferred) | NW_004936664 | 3482562 | 3488663 | Squirrel | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13927234 | BCL2L12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | | | | Pig | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18670943 | BCL2L12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | | | | Green Monkey | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918064 | Bcl2l12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | | | | Naked Mole-Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284552669 | bcl2l12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626010285 | Bcl2l12 | BCL2 like 12 | ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOU ND IN nucleus (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1306985 | Bcl2l13 | Bcl2-like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,4-dinitrotoluene; acetamide; bisphenol A | 4 | 155728284 | 155785058 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315911 | BCL2L13 | BCL2 like 13 | This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] | 22 | 17628877 | 17730855 | Human | 113 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315912 | Bcl2l13 | BCL2 like 13 | Acts upstream of or within several processes, including canonical glycolysis; fat cell differentiation; and mitophagy. Is active in mitochondrion. Orthologous to human BCL2L13 (BCL2 like 13). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 120813167 | 120869803 | Mouse | 127 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8929159 | Bcl2l13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (ortholog); mitochondrion (ortholog) | NW_004955454 | 5692027 | 5770897 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11817228 | BCL2L13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred) | 22 | 1069082 | 1161771 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12283982 | BCL2L13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred) | 27 | 45257017 | 45345085 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12682634 | Bcl2l13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred) | NW_004936807 | 601759 | 678531 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14275924 | BCL2L13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred) | | | | Pig | 24 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18913907 | Bcl2l13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN mitochondrion (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083425 | bcl2l13 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598130265 | BCL2L13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625932274 | Bcl2l13 | BCL2 like 13 | INVOLVED IN apoptotic process (ortholog); ATP biosynthetic process (ortholog); canonical glycolysis (ortholog); FOUND IN membrane (ortholog); mitochondrion (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1557691 | Bcl2l14 | BCL2 like 14 | Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in cytosol. Is expressed in early embry o; genitourinary system; gut; and submandibular gland primordium. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 134373292 | 134415687 | Mouse | 110 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562777 | Bcl2l14 | Bcl2-like 14 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN apoptotic process (ortholog); positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,5-hexanedione; 3-chloropr opane-1,2-diol; bisphenol A | 4 | 168948919 | 168989450 | Rat | 104 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603380 | BCL2L14 | BCL2 like 14 | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009] | 12 | 12049861 | 12099695 | Human | 105 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8865675 | Bcl2l14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN apoptotic process (ortholog); positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (ortholog) | NW_004955413 | 9040272 | 9069266 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11958067 | BCL2L14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (inferred) | 12 | 12072021 | 12122015 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12388907 | BCL2L14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN apoptotic process (inferred); regulation of apoptotic process (inferred); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (inferred) | 27 | 34179481 | 34216374 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12574707 | Bcl2l14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (inferred) | NW_004936587 | 5160085 | 5174855 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13908125 | BCL2L14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN apoptotic process (inferred); regulation of apoptotic process (inferred); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 13 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18623937 | BCL2L14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (inferred) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903526 | Bcl2l14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243142 | bcl2l14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625882236 | Bcl2l14 | BCL2 like 14 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN apoptotic process (ortholog); positive regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH prostate carcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1562344 | Bcl2l15 | Bcl2-like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 194019158 | 194032516 | Rat | 57 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603456 | BCL2L15 | BCL2 like 15 | Predicted to be involved in apoptotic process and regulation of apoptotic process. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 113876816 | 113887581 | Human | 60 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 2302590 | Bcl2l15 | BCLl2-like 15 | Predicted to be involved in regulation of apoptotic process. Located in cytosol and nucleus. Orthologous to human BCL2L15 (BCL2 like 15). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 103738331 | 103761934 | Mouse | 70 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9038488 | Bcl2l15 | BCL2 like 15 | FOUND IN cytosol (ortholog); nucleus (ortholog) | NW_004955435 | 17151721 | 17158808 | Chinchilla | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11923623 | BCL2L15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | 1 | 88668777 | 88680817 | Bonobo | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12270731 | BCL2L15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | 17 | 51690426 | 51696760 | Dog | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12707397 | Bcl2l15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | NW_004936690 | 2245609 | 2250622 | Squirrel | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14084009 | BCL2L15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred); INTERACTS WITH graphene oxide | | | | Pig | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18513360 | BCL2L15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18936411 | Bcl2l15 | BCL2 like 15 | INVOLVED IN regulation of apoptotic process (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625987733 | Bcl2l15 | BCL2 like 15 | FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284153289 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933597 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933684 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933782 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934244 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934424 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934711 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935027 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596936095 | bcl2l13l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 285114161 | bcl2l10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 287527729 | bcl2l10.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250436 | bcl2l11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256662 | bcl2l11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083116 | bcl2l12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288056858 | bcl2l12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 9587211 | BCL2L12P1 | BCL2 like 12 pseudogene 1 | | 3 | 131526468 | 131527141 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 286220693 | bcl2l13.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405855974 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857405 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858620 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862984 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626175905 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626178201 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626184878 | bcl2l14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243141 | bcl2l14.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1586461 | Bcl2l12-ps1 | Bcl2 like 12, pseudogene 1 | | 3 | 154605757 | 154606532 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41394605 | Bcl2l12-ps2 | BCL2 like 12, pseudogene 2 | | 10 | 5101241 | 5103499 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1589918 | Bcl2l13-ps1 | Bcl2-like 13, pseudogene 1 | | 1 | 30721298 | 30729765 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 737535 | IL15 | interleukin 15 | The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus nega tively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] | 4 | 141636583 | 141733987 | Human | 298 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1313009 | IL15RA | interleukin 15 receptor subunit alpha | This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is stru cturally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] | 10 | 5948900 | 5978741 | Human | 129 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737523 | STAT5A | signal transducer and activator of transcription 5A | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] | 17 | 42287439 | 42311943 | Human | 406 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1319194 | STAT6 | signal transducer and activator of transcription 6 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] | 12 | 57095408 | 57111362 | Human | 360 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1624440 | Morrbid | myeloid RNA regulator of BCL2L11 induced cell death | Orthologous to human MIR4435-2HG (MIR4435-2 host gene). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 128140583 | 128271271 | Mouse | 43 | name | gene, ncrna, VALIDATED [RefSeq] |