BCL2L1 (BCL2 like 1) - Rat Genome Database

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Gene: BCL2L1 (BCL2 like 1) Canis lupus familiaris
Analyze
Symbol: BCL2L1
Name: BCL2 like 1
RGD ID: 12261823
Description: ENCODES a protein that exhibits BH domain binding (ortholog); clathrin binding (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); INVOLVED IN aging (ortholog); apoptotic process (ortholog); apoptotic process in bone marrow cell (ortholog); PARTICIPATES IN erythropoietin signaling pathway; interleukin-3 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN clathrin-coated pit (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bcl-2-like protein 1; BCL-XL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,792,367 - 20,843,516 (-)NCBI
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBI
UMICH_Zoey_3.12421,109,822 - 21,160,959 (-)NCBI
UNSW_CanFamBas_1.02421,214,910 - 21,266,211 (-)NCBI
UU_Cfam_GSD_1.02421,645,527 - 21,696,882 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
cryptorchidism  (ISO)
dilated cardiomyopathy  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
gastric ulcer  (ISO)
Head and Neck Neoplasms  (ISO)
Hearing Loss  (ISO)
hematopoietic system disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
leiomyoma  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
mental depression  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephroblastoma  (ISO)
ocular hypertension  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell neoplasm  (ISO)
polycythemia vera  (ISO)
prostate carcinoma  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Retina Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterus interstitial leiomyoma  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
apoptotic process  (ISO)
apoptotic process in bone marrow cell  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to alkaloid  (IEA,ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to astaxanthin  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to gamma radiation  (IEA,ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to prolactin  (ISO)
cellular response to thapsigargin  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (ISO)
defense response to virus  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
fertilization  (IEA,ISO)
germ cell development  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
male gonad development  (IEA,ISO)
mitochondrion morphogenesis  (IEA,ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA)
negative regulation of execution phase of apoptosis  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of protein localization to plasma membrane  (IEA)
neuron apoptotic process  (IEA,ISO)
ovarian follicle development  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of synaptic vesicle clustering  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of synaptic vesicle exocytosis  (ISO)
regulation of apoptotic process  (ISO)
regulation of cytokinesis  (IEA)
regulation of growth  (IEA,ISO)
regulation of long-term synaptic depression  (ISO)
regulation of mitochondrial membrane permeability  (IEA)
regulation of mitochondrial membrane potential  (IEA)
release of cytochrome c from mitochondria  (IEA,ISO)
response to cycloheximide  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to electrical stimulus  (ISO)
response to erythropoietin  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to ischemia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (IEA,ISO)
suppression by virus of host apoptotic process  (IEA,ISO)
synaptic vesicle recycling via endosome  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21781600   PMID:32260403  


Genomics

Comparative Map Data
BCL2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,792,367 - 20,843,516 (-)NCBI
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBI
UMICH_Zoey_3.12421,109,822 - 21,160,959 (-)NCBI
UNSW_CanFamBas_1.02421,214,910 - 21,266,211 (-)NCBI
UU_Cfam_GSD_1.02421,645,527 - 21,696,882 (-)NCBI
BCL2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2031,664,452 - 31,723,989 (-)EnsemblGRCh38hg38GRCh38
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,252,255 - 30,311,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBINCBI36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,171 - 30,214,537 (-)NCBICHM1_1
Bcl2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,675,723 (-)NCBIGRCm39mm39
GRCm39 Ensembl2152,622,588 - 152,673,648 (-)Ensembl
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIGRCm37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBImm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Bcl2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,253,508 - 141,304,582 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3141,253,523 - 141,303,479 (-)Ensembl
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
Bcl2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,254,216 - 29,308,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,254,440 - 29,307,104 (+)NCBIChiLan1.0ChiLan1.0
BCL2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,088,055 - 29,147,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,088,055 - 29,146,585 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02027,955,688 - 28,015,950 (-)NCBIMhudiblu_PPA_v0panPan3
Bcl2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,222,682 - 170,275,934 (-)NCBI
SpeTri2.0NW_00493648518,654,046 - 18,707,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,366,141 - 35,415,359 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,366,139 - 35,415,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,303,991 - 40,304,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,059,024 - 36,118,332 (-)NCBI
ChlSab1.1 Ensembl236,058,919 - 36,116,470 (-)Ensembl
Vero_WHO_p1.0NW_02366605090,796,126 - 90,855,484 (+)NCBI
Bcl2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624741788,445 - 838,513 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 19 3 6 3 6 6 12 8 10 6
Low 3 3 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014106833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014106834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000011308   ⟹   ENSCAFP00000010478
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)Ensembl
RefSeq Acc Id: NM_001003072   ⟹   NP_001003072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,196,352 (-)NCBI
Dog10K_Boxer_Tasha2420,792,367 - 20,843,516 (-)NCBI
ROS_Cfam_1.02421,831,865 - 21,883,036 (-)NCBI
UMICH_Zoey_3.12421,109,822 - 21,160,959 (-)NCBI
UNSW_CanFamBas_1.02421,214,910 - 21,266,211 (-)NCBI
UU_Cfam_GSD_1.02421,645,527 - 21,696,882 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634674   ⟹   XP_005634731
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,197,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634675   ⟹   XP_005634732
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,209,425 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634676   ⟹   XP_005634733
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,197,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634677   ⟹   XP_005634734
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,209,425 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014106833   ⟹   XP_013962308
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,209,425 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014106834   ⟹   XP_013962309
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,145,214 - 21,209,425 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022408808   ⟹   XP_022264516
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,175,325 - 21,197,193 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038432792   ⟹   XP_038288720
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,883,869 (-)NCBI
RefSeq Acc Id: XM_038432793   ⟹   XP_038288721
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,883,869 (-)NCBI
RefSeq Acc Id: XM_038432794   ⟹   XP_038288722
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,884,341 (-)NCBI
RefSeq Acc Id: XM_038432795   ⟹   XP_038288723
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,884,341 (-)NCBI
RefSeq Acc Id: XM_038432796   ⟹   XP_038288724
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBI
RefSeq Acc Id: XM_038432797   ⟹   XP_038288725
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBI
RefSeq Acc Id: XM_038432798   ⟹   XP_038288726
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02421,861,798 - 21,883,874 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005634732   ⟸   XM_005634675
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013962309   ⟸   XM_014106834
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005634734   ⟸   XM_005634677
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013962308   ⟸   XM_014106833
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005634731   ⟸   XM_005634674
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005634733   ⟸   XM_005634676
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003072   ⟸   NM_001003072
- UniProtKB: Q76LT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022264516   ⟸   XM_022408808
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000010478   ⟸   ENSCAFT00000011308
RefSeq Acc Id: XP_038288725   ⟸   XM_038432797
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288724   ⟸   XM_038432796
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288723   ⟸   XM_038432795
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288722   ⟸   XM_038432794
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288721   ⟸   XM_038432793
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288720   ⟸   XM_038432792
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288726   ⟸   XM_038432798
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007053 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000010478 ENTREZGENE
Ensembl Transcript ENSCAFT00000011308 ENTREZGENE
NCBI Gene BCL2L1 ENTREZGENE
UniProt Q76LT7 ENTREZGENE
VGNC ID VGNC:38408 ENTREZGENE